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Short Heterodimer Partner as a Regulator in OxLDL-induced Signaling Pathway

  • Kimpak, Young-Mi
    • Proceedings of the PSK Conference
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    • 2001.10a
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    • pp.109-113
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    • 2001
  • Oxidized low-density lipoprotein (oxLDL) has been shown to modulate transactivations by the peroxisome proliferator activated receptor (PPAR)$\gamma$ and nuclear factor-kappa B (NF$\kappa$B). In this study, the oxLDL signaling pathways involved with the NF$\kappa$B transactivation were investigated by utilizing a reporter construct driven by three upstream NF$\kappa$B binding sites, and various pharmacological inhibitors. OxLDL and its constituent lysophophatidylcholine (lysoPC) induced a rapid and transient increase of intracellular calcium and stimulated the NF-KB transactivation in resting RAW264.7 macrophage cells in an oxidation-dependent manner. The NF$\kappa$B activation by oxLDL or lysoPC was inhibited by protein kinase C inhibitors or an intracellular calcium chelator. Tyrosine kinase or PI3 kinase inhibitors did not block the NF$\kappa$B transactivation. Furthermore, the oxLDL-induced NF$\kappa$B activity was abolished by the PPAR$\gamma$ ligands. When the endocytosis of oxLDL was blocked by cytochalasin B, the NF$\kappa$B transactivation by oxLDL was synergistically increased, while PPAR transactivation was blocked. These results suggest that oxLDL activates NF-$\kappa$B in resting macrophages via protein kinase C- and/or calcium-dependent pathways, which does not involve the endocytic processing of oxLDL. The endocytosis-dependent PPAR$\gamma$ activation by oxLDL may function as an inactivation route of the oxLDL induced NF$\kappa$B signal. Short heterodimer partner (SHP), specifically expressed in liver and a limited number of other tissues, is an unusual orphan nuclear receptor that lacks the conventional DNA-binding domain. In this work, we found that SHP expression is abundant in murine macrophage cell line RAW 264.7 but suppressed by oxLDL and its constituent I3-HODE, a ligand for peroxisome proliferator-activated receptor y. Furthermore, SHP acted as a transcription coactivator of nuclear factor-$\kappa$B (NF$\kappa$B) and was essential for the previously described NF$\kappa$B transactivation by lysoPC, one of the oxLDL constituents. Accordingly, NF$\kappa$B, transcriptionally active in the beginning, became progressively inert in oxLDL-treated RAW 264.7 cells, as oxLDL decreased the SHP expression. Thus, SHP appears to be an important modulatory component to regulate the transcriptional activities of NF$\kappa$B in oxLDL-treated, resting macrophage cells.

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A Study on 3D Model Building of Drones-Based Urban Digital Twin (드론기반 도심지 디지털트윈 3차원 모형 구축에 관한 연구)

  • Lim, Seong-Ha;Choi, Kyu-Myeong;Cho, Gi-Sung
    • Journal of Cadastre & Land InformatiX
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    • v.50 no.1
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    • pp.163-180
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    • 2020
  • In this study, to build a spatial information infrastructure, which is a component of a smart city, a 3D digital twin model in the downtown area was built based on the latest spatial information acquisition technology, the drone. Several analysis models were implemented by utilizing. While the data processing time and quality of the three types of drone photogrammetry software are different, the accuracy of the construction model is ± 0.04 in the N direction and ± 0.03m in the E direction. In the m and Z directions, ± 0.02m was found to be less than 0.1m, which is defined as the allowable range of surveying performance and inspection performance for the boundary point in the area where the registration of the boundary point registration is executed. 1: 500 to 1 of the aerial survey work regulation: The standard deviation, which is the error limit of the photographic reference point of the 600 scale, appeared within 0.14 cm, and it was found that the error limit of the large scale specified in the cadastral and aerial survey was satisfied. In addition, in order to increase the usability of smart city realization using a drone-based 3D urban digital twin model, the model built in this study was used to implement Prospect right analysis, landscape analysis, Right of light analysis, patrol route analysis, and fire suppression simulation training. Compared to the existing aerial photographic survey method, it was judged that the accuracy of the naked eye reading point is more accurate (about 10cm) than the existing aerial photographic survey, and it is possible to reduce the construction cost compared to the existing aerial photographic survey at a construction area of about 30㎢ or less.

