• 한국사회복지학
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• 제59권2호
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• pp.251-275
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• 2007

아동학대는 그 자체로 아동의 전반적 발달에 영향을 주며, 심각한 사회문제를 야기할 수 있기 때문에 중요하게 검토되어야 할 문제이다. 이와 관련하여 아동학대 연구가 활발히 진행되고 있으나, 대부분의 연구가 학대의 부정적 결과에만 초점을 두고 있어 아동학대를 경험했음에도 불구하고 성공적으로 적응하는 적응유연 한 아동들을 설명하는데 제한적이었다. 이에 본 연구는 학대경험에도 불구하고 유능함을 보이는 아동의 특성, 즉 보호요인에 초점을 두고 보호요인이 어떻게 적응유연성에 영향을 미치는지 살펴보고자 한다. 이를 위해 한국청소년개발원에서 2004년에 전국의 초등학교 4학년 아동을 대상으로 조사한 한국청소년패널조사(KYPS) 자료를 사용하였다. 분석방법은 측정모형과 구조모형을 동시에 고려하고 측정오차를 포함하여 분석하는 구조방정식모형인 Mplus를 사용하였다. 분석결과, 위험요인인 학대는 아동의 적응유연성에 부정적 영향을 미치며, 보호요인은 적응유연성에는 긍정적 영향을 미치고, 위험요인이 적응유연성에 미치는 부정적 영향을 매개하여 완화시키는 것으로 나타났다. 이상의 결과를 토대로 피학대아동의 적응유연성을 향상시키기 위한 실천적 개입전략을 살펴보았다.

• 한국환경복원기술학회지
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• 제21권1호
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• pp.133-143
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• 2018

In spite of the growing importance of landscaping trees, the rate of flawed and withered trees damaged by pest, disease, drought or frost is increasing. In order to evaluate the performance of the Tree Protective Pad, which are developed to reduce the failure ratio in landscape planting, the tree protective pad for 'digging', 'pest controlling', and 'insulating' are tested based on the five functional criteria; moisturizing effect, wither preventive effect, pest and disease control, thermal effect, tensile strength, and environmental performance. The result of this study is as follows. The moisturizing effect of the tree protective pad for digging is found to be outstanding. According to the result of testing the pad on trees, in particular, it is better than jute tape in wither preventive effect, which means it is expected to prevent flaw and wilt from planting during the improper seasons like summertime. The experiment of installing the protective tree pad for pest controlling to the trunk of Quercus mongolica shows that preventive effect of the pad from diseases and insects is superior, and it also has economical effect by reducing the use of agricultural chemicals. The comparative test of the pad for insulating and jute tape proves that the temperature of the pad is about $2^{\circ}C$ higher than outside. The rate of tensile strength and biodegradation of the pad exceeds the optimal level, so it is revealed that the pad may be the work efficient and environment-friendly product. Likewise, by timely irrigating trees, the tree protective pad economically prevents trees from pest, disease,drought or frost, which may be caused by improper seasonal or delayed planting. As a means of reducing the flaw and facilitating the growth of trees, the exceptional performance of the pad is expected to effectively used in landscape planting and management.

• International Journal of Oral Biology
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• 제33권4호
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• pp.137-141
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• 2008

The present study reports the protective properties of a total methanol extract of B. platyphylla var. japonica against ultraviolet (UV)-C irradiation. Pretreatment of Chinese hamster fibroblast (V79-4) cells with a total methanol extract significantly increased cell survival following $300\;J/m^2$ of UV-C irradiation. The total methanol extract was further fractionated into 5 fractions: n-hexane, dichloromethane, ethylacetate, n-butanol and water fractions. Among these fractions, B. platyphylla var. japonica ethylacetate, butanol and water fractions showed significant protective effects against the cellular damage induced by UV-C irradiation. In order to elucidate the mechanism underlying this protective effect, DPPH (Editor note: abbreviations should be spelled out at first use.) radical scavenging and lipid peroxidation inhibitory activity were measured. Significant radical scavenging and lipid peroxidation inhibitory activities were observed for the ethylacetate fraction. In summary, the present data demonstrate that an extract of B. platyphylla var. japonica has a significant protective effect against UV-C irradiation. The underlying mechanism of this protective effect may involve radical scavenging and inhibition of lipid peroxidation by the B. platyphylla var. japonica extract.

