• Translational and Clinical Pharmacology
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• v.26 no.4
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• pp.160-165
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• 2018

Indobufen ($Ibustrin^{(R)}$), a reversible inhibitor of platelet aggregation, exists in two enantiomeric forms in 1:1 ratio. Here, we characterized the anti-platelet effect of S- and R-indobufen using response surface modeling using $NONMEM^{(R)}$ and predicted the therapeutic doses exerting the maximal efficacy of each enantioselective S- and R-indobufen formulation. S- and R-indobufen were added individually or together to 24 plasma samples from drug-naïve healthy subjects, generating 892 samples containing randomly selected concentrations of the drugs of 0-128 mg/L. Collagen-induced platelet aggregation in platelet-rich plasma was determined using a Chrono-log Lumi-Aggregometer. Inhibitory sigmoid $I_{max}$ model adequately described the anti-platelet effect. The S-form was more potent, whereas the R-form showed less inter-individual variation. No significant interaction was observed between the two enantiomers. The anti-platelet effect of multiple treatments with 200 mg indobufen twice daily doses was predicted in the simulation study, and the effect of S- or R-indobufen alone at various doses was predicted to define optimal dosing regimen for each enantiomer. Simulation study predicted that 200 mg twice daily administration of S-indobufen alone will produce more treatment effect than S-and R-mixture formulation. S-indobufen produced treatment effect at lower concentration than R-indobufen. However, inter-individual variation of the pharmacodynamic response was smaller in R-indobufen. The present study suggests the optimal doses of R-and S-enantioselective indobufen formulations in terms of treatment efficacy for patients with thromboembolic problems. The proposed methodology in this study can be applied to the develop novel enantio-selective drugs more efficiently.

• Korean Journal of Comparative Education
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• v.28 no.5
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• pp.47-69
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• 2018

The purpose of this study is to classify the lifelong learning policy implementation process of lifelong learning in Korea according to the policy making decision models and to suggest developmental tasks. Korea's lifelong learning policy came to a full-fledged start with the enactment of the Lifelong Education Act in 2000. The Lifelong Education Act proposed the establishment of an open educational system as a strategy to realize the lifelong learning society. According to the Lifelong Education Act, the Korean government has developed several lifelong education policies such as providing learning opportunity for the underprivileged, facilitating lifelong learning city project, building lifelong learning culture, recognizing of experiential learning result, funding lifelong learning hub university, launching lifelong learning supporting administrative etc. The Korean lifelong system is characterized as Allison's (1971) governmental/bureaucratic, Ziegler and Johnson's (1972) legislative, Griffin's(1987) social control and Green's (2000) state-led models which make policy through the coordination between the government and the parliament and control bureaucratic power and educational qualifications. Lifelong learning policies should be managed in terms of supply and demand at the learning market. In addition, the state has to strengthen lifelong learning through supporting NGOs' activities and adult learners' tuition fee for the disadvantaged group of people.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.37 no.1
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• pp.29-42
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• 2019

In order to expand the qualitative aspects of public facility, this study used SNS data to derive user-oriented preference factors for public facilities and then were quantified in terms of supply side and demand side. To derive preference factor, LDA, one of topic modeling, was used and attraction index was calculated for each facility. In addition we analyzed spatial accessibility to measure the degree of service experience of users by using 2SFCA model. The study area covered public libraries of Seoul, Korea. As a result of study, five topics were extracted as preference factors for the public library: Circumstance, Scale of facility, Cultural program, Parenting, Books and materials. In particular topic of circumstance and parenting were newly derived preference factors unknown in previous studies. As a result of calculating attraction index for each library, the index of Songpa Library, Jungdok Library, and Namsan Library was high. Songpa library has received good evaluation in parenting factor, and Jungdok & Namsan library in circumstance factor. The accessibility of each region seems to better in center of Seoul where public libraries are crowded, but shrinking toward the outskirts. We expect that the proposed method will contribute to user-oriented public facility evaluation and policy decision making.