A Development of Active Monitoring and Approach Alarm System for Marine Buoy Protection and Ship Accident Prevention based on Trail Cameras and AIS (해상 부이 보호 및 선박 사고 예방을 위한 트레일 카메라-AIS 연계형 능동감시 및 접근경보 시스템 개발)

  • Hwang, Hun-Gyu;Kim, Bae-Sung;Kim, Hyen-Woo;Gang, Yong-Soo;Kim, Dae-Han
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.22 no.7
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    • pp.1021-1029
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    • 2018
  • The marine buoys are operated in various domains, which are navigation route and danger maker, weather and environment monitoring, military strategical element, etc. If the marine buoy is damaged, there consumes many cost and time for recovery or replacement, because of severe environmental condition, and causes a risk possibility of secondary accident. In this paper, we developed an active monitoring and approach alarm providing system using trail cameras and AIS for protection for the marine buoys. To do this, we analyzed existing researches and similar systems, extracted requirements for enhancement, and designed the system architecture that applied the enhanced elements. The main considerations of system enhancement are: integration of AIS and trail cameras, adopting of phased alarm technique by approaching ships, applying of selective communication module, conducting the image processing of ships for providing alarm, and applying thermal cameras. After that, we developed the system using designed architecture and verified effectiveness of the system based on laboratory or field-level tests.

QoS Routing Protocol using multi path in Unidirectional Mobile Ad Hoc Networks (단방향 이동 Ad Hoc 망에서의 다중경로를 이용한 QoS 라우팅 프로토콜)

  • Kang, Kyeong-In;Park, Kyong-Bae;Yoo, Choong-Yul;Jung, Chan-Hyeok;Lee, Kwang-Bae;Kim, Hyun-Ug
    • The KIPS Transactions:PartC
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    • v.9C no.6
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    • pp.935-944
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    • 2002
  • It is the Mobile Ad Hoc Networks that constituted with serveral mobile node that can communicate with other mobile nodes. Until now, there were no routing protocols considering such as Multimediadata, VOD (Video On Demand), which is required of lots of bandwidth in Mobile Ad Hoc Network, io we are in the need of QoS (Quality of Service)routing protocol to transmit the data packets faster and more accurate. Also, there are an unidirectional links due to asymmetric property of mobile terminals or current wireless environments on practical mobile ad hoc networks. However, at present, the existing mobile ad hoc routing protocols are implemented to support only bidirectional links. In this paper, we propose the Advanced Routing routing protocol in order to implement a new routing protocol, which is fit to mobile ad hoc networks containing unidirectional links and to support QoS service. For the performance evaluation, we use NS-2 simulator of U.C. Berkeley. We could get not only increased received data rate and decreased average route discovery time, but also network load decreases with compared Best effort service.

A Research of LEACH Protocol improved Mobility and Connectivity on WSN using Feature of AOMDV and Vibration Sensor (AOMDV의 특성과 진동 센서를 적용한 이동성과 연결성이 개선된 WSN용 LEACH 프로토콜 연구)

