• The Korean Society of Law and Medicine
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• v.8 no.2
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• pp.119-164
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• 2007

Improving the formal objection system regarding reviewing medical expenses requires authority and confidence in the aspect of well-functioning the health insurance review and assessment system, legally and appropriately. The purposes of improvement of the formal objection system should aim for protecting the people's right of health. On handling the formal objections, the disputes of the rights should be settled economically and promptly by fairness, specialty, and objectivity in the health insurance review and assessment administration. Therefore, in order to promote the administrative specialty of health insurance, the formal objection committee needs to be organized independently and guaranteed expertly. Under the current formal objection system, however, the organization of committee lacks right-relief function, recognition and public relation as a health insurance appeal system, and related professional man powers. It is also analyzed that there are several controversial points, such as mass deliberation to the formal objection committee and its conference procedure. As a measure of improvement, it is analyzed that the committee needs to be organized independently with a proper number of professional man powers. The strict deliberation procedures and the prohibition of the decision-making by non-conference are also required to be empowered. The formal objection procedure provides the beneficiaries and the claims legitimately, so that it secures the legal relations on the health insurance system. Therefore, on the conference process of formal objection, the expert and guaranteed protection should be provided promptly, and its procedures to the appellants should also be assisted kindly.

• Journal of Life Science
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• v.24 no.12
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• pp.1378-1382
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• 2014

Phospholipase D (PLD) catalyzes the hydrolysis of phospholipid to phosphatidic acid (PA), a lipid secondary messenger. Two forms of PLD isozymes, phosphatidylcholine-specific PLD1 and PLD2, have been identified. PLD has emerged as a critical regulator of cell proliferation and survival signaling, and dysregulation of PLD occurs in a various illnesses, including cancer. PLD activity is essential for cell survival and protection from apoptosis. Overexpression of PLD isozymes or PLD-generated PA attenuates the expression of apoptotic genes and confers resistance to apoptosis. The apoptosis-related molecular mechanisms of PLD remain largely unknown. Recently, the dynamics of PLD turnover during apoptosis have been reported. The cleavage of PLD isozymes as specific substrates of caspase differentially regulates apoptosis. PLD1 is cleaved at one internal site, and PLD2 is cleaved two sites at the front of the N-terminus. The cleavage of PLD1 reduces its enzymatic activity, probably via the dissociation of two catalytic motifs, whereas the cleavage of PLD2 does not affect the catalytic motifs and its activity. Thus, PLD2 maintains antiapoptotic capacity, despite its cleavage. Therefore, the differential cleavage pattern of PLD isozymes by caspase affects its enzymatic activity and antiapoptotic function. Thus, PLD is considered a potential target for cancer therapy. We summarize recent studies regarding the functional role of PLD in apoptosis.

• Toxicological Research
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• v.29 no.1
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• pp.61-67
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• 2013

Development of a therapy providing protection from, or reversing gentamicin-sulfate (GS)-induced oxidative stress and nephrotoxicity would be of great clinical significance. The present study was designed to investigate the protective effects of Houttuynia cordata Thunb. (HC) against gentamicin sulfate-induced renal damage in rats. Twenty-eight Sprague-Dawley rats were divided into 4 equal groups as follows: group 1, control; group 2, GS 100 mg/kg/d, intraperitoneal (i.p.) injection; group 3, GS 100 mg/kg/d, i.p. + HC 500 mg/kg/d, oral; and group 4, GS 100 mg/kg/d i.p. + HC 1000 mg/kg/d, oral administration). Treatments were administered once daily for 12 d. After 12 d, biochemical and histopathological analyses were conducted to evaluate oxidative stress and renal nephrotoxicity. Serum levels of creatinine, malondialdehyde (MDA), and blood urea nitrogen (BUN), together with renal levels of MDA, glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) were quantified to evaluate antioxidant activity. Animals treated with GS alone showed a significant increase in serum levels of creatinine, BUN, and MDA, with decreased renal levels of GSH, SOD, and CAT. Treatment of rats with HC showed significant improvement in renal function, presumably as a result of decreased biochemical indices and oxidative stress parameters associated with GS-induced nephrotoxicity. Histopathological examination of the rat kidneys confirmed these observations. Therefore, the novel natural antioxidant HC may protect against GSinduced nephrotoxicity and oxidative stress in rats.

