• The Journal of Internal Korean Medicine
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• v.43 no.6
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• pp.1247-1254
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• 2022

Objectives: The purpose of this study was to report the clinical effects of pharmacopuncture, acupuncture, and ohrimsan on prostatitis that was not improved by antibiotics. Methods: The patient underwent So-Yeom pharmacopuncture injection, acupuncture, and ohrimsan. A numerical rating scale (NRS) was used to obtain a sense of residual urine and the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was used to evaluate the treatment effects. Results: NRS for the sense of residual urine decreased from 70 before treatment to 0 after treatment. The NIH-CPSI was 19 on the first day of admission and decreased to 8 on the day of discharge. No side effects were observed after treatment. Conclusions: The traditional Korean medicine of pharmacopuncture, acupuncture, and ohrimsan is effective for treating prostatitis that is not improved by antibiotics.

• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.3
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• pp.201-208
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• 2016

Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is a common disorder to men that involved urinary symptoms and sexual activity-related discomfort. As a pathophysiology of the diseases has not been established, CP/CPPS is diagnosed on the basis of symptoms, principally pain or discomfort in the pelvic region. The purpose of this study is to report the clinical effects of Korean medicine, Sibimijihwang-tang(十二味地黃湯), bee venom pharmacopuncture, and acupuncture treatment on 6 cases of CP/CPPS. 6 patients were treated with Korean medicine, Sibimijihwang-tang and acupuncture and bee venom pharmacopuncture was given into Hoeeum(CV1) et al. National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was used to assess treatment effect. After treatment, NIH-CPSI decreased significantly all the patients. Sibimijihwang-tang, bee venom pharmacopuncture and acupuncture treatment was shown fairly effective to CP/CPPS.

• Parasites, Hosts and Diseases
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• v.50 no.2
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• pp.157-159
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• 2012

The aim of this study was to assess the usefulness of PCR for diagnosis of Trichomonas vaginalis infection among male patients with chronic recurrent prostatitis and urethritis. Between June 2001 and December 2003, a total of 33 patients visited the Department of Urology, Hanyang University Guri Hospital and were examined for T. vaginalis infection by PCR and culture in TYM medium. For the PCR, we used primers based on a repetitive sequence cloned from T. vaginalis (TV-E650). Voided bladder urine (VB1 and VB3) was sampled from 33 men with symptoms of lower urinary tract infection (urethral charge, residual urine sensation, and frequency). Culture failed to detect any T. vaginalis infection whereas PCR identified 7 cases of trichomoniasis (21.2%). Five of the 7 cases had been diagnosed with prostatitis and 2 with urethritis. PCR for the 5 prostatitis cases yielded a positive 330 bp band from bothVB1 and VB3, whereas positive results were only obtained from VB1 for the 2 urethritis patients. We showed that the PCR method could detect T. vaginalis when there was only 1 T. vaginalis cell per PCR mixture. Our results strongly support the usefulness of PCR on urine samples for detecting T. vaginalis in chronic prostatitis and urethritis patients.

• The Journal of Internal Korean Medicine
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• v.44 no.6
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• pp.1150-1175
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• 2023

Objectives: This study was conducted to examine the current status of traditional Korean medicine studies on chronic prostatitis in Korea, identify deficiencies, and suggest future medicine research methods to lay the foundation for traditional Korean medicine treatment. Methods: All domestic clinical research papers on the traditional Korean treatment of chronic prostatitis were selected from the literature published until October 2023 in three domestic databases. A total of 13 selected research data were classified into clinical research papers. Results: In clinical research papers, the basis for the diagnosis of cases was clinical symptoms through medical history listening and diagnosis through past visits to hospitals. The average treatment period was 7 weeks, and the duration of treatment was not significantly affected by the duration of the disease. The most widely used Korean medicine treatment intervention was herbal medicine. Conclusions: This study included all domestic clinical research papers on chronic prostatitis to identify research trends in the Korean oriental medicine community. Based on this, it is meaningful to confirm areas that need to be supplemented in future research plans.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.3
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• pp.271-279
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• 2014

