• KSII Transactions on Internet and Information Systems (TIIS)
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• 제18권3호
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• pp.685-703
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• 2024

Cloud computing provides each consumer with a large-scale computing tool. Different Cyber Attacks can potentially target cloud computing systems, as most cloud computing systems offer services to many people who are not known to be trustworthy. Therefore, to protect that Virtual Machine from threats, a cloud computing system must incorporate some security monitoring framework. There is a tradeoff between the security level of the security system and the performance of the system in this scenario. If strong security is needed, then the service of stronger security using more rules or patterns is provided, since it needs much more computing resources. A new way of security system is introduced in this work in cloud environments to the VM on account of resources allocated to customers are ease. The main spike of Fog computing is part of the cloud server's work in the ongoing study tells the step-by-step cloud server to change the tremendous measurement of information because the endeavor apps are relocated to the cloud to keep the framework cost. The cloud server is devouring and changing a huge measure of information step by step to reduce complications. The Medical Data Health-Care (MDHC) records are stored in Cloud datacenters and Fog layer based on the guard intensity and the key is provoked for ingress the file. The monitoring center sustains the Activity Log, Risk Table, and Health Records. Cloud computing and Fog computing were combined in this paper to review data movement and safe information about MDHC.

• Asia Marketing Journal
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• 제13권2호
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• pp.99-130
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• 2011

최근, 제품 디자인의 차별화 방법 중 하나로 제품에 명화(名畵)를 차용하는 이른바 '명화 마케팅(masterpiece marketing)'이 각광받고 있다. 본 연구는 시장에서 널리 사용되고 있는 명화 마케팅에 체계적이고 과학적인 방법을 적용하여, 명화에서 유발되는 감정이 제품 속성 평가에 영향을 미치는 중요한 요소임을 밝혀내고자 하였다. 본 연구는 명화가 가지는 본질적 기능인 감상자의 정서 유발에 초점을 맞추어, 차용된 명화에서 유발되는 감정(affect)이 해당 제품 평가에 어떠한 영향을 미치는 가에 대한 가설을 세웠다. 보다 구체적으로 기존 감정 연구에서 제시된 감정의 두 축, 쾌(pleasure), 환기(arousal)의 수준에서 차이가 나는 명화가 각각 제품에 차용되었을 경우, 소비자의 제품 평가에 어떠한 영향을 미치는 가에 대해 제품의 유형(실용재/ 쾌락재)과 각 속성(실용적 속성/ 쾌락적 속성)에 대한 평가의 차이를 통해 살펴보았다. 분석 결과, 긍정 감정을 야기하는 명화에 대한 선호도가 부정감정을 야기하는 명화에 대한 선호도보다 높았으며, 제품 유형에 관계없이 긍정감정을 유발하는 명화를 제품에 차용하였을 경우 부정감정을 유발하는 명화를 제품에 차용했을 때보다 제품태도가 더 높게 나타났다. 또한 이를 바탕으로 명화가 유발하는 감정이 제품태도에 미치는 영향은 명화에 대한 선호도에 의해 매개됨을 밝혀냈다. 감정의 또 다른 한 축인 환기 수준이 높은 명화를 실용재인 우유에 차용했을 경우, 쾌락적 속성에 대한 평가가 높아진 반면, 환기 수준이 낮은 명화를 차용했을 경우에는 실용적 속성에 대한 평가가 높아졌다. 그러나 쾌락재인 초콜릿의 경우 이러한 차이가 발견되지 않아 제품에 차용된 명화에서 유발되는 감정 수준(환기 수준)이 제품 유형에 따라 각각 다른 영향을 미치고 있음을 확인할 수 있었다. 본 연구는 다음과 같은 점에서 의의가 있다. 첫째, 시장에서 널리 사용되고 있는 명화 마케팅에 체계적이고 과학적인 방법을 적용하여, 명화에서 유발되는 감정이 제품 속성 평가에 영향을 미치는 중요한 요소임을 밝혀내었다. 둘째, 긍정/부정 감정에 초점을 두어 진행되었던 기존 연구에서 더 나아가 감정의 또 다른 축인 환기가 제품 속성평가에 차별적인 영향을 미칠 수 있음을 확인하였다.