• Korean Journal of Veterinary Research
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• v.36 no.1
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• pp.209-219
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• 1996

This study examined the effect of alcohol(AL) and/or paraquat(PQ) on serum TSH, thyroid hormones and enzyme activities, and the protective effect of selenium(SE) againse alcohol and/or paraquat-induced thyroid toxicity in guinea pigs. The experomental group consisted of control, 15% alcohol(AL), 4ppm sodium selentite(SE), 200ppm paraquat(PQ), AL+PQ, AL+SE, PQ+SE and AL+PQ+SE mixed in drinking water-fed guinea pigs for 4 weeks. The morphological changes of thyroid gland were studies on paraffin-embedded sections stained with H-E stain. Body weight losses, high serum concentration in TSH and cholesterol, and low values on triiodothyronine($T_3$), thyrozine($T_4$), free $T_4$ and alkaline phosophatase(ALP) were produced in the groups fed AL and/or PQ. We also noted that AL+PQ-fed group was marked increase in serum TSH. In AL or AL+PQ-fed groups when cpmpared to control group had increased the ratio of thyroid weight to body weight(ratio Twt/Bwt), whereas the ratio Twt/Bwt was decresed in SE or PQ-fed groups. However, the serum TSH, $T_3$,$T_4$ free $T_4$ and cholesterol values, and the ratio Twt/Bwt were reversed in groups given the combination of SE, compared with AL and/or Pq-fed groups, also ALP values were reversed in groups given the combination of SE, compared with AL or AL+PQ-fed groups. In microscope, morphological changes showed a remarkable between the AL or PQ-fed group and controls. In AL+PQ+SE-fed guinca pig, follicular colloid is high density in thyroid follicle and increased in connective tissue around the thyroid cells, and thyroidal epithelia were composed of cuboidal or columnar epithelium. The indicated that the morphological changes of thyroid were direct action in the thyroid cell. The results of this study confirmed that the toxic effect of AL or PQ on thyroid occur independently of changes in liver function, and that SE confers marked protection against AL or PQ-induced thyroid toxicity.

• Journal of Chest Surgery
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• v.29 no.2
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• pp.239-243
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• 1996

Chest wall reconstruction Is difficult because of the physiological and anatomical functions of thoracic cavity where the thoracic cavity must be stabilized in order to prevent paradoxical motion, and adequate protection must be provided to the mediastinal structures. A 37-year-old male patient with full-thickness defect on the left anterior thoracic cavity due to traffic accident was treated. Emergency operation was performed for debridement and bleeding control, and on postoperative 25 days, chest wall reconstruction was performed as a second-stage operation. Left anterior chest wall was reconstructed with latissimus dorsi myocutaneous flap which had thoracodorsal arterial pedicle, and split-thickness skin grift from the left thigh was done. After chest wall reconstruction, spontaneous self-respiration was possible without ventilatory support. The pulmonary function test performed at postoperative 3 months revealed 80% of predicted values (FVC, FEV1.0). The postoperative result of chest wall reconstruction using latissimus dorsi myocutaneous flap was excellent anatomically, physiologically and aesthetically.

• Korean Journal of Environmental Agriculture
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• v.25 no.2
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• pp.109-117
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• 2006

Photoinhibition and photoprotection of PSII in the leaves of hot pepper (Capsicum annuum L.) grown in Hoagland solution and Tap water were compared. Though changes in the rates of $O_2$ evolution as a function of photon fluence rate (PFR) were comparable, the rates of respiration in the dark was 3 times higher in the Hoagland solution grown leaves than in the Tap-water grown ones. Compared to Hoagland solution grown plane, PSIIs of Tap water grown pepper leaves were more susceptible to photoinhibitory light treatment. In order to inactivate functional PSII to the same extents, Hoagland solution grown plants required almost 2-fold high light $(1600{\mu}molm^{-2}s^-)$ treatment than those of Tap water $(900{\mu}molm^{-2}s^-)$. Interestingly, the remaining fraction of PSII in Hoagland grown pepper was able to survive under prolonged illumination in the presence of lincomycin, which probably means that the growth condition of plant seemed to have an effect on the recovery of PSII from light stress. When PSII was severly photoinactivated at a chilling temperature, recovery was observed only if the residual functional PSII were not inhibited with DCMU, Nigericin and MV during recovery. In conclusion, PSIIs grown in the Hoagland solution was more resistant to excess light than in the Tap water grown one and the recovery of PSII from photodamage was more efficient in Hoagland grown pepper leaves than Tap water grown one, which means that the increased dark respiration may play a important role in the protection of PSII from photoinhibition by helping repair photosynthetic proteins (in particular, the D1 protein of PSII) degraded by photoinhibition.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.11
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• pp.2341-2346
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• 2012

