• 제목/요약/키워드: Probiotics

검색결과 962건 처리시간 0.021초

프로바이오틱스의 건강증진과 질병치료 효능 (Health Improvement and Treatment Effect of Probiotics)

  • 백영미;김경순;이연월;조종관;유화승
    • 혜화의학회지
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    • 제19권1호
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    • pp.25-34
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    • 2010
  • Background : The human being and the bacteria have accomplished a balance and have coexisted each other during long time. Probiotics have evolved with the human host to exist and the result they have operated profitably to human host. So it requires that the functions of probiotics are expounded in view of Traditional Korean Medicine. Aim : Suggest the functions of probiotics in view of Traditional Korean Medicine. Method : The author's research has been performed to review the related references. Results : Probiotics assist the absorption of the lactose, proteins and minerals and product several kinds of vitamins, organic acids. Probiotics suppresses the growth of noxious bacteria and the production of harmful substances or gases. They absorbed and discharge the bile acid, and thus help us maintain the optimal level of blood cholesterol concentration. They can reinforce the immune response of the mucous membrane and control the hypersensitivity immune reaction such as asthma, atopy on the other hand. Probiotics have right functions as above and so can be applied widely in treatment of various disease and symptom. Conclusion : Considering the functions of probiotics in view of Traditional Korean Medicine, they participate in our spleen-earth-system (digestion and synthesis) and liver-wood-system (regulation of digestion, metabolism, internal secretion etc.), assist the function of lung-metal system(respiration and regulation of water metabolism) and regulate wi-chi (reinforce/control immune system). Consequently, hereafter there would be a necessity of control a circumstance in treatment of various diseases under these categories that probiotics should be able to do their right functions inside the human body.

국내외 프로바이오틱스 제품 개발 현황 (Trends in probiotics product)

  • 성영제;박명수
    • 식품과학과 산업
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    • 제52권3호
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    • pp.229-240
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    • 2019
  • 2002년 FAO와 WHO에 의하여 "적절한 양을 섭취했을 때 숙주(사람)의 건강에 이로운 작용을 하는 생균"으로 정의된 이래 프로바이오틱스는 연구적인 측면뿐 아니라 제품화를 통한 시장의 지속적인 성장을 거듭하여 기능성 식품의 매우 중요한 부분을 차지하고 있다. 최근에는 마이크로바이옴 연구에 힘입어 프로바이오틱스가 장 건강뿐 아니라 전신의 건강과 관련되어 다양한 역할이 밝혀지고 있으므로 더욱 다양한 형태 및 기능을 갖는 제품의 개발이 기대되고 있다. 아울러 국제적으로 경쟁력을 가지고 유통되기 위해서는 글로벌 기준에 맞는 품질관리를 통한 인증 등에 대한 노력이 필요하다. 본 논문에서는 프로바이오틱스의 새로운 정의, 프로바이오틱스의 국내외 관리기준, 효능의 균주 특이성, 마이크로바이옴과의 연관성, 시장 동향에 대하여 살펴보았다.

Monitoring Cellular Immune Responses after Consumption of Selected Probiotics in Immunocompromised Mice

  • Kang, Seok-Jin;Yang, Jun;Lee, Na-Young;Lee, Chang-Hee;Park, In-Byung;Park, Si-Won;Lee, Hyeon Jeong;Park, Hae-Won;Yun, Hyun Sun;Chun, Taehoon
    • 한국축산식품학회지
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    • 제42권5호
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    • pp.903-914
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    • 2022
  • Probiotics are currently considered as one of tools to modulate immune responses under specific clinical conditions. The purpose of this study was to evaluate whether oral administration of three different probiotics (Lactiplantibacillus plantarum CJLP243, CJW55-10, and CJLP475) could evoke a cell-mediated immunity in immunodeficient mice. Before conducting in vivo experiments, we examined the in vitro potency of these probiotics for macrophage activation. After co-culture with these probiotics, bone marrow derived macrophages (BMDMs) produced significant amounts of proinflammatory cytokines including interleukin-6 (IL-6), IL-12, and tumor necrosis factor-α (TNF-α). Levels of inducible nitric oxide synthase (inos) and co-stimulatory molecules (CD80 and CD86) were also upregulated in BMDMs after treatment with some of these probiotics. To establish an immunocompromised animal model, we intraperitoneally injected mice with cyclophosphamide on day 0 and again on day 2. Starting day 3, we orally administered probiotics every day for the last 15 d. After sacrificing experimental mice on day 18, splenocytes were isolated and co-cultured with these probiotics for 3 d to measure levels of several cytokines and immune cell proliferation. Results clearly indicated that the consumption of all three probiotic strains promoted secretion of interferon-γ (IFN-γ), IL-1β, IL-6, IL-12, and TNF-α. NK cell cytotoxicity and proliferation of immune cells were also increased. Taken together, our data strongly suggest that consumption of some probiotics might induce cell-mediated immune responses in immunocompromised mice.