• Preventive Nutrition and Food Science
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• 제7권3호
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• pp.238-244
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• 2002

Protective effect of skin by antioxidative dietary buchu (Chinese chives, Allium tuberosum Router), was evaluated in ICR mice fed diets containing 2% or 5% buchu for 12 months. Lipid peroxidation and protein oxidation in skin, with or without ultraviolet B (UVB) irradiation, activities of antioxidative enzymes, total glutathione concentrations, and non-soluble collagen contents were measured. Dietary buchu decreased significantly in TBARS and protein carbonyl levels in skin compared to the control group, and were lower in those fed 5% than 2% buchu diet group. ICR mice exhibited an age-dependent decrease in antioxidative enzyme activities and total glutathione concentrations on the control diet, but in the groups fed buchu diet the enzyme activities and glu-tathione concentrations remained at youthful levels for most of the study. SOD, glutathione peroxidase, and catalase activities as well as total glutathione concentrations increased with time in the skins of the mice fed buchu diets. Lipid peroxidation and protein oxidation provoked by UVB irradiation on ICR mice skin homogenates were also significantly inhibited by dietary buchu. The buchu diets also decreased the formation of non-soluble collagen in mice skin, compared to the control group. These results suggest that antioxidative components and sulfur-compounds in buchu may confer protective effect against oxidative stress resulting from aging and exposure to ultraviolet irradiation.

• Parasites, Hosts and Diseases
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• 제54권1호
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• pp.31-38
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• 2016

Specific gene expressions of host cells by spontaneous STAT6 phosphorylation are major strategy for the survival of intracellular Toxoplasma gondii against parasiticidal events through STAT1 phosphorylation by infection provoked $IFN-{\gamma}$. We determined the effects of small molecules of tyrosine kinase inhibitors (TKIs) on the growth of T. gondii and on the relationship with STAT1 and STAT6 phosphorylation in ARPE-19 cells. We counted the number of T. gondii RH tachyzoites per parasitophorous vacuolar membrane (PVM) after treatment with TKIs at 12-hr intervals for 72 hr. The change of STAT6 phosphorylation was assessed via western blot and immunofluorescence assay. Among the tested TKIs, Afatinib (pan ErbB/EGFR inhibitor, $5{\mu}M$) inhibited 98.0% of the growth of T. gondii, which was comparable to pyrimethamine ($5{\mu}M$) at 96.9% and followed by Erlotinib (ErbB1/EGFR inhibitor, $20{\mu}M$) at 33.8% and Sunitinib (PDGFR or c-Kit inhibitor, $10{\mu}M$) at 21.3%. In the early stage of the infection (2, 4, and 8 hr after T. gondii challenge), Afatinib inhibited the phosphorylation of STAT6 in western blot and immunofluorescence assay. Both JAK1 and JAK3, the upper hierarchical kinases of cytokine signaling, were strongly phosphorylated at 2 hr and then disappeared entirely after 4 hr. Some TKIs, especially the EGFR inhibitors, might play an important role in the inhibition of intracellular replication of T. gondii through the inhibition of the direct phosphorylation of STAT6 by T. gondii.

• 대한수의학회지
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• 제37권2호
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• pp.235-244
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• 1997

The present study was performed to investigate the patterns of appearance of lectin in trachea of fetuses of 60, 90 and 120 days old and neonates of Korean native goat. Carbohydrate markers were used in histochemistry for the determination of the lectin by staining of avidin-biotin-peroxidase complex(ABC), and the markers consisted of biotin-labeled concanavalin A(Con A), dolichos biflorus agglutinin(DBA), rincinus communis agglutinin(RCA-I), ulexeuropalus communis agglutinin(UEA) and wheat germ agglutinin(WGA). 1. The Con A-binding reactions appeared moderately on the apical surface of the tracheal epithelia in 60 days old fetuses, and the reactions were similar on the tracheal epithelia and glands in 90 and 120 days old fetuses and neonates. 2. Reaction of the DBA appeared as the strongest meanwhile the DBA-binding reactions were determined strongly on the apical surface of the tracheal epithelia in the 60 days old fetuses. Reaction for the DBA on the tracheal epithelia and glands of 90 and 120 days old fetuses and neonates were in same manner. 3. The RCA-I-binding reactions appeared very strongly on the apical surface of the tracheal epithelia in 60 and 90 days old fetuses. Reaction to the RCA-1 appeared moderately on certain apical surface of tracheal epithelia and glands in 120 days old fetuses and neonates. 4. No reactions provoked for the UEA in trachea of 60 days old fetuses and neonates, but the UEA-binding reactions appeared moderately in the tracheal epithelia of 90 days old fetuses and weakly in 120 days old fetuses. 5. The WGA-binding reactions appeared very strongly on the apical surface of the tracheal epithelia in 60 and 90 days old fetuses, and moreover, the reactions were determined on the luminal surface of the tracheal gland in 90 days old fetuses. On the other hand, goblet cells of the tracheal epithelia and glands in neonates reacted moderately to the WGA.

