• 제목/요약/키워드: Prompt NO

검색결과 218건 처리시간 0.029초

Twenty-one-year follow-up of variable onset MELAS syndrome with heteroplasmic nt3243A>G mtDNA mutation: A case report

  • Song, Wung Joo;Lee, Yoon Jin;Kang, Joon Won;Chang, Mea Young;Song, Kyu Sang;Kang, Dae Young;Kim, Sook Za
    • Journal of Genetic Medicine
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    • 제16권1호
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    • pp.31-38
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    • 2019
  • Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disorder of which m.3243A>G is the most commonly associated mutation, resulting in an inability to meet the energy requirements of various organs. MELAS poses a diagnostic challenge owing to its multiple organ involvement and great clinical variability due to its heteroplasmic nature. We report three cases from a family who were initially misdiagnosed with myasthenia gravis or undiagnosed. Although there is no optimal consensus treatment approach for patients with MELAS because of the disease's heterogeneity, our 21-year-long therapy regimen of ${\text\tiny{L}}-arginine$, ${\text\tiny{L}}-carnitine$, and coenzyme Q10 supplementation combined with dietary management appeared to provide noticeable protection from the symptoms and complications. Prompt early diagnosis is important, as optimal multidisciplinary management and early intervention may improve outcomes.

Exploring How Gamification Design Drives Customers' Co-Creation Behavior in Taiwan

  • CHEN, Tser-Yieth;HUANG, Yu-Chen;LI, Pei-Fang
    • The Journal of Asian Finance, Economics and Business
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    • 제9권4호
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    • pp.109-120
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    • 2022
  • This study has incorporated the mechanics-dynamics-emotions (MDE) and two behavioral learning paths to investigate the customers' co-creation behavior in Taiwan. The intuitive path begins with a gamification design that reflects the customers' proactive and innovative behavior; the cognitive path begins with persuasion knowledge remarks based on rational and reactive reasoning. These two paths conclude what forms user co-creation. The study collects data of 505 active social media users in Taiwan and employs structural equation modeling. The empirical findings demonstrate persuasive knowledge and gamification design are significantly associated with self-reference, and in turn, positively associated with co-creation. It indicates that cognitive behavior plays the main role in forming co-creation. Participants are more drawn to co-creation behaviors by the marketing contents that prompt reactive behaviors than proactive ones. Therefore, marketing managers can use appropriate stimuli to enhance co-creation behavior. Companies can design activities related to users, and more accessible for reactive, instead of proactive behavior, i.e., asking for their initiatives. It also suggests that companies' marketing campaigns should involve key opinion leaders matching the product image and the target audience's preferences. The novelty of this study is to introduce a novel augmented MDE framework to extend the "dynamics" into the incubation and implementation stage.

Application of probabilistic safety assessment (PSA) to the power reactor innovative small module (PRISM)

  • Alrammah, Ibrahim
    • Nuclear Engineering and Technology
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    • 제54권9호
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    • pp.3324-3335
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    • 2022
  • Several countries show interest in the Generation-IV power reactor innovative small module (PRISM), including: Canada, Japan, Korea, Saudi Arabia and the United Kingdom. Generation IV International Forum (GIF) has recommended the utilizing of probabilistic safety assessment (PSA) in evaluating the safety of Generation-IV reactors. This paper reviews the PSA performed for PRISM using SAPHIRE 7.27 code. This work shows that the core damage frequency (CDF) of PRISM for a single module is estimated by 8.5E-8/year which is lower than the Generation-IV target that is 1E-6 core damage per year. The social risk of PRISM (likelihood of latent cancer fatality) with evacuation is estimated by 9.0E-12/year which is much lower than the basic safety objective (BSO) that is 1E-7/year. The social risk without evacuation is estimated by 1.2E- 11/year which is also much lower than the BSO. For the individual risk (likelihood of prompt fatality), it is concluded that it can be considered negligible with evacuation (1.0E-13/year). Assuming no evacuation, the individual risk is 2.7E-10/year which is again much lower than the BSO. In comparison with other PSAs performed for similar sodium fast reactors (SFRs), it shows that PRISM concept has the lowest CDF.

