• 한국재난정보학회 논문집
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• 제5권2호
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• pp.10-21
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• 2009

This study contains the fire protection safety of the public-utilization shops. The toll of fires in the public-utilization shops is so heavy in spite the less occurency. The shops are mostly compartmented into small rooms by partition wall which hinders the evacuation of the people on fire. This study provides additional requirements on the fire safety of the public-utilization shops needed for human life and property.

• 한국통신학회논문지
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• 제27권4C호
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• pp.316-325
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• 2002

This paper investigates the restoration schemes which are applied to the MPLS domain upon a network failure. We define the following three restoration service models by combining the various restoration schemes: "FIS-based protection service" (FIS: failure indication signal), "inversion traffic protection service" and "1+1 protection service". After a qualitative analysis of the performance in them, we have analyzed it on quantitative basis by the simulation. According to the simulation results, "1+1 protection service" guarantees the fastest and most lossless restoration service among them; however, it results in consuming considerable bandwidth and producing an amount of control traffic, which means poor network utilization. On the other hand, "FIS-based protection service" spends less bandwidth and generates less control traffic, which means better network utilization, but produces poor restoration service. "Inversion traffic protection service" provides the medium restoration service and utilization between "1+1 protection service" and "FIS-based protection service."

• Bulletin of the Korean Chemical Society
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• 제29권7호
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• pp.1386-1390
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• 2008

Artemisinin, the effective ingredient of Chinese herb Artemisia annua L (Qinghao in Chinese), has been proved to be effective to antimalarial. Herein, a reliable, sensitive and convenient electrochemical method was developed for the determination of artemisinin utilizing the excellent properties of multi-wall carbon nanotube (MWNT). The electrochemical behavior of artemisinin was investigated. It is found that the reduction peak current of artemisinin remarkably increases and the peak potential shifts positively by 240 mV at the MWNT film-modified electrode. These phenomena indicate that the MWNT film exhibits efficient catalytic activity to the electrochemical reduction of artemisinin. The effects of pH value, amount of MWNT, scan rate and accumulation time were examined. The limit of detection (S/N = 3) is as low as 10 $\mu$ g $L^{-1}$. Finally, this newly developed method was used to determine the content of artemisinin in Artemisia annua L.

• Animal Bioscience
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• 제36권1호
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• pp.144-155
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• 2023

Objective: Adipocyte differentiation is regulated by a variety of functional genes and noncoding RNAs. However, the role of miRNAs in lipid deposition of goat white adipose tissue is still unclear. Therefore, this study revealed the miRNA expression profile in goat subcutaneous adipocytes by sRNA-seq. Methods: The miRNA expressed in goat subcutaneous preadipocytes and the mature adipocytes were sequenced by sRNA-seq. The differentially expressed miRNAs (DEm) were screened and gene ontology (GO) and Kyoto encyclopedia for genes and genomes (KEGG) analyses were performed. Gain-of-function and loss-of-function combined with oil red O staining, Bodipy staining, and quantitative reverse-transcription polymerase chain reaction (qPCR) were utilized to determine the effect of miR-133a-3p on adipocyte differentiation. Results: A total of 218 DEm were screened out. The target genes of these DEm were significantly enriched in GO items such as biological regulation and in KEGG terms such as FAK signaling pathway and MAPK signaling pathway. qPCR verified that the expression trend of miRNA was consistent with miRNA-seq. The gain-of-function or loss-of-function of miR-133a-3p showed that it promoted or inhibited the accumulation of lipid droplets, and CCAAT enhancer binding protein α (C/EBPα) and C/EBPβ were extremely significantly up-regulated or down-regulated respectively (p<0.01), the loss-of-function also led to a significant down-regulation of peroxisome proliferator activated receptor gamma (PPARγ) (p<0.01). Conclusion: This study successfully identified miRNAs expression patterns in goat subcutaneous adipocytes, and functional identification indicates that miR-133a-3p is a positive regulator of the differentiation process of goat subcutaneous adipocytes. Our results lay the foundation for the molecular mechanism of lipid deposition in meat-source goats from the perspective of miRNA.

• Journal of Radiation Protection and Research
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• 제1권1호
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• pp.42-48
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• 1976

• Journal of Microbiology and Biotechnology
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• 제30권10호
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• pp.1458-1466
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• 2020