Chronic prostatitis is a common disease among male. However, its cause and treatment are not known and it does easily come to the patients again after some treatment. Chinese has got an active research on chronic prostatitis of traditional Chinese medicine. We researched the Chinese publications from 2003 to 2013. After translating those publications, we analyzed total 64 publications by classifying those according to frequently used prescriptions, differentiation of symptoms, signs, addition and subtraction of each medicine and the quantity of frequently used medicines. Frequently used medicines were statistically analyzed. The prescription of chronic prostatitis was classified according to its stage. Paljeongsan(八正散) or Yongdamsagan-tang(龍膽瀉肝湯) was used during the early stage of chronic prostatitis, Sobokchukeo-tang(少腹逐瘀湯) or Hyeolbuchukeo-tang(血府逐瘀湯類) was used during the middle stage, and Jibaekjihwang-tang(知柏地黃湯) or Gyebujihwang-tang(桂附地黃湯) was used during the late stage. The most frequently used medicine was Phellodendri Cortex(黃柏), mentioned 43 times in the prescriptions. This analysis report would be able to provide the basis of taking a research on chronic prostatitis. In addition, it could be applied on a stereotype of chronic prostatitis as well as a variety of symptoms with frequently used prescription and addition and subtraction of each medicine.

• The Journal of Internal Korean Medicine
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• v.27 no.3
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• pp.639-652
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• 2006

Objective : The etiology of chronic prostatitis is likely multifactorial, resulting from either a cascade of events after an initiating factor or from a variety of etiologic mechanisms. There is substantiating evidence to support the role of the inflammatory responses in its pathogenesis, and the clinical value in the evaluation of therapeutic efficacy. Forsythiae Frucus has been traditionally used in treatment of inflammatory diseases, including of prostatitis and urinary tract inflammation. In this study, we investigated the effects of Forsythiae Frucus on inflammatory cytokines and cyto-pathological alternation in the rat model of chronic non-bacterial prostatitis induced by castration and $17{\beta}$-estradiol treatment. Methods : Two-month-old rats were treated with $17{\beta}$-estradiol after castration for induction of experimental non-bacterial prostatitis. which is similar to human chronic prostatitis in histopathological profiles. Forsythiae Frucus as an experimental specimen, and testosterone as a positive control, were administered orally. The prostates were evaluated by histopathologlcal parameters including the epithelial score and epithelio-stromal ratio for glandular damage. and the expression of inflammatory cytokine genes including interleukin (IL)-$1{\beta}$, IL-5, IL-12, tumor necrosis factor (TNF)-$\alpha$. eotaxin, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2(cox-2). Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation. the rats treated with Forsythiae Frucus showed a diminished range of tissue damage. Epithelial score was improved in the Forsythiae Frucus group over that of the control (P<0.05). The epithelia-stromal ratio was lower in the Forsythiae Frucus group when compared to that of the control (P<0.05). In the reverse transcription-polymerase chain reaction (RT-PCR) of inflammatory cytosine genes. Forsythiae Frucus inhibited the expression of IL-$1{\beta}$, TNF-$\alpha$, iNOS, cox-2 genes, while it modulated the expression of IL-5, which is an anti-inflammatory cytokine. Conclusions : These findings suggest that Forsythiae Frucus may protect the glandular epithelial cells and also inhibit stromal proliferation in association with the immune modulation including the suppression of inflammatory cytokines and increase of anti-inflammatory cytokines. From theses results. we suggest that Forsythiae Frucus could be a useful remedy agents for treating chronic non-bacterial prostatitis.

• The Journal of Korean Medicine
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• v.27 no.3 s.67
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• pp.51-62
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• 2006

Objective: Although chronic non-bacterial prostatitis is a common disease, it is very difficult to treat effectively. Lygodium japonicum has traditionally been used in treatment of urinary tract inflammation and voiding disturbance. In this study, we investigated the therapeutic effects and action mechanism of Lygodium japonicum in the rat model of non-bacterial prostatitis induced by castration and testosterone treatment. Methods: Five-month-old rats were treated with $17\beta-estradiol$ after castration for induction of experimental non-bacterial prostatitis, which is similar to human chronic prostatitis in histopathological profiles. Lygodium japonicum and testosterone were administered as an experimental specimen and a positive control, respectively. The prostates were evaluated by histopathological parameters including the epithelial score and epithelio-stromal ratio for glandular damage, proliferating cell nuclear antigen (PCNA) labeling index for cyto-proliferation and a TUNEL (deoxyuridine triphosphate biotin nick end-labeling) assay for cell apoptosis. Results: While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with Lygodium japonicum showed a lesser range of tissue damage. Epithelial score was improved in Lygodium japonicum than that of the control (P<0.05). The epithelio-stromal ratio was lower in Lygodium japonicum when compared to that of the control (P<0.05). Although there was no difference in PCNA and TUNEL positive cells of the glandular epithelia, we found an decreased number of PCNA positive cell and concurrent increase of TUNEL positive cells in the stroma of Lygodium japonicum treated rats (P<0.01). Conclusions: These findings suggest that Lygodium japonicum may protect the glandular epithelial cells and also inhibit stromal proliferation in association with suppression of cyto-proliferation and stimulation of apoptosis. We concluded that Lygodium japonicum may be a useful remedy agent for treating the chronic non-bacterial prostatitis.

