• Journal of Integrative Natural Science
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• v.17 no.2
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• pp.59-65
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• 2024

Dendritic cells play a very important role in the immune response as antigen-presenting cells that are critical for initiating both innate and acquired immunity. They recognize, process and present foreign antigens to other key immune cells to trigger and regulate the immune response. The ability to activate these dendritic cells can be used as a treatment for various immune diseases. Maqui berry has been reported to have anticancer, antibacterial and anti-inflammatory properties. However, its effect on the activity of dendritic cells has not been studied. In this study, we investigated the efficacy of maqui berry extract in modulating dendritic cell activity. Treatment of dendritic cells with maqui berry extract induced the costimulatory molecules CD80, CD86, and MHC class I and II in a concentration-dependent manner. Furthermore, the antigen-presenting capacity of dendritic cells was inhibited, which confirms their ability to present antigens, and the production of Interleukin (IL)-12, which is important for dendritic cell activity, was increased. These results indicated that Maqui berry extract activates dendritic cells maturation by inducing the production of co-stimulatory molecules and IL-12. These results suggest that maqui berry extract may act as an effective adjuvant to enhance dendritic cell-based immune responses.

• The Journal of Advanced Prosthodontics
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• v.5 no.4
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• pp.402-408
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• 2013

PURPOSE. The aim of this study was to evaluate the surface properties and in vitro bioactivity to osteoblasts of magnesium and magnesium-hydroxyapatite coated titanium. MATERIALS AND METHODS. Themagnesium (Mg) and magnesium-hydroxyapatite (Mg-HA) coatings on titanium (Ti) substrates were prepared by radio frequency (RF) and direct current (DC) magnetron sputtering.The samples were divided into non-coated smooth Ti (Ti-S group), Mg coatinggroup (Ti-Mg group), and Mg-HA coating group (Ti-MgHA group).The surface properties were evaluated using scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The surface roughness was evaluated by atomic force microscopy (AFM). Cell adhesion, cell proliferation and alkaline phosphatase (ALP) activity were evaluated using MC3T3-E1 cells. Reverse transcription polymerase chain reaction (RT-PCR) analysis was performed. RESULTS. Cross-sectional SEM images showed that Mg and Mg-HA depositionson titanium substrates were performed successfully. The surface roughness appeared to be similaramong the three groups. Ti-MgHA and Ti-Mg group had improved cellular responses with regard to the proliferation, alkaline phosphatase (ALP) activity, and bone-associated markers, such as bone sialoprotein (BSP) and osteocalcin (OCN) mRNA compared to those of Ti-S group. However, the differences between Ti-Mg group and Ti-MgHA group were not significant, in spite of the tendency of higher proliferation, ALP activity and BSP expression in Ti-MgHA group. CONCLUSION. Mg and Mg-HAcoatings could stimulate the differentiation into osteoblastic MC3T3-E1 cells, potentially contributing to rapid osseointegration.

• Proceedings of the IEEK Conference
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• 1999.11a
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• pp.479-482
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• 1999

In this paper, we implement and construct a kernel on handhold systems. The goal of this project is to develop issues related to the development of small devices: embedded kernel, power management, user interface issues, networking, and the development of applications for small devices. We explain basic system configuration, kernel activity, device drivers and developing environment in this paper. We also explain detail scheduler activity.

• Magazine of the Korean Society of Agricultural Engineers
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• v.8 no.1
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• pp.1048-1054
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• 1966

1. Data of this article come from actual soil survey activity by the UNKUP project personel. 2. Proper national land use must be solved because of the growing population and increasing economic activity. 3. Korea has to be developed for the natural resources of soil and water in the subwate\ulcorner rsheds. 4. This problem. depends On the result of land capability classification which was determind by the soil survey.

• Asia pacific journal of information systems
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• v.13 no.1
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• pp.103-118
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• 2003

Software project planning is usually represented by a project activity network that is composed of stages of tasks to be done and precedence restrictions among them. The project network is very complex and its construction requires a vast amount of field knowledge and experience. So this study proposes a case-based reasoning approach that can generate the project network automatically based on the past cases and modification knowledge. For the case indexing, we have adopted 17 factors, each with a few alternative values. A special structure of this problem is that the modification effort can be identified by each factor independently. Thus it is manageable to identify 85 primitive modification actions(add and delete activities) and estimate its modification efforts in advance. A specific case requires a combination of primitive modifications. Based on the modification effort knowledge, we have adopted the Least Modification approach as a metric of similarity between a new project and past cases. Using the Least Modification approach and modification knowledge base, we can automatically generate the project network. To validate the performance of Least Modification approach, we have compared its performance with an ordinary minimal distance approach for 21 test cases. The experiment showed that the Least Modification approach could reduce the modification effort significantly.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.3
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• pp.287-295
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• 2016

