• BMB Reports
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• v.49 no.10
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• pp.554-559
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• 2016

Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigen-presenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes ᴅ-alanyl-ᴅ-alanine dipeptidase, which catalyzes the hydrolysis of ᴅ-alanyl-ᴅ-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.13 no.4
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• pp.183-196
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• 2018

In this study, we conducted in - depth interviews of young entrepreneurs who are currently in the process of establishing new entrepreneurs management diagnosis and consulting for young entrepreneurs, and found the common difficulties experienced in young entrepreneurs' perception of entrepreneurship, In addition, through a case study, we verified product suitability through customer issue / solution suitability, idea marketability verification and MVP (Minimum Viable Product) using Lean Canvas according to the structure of Lean Start-up It is aimed at voluntary management diagnosis and consulting of small business owners, activation of young entrepreneurs' entrepreneurship, and reduction of startup failure rate. The purpose of this study is to examine the items of five young entrepreneurs from the perspective of the customer for about 10 months, focusing on the case of small entrepreneurs in the small entrepreneurs support project. Or we could provide the customer's problem or solution based on Lean Start-up. This study was conducted as a case - based qualitative study due to the limited sample and it is hoped that this study will be used as a basic research to verify the effectiveness of the lean start-up methodology for small business owners through quantitative research.

• Journal of Energy Engineering
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• v.21 no.3
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• pp.265-270
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• 2012

The delay in the construction permit for the building, which obtained the approval of business proposal, may lead to a difference in the maintenance cost ranging between 20% and 30% in the neighborhood where the residents moved in, along with the new project under construction in the surrounding area amidst rigorous regulations that aim to promote energy-saving and the heightened interest of the public in energy conservation, and such problem would become the major source of serious public complaints. Thus, the energy-saving plan needs to be prepared when the approval is granted to the business plan. In order to prevent public complaints or ensure effectiveness of government's energy plan, it may be effective to apply the energy-saving plan based on current standards upon the award of construction permit when two years have elapsed since the date of the scheduled commencement of construction or when the start of construction is delayed as stipulated in the Article 18 of the Enforcement Decree of Housing Act. If the energy-saving plan and related technologies are merely the parts of license and permit process without fully serving their purposes and functions, it would be waste of time to deploy a lot of workforce and review and seek consultation. The government or owners of buildings need to fully understand the energy-saving aspects and exert effort to enhance the energy efficiency of buildings.

• Journal of Technology Innovation
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• v.20 no.1
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• pp.45-73
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• 2012

In this paper, we analyse empirically the effects of financial characteristics on the relationship between R&D investment and market value of firms listed on Korea Exchange. The main results of this study can be summarized as follows. Firm size increase the market valuation of R&D investment because it provides economies of scale, easier access to capital market, and R&D cost spreading. Market share also positively effects the relationship between R&D investment and firm value. Alternatively, free cash flow has a negative effect on the relationship between R&D investment and firm value because firms with high free cash flow could be tempted to use the free cash flow to undertake negative NPV projects. The dependence on external finance is a handicap negatively assessed by the market when firms undertake R&D projects due to the higher information asymmetry associated with this kind of project. Labor intensity has a negative effect on the relationship between R&D investment and firm value because the abnormal profits arising from R&D investment are diluted among employees. Capital intensity also has a negative effect on the relationship between R&D investment and firm value due to the greater financial constraints faced by capital intensive firms. In conclusion, several financial characteristics(firm size and market share) positively effect the relationship between R&D investment and firm value, while others(free cash flow, dependence on external finance, labor intensity, and capital intensity) exert a negative effect. Therefore, we conclude that the effectiveness of R&D investment depends on these financial characteristics.

• Journal of Internet Computing and Services
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• v.17 no.2
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• pp.39-47
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• 2016

In software R&D artifacts including documents and program code are produced. There are two kinds of software R&D artifacts: Research artifacts and development artifacts. Research artifacts include software R&D planning document, annual report, final report, research note and so on. Software development artifacts include software requirements, software design description, testing plan, test report, and program code. It is important to verify the documents and to test code to check the direction of the R&D. Moreover, we should check relationships as such completeness and consistency between research and development artifacts. The verification and testing help project manager and researchers understand what they do during software projects. Therefore, in this study, we present a process to verify documents and program in software R & D. In the process we check documents produced in software R&D and test program code. We describe the process by using Essence elements including alpha, activity, and competency. We present a case study to show the effectiveness of the process.