Oligomeric proanthocyanidins (OPCs), classified as condensed tannins, have significant antioxidation, anti-inflammation and anti-cancer effects. This study was performed to investigate the anti-inflammatory effects of OPCs and the mechanism underlying these effects in lipopolysaccharide (LPS)-stimulated bovine mammary epithelial cells (MAC-T). Real-time PCR and ELISA assays indicated that OPC treatment at 1, 3 and 5 ㎍/ml significantly reduced the mRNA and protein, respectively, of oxidant indicators cyclooxygenase-2 (COX-2) (p < 0.05) and inducible nitric oxide synthase (iNOS) (p < 0.01) as well as inflammation cytokines interleukin (IL)-6 (p < 0.01), IL-1β (p < 0.01) and tumor necrosis factor-α (TNF-α) (p < 0.05) in LPS-induced MAC-T cells. Moreover, OPCs downregulated LPS-induced phosphorylation of p65 and inhibitor of nuclear factor kappa B (NF-κB) (IκB) in the NF-κB signaling pathway (p < 0.01), and they inhibited p65 translocation from the cytoplasm to the nucleus as revealed by immunofluorescence test and western blot. Additionally, OPCs decreased phosphorylation of p38, extracellular signal regulated kinase and c-jun NH₂-terminal kinase in the MAPK signaling pathway (p < 0.01). In conclusion, the anti-inflammatory and antioxidant activities of OPCs involve NF-κB and MAPK signaling pathways, thus inhibiting expression of pro-inflammatory factors and oxidation indicators. These findings provide novel experimental evidence for the further practical application of OPCs in prevention and treatment of bovine mastitis.

• 가정과삶의질연구
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• 제22권5호
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• pp.293-302
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• 2004

This study investigated the internship experiences of female college students who have participated in consumer counseling programs. The factors that determine interns' counseling time and interns' level of satisfaction with the programs were examined. Major results of this study are summarized in the following. First, interns' time spent on counseling consumers was the longest for the program at the Korean Consumer Protection Board, followed by the programs at consumer agencies and firms. The time spent on counseling by interns was shorter when there was l) a larger number of employees; 2) a smaller proportion of female employees: 3) a larger number of counseling rooms and a higher the frequency of counseling at the agency; and 4) a lower evaluation on the work performance of the counseling agency and the employees. Second, the level of utilization of interns was the highest in consumer agencies, followed by the Korean Consumer Protection Board. When all employees were female and the evaluated level of work performance of the counseling agency and employees was high, the level of intern utilization was also high. Third, the evaluated level of work performance was the highest at the Korean Consumer Protection Board, and interns' satisfaction with the internship program was the highest with the consumer agencies and the Korean Consumer Protection Board. Fourth, interns were highly satisfied with the program when the level of intern utilization was high and the agency's operation was evaluated as good.

• 한국한의학연구원논문집
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• 제8권2호통권9호
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• pp.47-65
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• 2002

This project is planned to grasp the present situation of traditional medicine part in our country and to study protection method about this by the intellectual property which is the international concerning point recently. Through this, we will be able to devise means to deal with protection method of traditional medicine being developed by WIPO now. Traditional medicine field In our country Is organized with specific condition separated into the part of institution and the part of non-institution. So, because of the closed peculiarity, we have experienced the difficulties to understand the real facts about traditional medicine. We cannot be indifferent to the matter anymore. Because the expectation of object people is high, we could expect the realization of research content. In 1 detail project, we investigated the situation of traditional medicine in our country through various collecting methods for excavation of oriental treatment technique and herb medicine which is worth protecting. With it, we sorted again into 56 kinds of 11 parts through analysis of validity in the way of oriental medicine. And we tried to link this up 2 detail project which is about legal and institutional guarantee concerning protection. furthermore, we tried to find approach ways for security of objectivity into 4 steps with the example of model disease. we could complete practical classification of traditional medicine in our country. In 2 detail project, we studied the protection method by the intellectual property through research result in 1 detail project. For this, we observed an outline of the intellectual property including a patent application analysis in folk traditional medicine part, and problems of traditional medicine protection and world trend by traditional knowledge protection tendency and the patent law In domestic traditional medicines, the aspects unprotectable with the patent law now were remained. So, we suggested supplementary plan. And we also suggested the freedom of utilization between traditional medicine possession countries (in-situ utilization) and the demand compensation payment for a third country (ex-situ utilization) in connection with international movement.

• Journal of Radiation Protection and Research
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• 제8권2호
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• pp.47-59
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• 1983

• 융합보안논문지
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• 제19권5호
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• pp.63-73
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• 2019

4차 산업혁명기에는 정보통신기술(ICT)의 비약적인 발전으로 사람과 사물로부터 정보를 수집하여 분석하고 가치를 창출하는 것이 가능하다. 그러나 사람을 대상으로 하는 정보의 수집은 법적으로나 제도적으로 많은 제한이 있다. 따라서 급변하는 사이버 안보환경에서 개인정보의 보호와 이용에 관한 심도 있는 연구가 필요하다. 본 연구의 목적은 4차 산업혁명기 인공지능(AI)과 빅데이터 운용을 위한 개인정보의 보호와 이용에 관한 패러다임의 전환을 모색하는 것이다. 이를 위한 연구의 구성은 제1장에서는 4차 산업혁명기 개인정보가 갖는 의미를 알아보고, 제2장에서는 선행연구 검토와 분석의 틀을 제시하였으며, 제3장에서는 주요 국가들의 개인정보의 보호와 이용을 위한 정책을 분석 한 후, 제4장에서는 4차 산업혁명기 개인정보 보호의 패러다임 변화 전망과 대응 방안을 고찰하였으며, 제5장에서는 개인정보의 보호와 이용을 위한 몇 가지 정책적 제언을 하였다.