Involuntary physical activity induced by the avoidance of electrical shock leads to improved endurance exercise capacity in animals. However, it remains unknown whether voluntary stand-up physical activity (SPA) without forced simulating factors improves endurance exercise capacity in animals. We examined the effects of SPA on body weight, cardiac function, and endurance exercise capacity for 12 weeks. Twelve male Sprague-Dawley rats (aged 8 weeks, n=6 per group) were randomly assigned to a control group (CON) or a voluntary SPA group. The rats were induced to perform voluntary SPA (lifting a load equal to their body weight), while the food height (18.0 cm) in cages was increased progressively by 3.5 every 4 weeks until it reached 28.5 cm for 12 weeks. The SPA group showed a lower body weight compared to the CON group, but voluntary SPA did not affect the skeletal muscle and heart weights, food intake, and echocardiography results. Although the SPA group showed higher grip strength, running time, and distance compared to the CON group, the level of irisin, corticosterone, genetic expression of mitochondrial biogenesis, and nuclei numbers were not affected. These findings show that voluntary SPA without any forced stimuli in rats can effectively reduce body weight and enhance endurance exercise capacity, suggesting that it may be an important alternative strategy to enhance endurance exercise capacity.

• Korean Journal of Construction Engineering and Management
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• v.24 no.4
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• pp.44-51
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• 2023

Occupational safety and health management cost (OSHMC) is helpful for managing safety in construction sites. However, OSHMC has been criticized for various aspects, including the fact that OSHMC cannot reflect features of individual constructions when counting up and executing OSHMC. This study proposes the approach to distribute OSHMC by project size and activity type with the consideration of accident rates for various activities. Using 1,046 data obtained from Construction Safety Management Integrated Information (CSI), this study calculated the relative risk factors for each activity. The distribution of OSHMC is proposed based on the risk factors. The results were validated by industry expert interviews. The distribution proposed in this study will help construction managers establish and execute OSHMC usage plan effectively.

• Architectural research
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• v.4 no.1
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• pp.53-61
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• 2002

The typical Critical Path Method (CPM) leaves it to the construction managers to overcome two problems in developing networks. First, the construction manager needs to prepare information on the type of activities and their precedence relations in order to develop a network schedule. Second, he or she can include space information into the network schedule such as the locations where the activities take place, only with difficulty. These two problems make it difficult for an inexperienced person to create a network. The purpose of this paper is to provide construction managers with set equations of creating a network schedule for multiunit projects. A space-resource combined network creation are presented in this paper, which includes equations for generating a list of required activities, their precedence relations, and information on their location. Information on the space (location) and the resource is the required data for this method. Based on this information, this method divides a project into a number of activities so that each activity contains the information on the location where the activity takes place and the principal resource required for that activity. Precedence relations are then obtained from the sequence of space and resource. This method has the potential to reduce human efforts in scheduling activities.

• YAKHAK HOEJI
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• v.56 no.5
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• pp.309-313
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• 2012

Antiobesity, hypotriglyceridemic and antihypertensive activities of isoflavone-free peptide mixture (black soybean peptide, BSP) were reported in our previous experiments. In the present study, angiotensin converting enzyme inhibitory (ACEi) activity was decreased in the aorta tissues of spontaneously hypertensive rats (SHRs) treated with BSP (1% in drink water) for 4 weeks, but not in serum. BSP administration significantly decreased ACE activity by 17.5% (from $33.2{\pm}4.5$ to $27.4{\pm}1.96$ mUnit/mg, p=0.0013) in aorta tissue hydrolysate. BSP treatment also decreased significantly mean blood pressure (BP) (from $213.0{\pm}16.96$ to $184.0{\pm}6.53$ mmHg, p<0.0001) as expected. These results indicate that BSP has antihypertensive activity as well as ACEi activity.

• International conference on construction engineering and project management
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• 2009.05a
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• pp.732-737
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• 2009

Due to various project delivery methods and the complexity of construction projects in the construction industry, developing the framework of construction management for critical, highly complex projects in the construction industry has become problematic. Currently, a set of construction manuals play a pivotal role in planning and managing construction projects as subcontractors try to complete their scope of work according to the instructions of a general contractor. It is challenging for general contractors to write a construction management procedure manual to cover various types of project delivery methods and construction projects. In construction, the construction procedure manuals describe specific actions to be taken through the project. In reality a few contactors own such manuals and their construction schedules include more construction operation activities. Thus, it is hard to estimate the workload and productivity of construction managers because the manual and the schedule do not present the amount of management efforts required to complete a project. This paper proposes a framework to present construction management tasks according to project delivery methods which can be applied to various construction projects. Actions for management tasks were mapped and were integrated with construction activities throughout the project life cycle. The framework can then be used to give specific instructions to project participants, collect management actions, and replicate management actions throughout the project life cycle. The framework can also be can used to visualize complete construction project to analyze and manage construction management activities in each phase of a project in order to enhance productivity and efficiency. The studies of existing construction manuals were carried out to identify construction managers' responsibilities. An artificial intelligence program, CLIPS (C-Language Integrated Production System) was used to search for appropriate actions for impending tasks from a set of predefined actions to be performed for a given situation. The framework would significantly help construction managers to understand interrelations among management tasks or actions within a project. Furthermore, the framework can be embedded into Building Information Modeling (BIM) or Facility Management Systems (FMS) so that designers and constructors would execute constructability review before construction begins.