• Biomedical Science Letters
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• v.24 no.4
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• pp.285-291
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• 2018

Gremlin-1 (GREM1) has been defined as an antagonist of bone morphogenetic proteins (BMPs), particularly during embryonic development and tissue differentiation. However, recent studies have shown that GREM1 has BMPs-dependent or -independent functions in diverse human diseases. GREM1 plays a key role in the process of organ fibrosis, including lungs, kidneys, and so on. The GREM1-induced fibrosis typically promotes the development of other diseases, such as pulmonary hypertension, renal inflammation, and diabetic nephropathy. More recently, considerable evidence has been reported showing that GREM1 is involved in the promotion and/or progression of tumors in vitro and in vivo. It also performs an oncogenic role in the maintenance of cancer stem cells. Although GREM1 is known to function in a variety of diseases, here we focus on the role of GREM1 in cancer, and suggest GREM1 as a potential therapeutic target in certain types of cancer.

• International Journal of Advanced Culture Technology
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• v.6 no.4
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• pp.80-86
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• 2018

The intervention of Autism Spectrum Disorder (ASD) is limited research focus on the effect of occupational-based intervention. This study sought to determine the effect of occupational-based intervention of chopstick skills for children with ASD. This study included a total of 3 children with ASD.Using single-subject study design, a changing criterion design and ABC design were implemented. The participants' behavior was observed and recorded throughout each session. In this study, the results were analyzed through visual graphs. The amount of food that was moved using the chopsticks was gradually increased. The results show that all participants significantly improved in their ability to use chopsticks in each intervention session. In addition, Assessment of Motor and Process Skills (AMPS) improved the generalization. According to the AMPS, both the overall motor and process skills increased from baseline an average of 0.7 logit. The results of this study showed occupational-based intervention on chopsticks skill to be effective in acquisition and generalization of chopstick skill in children with ASD.

• Food Science and Industry
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• v.52 no.3
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• pp.241-260
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• 2019

Prebiotics are defined as substrates that are selectively utilized by host microorganisms conferring various health benefits. Current prebiotic researches not only focus on non-digestible oligosaccharides, but also extend to polyphenols and peptides. However, the extended scope of prebiotic research pertains its original purposes: promotion of beneficial bacteria in host guts and production of valuable metabolites. Maintenance of optimal gut microflora plays a key role in host health care benefits including anti-cancer activity, immune response modulation, blood lipid level reduction, increased mineral absorption, and weight loss. With increasing probiotics markets, prebiotics have also received much attention in functional food markets. Hence, many global food companies tempt to develop new prebiotics applicable for preventing human diseases as well as modulating immune system. In this review, we discuss current status of prebiotics research, market progress, and future perspectives of prebiotics.

• International Journal of Advanced Culture Technology
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• v.8 no.4
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• pp.1-7
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• 2020

Recently, new media such as YouTube and AR/VR have emerged, and media content has become more complex and diversified. To respond to the new media environment, the Korean government wanted to increase people's access to media and to enhance their ability to utilize it through the establishment of viewer-media center. In this paper, based on the score of media literacy, education programs of the viewer-media center were verified to provide their effectiveness. This paper also suggests and comments on the programs that the viewer-media center should focus on by comparing and analyzing the efficacy among educational programs.

• International Journal of Advanced Culture Technology
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• v.8 no.4
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• pp.177-182
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• 2020

In the age of technology and information, communicating with people from different cultures is significantly important. Regarding this perspective, communicative competence has been the focus in the EFL educational context. The purpose of this study is to investigate the effectiveness of using movies in a culture-integrated English reading course at the college level. In order to achieve this purpose, pre- and post-reading comprehension tests, pre- and post-surveys and in-depth interviews were conducted. The results of data analysis showed that using movies in the culture-integrated English reading class positively affected students' interest and confidence towards English reading as well as their reading achievement. In this respect, we suggest that cultural teaching through movies in English classes should be learner-centered so that learners can proactively analyze and understand different cultural backgrounds shown in the movies and build schemas which can be used in their learning process.