Voice phishing against the old or weak persons have used the methods which are social engineering in the object and financial structure and function. Until recently Voice phishing from Chaina caused economic devastation and the economic loss by phishing grows with the South Koreans in the whole. Korean government and public organizations involved have been strengthening protection system and a financial security devices. But it is not easy to verify how much effects of security measures are. In this paper I will study the economic loss caused by voice phishing and potential economic effects of security measures and security device reinforcements of the Republic of Korea. Direct costs are reported about 100 million dollars and potential economic effects of voice phinshing secure measures may be around 320 million dollars.

• Journal of Broadcast Engineering
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• v.13 no.5
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• pp.662-676
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• 2008

This paper presents a video copy detection algorithm that blocks online transfer of illegally copied DTV broadcast programs. Particularly, the proposed algorithm establishes a set of keyframes by detecting abrupt changes of luminance, and then exploits the spatio-temporal features of keyframes. Comparing with the preregistered features stored in the database of DTV broadcast programs, the proposed scheme performs a function of video filtering in order to distinguish whether an uploaded video is illegally copied or not. Note that we analyze only a set of keyframes instead of an entire video frame. Thus, it is highly efficient to identify illegal copied video when we deal with a vast size of broadcast programs. Also, we confirm that the proposed technique is robust to a variety of video edit-effects that are often applied by online video redistribution, such as apsect-ratio change, logo insertion, caption insertion, visual quality degradation, and resolution change (downscaling). In addition, we perform a benchmark test in which the proposed scheme outperforms previous techniques.

• Journal of Energy Engineering
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• v.10 no.3
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• pp.233-242
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• 2001

This paper attempts to analyze the effects of promotion of natural gas vehicles (NGVs) on LNG storage facilities and load patterns, and to verify economic feasibilities of NGVs as a DSM (Demand-Side Management) strategy. For these purpose, we have established an econometric mode. Results from the model indicate that natural gas demand in transportation sector will increase continuously, having a 7.84% share in total natural gas demand in 2014. By this analysis, the increased use of NGVs can result in a decreased requirement on the volume of around 1.3 LNG tanks lower in 2014. Also, it shows that TDRs can be reduced by 0.4 for the city gas and by 0.15 for the total LNG in 2014. As a conclusion, we suggest that the promotion of NGVs may play an efficient role as a DSM strategy, and should be considered as a promising strategy to optimize the investment needs in LNG sector as well as an environmental protection measures. Lastly, we acknowledge that a transportation module in our model is based on a Korean government's NGVs promotion plan, not on a market function.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.03a
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• pp.278-287
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• 2009

This thesis studied effect of zoning on seepage flow in concrete faced gravel-fill dam (CFGD) designed to have selected main rockfill or gravel-fill zone, Zone 3Bs with higher permeability to enhance the safety against accidental water infiltration into the dam. For this purpose, centrifuge model tests with two cases, with and without Zone 3Bs, were performed in order to investigate the necessity and the function of Zone 3Bs. Model dams were made by soil samples with modified coefficients of permeability and concrete faced slab was simulated with aluminum alloy. Water infiltration was simulated by rising water table over cracks on the facing. Behaviors of model dams were measured by LVDTs, strain gages, pore water pressures and cameras. Form the results of centrifuge tests, it was found out that the Zone 3Bs acts as a protection of main gravel-fill zone by inducing flow paths for infiltrated water into it as well as by draining off the infiltrated water out of the dam in a short time.