  • Lee, Yang-Min;Won, Joon-We;Cha, Mi-Yang;Lee, Jae-Kee
    • The KIPS Transactions:PartC
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    • v.18C no.3
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    • pp.167-178
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    • 2011
  • As the growth of ubiquitous services, various types of ad hoc networks have emerged. In particular, wireless sensor networks (WSN) and mobile ad hoc networks (MANET) are widely known ad hoc networks, but there are also other kinds of wireless ad hoc networks in which the characteristics of the aforementioned two network types are mixed together. This paper proposes a variant of the Low Energy Adaptive Cluster Hierarchy (LEACH) routing protocol modified to be suitable in such a combined network environment. That is, the proposed routing protocol provides node detection and route discovery/maintenance in a network with a large number of mobile sensor nodes, while preserving node mobility, network connectivity, and energy efficiency. The proposed routing protocol is implemented with a multi-hop multi-path algorithm, a topology reconfiguration technique using node movement estimation and vibration sensors, and an efficient path selection and data transmission technique for a great many moving nodes. In the experiments, the performance of the proposed protocol is demonstrated by comparing it to the conventional LEACH protocol.

Design and Implementation of JBI Component Deployment tool Based on the open sources (오픈소스 기반의 JBI 컴포넌트배치도구의 설계 및 구현)

  • Park, Jae-Won;Choi, Jae-Hyun;Lee, Jae-Sung;Lee, Nam-Yong
    • The KIPS Transactions:PartD
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    • v.16D no.5
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    • pp.715-728
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    • 2009
  • The Enterprise Service Bus based on Java Business Integration is an web service standard and one of the methods for implementing distribution channels of Service Oriented Architecture. Consisting of open source group, extensive venders and users, the ESB based JBI has the problems of ineffectiveness as well as advantages of extensibility of service plug-in. That is, in case users need to use Service plug-in, manual connection of packaging process and sequential distribution method is required. This study, therefore, proposes as a way of trouble-shooting the user-oriented component deployment tool which can manage entire process for deploying The ESB middleware platform to Service unit. At the same time, this study elicited the requirements based on issues of JBI-based ESB and has developed the modeling property, packaging, distribution and evaluation thru Schema analysis of JBI-compatible component. Using the deployment tool this study proposed, users will be able to perform and manage the whole deploying process without additional manual work for connecting component. Not only it is expected that interface based on Graphic User Interface provide usability and convenience but they can also minimize the errors rate through component and route validity verification function provided in deployment tool.

Implementation of virtual reality for interactive disaster evacuation training using close-range image information (근거리 영상정보를 활용한 실감형 재난재해 대피 훈련 가상 현실 구현)

  • KIM, Du-Young;HUH, Jung-Rim;LEE, Jin-Duk;BHANG, Kon-Joon
    • Journal of the Korean Association of Geographic Information Studies
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    • v.22 no.1
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    • pp.140-153
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    • 2019
  • Cloase-range image information from drones and ground-based camera has been frequently used in the field of disaster mitigation with 3D modeling and mapping. In addition, the utilization of virtual reality(VR) is being increased by implementing realistic 3D models with the VR technology simulating disaster circumstances in large scale. In this paper, we created a VR training program by extracting realistic 3D models from close-range images from unmanned aircraft and digital camera on hand and observed several issues occurring during the implementation and the effectiveness in the case of a VR application in training for disaster mitigation. First of all, we built up a scenario of disaster and created 3D models after image processing with the close-range imagery. The 3D models were imported into Unity, a software for creation of augmented/virtual reality, as a background for android-based mobile phones and VR environment was created with C#-based script language. The generated virtual reality includes a scenario in which the trainer moves to a safe place along the evacuation route in the event of a disaster, and it was considered that the successful training can be obtained with virtual reality. In addition, the training through the virtual reality has advantages relative to actual evacuation training in terms of cost, space and time efficiencies.