• Journal of Sensor Science and Technology
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• v.28 no.1
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• pp.41-46
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• 2019

In order to develop novel thermal imaging materials for microbolometer applications, $[(Ni_{0.3}Mn_{0.7})_{1-x}Cu_x]_3O_4$ ($0.18{\leq}x{\leq}0.26$) thin films were fabricated using metal-organic decomposition. Effects of Cu content on the electrical properties of the annealed films were investigated. Spinel thin films with a thickness of approximately 100 nm were obtained from the $[(Ni_{0.3}Mn_{0.7})_{1-x}Cu_x]_3O_4$ films annealed at $380^{\circ}C$ for five hours. The resistivity (${\rho}$) of the annealed films was analyzed with respect to the small polaron hopping model. Based on the $Mn^{3+}/Mn^{4+}$ ratio values obtained through x-ray photoelectron spectroscopy analysis, the hopping mechanism between $Mn^{3+}$ and $Mn^{4+}$ cations discussed in the proposed study. The effects of $Cu^+$ and $Cu^{2+}$ cations on the hopping mechanism is also discussed. Obtained results indicate that $[(Ni_{0.3}Mn_{0.7})_{1-x}Cu_x]_3O_4$ thin films with low temperature annealing and superior electrical properties (${\rho}{\leq}54.83{\Omega}{\cdot}cm$, temperature coefficient of resistance > -2.62%/K) can be effectively employed in applications involving complementary metal-oxide semiconductor (CMOS) integrated microbolometer devices.

• Journal of IKEEE
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• v.22 no.4
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• pp.1140-1146
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• 2018

Recently, a methodology for analyzing complex bio-signals using a deep learning model has emerged among studies that recognize human emotions. At this time, the accuracy of emotion classification may be changed depending on the evaluation method and reliability depending on the kind of data to be learned. In the case of biological signals, the reliability of data is determined according to the noise ratio, so that the noise detection method is as important as that. Also, according to the methodology for defining emotions, appropriate emotional evaluation methods will be needed. In this paper, we propose a wavelet -based noise threshold setting algorithm for verifying the reliability of data for multimodal bio-signal data labeled Valence and Arousal and a method for improving the emotion recognition rate by weighting the evaluation data. After extracting the wavelet component of the signal using the wavelet transform, the distortion and kurtosis of the component are obtained, the noise is detected at the threshold calculated by the hampel identifier, and the training data is selected considering the noise ratio of the original signal. In addition, weighting is applied to the overall evaluation of the emotion recognition rate using the euclidean distance from the median value of the Valence-Arousal plane when classifying emotional data. To verify the proposed algorithm, we use ASCERTAIN data set to observe the degree of emotion recognition rate improvement.

• Korean Journal of Remote Sensing
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• v.34 no.6_3
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• pp.1329-1350
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• 2018

There have been many applications to observe Earth using synthetic aperture radar (SAR) since it could acquire Earth observation data without reference to weathers or local times. However researches about digital map generation using SAR have hardly been performed due to complex raw data processing. In this study, we suggested feasibility of producing digital map using SAR stereo images. We collected two sets, which include an ascending and a descending orbit acquisitions respectively, of KOMPSAT-5 stereo dataset. In order to suggest the feasibility of digital map generation from SAR stereo images, we performed 1) rational polynomial coefficient transformation from radar geometry, 2) digital resititution using KOMPSAT-5 stereo images, and 3) validation using digital-map-derived reference points and check points. As the results of two models, root mean squared errors of XY and Z direction were less than 1m for each model. We discussed that KOMPSAT-5 stereo image could generated 1:25,000 digital map which meets a standard of the digital map. The proposed results would contribute to generate and update digital maps for inaccessible areas and wherever weather conditions are unstable such as North Korea or Polar region.

• Korean Journal of Remote Sensing
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• v.34 no.6_3
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• pp.1415-1425
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• 2018

Kompsat-5 is the first Earth Observation Satellite which is equipped with an SAR in Korea. SAR images are generated by receiving signals reflected from an object by microwaves emitted from a SAR antenna. Because the wavelengths of microwaves are longer than the size of particles in the atmosphere, it can penetrate clouds and fog, and high-resolution images can be obtained without distinction between day and night. However, there is no color information in SAR images. To overcome these limitations of SAR images, colorization of SAR images using Cycle GAN, a deep learning model developed for domain translation, was conducted. Training of Cycle GAN is unstable due to the unsupervised learning based on unpaired dataset. Therefore, we proposed MS Cycle GAN applying multi-scale discriminator to solve the training instability of Cycle GAN and to improve the performance of colorization in this paper. To compare colorization performance of MS Cycle GAN and Cycle GAN, generated images by both models were compared qualitatively and quantitatively. Training Cycle GAN with multi-scale discriminator shows the losses of generators and discriminators are significantly reduced compared to the conventional Cycle GAN, and we identified that generated images by MS Cycle GAN are well-matched with the characteristics of regions such as leaves, rivers, and land.