• 대한한방부인과학회지
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• 제24권2호
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• pp.33-51
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• 2011

Objectives: This study was performed to assess the protective effect of Saengmaek-san (SM) on UVB-induced HaCaT cell damage. Methods: The protective effects of Saengmaek-san(SM) were determined by UVB-induced HaCaT assay. We assessed protective effects of Saengmaek-san (SM) on LDH release and nitrite release from HaCaT. And COX-2, Bcl-2, Bax, $TNF{\alpha}$, c-jun, c-fos, NF-kB, iNOS, Bcl-xL gene expression were determined in HaCaT using real-time PCR method. Results: 1. SM inhibited LDH-release, nitrite production in UVB-exposed HaCaT. 2. SM suppressed the gene expression of COX-2, $TNF{\alpha}$ in UVB-exposed HaCaT. 3. SM increased the gene expression of Bcl-2, Bax, Bcl-xL family protein in UVB-exposed HaCaT. 4. SM suppressed the gene expression of c-jun, c-fos, NF-kB in UVB-exposed HaCaT. Conclusions: The study showed SM inhibited the cell damage in UVB-exposed HaCaT.

• 대한의생명과학회지
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• 제14권1호
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• pp.27-32
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• 2008

To clerify the antioxidant effect of Crataegi Fructus (CF) extract on reactive oxygen species (ROS), The C6 glioma cells were treated with various concentrations of hydrogen peroxide ($H_2O_2$). The $H_2O_2$-induced neurotoxicity was measured by XTT assay for the cell viability. For the protective effect of CF extract on the cytotoxicity induced by $H_2O_2$, cell viability, lactate dehydroganase (LDH) activity, and the inhibitive activity of lipid peroxidation of CF extract were performed. In this study, $H_2O_2$ decreased cell viability dose- and time-dependent manners and increased LDH activity compared with the control. In the protective effect on $H_2O_2$, CF extract increased cell viability and decreased LDH activity on $H_2O_2$-induced cytotoxicity, lipid peroxidation by FTC assay. From these results, It is suggested that $H_2O_2$ was highly toxic on cultured C6 glioma cells, and also, CF extract showed the protective effect on $H_2O_2$-mediated cytotoxicity.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 춘계학술대회
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• pp.92-92
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• 1995

It has been suggested that oxygen-derived free radicals have an important role in the pathophysiology of acute gastric ulceration induced by NSAIDs and ischemia-reperfusion. Taurine is hypothetized to exert its protective effect on NSAIDS-induced gastric injury by its antioxidant properties, Protect ive effect of taurine on indomethacin-induced gastric mucosal lesion and its protective mechanism were investigated. Intragastric administration of 25 mg/kg of indomethacin induced hemorrhagic lesions on the glandular stomach in rats, Pretreatment with 0.25 g/kg of taurine for 3 days significantly reduced the gastric lesion formation and Inhibited the elevation of lipid peroxide level In gastric mucosa. Both resting and FMLP-induced luminol-dependent chemiluminescence of rat peritoneal neutrophils increased immediately after treatment of indomethacin. 5-20mM of taurine inhibited chemiluminescence of neutrophils activated by indomethacin and/or FMLP. Human neutrophils (polymorphonuclear leukocytes) significantly adhered to confluent monolayer of human umbilical vein endothelial cells(HUVEC) after coincubation with aspirin or indomethacin. Also taurine prevented neutrophil adhesion induced by these drugs to HUVEC in dose-dependent manner. These results indicate that the protective effect of taurine against NSAIDS-induced gastric mucosal Injury is due to its antioxidant effect, which inhibits lipid peroxidation and neutrophil activation.

• Bulletin of the Korean Chemical Society
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• 제35권1호
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• pp.117-122
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• 2014

As a Chinese herbal medicine used in East Asia for thousands years, Cortex Magnoliae Officinalis (CMO) was observed to possess a protective effect against OH-induced DNA damage in the study. To explore the mechanism, the antioxidant effects and chemical contents of five CMO extracts were determined by various methods. On the basis of mechanistic analysis, and correlation analysis between antioxidant effects & chemical contents, it can be concluded that CMO exhibits a protective effect against OH-induced DNA damage, and the effect can be attributed to the existence of phenolic compounds, especially magnolol and honokiol. They exert the protective effect via antioxidant mechanism which may be mediated via hydrogen atom transfer (HAT) and/or sequential electron proton transfer (SEPT). In the process, the phenolic-OH moiety in phenylpropanoids is oxidized to the stable quinine-like form and the stability of quinine-like can be ultimately responsible for the antioxidant.