Effect of Green Tea Probiotics on the Growth Performance, Meat Quality and Immune Response in Finishing Pigs

  • Ko, S.Y.;Yang, C.J.
    • Asian-Australasian Journal of Animal Sciences
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    • 제21권9호
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    • pp.1339-1347
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    • 2008
  • The objective of this study was to determine the effects of green tea probiotics on growth performance, meat quality and immune response in finishing pigs, and to assess the possibility of substituting green tea probiotics for antibiotics in diets of finishing pigs. This green tea probiotics is made by mixing green tea powder and excipients (defatted rice bran and wheat bran) and fermenting the mixture with beneficial bacteria. A total of 90 crossbreed "Landrace$\times$Yorkshire" finishing pigs with an average body weight of $72.5{\pm}2.5kg$ were assigned to 5 dietary treatments in a completely randomized design. Each treatment had 3 replications with 6 pigs per replication. The five dietary treatments were control, antibiotic (0.003% chlortetracycline added) and 0.1, 0.5 and 1.0% of green tea probiotics. There were no significant differences in final body weight, daily weight gain, daily feed intake and feed conversion ratio in the green tea probiotics and antibiotic treatments (p>0.05). Crude protein content was significantly increased in the 0.1 and 1.0% green tea probiotics treatment groups (p<0.05) and there was no significant difference in crude fat content of the meat among the treatments. The TBA value of meat was significantly lowered with 0.5 and 1.0% green tea probiotics treatments compared to that of controls and statistically similar to the antibiotic treatment after 3 weeks of storage (p<0.05). The growth of spleen cells stimulated with Con A (0.1 and $1.0{\mu}g/ml$) was significantly increased with 1.0% green tea probiotics treatment compared to that of the control treatment (p<0.05). The growth of spleen cells stimulated with LPS (1.0, 3.0 and $10{\mu}g/ml$) was significantly increased in the 0.5% green tea probiotics group compared to the antibiotic group (p<0.05). In Con A ($1.0{\mu}g/ml$) medium, IL-6 production of spleen cells was significantly increased with 1.0% green tea probiotics treatment compared to that of the control (p<0.05). In LPS ($10.0{\mu}g/ml$) medium, TNF-${\alpha}$ production of spleen cells increased significantly in all green tea probiotics treatment groups compared to that of the control (p<0.05). Finally it can be summarized that addition of green tea probiotic has a positive effect similar to antibiotic and 0.5% is the suitable dietary supplementation dose for finishing pig production.

Surface-Displayed IL-10 by Recombinant Lactobacillus plantarum Reduces Th1 Responses of RAW264.7 Cells Stimulated with Poly(I:C) or LPS

  • Cai, Ruopeng;Jiang, Yanlong;Yang, Wei;Yang, Wentao;Shi, Shaohua;Shi, Chunwei;Hu, Jingtao;Gu, Wei;Ye, Liping;Zhou, Fangyu;Gong, Qinglong;Han, Wenyu;Yang, Guilian;Wang, Chunfeng
    • Journal of Microbiology and Biotechnology
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    • 제26권2호
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    • pp.421-431
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    • 2016
  • Recently, poly-γ-glutamic acid synthetase A (pgsA) has been applied to display exogenous proteins on the surface of Lactobacillus casei or Lactococcus lactis, which results in a surface-displayed component of bacteria. However, the ability of carrying genes encoded by plasmids and the expression efficiency of recombinant bacteria can be somewhat affected by the longer gene length of pgsA (1,143 bp); therefore, a truncated gene, pgsA, was generated based on the characteristics of pgsA by computational analysis. Using murine IL-10 as an exogenous gene, recombinant Lactobacillus plantarum was constructed and the capacity of the surface-displayed protein and functional differences between exogenous proteins expressed by these strains were evaluated. Surface expression of IL-10 on both recombinant bacteria with anchorins and the higher expression levels in L. plantarum-pgsA'-IL-10 were confirmed by western blot assay. Most importantly, up-regulation of IL-1β, IL-6, TNF-α, IFN-γ, and the nuclear transcription factor NF-κB p65 in RAW264.7 cells after stimulation with Poly(I:C) or LPS was exacerbated after co-culture with L. plantarum-pgsA. By contrast, IL-10 expressed by these recombinant strains could reduce these factors, and the expression of these factors was associated with recombinant strains that expressed anchorin (especially in L. plantarum-pgsA'-IL-10) and was significantly lower compared with the anchorin-free strains. These findings indicated that exogenous proteins could be successfully displayed on the surface of L. plantarum by pgsA or pgsA', and the expression of recombinant bacteria with pgsA' was superior compared with bacteria with pgsA.