• 디지털콘텐츠학회 논문지
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• 제19권4호
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• pp.673-683
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• 2018

세월호 사건은 재난의 일반적인 피해 수준을 넘어 온 국민들에게 정신적 충격을 준 참사이다. 이 연구는 세월호 사건과 관련한 미디어 이용으로 대리된(vicarious) 재난 경험과 이용자의 외상 후 스트레스 장애(post-traumatic stress disorder: PTSD) 간의 연관성을 탐색하는 데 목적이 있다. 이를 위해 세월호 사건 발생 직후인 2014년 4월 28일부터 12일 동안 수도권 소재 종합대학과 중고등학교 학생 417명을 대상으로 수집한 답변 자료를 분석한 결과, 세월호 사태 기간 중에 주요 재난 사건 뉴스정보를 접하는 채널이 소셜 미디어인 경우 신문이나 TV방송보다 더 높은 수준의 외상을 나타냈다. 또한 재난 사건 뉴스정보와 소셜 미디어 이용량이 많을수록 PTSD와 정적인 인과관계를 나타냈다. 본 연구 결과는 재난 사건에 대한 미디어 매개 심리적 외상 문제의 작동기제와 경험적 결과를 제시하며 후속 연구를 촉발한다는 데 의의가 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5709-5714
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• 2012

Objective: To evaluate the effects of curcumin on matrixmetalloproteinase-9 (MMP-9) and invasion ability induced by transforming growth factor-${\beta}1$ (TGF-${\beta}1$) in MDA-MB-231 cells and potential mechanisms. Methods: Human breast cancer MDA-MB-231 cells were used with the CCK-8 assay to measure the cytotoxicity of curcumin. After treatment with 10 ng/ml TGF-${\beta}1$, with or without curcumin (${\leq}10{\mu}M$), cell invasion was checked by transwell chamber. The effects of curcumin on TGF-${\beta}1$-stimulated MMP-9 and phosphorylation of Smad2, extracellular-regulated kinase (ERK), and p38 mitogen activated protein kinases (p38MAPK) were examined by Western blotting. Supernatant liquid were collected to analyze the activity of MMP-9 via zymography. Following treatment with PD98059, a specific inhibitor of ERK, and SB203580, a specific inhibitor of p38MAPK, Western blotting and zymography were employed to examine MMP-9 expression and activity, respectively. Results: Low dose curcumin (${\leq}10{\mu}M$) did not show any obvious toxicity to the cells, while $0{\sim}10{\mu}mol/L$ caused a concentration-dependent reduction in cell invasion provoked by TGF-${\beta}1$. Curcumin also markedly inhibited TGF-${\beta}1$-regulated MMP-9 and activation of Smad2, ERK1/2 and p38 in a dose- and time-dependent manner. Additionally, PD98059, but not SB203580, showed a similar pattern of inhibition of MMP-9 expression. Conclusion: Curcumin inhibited TGF-${\beta}1$-stimulated MMP-9 and the invasive phenotype in MDA-MB-231 cells, possibly associated with TGF-${\beta}$/Smad and TGF-${\beta}$/ERK signaling.