• Economic and Environmental Geology
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• v.52 no.2
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• pp.199-212
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• 2019

In the machine learning techniques, the sampling strategy of the training data affects a performance of the prediction model such as generalizing ability as well as prediction accuracy. Especially, in landslide susceptibility analysis, the data sampling procedure is the essential step for setting the training data because the number of non-landslide points is much bigger than the number of landslide points. However, the previous researches did not consider the various sampling methods for the training data. That is, the previous studies selected the training data randomly. Therefore, in this study the authors proposed several different sampling methods and assessed the effect of the sampling strategies of the training data in landslide susceptibility analysis. For that, total six different scenarios were set up based on the sampling strategies of landslide points and non-landslide points. Then Random Forest technique was trained on the basis of six different scenarios and the attribute importance for each input variable was evaluated. Subsequently, the landslide susceptibility maps were produced using the input variables and their attribute importances. In the analysis results, the AUC values of the landslide susceptibility maps, obtained from six different sampling strategies, showed high prediction rates, ranges from 70 % to 80 %. It means that the Random Forest technique shows appropriate predictive performance and the attribute importance for the input variables obtained from Random Forest can be used as the weight of landslide conditioning factors in the susceptibility analysis. In addition, the analysis results obtained using specific sampling strategies for training data show higher prediction accuracy than the analysis results using the previous random sampling method.

• Journal of the Korea Society for Simulation
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• v.27 no.4
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• pp.47-60
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• 2018

Today's unmanned technology, which is being used in various industries, is expected to be able to make autonomous judgements as autonomous technology matures, in the long run aspects. In order to improve the usability of unmanned system in the military field, it is necessary to develop a technique for systematically and quantitatively analyzing the efficiency and effectiveness of the unmanned system by means of a substitute for the tasks performed by humans. In this paper, we propose the method of representing rule-based tactical behavior and modeling manned and unmanned reconnaissance agents that can effectively analyze the path alternatives which is required for the future armored cavalry to establish a reconnaissance mission plan. First, we model the unmanned ground vehicle, small tactical vehicle, and combatant as an agent concept. Next, we implement the proposed agent behavior rules, e.g., maneuver, detection, route determination, and combatant's dismount point selection, by NetLogo. Considering the conditions of maneuver, enemy threat elements, reconnaissance assets, appropriate routes are automatically selected on the operation area. It is expected that it will be useful in analyzing unmanned ground system effects by calculating reconnaissance conducted area, time, and combat contribution ratio on the route.

• Korean Journal of Environment and Ecology
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• v.33 no.3
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• pp.366-374
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• 2019

This study aims to analyze the characteristics of ventilation corridor and propose its utilization strategies in Jeonju city in order to discuss how to utilize urban ventilation corridors as a planning factor for reducing heat wave impact and fine particle pollution. For these purposes, cold air characteristics such as cold air flow and height of cold air in Jeonju area located in the Honam Jeongmaek were analyzed and major ventilation corridors were specified. Based on them, we proposed mountain management strategies for securing and utilizing ventilation corridors. We used KALM (Kaltluftabflussmodell), a cold air simulation model developed in Germany and identified both the cold air flow and the height of cold air layer generated during 6 hours at night. As a result, the cold air flow generated in the forests located in the northeast and east sides of the Jeonju city became clear and the height of cold air layer increased in the valley terrain and farmland areas with time. In particular, Jeonju City has an ideal structure of urban ventilation corridor. Based on the results, the area where the cold air generation is active was designated as the 'cold air conservation area', and the area requiring the management for the good cold air flow was as the 'cold air management area'. This study is expected to be used as basic data of policy making and research for reducing heat wave impact and fine particle pollution such as climate change adaptation policy and urban forest plans for ventilation corridor composition.