• 대한한방내과학회지
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• 제34권3호
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• pp.256-266
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• 2013

Objectives : The purpose of this study was to investigate the protective effects of Magnolia Officinalis extracts on the animal model of depression induced by immobilization stress. Methods : The subjects were divided into 4 groups : normal, saline solution-administered during immobilization stress, 200 mg/kg of magnolia extracts-administered (magnolia extract 200), and 400 mg/kg of magnolia extracts- administered (magnolia extract 400). During 2 days of immobilization stress treatment, they underwent forced swimming test (FST) and tail suspension test (TST). The number of serotonin (5-HT) immunostained nuclei in the dorsal raphe nucleus regions was measured by immunohistochemistry. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) in blood were measured. Results : In FST, magnolia-administered groups showed significantly decreased immobilization. In TST, the magnolia extract 400 group showed decreased immobilization. The stress group showed significantly decreased number of 5-HT immunostained nuclei in the dorsal raphe nucleus regions, while magnolia extract 400 group showed increased number of 5-HT immunostained nuclei. Stress group showed decrease in serum level of SOD and GPX, while the magnolia extract 200 group showed increase in serum level of SOD and GPX. Conclusions : These results suggest potent effectiveness of magnolia extracts in the treatment of depression.

• 동의신경정신과학회지
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• 제18권2호
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• pp.45-55
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• 2007

Objective : The purpose of this study was to investigate the protective effects of Radix Curcumae on the animal model of depression induced immobilization stress. Method : 1) Male rats were used for this experiment. The subject were divided into 4 groups(1. normal 2. saline solution administered during immobilization stress treatment 3. Radix Curcumae of l00mg/kg administered 4. Radix Curcumae of 400mg/kg administered). 2) Immobilization stress was treated for 1 hours on day. During 2 days of immobilization stress treatment, they were executed forced swimming test, passive avoidance test, elevated plus maze test. Corticosterone in blood were measured. Results : 1) In EPM test, stress group showed significantly increased anxiety, Radix Curcumae of 400mg/kg group showed significantly decreased anxiety. 2) In forced swimming test, Radix Curcumae of 400mg/kg group showed significantly decreased immobilization. 3) In passive avoidance test, stress group showed significantly decreased learning execution, Radix Curcumae groups showed significantly increased learning execution. 4) Stress group showed significantly increase in serum level of corticosterone, Radix Curcumae of 400mg/kg group showed significantly decreased serum level of corticosterone. Conclusion : These results suggest that Radix Curcumae is effective in the treatment of depression.

• 수산해양기술연구
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• 제37권2호
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• pp.147-152
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• 2001

본 연구에서는 수도수 중에서 Mg합금유전양극에 의한 연강재 온수보일러의 음극방식특성을 연구한 결과 다음과 같은 결론을 얻었다. 1) 온수보일러 관체의 개로전위에서나 전위가 높은 구간에서 모재의 부식전류밀도가 용접부위의 부식전류밀도보다 더 적게 배류된다. 2) 주조된 표면 그대로의 Mg합금 유전양극의 전류밀도는 주조된 표면을 연마한 상태의 Mg합금 유전양극의 전류밀도보다 더 많이 배류된다. 3) Mg합금 유전양극으로부터 거리가 멀어질수록 연강재 온수보일러의 음극방식전위는 높게 나타나고, 음극방식시간이 경과하면서 방식전위는 높게 나타나다가 6-10일 이후부터 방식전위는 안정되고 있다.

• 한국분말재료학회지
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• 제14권6호
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• pp.372-379
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• 2007

The microstructure, mechanical and electrochemical properties of plasma electrolytic coatings (PEO) coatings on Mg-4.3 wt%Zn-1.0 wt%Y and Mg-1.0 wt%Zn-2.0 wt%Y alloys prepared by gas atomization, followed by compaction at 320 for 10 min under the pressure of 700 MPa and sintering at 380 and 420 respectively for 24 h, were investigated, which was compared with the cast Mg-1.0 wt%Zn alloy. All coatings consisting of MgO and $Mg_2SiO_4$ oxides showed porous and coarse surface features with some volcano top-like pores distributed disorderly and cracks between pores. In particular, the surface of coatings on Mg-1.0 wt%Zn-2.0 wt%Y alloy showed smaller area of pores and cracks compared to the Mg-4.3 wt%Zn-1.0 wt%Y and Mg-1.0 wt%Zn alloys. The cross section micro-hardness of coatings on the gas atomized Mg-Zn-Y alloys was higher than that on the cast Mg-1.0 wt%Zn alloy. Additionally, the coated Mg-1.0 wt%Zn-2.0 wt%Y alloy exhibited the best corrosion resistance in 3.5%NaCl solution. It could be concluded that the addition of Y has a beneficial effect on the formation of protective and hard coatings on Mg alloys by plasma electrolytic oxidation treatment.