Causal Relationship between e-Service Quality, Online Trust and Purchase Intentions on Lazada Group, An Asia's Leading E-commerce Platform

  • RUANGUTTAMANUN, Chutima;PEEMANEE, Jindarat
    • 유통과학연구
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    • 제20권1호
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    • pp.13-26
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    • 2022
  • Purpose: The Covid-19 pandemic has accelerated and triggered changes in online shopping especially in an emerging market. This paper develops a modification of SERVQUAL model to examine the relationship between individual dimensions of e-service quality, online trust and purchase intentions in singular online shopping platform. Research design, data and methodology: Data from an online survey of 385 Lazada's shoppers were used to test the research model. The structural equation modeling technique was performed to test the research model. Results: The analytical results revealed that five dimensions of e-service quality were positively correlated with one another whereas some dimensions were negatively correlated with purchase intentions. The results of this study provide new insight into the literature as well as practical implications for marketers especially in Thai online market. Conclusion: This study develops the instrument dimensions of e-service quality through modifying the SERVQUAL model to examine the e-commerce context and to testify how these individual dimensions are interlinked with one another. It also suggests that responsiveness has two-sided affects that in responses which are too prompt and insistent could make the customer feel uncomfortable and perhaps ending up with no interaction and transaction.

Types of Unfair Activity under Subcontracting and their Solutions: Qualitative Research Design

  • Ji-Heon HA;Tae-Hyung KIM
    • 산경연구논집
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    • 제14권8호
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    • pp.19-25
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    • 2023
  • Using a procurement and construction stage emphasis on the capabilities of the Sub-Contractor (SC), the present research aims to discover the types of unfair activities between the Main Contractor (MC) and SC and their influence on project completion. This research also tries to figure out solutions which can reduce unfair activities between MC and SC. Research design, data and methodology: The qualitative textual analysis was selected for the current research and has been used by numerous previous researchers commonly to review relevant themes in the prior resources and suggested for researchers who conduct a reviewing procedure to analyze meta-analysis approach for figuring out better research findings from prior resources. Results: The result indicates the prevalence and consequences of bid shopping, emphasizing the need for transparency and fair bidding practices. Late payment issues were also found to be crucial for subcontractors' financial stability, urging the implementation of prompt payment legislation and agreements. Conclusions: In conclusion, the research revealed that subcontracting is common in construction projects, with general contractors relying on multiple subcontractors to carry out specific work items. The accomplishment of building projects hinges on the collaborative efforts between the main contractor (MC) and subcontractors (SCs), each focusing on different aspects of the project.

Dynamic Reconstruction of Anal Sphincter with Camera Shutter Style Double-Opposing Gracilis Flaps

  • Allen Wei-Jiat Wong;Grace Hui-Min Tan;Frederick Hong-Xiang Koh;Min Hoe Chew
    • Archives of Plastic Surgery
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    • 제50권5호
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    • pp.496-500
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    • 2023
  • Fournier's gangrene is a life-threatening infection which requires prompt recognition, early surgical debridement of unhealthy tissue, and initiation of broad-spectrum antibiotics. Relook debridement are usually performed until all the devitalized tissue has been removed. Involvement of the anal sphincter may result in significant morbidity such as permanent incontinence. Dynamic reconstruction of the anal sphincter has always been one of the holy grails in the field of pelvic reconstruction. We demonstrate a new method of camera shutter style double-opposing gracilis muscle flaps that allows dynamic sphincteric function without the need for electrostimulation. The bilateral gracilis muscles are inset in a fashion that allows orthograde contraction of the muscle to narrow and collapse the neoanal opening. With biofeedback training, the patient is able to regain dynamic continence and return to function without a stoma. There was also no need for neurotization or microsurgery techniques to restore sphincteric function to the anus. The patient was able to reverse his stoma 14 months after the initial insult and reconstruction with biofeedback training without the use of electrostimulation.

Community Integration Study through Rehabilitation Medical Support for People with Disabilities

