• Journal of Life Science
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• v.29 no.7
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• pp.809-816
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• 2019

The ubiquitous plant metabolite p-coumaric acid (p-CA) has antioxidant and anti-inflammatory properties, but its anti-cancer activity has not been established in gastric cancer cell lines. In this study, we investigated the effects of p-CA on the proliferation and transcriptome profile of SNU16 gastric cancer cells. Treatment with p-CA induced apoptosis of the SNU-16 cells by regulating the expression of pro-apoptotic and anti-apoptotic proteins, such as Bcl-2, poly (ADP-ribose) polymerase (PARP), Bax, procaspase-3, and cleaved-caspase-3. The genes differentially expressed in response to p-CA treatment of the SNU-16 cells were identified by RNA sequencing analysis. Genes regulated by p-CA were involved mainly in the inflammatory response, apoptotic processes, cell cycle, and immune response. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that the phosphatidylinositol-3-kinase-Akt and cancer signaling pathways were altered by p-CA. Protein-protein interaction (PPI) network analysis also revealed that p-CA treatment was correlated with differential expression of genes associated with the inflammatory response and cancer. Collectively, these results suggest that p-CA has potential utility in gastric cancer prevention.

• Economic and Environmental Geology
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• v.53 no.5
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• pp.553-564
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• 2020

Transition between explosive and effusive eruption in Ulleung Island is observed in the Nari Scoria Deposits and Albong Trachyandesite (lava dome) origined by dome-building eruption and may be related to factors such as magma influx, ascent rate and degassing. However, the interpretation of them has not been resolved yet because the interaction between these factors is not complex but also the resulting behaviour during eruption is unpredictable. This paper focuses on the explosive and effusive activity perceived during building the Albong lava dome in Nari caldera. Samples were collected along with time from the scoria deposits and lava dome, linked to eruption stage and style of activity. Textures of groundmass feldspar microlites from these samples are quantitatively analyzed, including measurements of areal number density, mean microlite size, crystal aspect ratio, groundmass crystallinity and crystal size. The microlite textures show that shallow pre- and syn-eruptive magmatic processes acted to govern the changing behaviour during the eruption. Transition between explosive and effusive eruption was driven by the dynamics of magma ascent in the conduit, with degassing and crystallisation acting via feedback mechanisms, resulting in a cycle of effusive and explosive eruption.

• Journal of Korea Multimedia Society
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• v.14 no.10
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• pp.1348-1364
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• 2011

As the existing edutainment contents for children are mostly comprised of educational tools which unilaterally induce educatees to passively respond to them, the content-creating methodologies in terms of which active and voluntary learning is made possible is urgently needed. In this paper, we present the implementation of the tangible 'electronic dice' interface as an interactive tool for behavior-based edutainment contents, and propose a methodology for developing edutainment contents for children by utilizing the recognition technique of hand movement based on depth-image information. Also proposed in the paper are an authoring and management tool of learning quizzes that allows educators to set up and manage their learning courseware, and a log analysis system of learning achievement for real-time monitoring of educational progress. The behavior-based tangible interface and edutainment contents that we propose provide the easy-to-operate interaction with a real object, which augments educatees' interest in learning, thus leading to their active and voluntary attitude toward learning. Furthermore, The authoring and management tool and log analysis system allow us to construct learning programs by children's achievement level and to monitor in real-time the learning development of children educatees by understanding the situation and behavior of their learning development from the analytic results obtained by observing the processes of educatees' solving problems for themselves, and utilizing them for evaluation materials for lesson plans.

