• Nuclear Engineering and Technology
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• 제52권6호
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• pp.1137-1147
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• 2020

The discrete ordinates method (S_N) is one of the major shielding calculation method, which is suitable for solving deep-penetration transport problems. Our objective is to explore the available quadrature sets and to improve the accuracy in shielding problems involving strong anisotropy. The linear discontinuous finite-element (LDFE) quadrature sets based on the icosahedron (in short, ICLDFE quadrature sets) are developed by defining projected points on the surfaces of the icosahedron. Weights are then introduced in the integration of the discontinuous finite-element basis functions in the relevant angular regions. The multivariate secant method is used to optimize the discrete directions and their corresponding weights. The numerical integration of polynomials in the direction cosines and the Kobayashi benchmark are used to analyze and verify the properties of these new quadrature sets. Results show that the ICLDFE quadrature sets can exactly integrate the zero-order and first-order of the spherical harmonic functions over one-twentieth of the spherical surface. As for the Kobayashi benchmark problem, the maximum relative error between the fifth-order ICLDFE quadrature sets and references is only -0.55%. The ICLDFE quadrature sets provide better integration precision of the spherical harmonic functions in local discrete angle domains and higher accuracy for simple shielding problems.

• IMMUNE NETWORK
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• 제12권2호
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• pp.48-57
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• 2012

Acute viral encephalitis caused by neurotrophic viruses, such as mosquito-borne flaviviruses, is an emerging and re-emerging disease that represents an immense global health problem. Considerable progression has been made in understanding the pathogenesis of acute viral encephalitis, but the immune-pathological processes occurring during the progression of encephalitis and the roles played by various molecules and cellular components of the innate and adaptive systems still remain undefined. Recent findings reveal the significant contribution of Toll-like receptors (TLRs) and regulatory $CD4^+$ T cells in the outcomes of infectious diseases caused by neurotrophic viruses. In this review, we discuss the ample evidence focused on the roles of TLRs and $CD4^+$ helper T cell subsets on the progression of acute viral encephalitis. Finally, we draw attention to the importance of these molecules and cellular components in defining the pathogenesis of acute viral encephalitis, thereby providing new therapeutic avenues for this disease.

• Journal of information and communication convergence engineering
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• 제7권4호
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• pp.475-479
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• 2009

In ad hoc network, the scarce energy management of the mobile devices has become a critical issue in order to extend the network lifetime. Current research activity for the Minimum Energy Multicast (MEM) problem has been focused on devising efficient centralized greedy algorithms for static ad hoc networks. In this paper, we consider mobile ad hoc networks(MANETs) that could provide the reliable monitoring and control of a variety of environments for remote place. Mobility of MANET would require the topology change frequently compared with a static network. To improve the routing protocol in MANET, energy efficient routing protocol would be required as well as considering the mobility would be needed. In this paper, we propose a new method, the CACH(Context-aware Clustering Hierarchy) algorithm, a hybrid and clustering-based protocol that could analyze the link cost from a source node to a destination node. The proposed analysis could help in defining the optimum depth of hierarchy architecture CACH utilize. The proposed CACH could use localized condition to enable adaptation and robustness for dynamic network topology protocol and this provide that our hierarchy to be resilient. As a result, our simulation results would show that CACH could find energy efficient depth of hierarchy of a cluster.

• 한국통신학회논문지
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• 제42권2호
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• pp.389-392
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• 2017

멀티홉 무선망에서 플로우가 교차하는 노드의 네트워크 코딩 가능 여부를 검사하기 위한 조건인 PCC와 RFCC가 기존에 제안되었다. PCC의 경우 교차 노드가 하나인 경우에만 정확하게 동작한다. 이 문제를 해결하기 위해 RFCC는 중간 노드의 디코딩 가능성을 고려한 네트워크 코딩 조건을 정의했다. 그러나 중간 노드의 디코딩 가능성 검사와 디코딩으로 인한 코딩 연산 횟수가 증가하는 문제가 있다. 본 논문에서는 이 오버헤드를 줄이기 위해서 목적지 노드에서만 디코딩이 가능하도록 하고, 이를 위한 네트워크 코딩 조건인 DCC를 정의한다. DCC의 성능을 시뮬레이션 수행을 통해 분석한다.

• Ocean Systems Engineering
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• 제1권2호
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• pp.157-169
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• 2011

To provide more rational design solutions at conceptual design level, axiomatic design method has been applied to solve critical part of a new engineering problem called Mobile Harbor. In the implementation, the Mobile Harbor, a functional harbor system that consists of a vessel with container crane approaches to a container ship anchored in the open sea and establishes a secure mooring between the two vessels to carry out loading and unloading of containers. For this moving harbor system to be able to operate successfully, a reliable and safe strategy to moor and maintain constant distance between the two vessels in winds and waves is required. The design process of automatic ship-to-ship mooring system to satisfy the requirements of establishing and maintaining secure mooring has been managed using axiomatic design principles. Properly defining and disseminating Functional Requirements, clarifying interface requirements between its subsystems, and identifying potential conflict, i.e. functional coupling, at the earliest stage of design as much as possible are all part of what need to be managed in a system design project. In this paper, we discuss the automatic docking system design project under the umbrella of KAIST mobile harbor project to illustrate how the Axiomatic Design process can facilitate design projects for a large and complex engineering system. The solidified design is presented as a result.