  • Eun-Mee CHOI;Chang-Gun LEE;Lee-Seung KWON
    • 웰빙융합연구
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    • 제7권1호
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    • pp.51-65
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    • 2024
  • Purpose: This study is to propose the establishment and direction of a public health-medical cooperation system for rehabilitation medical services for people with physical and brain disabilities in Gangneung, Korea. Research design, data and methodology: The study focused on 30 individuals with these disabilities registered. Data was collected from December 20, 2021, to December 31, 2021, through structured surveys administered by researchers visiting disability-related facilities, utilizing convenience and random sampling methods. Descriptive statistics and cross-analysis were applied for analysis. Results: Specifically, among respondents with physical disabilities, a total of 20 needs were identified, with 'Visiting health services' (25.0%) and 'Oral health services' (20.0%) ranking highest. The survey results regarding visit-based rehabilitation services for disability support showed a high demand, emphasizing the necessity of service provision tailored to the needs of recipients, focusing on disability prevention, health management, and motor function recovery, rather than solely medical or therapeutic concepts. Conclusions: Gangwon National University Hospital, as the regional referral hospital in Gangwon, should collaborate with Gangwon Province Rehabilitation Hospital to provide prompt acute rehabilitation services. Moreover, cooperation and collaboration with Gangneung Asan Hospital, the tertiary hospital in the region, are essential to ensure continued acute and recovery phase rehabilitation therapy for a certain period in the Gangneung area.

다양한 광원으로 중합한 치과용 접착제의 전단강도에 관한 비교 연구 (THE COMPARATIVE STUDY FOR THE SHEAR BOND STRENGTH OF DENTAL ADHESIVES CURED WITH VARIOUS LIGHT SOURCES)

  • 최남기;조성훈;김선미
    • 대한소아치과학회지
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    • 제38권1호
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    • pp.33-41
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    • 2011
  • 본 연구의 목적은 상업용으로 시판되고 있는 수종의 치과용 접착제를 세대별로 분류하여 서로 다른 광원에 노출 시켜 중합하고 접착면의 전단 강도 측정을 통해 결합강도를 비교함으로써 간접적으로 광원에 따른 접착제의 중합 양상을 알아보고 소아치과 영역에서 가장 권장할만한 치과용 접착제와 광원 종류의 조합을 알아보고자 함이다. 본 연구에서는 최근에 개발된 치과용접착제를 대상으로 다른 유형의 광원으로 중합하였을 때 영구치 상아질에 대한 결합력 비교 평가하여 임상에서 상아질결합제와 광중합 시스템의 적절한 조합을 선택하는데 도움을 주고자 시행하였으며, 실험재료로 Adper Scotchbond Multi-purpose Plus Adhesive (SM; 3M ESPE, USA), Adper Single bond 2 (SB; 3M ESPE, USA), Clearfil SE Bond (SE; Kuraray Medical Inc., Japan), Adper Prompt L-Pop (PL; 3M ESPE, USA), GBond (GB; GC Cooperation Toyko, Japan)을 이용하여 Elipar Free light 2(LED; 3M ESPE, USA), OptiLux 501 (Halogen, Kerr, USA), Flipo (PAC, LOKKI, FRA) 세 가지의 광원으로 중합하고 전단결합강도를 평가한 뒤 다음과 같은 결과를 얻었다. 1. Freelight 2로 중합하였을 때 전단결합강도는 SM이 가장 높았으며($28.22{\pm}5.56$), SB($21.68{\pm}7.44$), SE($20.13{\pm}9.88$), PL($14.18{\pm}5.88$), GB($14.30{\pm}6.81$) 순이었다. SM은 PL, GB와 유의한 차이가 있었으나 (p<0.05), SB, SE, PL, GB 간에는 차이가 없었다. 2. Optiux 501로 중합하였을 때 전단결합강도는 SM이 가장 높았으며 ($22.06{\pm}7.95$), PL($12.94{\pm}4.96$), SB($12.80{\pm}3.35$), SE($12.43{\pm}4.79$), GB($10.00{\pm}3.47$) 순이었고, SM만 유의한 차이가 있었으나 (p<0.05), 다른 군 간에는 차이가 없었다. 3. Flipo로 중합하였을 때 전단결합강도는 SM이 가장 높았으며 ($26.82{\pm}11.16$), PL($15.42{\pm}9.35$), SB($10.96{\pm}3.74$), SE($9.39{\pm}3.74$), GB($7.85{\pm}2.22$) 순이었다. SM은 SB, SE, GB 군과 유의한 차이가 있었으나 (p<0.05), 다른 군 간에는 차이가 없었다. 4. 광원에 따른 차이는 SB와 GB에서만 유의성이 있었고, 다른 결합제에서는 유의한 차이가 없었다. 광원에 따른 유의성을 나타낸 결합제 중 SB는 Freelight 2가 다른 광원에 비해 유의한 차이를 보였고 OptiLux 501과 Flipo간의 차이가 없었던 반면, GB는 Freelight 2와 Flipo 간에만 유의한 차이를 나타냈다.