• Journal of Korea Water Resources Association
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• v.45 no.6
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• pp.557-568
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• 2012

In order to understand the hydrological processes on the mountainous forest, the configuration of soil evaporation (E) out of evapotranspiration (ET) is a challenging and important topic. In this study, we attempted to understand the soil evaporation process for a humid forest hillslope via measuring and analyzing soil moistures with a sampling interval in 2 hours at three locations for 10 days between May 22th and 31th 2009. Two methods were used to estimate soil evaporation in every 2hr; one is a method using soil moisture measurement ($E_{SM}$), the others methods are based on Penman equation (Penman (1948), Staple (1974), Konukcu (2007), Equilibrium Penman ($E_{equili}$)). As a critical parameter in determining $E_{SM}$, the dry surface layer (DSL), was estimated using energy balance equation. The accumulated soil evaporation ($E_{SM}$) of A, B, C points were estimated as 2.09, 1.08 and 2.88 mm, respectively. The estimated evaporation of Penman (1948), Staple (1974), Konukcu (2007), $E_{equili}$ were 4.91, 8.80, 8.63 and 3.28 mm. The proposed method with soil moisture measurement showed lower soil evaporations than the other conventional methods. The increasing soil temperature and interaction between soil and atmosphere due to existence of litter and DSL are considered as dominant factors for soil evaporation. The $E_{SM}$ has the apparent lag time between 2 and 4 hr compared with $E_{equili}$ and net radiation. The DSL and surface resistance ($r_s$) were increased as soil moisture was decreased for in this study. The estimated DSL through the temporal distribution analysis of soil moisture and tension measurements was also similar to that of the energy balance relationship.

• Journal of the Korean Geographical Society
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• v.43 no.6
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• pp.808-823
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• 2008

Sediment abrasion in rivers is caused by the interaction between bedrock channel bed and sediment particles transported through the river. Abrasion rate of sediment particles in rivers is controlled by two major factors; Sediment transport conditions including hydraulic conditions form the erosive forces and physical and chemical strengths of the particles form a resistance force against abrasion and other erosional processes. Physical experiments were performed to find the role of each variable on sediment abrasion process. Total 266 sediment particles were used in this experiment. All sediment particles were divided into 11 independent sediment groups with sediment particle size and sediment loads. Each sediment groups were abraded in tumbling mill for up to 8 hours. Changes in weight were recorded by run and total: 2,128 cases of abrasion rate were recoded. Physical strength of rock particles was measured with point load strength index. It is found that sediment abrasion rate has a negative functional relationship point load strength index ($I_{a(50)}$) ($R^2=0.22$). It was suggested that physical strength of sediment particles set the "maximum possible abrasion rate'. As sediment flux increases, abrasion rates of sediment particles with similar point load strength index were changed. It could be concluded that not only physical characteristics of sediment particles, but also sediment transport conditions control sediment abrasion rates.

• Journal of the Korea Convergence Society
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• v.9 no.5
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• pp.191-202
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• 2018

Artificial intelligence (AI) is already being utilized in certain personnel selection processes in organizations; AI will eventually make even final decisions for personnel selection. The present study investigated potential job candidates' perceptions of an AI recruiter by comparing the selection procedures carried out by an AI recruiter to those carried out by a human recruiter. For this study college students in South Korea were recruited. They were each shown one of two recruitment scenarios (human recruiter vs. AI recruiter; between-subject design) followed by questionnaires measuring their satisfaction with the selection procedures and procedural justice, their trust in the recruiter, and their belief in a just world. Results show that potential job candidates were more satisfied with the selection procedures used by the AI recruiter than the human recruiter; they perceived the procedures as fairer than those used by the human recruiter. In addition, potential job candidates' trust in the AI recruiter was significantly higher than their trust in the human recruiter. This study also explored whether potential job candidates' perceptions of the AI and human recruiter were contingent upon their beliefs in a just world. The present study suggests a direction for future research.