A Study on the Design and Implementation of Multi-Disaster Drone System Using Deep Learning-Based Object Recognition and Optimal Path Planning (딥러닝 기반 객체 인식과 최적 경로 탐색을 통한 멀티 재난 드론 시스템 설계 및 구현에 대한 연구)

  • Kim, Jin-Hyeok;Lee, Tae-Hui;Han, Yamin;Byun, Heejung
    • KIPS Transactions on Computer and Communication Systems
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    • v.10 no.4
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    • pp.117-122
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    • 2021
  • In recent years, human damage and loss of money due to various disasters such as typhoons, earthquakes, forest fires, landslides, and wars are steadily occurring, and a lot of manpower and funds are required to prevent and recover them. In this paper, we designed and developed a disaster drone system based on artificial intelligence in order to monitor these various disaster situations in advance and to quickly recognize and respond to disaster occurrence. In this study, multiple disaster drones are used in areas where it is difficult for humans to monitor, and each drone performs an efficient search with an optimal path by applying a deep learning-based optimal path algorithm. In addition, in order to solve the problem of insufficient battery capacity, which is a fundamental problem of drones, the optimal route of each drone is determined using Ant Colony Optimization (ACO) technology. In order to implement the proposed system, it was applied to a forest fire situation among various disaster situations, and a forest fire map was created based on the transmitted data, and a forest fire map was visually shown to the fire fighters dispatched by a drone equipped with a beam projector. In the proposed system, multiple drones can detect a disaster situation in a short time by simultaneously performing optimal path search and object recognition. Based on this research, it can be used to build disaster drone infrastructure, search for victims (sea, mountain, jungle), self-extinguishing fire using drones, and security drones.

A Mobility Service for the Transportation Vulnerable Based on MyData (마이데이터 기반 교통약자 이동지원서비스 모델)

  • Choi, Hee Seok;Lee, Seok Hyoung;Park, Moon Soo
    • KIPS Transactions on Software and Data Engineering
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    • v.12 no.1
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    • pp.31-40
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    • 2023
  • Various policies and services are being implemented in Korea and other countries, such as the expansion of convenience facilities for mobility support, the provision of special means of transportation, and the establishment of public transportation route plans and fare policies based on data and AI-based movement pattern analysis to ensure the mobility rights of the weak in transportation. However, A research is still needed to improve service convenience in order to more conveniently use the desired means of transportation in a necessary situation from the viewpoint of the transportation vulnerable. This study examines the policies and services for the promotion of mobility for the transportation disadvantaged, and presents a MyData-based service model for mobility support for the transportation disadvantaged. In the proposed service model, the transportation-disabled person can freely choose and use the means of transportation according to individual circumstances, and receive the same transportation welfare voucher benefits provided by the state or government. The proposed service model defines the MyData platform that supports the safe collection and use of personal data, the authentication of traffic welfare recipients based on MyData, and the payment function for fee settlement after using the service as key components. In this research, the service satisfaction from the user's point of view was investigated by implementing the proposed service model and providing a demonstration service for the transportation vulnerable in Daejeon.

Verification of Ground Subsidence Risk Map Based on Underground Cavity Data Using DNN Technique (DNN 기법을 활용한 지하공동 데이터기반의 지반침하 위험 지도 작성)

  • Han Eung Kim;Chang Hun Kim;Tae Geon Kim;Jeong Jun Park
    • Journal of the Society of Disaster Information
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    • v.19 no.2
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    • pp.334-343
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    • 2023
  • Purpose: In this study, the cavity data found through ground cavity exploration was combined with underground facilities to derive a correlation, and the ground subsidence prediction map was verified based on the AI algorithm. Method: The study was conducted in three stages. The stage of data investigation and big data collection related to risk assessment. Data pre-processing steps for AI analysis. And it is the step of verifying the ground subsidence risk prediction map using the AI algorithm. Result: By analyzing the ground subsidence risk prediction map prepared, it was possible to confirm the distribution of risk grades in three stages of emergency, priority, and general for Busanjin-gu and Saha-gu. In addition, by arranging the predicted ground subsidence risk ratings for each section of the road route, it was confirmed that 3 out of 61 sections in Busanjin-gu and 7 out of 68 sections in Sahagu included roads with emergency ratings. Conclusion: Based on the verified ground subsidence risk prediction map, it is possible to provide citizens with a safe road environment by setting the exploration section according to the risk level and conducting investigation.