• 인터넷정보학회논문지
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• 제18권6호
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• pp.75-84
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• 2017

As there has been growing interests in PHR-based personalized health management project, various institutions recently explore safe methods of recording personal medical and health information. In particular, innovative medical solution can be realized when medical researchers and medical service institutes can generally get access to patient data. As EMR data is extremely sensitive, there has been no progress in clinical information exchange. Moreover, patients cannot get access to their own health data and exchange it with researchers or service institutions. It can be operated in terms of technology, yet policy environment are affected by state laws as well as Privacy and Security Policy. Blockchain technology-independent, in transaction, and under test-is introduced in the medical industry in order to settle these problems. In other words, medical organizations can grant preliminary approval on patient information exchange by using the safely encrypted and distributed Blockchain ledger and can be managed independently and completely by individuals. More apparently, medical researchers can gain access to information, thereby contributing to the scientific advance in rare diseases or minor groups in the world. In this paper, we focused on how to manage personal medical information and its protective use and proposes medical treatment exchange system for patients based on a permissioned Blockchain network for the safe PHR operation. Trusted Model for Sharing Medical Data (TMSMD), that is proposed model, is based on exchanging information as patients rely on hospitals as well as among hospitals. And introduce medical treatment exchange system for patients based on a permissioned Blockchain network. This system is a model that encrypts and records patients' medical information by using this permissioned Blockchain and further enhances the security due to its restricted counterfeit. This provides service to share medical information uploaded on the permissioned Blockchain to approved users through role-based access control. In addition, this paper presents methods with smart contracts if medical institutions request patient information complying with domestic laws by using the distributed Blockchain ledger and eventually granting preliminary approval for sharing information. This service will provide an independent information transaction and the Blockchain technology under test will be adopted in the medical industry.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2012년도 추계총회 및 학술대회 논문집
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• pp.16-16
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• 2012

Mg and its alloys have been of great interest because of their low density of 1.7, 30% lighter than Al, but their wide applications have been limited because of their poor resistances against corrosion and/or abrasion. Corrosion resistance of Mg alloys can be improved by formation of anodic films using anodic oxidation method in aqueous electrolytes. Plasma electrolytic oxidation (PEO) is one of anodic oxidation methods by which hard anodic films can be formed as a result of micro-arc generation under high electric field. PEO method utilize not only substrate elements but also chemical components in electrolytes to form anodic films on Mg alloys. PEO films formed on AM50 magnesium alloy in an acidic fluozirconate electrolyte were observed to consist of mainly $ZrO_2$ and $MgF_2$. Liu et al reported that PEO coating on AM30 Mg alloy consists of $MgF_2$-rich outer porous layer and an MgO-rich dense inner layer. PEO films prepared on ACM522 Mg die-casting alloy in an aqueous phosphate solution were also reported to be composed of monoclinic $Mg_3(PO_4)_2$. $CeO_2$-incorporated PEO coatings were also reported to be formed on AZ31 Mg alloys in $CeO_2$ particle-containing $Na_2SiO_3$-based electrolytes. Magnesium tin hydroxide ($MgSn(OH)_6$) was also produced on AZ91D alloy by PEO process in stannate-containing electrolyte. Effects of $OH^-$, $F^-$, $PO{_4}^{3-}$ and $SiO{_3}^{2-}$ ions and alloying elements of Al and Sn on the formation of PEO films on pure Mg and Mg alloys and their protective properties against corrosion have been investigated in this work. $PO{_4}^{3-}$, $F^-$ and $SiO{_3}^{2-}$ ions were observed to contribute to the formation of PEO films but $OH^-$ ions were found to break down the surface films under high electric field. The effect of pulse current on the formation of PEO films will be also reported.

• Corrosion Science and Technology
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• 제5권6호
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• pp.218-221
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• 2006

Influence of microstructure on the corrosion property of Mg-Al-Zn alloy was investigated using potentiodynamic polarization experiments, galvanic coupling experiments, and scanning electron microscopy in sodium chloride solutions. Pitting was the most common form of attack in chloride solution, and filiform corrosion was also occurred in AZ91D-T4 alloy. On the contrary, filiform attack in the bulk matrix was predominant corrosion form in AZ91D-T6 alloy, and the number and size of pit were decreased than those of AZ91D-T4 alloy. Galvanic coupling effect between $Mg_{17}Al_{12}$ and matrix was existed, but the propagation of galvanic corrosion was localized only near the $Mg_{17}Al_{12}$ phase in AZ91D-6T alloy. The corrosion resistance of Mg-Al matrix increased with decreasing Al content in the matrix. And, it could be regarded that Al content in the matrix is decreased by precipitation of $Mg_{17}Al_{12}$ during the aging treatment and it decreases the anodic reaction rate of the matrix and galvanic effect in AZ91D-T6 alloy. It could be considered that the composition and microstructure of surface protective layer would be varied by precipitation of $Mg_{17}Al_{12}$ and subsequent decreasing of Al content in the matrix. And it would contribute the corrosion resistance of AZ91D-T6 aging alloy.