• Journal of the Korea Society of Computer and Information
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• v.19 no.3
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• pp.73-85
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• 2014

As the importance of big data analysis increases to improve the competitiveness of a corporate, a unified big data project development methodology is required in order to study the problem of a corporate in a systematic way and evaluate the problem w.r.t. a business value after solving the problem. This paper propose Scientific Data Anslysis and Development methodology(SDAD) which are integrated methodology of software development and project management for easier application into a field project. SDAD consisits of 6 stages(problem definition stage, data preparation stage, model design stage, model development stage, result extraction stage, service development state), each stages has detailed processes(47) and productions(93). SDAD, furthermore, unified previous ISP, DW, SW development methodologies in terms of the data analysis and can easily interchange the productions with them. This paper, lastly, introduces a way to assign responsible persons for each process and provide communication procedures in RACI chart to improves the efficiency of the interaction among professionals from different subjects. SDAD is applied to a Bigdata project in Korea Employment Information Services institution and the result turned out to be acceptable when evaluated by the supervision.

• Journal of the Korea Knowledge Information Technology Society
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• v.13 no.2
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• pp.273-286
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• 2018

Korean government has taken various population policy so far According to demographic results, The aging population is rapidly aging and it is expected to deepen in the future. However, many senior citizens are also exposed to poor economic conditions and inconsistent health care risks Most seniors suffer from mental illness and chronic diseases. seniors in traditional cities feel very alienated as they change from large family to small family. As the number of elderly people living alone grows, social problems increase. At present, the health care for the elderly who live alone is not being taken properly, and they are under a very poor management system, both physically and mentally. Every human being has to be old, and we aim to spend our old age processes physically and mentally healthy. As the basic age of the elderly increases, it is necessary to consider various aspects of the welfare policies and medical policies that are followed. In this study, 100 elderly people over the age of 65 were surveyed for economic situations and physical and mental health conditions, and specially performed study on utility of 'urban senior multi care zone' to prove the necessity of introducing the latest digital devices to resolve these problems more effectively by analyzing serious feelings of alienation, loneliness, and emotional situations. Lastly, We conducted this research to find ways to help the elderly through customized health care.

• Journal of Science and Technology Studies
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• v.18 no.1
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• pp.177-217
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• 2018

This study examines the case of living lab applied in the R&D initiatives for solving societal problems and challenges. It discusses how to use the living lab in national R&D projects. The analyzed cases are 'Develop portable fundus camera for eye disease screening test to resolve health inequalities' and 'Auto-sensing integrated system development in rural pedestrian crosswalk'. As a result of the analysis, both cases were designed as a user participatory R&D structure by utilizing living lab. In other words, living lab has operated as a system that evolves technology-products-services into an infrastructure. It can realize final demand specification, product, service improvement and demonstration through continuous interaction of end users. As a result of the case analysis, the following policy tasks can be derived. First, living lab is a new concept and it is in the early stage of implementation in Korea. Therefore, it is necessary to monitor and evaluate living lab experiments and build suitable models for Korean society by sharing cases and achievements. Second, the strategic niche management are necessary for the introduction of living lab. Third, living lab can be used as a tool to transform the existing technology acquisition centered innovation policy to the policy for customer needs and problem solving. Fourth, there is a need for flexibility and adaptability in strategy and system to correct errors that appear in the living lab processes.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.14 no.2
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• pp.136-150
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• 2002

To improve the water quality of the recently constructed Siwhaho, sluice gates were operated to allow free exchange of water with the sea. This estuarine lake connected to the outer sea through narrow gates is affected mainly by flushing by gate operation and river flows and wind forcing sometimes. As a predicting tool far the water qualities, a three-dimensional finite volume model CE-QUAL-ICM is incorporated into a finite element hydrodynamic model, TIDE3D. In coupling these two different modules, a new error minimization technique is applied by considering conservation of mass. Model tests for one year after calibration and validation using field observation show that eutrophication and other biological changes reach quasi-steady state after initial 60 days of simulation, thus it would be necessary to consider moderate ramp up option to remove initial uncertainties due to cold start option. Sediment-water interaction might not be a concern in the long-term simulation, since its effect is negligible. Simulated results show the newly applied scheme can be applied with satisfaction not only fur lessening of eutrophic processes in an estuarine lake but also looking for some active circulation to improve water quality.