• 한국공간정보시스템학회:학술대회논문집
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• 한국공간정보시스템학회 2005년도 추계학술대회
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• pp.257-270
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• 2005

Many studies states that improperly uprising of infrastructure may cause leading the forest degradation and canopy reduction in many tropical forest of Asian countries. Other studies revealed that habitat destruction and fragmentation, edge effects, exotic species invasions, pollution are provoked by roads. Similarly, environmental effects of road construction in forests are problematic. Similarly, many researches have been indicated that roads have a far greater impact on forests than simply allowing greater access for human use. Moreover, people using river as means of transportation hence illegal logging and felling cause canopy depletion in many countries. Therefore, it is important to comprehend the study about spatial relation of road, river and suburb followed by temporal change of forest canopy phenomena. This study also tried to examine the effect of road, river and suburb in forest canopy density change of Terai forest of Nepal from you 1988 to 2001. So, Landsat TM88, 92 and 001 and FCD (Forest Canopy Density) mapper were used to perform the spatial .elation of canopy density change. ILWIS (Integrated Land and Water Information System) which is GIS software and compatible with remote sensing data was used to execute analysis and visualize the results. Study found that influence of distance to suburb and river had statistically significance influenced in canopy change. Though road also influenced canopy density much but didn't show a statistical relation. It can be concluded from this research that understanding of spatial relation of factors respect with canopy change is quite complex phenomena unless detail analysis of surrounding environment. Hence, it is better to carry out comprehensive analysis with other additional factors such as biophysical, anthropogenic, social, and institutional factors for proper approach of their effect on canopy change.

• 한국언론정보학보
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• 제19권
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• pp.65-93
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• 2002

이 연구는 최근 들어 방송기술의 발달로 위성방송, 인터넷방송과 같이 전국성을 띠는 방송미디어가 속속 등장하면서 논란이 제기된 방송 권역 문제를 다루고 있다. 방송 권역의 문제는 위성방송 문제로 불거졌지만, 이 문제는 한국의 방송 철학과 이념에 대한 근본적인 문제를 제기하고 있다. 즉 방송 권역 문제는 새로운 미디어의 육성을 지향할 것인가? 커뮤니케이션 기술이 발달하더라도 지역문화, 지역언론의 역할을 중시해야 할 것인가? 등의 다양한 방송 이념과 관련 있기 때문이다. 이 연구에서는 방송 권역에 대한 기존의 논의를 평가한 뒤 방송 권역의 쟁점으로 방송 권역외 재송신, 위성방송 사업자의 지상파방송 재전송, 방송 권역의 광역화 등을 다루고 있다. 이 연구에서는 방송 권역의 목적이 기술적인 의미보다는 지역방송의 보호를 위해 유지되고 있으나, 방송 기술의 발전과 새로운 미디어의 등장으로 그 의미마저 상실되고 있음을 논의하고 있다. 따라서 방송 권역 개편을 통해 지역방송의 경쟁력을 강회하고 방송 권역과 관련된 방송사업자들의 문제를 풀어야 한다고 주장한다. 즉 디지털 멀티미디어 시대에 '방송 권역'의 의미를 재검토해야 한다고 주장하고 있다.

• IMMUNE NETWORK
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• 제12권1호
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• pp.27-32
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• 2012

Background: Toll-like receptors (TLRs) have been extensively studied in recent years. However, functions of these molecules in murine B cell biology are largely unknown. A TLR4 stimulant, LPS is well known as a powerful polyclonal activator for murine B cells. Methods: In this study, we explored the effect of a murine TLR9 stimulant, M6-395 (a synthetic CpG ODNs) on B cell proliferation and Ig production. Results: First, M6-395 was much more potent than LPS in augmenting B cell proliferation. As for Ig expression, M6-395 facilitated the expression of both TGF-${\beta}1$-induced germ line transcript ${\alpha}$ ($GLT{\alpha}$) and IL-4-induced $GLT{\gamma}1$ as levels as those by LPS and Pam3CSK4 (TLR1/2 agonist) : a certain Ig GLT expression is regarded as an indicative of the corresponding isotype switching recombination. However, IgA and IgG1 secretion patterns were quite different--these Ig isotype secretions by M6-395 were much less than those by LPS and Pam3CSK4. Moreover, the increase of IgA and IgG1 production by LPS and Pam3CSK4 was virtually abrogated by M6-395. The same was true for the secretion of IgG3. We found that this unexpected phenomena provoked by M6-395 is attributed, at least in part, to its excessive mitogenic nature. Conclusion: Taken together, these results suggest that M6-395 can act as a murine polyclonal activator but its strong mitogenic activity is unfavorable to Ig isotype switching.