• International Journal of Advanced Culture Technology
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• v.9 no.4
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• pp.345-354
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• 2021

Data quality issue in information systems is analyzed with focus on conceptual data modeling. Extensive investigation through triangulation of case studies is attempted to find how much extent inappropriate data modeling practices exercised in real workplace environment. It is revealed that more than 40 percent of data adversely contributed to unnecessary data redundancy, i.e., the level of data obesity is over 40 percent. Another contribution of this paper lies in excavation of all the categories of inappropriate data modeling practices, which has been previously only partially uncovered in the literature. New findings in this paper prove that the extent of inappropriate modeling is more serious that previously reported.

• International Journal of Advanced Culture Technology
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• v.10 no.4
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• pp.444-452
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• 2022

This research aims to investigate the relationship between safety climate and safety perception and safety behavior. Safety perception of the relationship is considered to have a mediating effect. Previous literature has tended to regard safety perception as an independent variable at the same level as the safety climate, which can be said to depend on behavioralism to approach the causal relationship to an one-way perspective. The survey was administrated through full- service carries in Korea such as Korean Air and Asiana Airlines, and low-cost carriers such as JeJu air, Jin air, and Air Pusan. It can identify a mediator of safety perception between safety climate and safety behavior. There are significant indirect effects of each value, which means mediators values of safety perception of safety climate variables and safety behavior. The study highlights that airlines should focus on the importance of their psychological aspects to strengthen the safety behavior of flight attendants and the value of organizational efforts to mature safety perceptions, suggesting some implications of theoretical and practical aspects.

• International Journal of Advanced Culture Technology
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• v.10 no.4
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• pp.396-402
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• 2022

Since the 21st century, the internet has been an essential existence due to the 4th industrial revolution and the development of IT technology, but the focus of the existing development direction has changed a lot over the past three years. COVID-19, also known as a pandemic, first occurred in 2020 escalating rapidly and cutting off society existing as an off-line form in every country. As non-face-to-face life continues, everyday technologies using online such as hybrid work have promptly developed, and an online virtual world called Metaverse excelled and became a phenomenal topic. In this study, theoretical considerations and the current status of the metaverse, which are being highlighted as global trend keywords, are examined, and the utility of the metaverse in the fashion industry was studied. Based on this study, it is expected that the work is recognized and brings helpful intuitions as a way to revitalize the shrinking fashion industry by using the metaverse, which is still in its infancy.

• International Journal of Advanced Culture Technology
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• v.10 no.4
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• pp.561-568
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• 2022

This study investigated how pre-service English teachers perceive the effects of machine teaching on their English writing competence. 35 Korean students who are majoring in English education participated in this study. The participants used machine translators for one of the required courses related to English composition. A survey and focus group interview were conducted at the end of the course. They were asked to answer to what degree they perceive the effects of machine translators on their writing in terms of lexical, sentential, and discourse levels. Furthermore, their perspectives on the effects of machine translation on English teaching including limitations of machine translators, were interviewed in more detail. The results show that the participants perceive machine translators quite positively in terms of improving their writing competence, but they also point out some critical limitations of machine translators. These findings have some pedagogical implications for English writing course instructors, English teacher educators, and program developers.

• International Journal of Advanced Culture Technology
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• v.11 no.3
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• pp.231-235
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• 2023

Currently, China's urban landscape is undergoing a gradual shift from incremental development to stock renovation. Furthermore, the planning and development objectives of urban communities have evolved from solely focusing on physical space construction to promoting sustainable development within a humanistic society. The current approach to community planning and construction, which emphasizes a singular dimension of residential life, overlooks the multifaceted aspects of community life and production. This oversight leads to a lack of attention to interpersonal relationships within the community, difficulties in establishing a connection between people and their environment, and numerous other issues. Consequently, this paper seeks to redefine the concept of sociality within community spaces by considering the continuum of time and space within communities. It aims to delineate the roles of "power" and "rights" within the community context, with a particular focus on everyday life, in order to reevaluate strategies and methods for fostering dynamic community development.