• Steel and Composite Structures
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• 제9권6호
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• pp.569-584
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• 2009

Corrosion of steel rebars in bridge decks which are faced to harsh conditions, is a common problem in construction industries due to the porosity of concrete. In this research, the behavior of one-way concrete slabs reinforced with Glass fiber reinforced polymer (GFRP) molded grating is investigated both theoretically and experimentally. In the analytical method, a closed-form solution for load-deflection behavior of a slab under four-point bending condition is developed by considering a concrete slab as an orthotropic plate and defining stiffness coefficients in principal directions. The available formulation for concrete reinforced with steel is expanded for concrete reinforced with GFRP molded grating to predict ultimate failure load. In finite element modeling, an exact nonlinear behavior of concrete along with a 3-D failure criterion for cracking and crushing are considered in order to estimate the ultimate failure load and the initial cracking load. Eight concrete slabs reinforced with steel and GFRP grating in various thicknesses are also tested to verify the results. The obtained results from the models and experiments are relatively satisfactory.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 제2회 추계심포지움
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• pp.61-67
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• 1994

One fundamental problem in developing an AIDS vaccine is antigenic variation of HIV. Despite a substantial induced immune response in gp120-immunized monkeys and humans, high titers of V3-directed type specific neutralizing antibodies may not be sufficient to neutralize continuously emerging new isolates. Several studies analyzing anti-gp120 antibodies in HIV-infected individuals have clearly indicated that most broadly neutralizing antibodies are directed to conformation-dependent epitopes. Therefore, it seems important to evaluate the potential efficacy of candidate gp120 vaccines at inducing such antibodies, that might be potentially protective against multiple HIV strains. One concern in the development of any recombinant protein as a vaccine is its stability when mixed with an adjuvant. This could be a particularly important factor for recombinant gp120, given the conformational nature of its major, broadly neutralizing, epitopes. We hypothesized that gp120 complexed with recombinant CD4 could stabilize the conformation-dependent epitopes and effectively deliver these epitopes to the immune system. In this study, a soluble gp120-CD4 complex in Syntex Adjuvant Formulation was tested in mice to analyze the anti-gp120 antibody response. With the aim of defining the fine specificity and neutalizing activities of the immune response, 17Mabs were generated and characterized. The studies indicate that the gp120-CD4 complex elicits neutralizing anti-gp120 antibodies, most of which are directed to the conformation dependent epitopes.

• 기술경영경제학회:학술대회논문집
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• 기술경영경제학회 1998년도 제13회 하계학술발표회 논문집
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• pp.208-215
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• 1998

Since the advent of conceptual prototype and seminal application, the notion of national systems of innovation(NSI) has drawn an increasing recognition. Although the morphological entanglement is still ubiquitous and the theoretical underpinning is fragile, NSI seems to be the last step toward an increasingly complex and encompassing concept of innovation research. Inevitably, NSI necessitates the comparative analysis in that it normatively attempts to draw best practices. Unfortunately, national profiles are too complex and diverse to derive a unified, concrete representation of the system, posing the problem of defining and modelling NSI for international comparison. This paper aims at providing an inductive taxonomy of NSI based on R&D structure of OECD member economies. Based on the similarity among national profiles, clustering method was applied to identify seven clusters such as (1) enterprise-government funding and enterprise-education performing group, (2) enterprise-government funding and balanced performing group, (3) balanced funding and enterprise-education performing group, (4) balanced funding and performing group, (5) enterprise-dominating group, (6) government-education dominating group and (7) government-education funding and education performing group. This paper by nature is descriptive and exploratory. R&D structure represents a static snapshot of innovative performance since it accounts for only the input side of NSI and thus may not offer convincing explanations of the holistic innovation system. A more detailed and extensive analysis on the economic/technological performance across clusters will shed light on the promising avenue to future research.

• 제3의학
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• 제1권1호
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• pp.37-44
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• 1996

This study has surveyed the problems raised through the standardization process of differentiation system and searched its solution, reaching the following conclusion. 1. The most serious problem is, most frequently occurred, an wilful application of differentiation system or constitutive classification for disease. 2. To overcome this wilfulness, we must make a definite understanding of the origin and its applicative limit of the theory. 3. And it must be preceded for a correct and objective differentiation to standardize in all choice of the differential diagnostics and its applicative condition. 4. To establish such a corresponding diagnostic scheme, it must be generally agreed on an individuality and inevitability of the suitability to differentiation principles. 5. And, though we can make a prescription through the frequency, degree, and clarified cause of the symptom, its flexibility of application must not be necessarily, ignored. 6. As this study for standardizing the disharmony between liver and pancreas(肝脾不調) shows, accordingly, we must begin by scrutinizing and defining what the chief cause, head, and inevitable symtoms are and discern them from its affinities, making necessarily a great deal attention to minute feelings and degree about its individual symptoms. On the ground of these recognition, we must go further to establish a general standardization and try to get a specific study series.

• 대한기계학회논문집B
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• 제23권6호
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• pp.703-712
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• 1999

This paper suggests an automatic elliptic grid generation method that is well-suited for the numerical mapping of complex geometries which are easily obtained from general CAD programs. An LBLADI solver is used for the governing mapping equations to have the strong diagonal dominance. The full boundary control method is adopted to determine the control functions of the equations, which allows the control of the grid regarding spacing and angle control at all boundary surfaces. The solution method presented here provides the capability of mapping very complicated geometries by defining grid point locations only along the boundaries. In the automated elliptic grid generation procedure, it is showed that strong diagonal dominance is essential to achieve successful mapping irrespective of the initial grid condition provided. To demonstrate the robustness of this method, it is applied to the thermal flow like the natural convection between eccentric cylinders. The results agree well with others.