• The Journal of Internal Korean Medicine
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• v.27 no.3
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• pp.664-676
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• 2006

Objective : Although chronic non-bacterial prostatitis is a common disease, it is very difficult to treat effectively. Lygodium japonicum has been traditionally used in treatment of urinary tract inflammation and voiding disturbance. In this study, we investigated the therapeutic effects and action mechanism of Lygodium japonicum in the rat model of non-bacterial prostatitis induced by castration and testosterone treatment. Methods : Five-month-old rats were treated with 17$\beta$-estradiol after castration for induction of experimental non-bacterial prostatitis, which is similar to human chronic prostatitis in histopathological profiles. Lygodium japonicum and testosterone were administered as an experimental specimen and a positive control. respectively. The prostates were evaluated by histopathological parameters including the epithelial score and epithelio-stromal ratio for glandular damage. PCNA labeling index for cyto-proliferation and a TUNEL(deoxyuridine triphosphate biotin nick end-labeling) assay for cell apoptosis. Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with Lygodium japonicum showed a diminished range of tissue damage. Epithelial score was improved in the Lygodium japonicum group over that of the control (P<0.05). The epithelio-stromal ratio was lower in the Lygodiutn japonicum group when compared to that of the control (P<0.05). Although there was no difference in PCNA and TUNEL positive cells of the glandular epithelia. we found an decreased number of PCNA positive cell and concurrent increase of TUNEL positive cells in the stroma of Lygodium japonicum treated rats (P<0.01). Conclusions : These findings suggest that Lygodium japonicum may protect the glandular epithelial cells and also inhibit stromal proliferation in association with suppression of cyto-proliferation and stimulation of apoptosis. We concluded that Lygodium japonicum could be a useful remedy agents for treating chronic non-bacterial prostatitis.

• The Journal of Internal Korean Medicine
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• v.22 no.4
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• pp.519-525
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• 2001

Objectives : In order to study the effect of oriental medical therapy on chronic prostatitis patient, the change of WBC counts on expressed prostatic secretion(EPS) was investigated. Methods : Chronic prostatitis patient who had been diagnosed by EPS test was re-tested as same way after improvement of symptom And then we investigated the change of WBC counts on EPS according to therapeutic period, age, usual habit, herb medicine and symptom of each patient, and his and his sexual partner's past history of STD or UTI. Results : According to the change of WBC counts on EPS, improvement rate was 83.3%, cure rate was 46.7%. The youth who didn't have the usual habit of enduring ejaculation during sexual intercourse, enduring urination and sitting long time a day was improved well. Conclusions : According to the above results, it is suggested that oriental medical therapy is effective to the change of WBC counts on EPS.

• The Journal of Internal Korean Medicine
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• v.36 no.3
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• pp.391-399
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• 2015

Objectives This case series reports the efficacy of Baenong Ickki San, a Bojungikki-tang -modified formula, in treating chronic prostatitis/chronic pelvic pain syndrome. Methods Patients diagnosed with chronic prostatitis/chronic pelvic pain syndrome (n=11) were treated with Baenong Ickki San. Changes in their condition were measured using the National Institutes of Health Chronic Prostatitis Symptoms Index (NIH-CPSI). Results NIH-CPSI scores showed a significant improvement in the disease. The mean NIH-CPSI total score significantly decreased from 37.6±5.8 at baseline to 7.5±3.9 at end point (p<0.001), i.e., a 30.2±7.3 mean decrease was noted. Conclusions Baenong Ickki San may be a potential new medicine for chronic prostatitis/chronic pelvic pain syndrome.