• 조명전기설비학회논문지
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• 제19권2호
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• pp.55-62
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• 2005

건설현장의 임시전력설비는 최소한의 보호장치, 산만한 작업환경, 전기설비의 노후화 등의 불안요인에 의해 타설비에 비해 많은 감전위해요인을 나타내고 있다. 이중 22.9[kV] 수전설비에 사용되는 계기용변성기 절연커버는 절연커버와 전선 인입 및 인출부 사이의 이격거리가 짧아 전기안전 측면에서 좋은 성능을 나타내지 못하고 있다. 절연커버와 부싱 사이의 크기 차이로 바람, 비등의 외부 환경에 의해 절연커버의 유동이 쉽게 발생하며, 트래킹에 의한 절연파괴로 이어질 수 있다. 따라서 본 논문에서는 전기재해를 효과적으로 방지할 수 있는 계기용변성기 절연커버를 제안하였으며 이미 실용신안으로 등록되었다. 특정 부위의 전계 집중을 감소시키기 위해 절연커버의 형상을 곡면으로 설계하였고 절연커버와 충전부 사이의 이격거리를 기존의 방식보다 더 길어지도록 조정하였다. 제안된 절연커버는 전계해석 프로그램에 의해 평가되었다.

• Corrosion Science and Technology
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• 제16권6호
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• pp.317-327
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• 2017

The change in the oxidation behavior of three types of B-added ultrahigh strength martensitic steels containing Ti and Nb induced by applying constant cathodic current was investigated. In a 3% NaCl+0.3% $NH_4SCN$ solution, the overall polarization behavior of the three alloys was similar, and degradation of the oxide film was observed in the three alloys after applying constant cathodic current. A significant increase in the anodic current density was observed in the Nb-added alloy, while it was diminished in the Ti-added alloy. Both Ti and Nb alloying decreased the hydrogen overpotential by forming NbC and TiC particles. In addition, the thickest oxide film was formed on the Ti-added alloy, but the addition of Nb decreased the film thickness. Therefore, it was concluded that the remarkable increase in the anodic current density of Nb-added alloy induced by applying constant cathodic current density was attributed to the formation of the thinnest oxide film less protective to hydrogen absorption, and the addition of Ti effectively blocked the hydrogen absorption by forming TiC particles and a relatively thick oxide film.

• Journal of Acupuncture Research
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• 제23권2호
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• pp.91-102
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• 2006

Objectives : Ulmus davidiana Planch (UD) has long been known to have anti-inflammatory and protective effects on damaged tissue, inflammation and bone among other functions. Methods : This study was undertaken to address whether the water extract of the bark of UD could modulate proliferation of mouse osteoclasts in vitro and to investigate its effect on cyclooxygenase-2 (COX-2), which converts arachidonic acid to prostaglandin E2 (PGE2) and is highly expressed in osteoclasts. Mouse osteoclasts were tested in vitro for growth inhibition, proliferation cell nuclear antigen expression, and COX-2 activity and expression after treatment with UD extract. Results : Its effects were compared with those of indomethacin (a nonselective COX inhibitor) and celecoxib (a selective COX-2 inhibitor) by Cell viability assay, Cell cycle analysis, Immunohistochemical analysis of PCNA expression, Western blot analysis and PGE2 Enzyme immunoassay (EIA). UD demonstrated a strong growth inhibitory action in both tested osteoclasts cells. The IC50s were $10\;{\mu}g/ml$ for UD, $6\;{\mu}M$ for celecoxib and $42\;{\mu}M$ for indomethacin. UD, as well as celecoxib and indomethacin, suppressed proliferation cell nuclear antigen expression and PGE2 synthesis in osteoclasts. UD inhibited COX-2 expression, whereas celecoxib inhibited COX-2 activity directly. Conclusion : UD selectively and effectively inhibits osteoclasts cell growth in vitro. Inhibitory action of PGE2 synthesis via suppression of COX-2 expression may be responsible for its anti-inflammatory activity.