Is Hiding Foot and Mouth Disease Sensitive Behavior for Farmers? A Survey Study in Sri Lanka

  • Gunarathne, Anoma;Kubota, Satoko;Kumarawadu, Pradeep;Karunagoda, Kamal;Kono, Hiroichi
    • Asian-Australasian Journal of Animal Sciences
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    • 제29권2호
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    • pp.280-287
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    • 2016
  • Foot and mouth disease (FMD) has a long history in Sri Lanka and was found to be endemic in various parts of the country and constitutes a constant threat to farmers. In Sri Lanka, currently there is no regular, nationwide vaccination programme devised to control FMD. Therefore, improving farmers' knowledge regarding distinguishing FMD from other diseases and ensuring prompt reporting of any suspicion of FMD as well as restricting movement of animals are critical activities for an effective FMD response effort. Therefore, the main purpose of this study was to clarify the relationship between farmers' knowledge levels and their behaviors to establish a strategy to control FMD. In our study, item count technique was applied to estimate the number of farmers that under-report and sell FMD-infected animals, although to do so is prohibited by law. The following findings were observed: about 63% of farmers have very poor knowledge of routes of FMD transmission; 'under-reporting' was found to be a sensitive behavior and nearly 23% of the farmers were reluctant to report FMD-infected animals; and 'selling FMD-infected animals' is a sensitive behavior among high-level knowledge group while it is a non-sensitive behavior among the low-level knowledge group. If farmers would understand the importance of prompt reporting, they may report any suspected cases of FMD to veterinary officials. However, even if farmers report honestly, they do not want to cull FMD-infected animals. Thus, education programs should be conducted not only on FMD introduction and transmission, but also its impact. Furthermore, consumers may criticize the farmers for culling their infected animals. Hence, not only farmers, but also consumers need to be educated on the economic impact of FMD and the importance of controlling an outbreak. If farmers have a high knowledge of FMD transmission, they consider selling FMD-infected animals as a sensitive behavior. Therefore, severe punishment should be levied for selling FMD-infected animals.

부가적 산부식 시간에 따른 자가 산부식 접착제의 법랑질 전단결합강도 (SHEAR BOND STRENGTH OF SELF-ETCHING ADHESIVES TO TOOTH ENAMEL WITH ADDITIONAL ETCHING)

  • 이형숙;김성기;이동수;김신;정태성
    • 대한소아치과학회지
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    • 제36권4호
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    • pp.514-521
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    • 2009
  • 이 연구의 목적은 유치와 영구치의 법랑질에 자가 산부식 접착제 적용 전 부가적인 산부식 시간을 달리 하였을 때, 전단결합강도에 미치는 영향을 알아보기 위함이다. 각각 65개의 발거된 건전한 유치와 영구치 협, 설면 법랑질 시편을 제작하고 두 종류의 자가 산부식 접착제를 적용하였다. 실험군은 $Clearfil^{TM}$ SE bond, $Adper^{TM}$ $Prompt^{TM}$ $L-pop^{TM}$으로 처리한 두 개 군으로 나누고, 이를 다시 산부식 시간에 따라 여섯 군(0, 5, 10, 15, 20, 30초)으로 분류하였다. 대조군으로는 total-etching system인 $Adper^{TM}$ $Scotchbond^{TM}$ Multi-purpose plus를 사용하였다. 접착제 처리면을 복합레진으로 충전하고 24시간 경과 후 전단결합강도를 측정하고 Mann-Whitney test와 Kruskal-Wallis test를 사용하여 통계분석 하였다. 결과는 자가 산부식 접착제를 적용한 군은 유치, 영구치 모두에서 total etching system에 비해 낮은 전단 결합강도를 보였다. 자가 산부식 접착제 사용 군내에서 산부식을 추가로 시행하였을 때 유치와 영구치 모두에서 결합강도가 증가하였으며, 10초 이상 산부식을 시행한 경우 결합력의 차이는 없는 것으로 나타났다. 유치와 영구치간 결합력의 차이는 인정되지 않았다. 결론적으로, 자가 산부식 접착제의 법랑질에 대한 전단결합강도는 유치, 영구치 모두에서 10초 이상의 부가적 산부식이 결합력의 증가에 유리하게 작용하는 것으로 나타났다.

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