• Archives of Pharmacal Research
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• 제19권2호
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• pp.85-90
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• 1996

It has been suggested that oxygen-derived free radicals play an important role in the pathophysiology of acute gastric ulceration induced by NSAIDs and ischemia-reperfusion. Taurine is hypothetized to exert its protective effect on NSAIDs-induced gastric injury by its antioxidant properties. Protective effect of taurine on indomethacin-induced gastric mucosal lesion and its protection mechanism were investigated. Intragastric administration of 25 mg/kg of indomethacin induced hemorrhagic lesions on the glandular stomach in rats. Pretreatment with 0.25 or 0.5 g/kg of taurine one day before or for 3 days significantly reduced the gastric lesion formation and inhibited the elevation of lipid peroxide level in gastric mucosa. The luminol-dependent chemiluminescence of rat peritoneal neutrophils increased immediately after treatment of FMLP or indomethacin. Taurine (5-20 mM) inhibited chemiluminescence of neutrophils activated by FMLP. Human neutrophils (polymorphonuclear leukocytes) significantly adhered to the confluent monolayer of human umbilical vein endothelial cells (HUVEC) after coincubation with indomethacin. This neutrophil adhesion induced by indomethacin to HUVEC was prevented by taurine in a dose-dependent manner. These results indicate that the protective effect of taurine against NSAIDs-induced gastric mucosal injury is due to its antioxidant effect, which inhibits lipid peroxidation and neutrophil activation.

• 사회복지연구
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• 제40권3호
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• pp.41-68
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• 2009

조손가족 청소년들은 일반 가족의 청소년들에 비해 부정적인 환경에 노출됨으로써 심리사회적으로 부정적인 영향을 받는 경향이 높기 때문에 중요하게 검토되어야 한다. 이와 관련하여 조손가족 청소년의 위험요인, 보호요인과 학교 적응유연성 간의 관계를 다룬 연구가 이루어지고 있으나, 대부분 청소년의 위험요인, 보호요인과 학교 적응유연성 간의 단편적인 관계를 설명하는데 그치고 있다. 이에 본 연구는 조손가족 청소년의 위험요인과 보호요인 간, 그리고 이들과 학교 적응유연성 간의 매개적인 경로와 인과관계를 살펴보는데 목적을 두었다. 이를 위해 전국 단위의 조손가족 청소년 328명을 대상으로 조사하였고, 분석방법은 SEM을 사용하였다. 분석결과는 다음과 같다. 조손가족 청소년의 위험요인, 보호요인과 학교적응유연성 간의 직접효과와 보호요인의 매개효과를 검증하기 위해 구조회귀모형을 검증한 결과 모형의 적합도가 타당하게 나타났다. 위험요인은 청소년의 학교적응유연성에 부정적 영향을 미치며(교사의 무관심, 부정적 애착관계, 우울불안 순), 보호요인은 학교 적응유연성에 긍정적 영향을 미쳤다(교사의 지지, 자아존중감 순). 또 보호요인은 위험요인이 학교 적응유연성에 미치는 부정적 영향을 매개하여 완화시키는 것으로 나타났다.

• 한국사회복지학
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• 제56권4호
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• pp.269-290
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• 2004

본 연구는 미국 청소년들의 문제성 음주에 대한 심리사회적 보호변인들과 위험변인들의 영향력을 확인하고, 이들 중 보호변인들의 역할을 보다 구체적으로 검토하기 위해서 개별 보호변인의 보상효과와 완충효과를 분석하였다. 연구 자료는 The Monitoring the Future 2002 연구의 10학년 4,362명의 사례를 활용하였으며, 자료 분석방법으로는 위계회귀분석이 사용되었다. 분석결과는 친구의 영향력, 감각추구성향, 일탈행동경험이 문제성 음주에 대해 유의미한 위험변인으로 기능함을 보여주었다. 보호변인의 경우에는 음주결과에 대한 부정적 기대, 부모와의 유대, 학교에 대한 유대, 친사회적 활동이 직접적으로 문제성 음주의 감소에 영향을 주는 보상효과를 나타냈다. 또한 음주결과에 대한 부정적 기대는 친구의 영향력을 완화시켜 문제성 음주를 감소시키는 유의미한 완충효과를 가지고 있었다. 본 연구는 이러한 결과를 바탕으로 문제성 음주에 대한 예방적 개입을 위한 실천적 방안을 제시하였다.