• Journal of Korean Society of Transportation
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• v.34 no.2
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• pp.107-122
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• 2016

This study aims to develop a framework to estimate mobile source emissions with the macroscopic travel demand model including enhanced estimates of intra-zonal travel emissions using Space Syntax analysis. It is acknowledged that "the land-use and transportation interaction model explains the influence of urban structure on accessibility and mobility pattern". Based upon this theory, the estimation model of intra-zonal travel emissions is presented with the models of total travel distance, total travel demand, and average travel speed of intra-zonal trips. Thess statistical models include several spatial indices derived from the Space Syntax analysis. It explains that urban spatial structure is a critical factor for intra-zonal travel emissions, which is lower in compact zone with smaller portion of land area, lower sprawl indicator, and more grid-type of road network. Also the suggested framework is applied in the evaluation of the effectiveness of bicycle lane project in Suwon, Korea. The estimated emissions including intra-zonal travel is as double as the results only with inter-zonal demands, which shows better performance of the suggested framework for more realistic outcomes. This framework is applicable to the estimation of mobile source emissions in nation-wide and the assessment of transportation-environment policies in regional level.

• Land and Housing Review
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• v.3 no.4
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• pp.307-314
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• 2012

This paper examines the characteristics and status of the major development policies for under-developed region by ministries and studies how the awareness or perspective of public officials on such policies impact the policy environment. This paper aims to redefine the goal and strategy of regional development policy so that it can effectively contribute to enhancing the quality of life of residents and improving competitiveness of the region. The problems and improvement direction found out through a documentational and practical research on the development policy for underdeveloped region can be summarized as follows: Firstly, more streamlined and integrated policies which are currently fragmented being implemented by different ministries are needed to enhance the effectiveness of policy execution. Secondly, improvements on the process of securing government funding and operating systems are needed to guarantee the rational standard of providing state subvention, the expansion of comprehensive subsidy and the independence of policy execution. Thirdly, amendments on the policy measures are needed to support the development and execution of the customized projects, strengthen cooperation among those projects by establishing a system for effective regional development project.

• Journal of the Economic Geographical Society of Korea
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• v.23 no.1
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• pp.82-92
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• 2020

This study attempts to explore the activities and performance of industry-academic cooperation with the perspective of the firm that has not been systematically addressed in the previous research. To do this, a survey of university family companies across the country was conducted to draw factors that influence the competencies of firms and universities on the performance of industry-academic cooperation and to compare differences by region. The main results of the study are as follows. First, it was found that the knowledge and technologies that universities retain and the active participation of companies in the activities of university-academic cooperation were the most important contributors to the corporate achievements in industry-academic cooperation. Second, when divided into the Seoul metropolitan area and non-capital area, it was found that there was a difference in the capabilities and performance of industry-academic cooperation between the two regions. Third, it was found that there were significant differences in the capabilities and performance of industry-academic cooperation in five areas. These findings suggest that industry-academic cooperation projects specialized for each region is necessary to enhance the effectiveness of industry-academic cooperation.

• Journal of Korean Home Economics Education Association
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• v.32 no.1
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• pp.145-165
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• 2020

This study developed teaching-learning materials for 10 class periods that applies design thinking process for the units of 'sustainable consumption' of home economic subject, and examined the learning experience of students in the class. After the classes, reflection journals and in-depth interviews from 276 male and female students in ten classes were analyzed. The main results are as follows: The five steps of the design thinking process of the Stanford University d-School were applied to develop teaching-learning materials for the 'Sustainable Consumption Practice Book Creation Project'. Students' positive learning experience was evidenced through sustainable consumption classes that applied design thinking. The students were able to reflect through the experience of sympathizing with the real problem, and experienced an improvement in problem-solving ability through the process of idea construction and prototyping. Students expressed difficulties in reaching consensus among the members, and in devising ideas and implementing prototypes. Based on the learning experience of students this study, it is suggested that home economic teachers further develop and implement classes of various topics to which design thinking process is applied. A future study may need to verify the effectiveness of home economic classes to which design thinking is applied.

• Journal of the Korean Institute of Intelligent Systems
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• v.25 no.2
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• pp.174-179
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• 2015

Failure Mode and Effects Analysis (FMEA) has been used by Dynamic Positioning (DP) system for risk and reliability analysis. However, there are limitations associated with its implementation in offshore project. 1) since the failure data measured from the SCADA system is missing or unreliable, assessments of Severity, Occurrence, Detection are based on expert's knowledge; 2) it is not easy for experts to precisely evaluate the three risk factors. The risk factors are often expressed in a linguistic way. 3) the relative importance among three risk factors are rarely even considered. To solve these problems and improve the effectiveness of the traditional FMEA, we suggest a Fuzzy-FMEA method for risk and failure mode analysis in Dynamic Positioning System of offshore. The information gathered from DP FMEA report and DP FMEA Proving Trials is expressed using fuzzy linguistic terms. The proposed method is applied to an offshore Dynamic Positioning system, and the results are compared with traditional FMEA.