Clostridium difficile-associated Intestinal Disease and Probiotics

  • Yun, Bohyun;Lee, Sang Dae;Oh, Sejong
    • Journal of Dairy Science and Biotechnology
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    • 제31권1호
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    • pp.1-7
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    • 2013
  • Probiotics are traditionally defined as viable microorganisms that have a beneficial effect in the prevention and treatment of pathologic conditions when they are ingested. Although there is a relatively large volume of literature that supports the use of probiotics to prevent or treat intestinal disorders, the scientific basis behind probiotic use has only recently been established, and clinical studies on this topic are just beginning to get published. Currently, the best studied probiotics are lactic acid bacteria, particularly Lactobacillus and Bifidobacterium species. Other organisms used as probiotics in humans include Escherichia coli, Streptococcus sp., Enterococcus sp., Bacteroides sp., Bacillus sp., Propionibacterium sp., and various fungi, and some probiotic preparations contain more than one bacterial strain. Probiotic use for the prevention and treatment of antibiotic-associated diarrhea caused by Clostridium difficile induced intestinal disease as well as for other gastrointestinal disorders has been discussed in this review.

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프로바이오틱스에 의한 알레르기 질환 제어 및 안전성 (Control of Allergy with Probiotics and Its Safety)

  • 이예원;윤요한
    • Journal of Dairy Science and Biotechnology
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    • 제38권1호
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    • pp.19-26
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    • 2020
  • Allergic diseases, including atopic dermatitis, asthma, allergic rhinitis, and food allergies, could be caused by dysbiosis that results in an immune system imbalance. The incidence of allergic diseases has been increasing and they are now one of the most common diseases throughout the world. Recently, probiotics have been suggested as an alternative intervention for the prevention and treatment of allergic diseases. Probiotics are endogenous microflora with functional effects within hosts. They have various clinical and immunological capacities and have recently been considered as a supplement for the treatment and prevention of allergic diseases. Probiotic bacteria modulate immune cells such as Th1, Th2, and regulatory T cells that are correlated with protection against atopic dermatitis, however, safety concerns for the use of probiotics have been raised. Therefore, further research is needed to clarify the efficacy and safety of probiotics in the treatment of allergic diseases.

Immune Disorders and Its Correlation with Gut Microbiome

  • Hwang, Ji-Sun;Im, Chang-Rok;Im, Sin-Hyeog
    • IMMUNE NETWORK
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    • 제12권4호
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    • pp.129-138
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    • 2012
  • Allergic disorders such as atopic dermatitis and asthma are common hyper-immune disorders in industrialized countries. Along with genetic association, environmental factors and gut microbiota have been suggested as major triggering factors for the development of atopic dermatitis. Numerous studies support the association of hygiene hypothesis in allergic immune disorders that a lack of early childhood exposure to diverse microorganism increases susceptibility to allergic diseases. Among the symbiotic microorganisms (e.g. gut flora or probiotics), probiotics confer health benefits through multiple action mechanisms including modification of immune response in gut associated lymphoid tissue (GALT). Although many human clinical trials and mouse studies demonstrated the beneficial effects of probiotics in diverse immune disorders, this effect is strain specific and needs to apply specific probiotics for specific allergic diseases. Herein, we briefly review the diverse functions and regulation mechanisms of probiotics in diverse disorders.

유산균 Probiotics와 생명의 연장에 대한 고찰 (Probiotics and Prolongation of Life)

  • 오세종
    • Journal of Dairy Science and Biotechnology
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    • 제26권2호
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    • pp.31-37
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    • 2008
  • One hundred one years have passed since Metchnikoff made his first scientific contribution to probiotics study. Intestinal lactic acid bacteria (LAB) for humans are closely associated with the host's health because LAB is an important biodefense factor in preventing colonization and subsequent proliferation of pathogenic bacteria in the intestine. A probiotic is recently defined as "live microorganisms that when administered in adequate amount confer a health benefit on the host". Some species of LAB have been claimed as probiotics, such as Lactobacillus acidophilus, L. casei, L. fermentum, L. plantarum, L. reuteri, and Lactococcus lactis. For understanding the general mechanism of probiotics, this paper would explore the early studies relating to probiotics and intestinal microbiota, and briefly introduce the Prolongation of Life written by Elie Metctmikoff.

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단위가축을 위한 생균제의 급여 효과 (Effect of Dietary Probiotics Supplementation to Feed for Monogastric Animals)

  • 민병준;김인호
    • 한국유기농업학회지
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    • 제10권4호
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    • pp.47-60
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    • 2002
  • 생균제는 항생제와 반대의 어원적 의미를 갖는 것으로 장내 미생물 균형을 기선함으로써 숙주 동물에게 유익한 작용을 유도할 수 있는 살아있는 미생물 첨가제로서 항생제를 대체할 수 있는 물질 중 하나로서 인식되어 왔다. Lactobacillus와 같은 젖산균은 유산을 생성하여 장의 산도를 pH를 저하시켜 잡균의 오염을 방지하며, 각종 비타민, 아미나산, 항균물질 등을 생산하여 가축 장내 미생물균총의 안정, 사료효율 증가, 내병성 증대 등의 효과가 있다. 또한, saccharomyces와 같은 효모균은 각종 소화효소를 생산하여 영양소 분해를 촉진하며 알코올과 글루타민산과 같은 사료의 기호성을 증진시키는 물질을 분비한다. 단위가축에 있어 생균제의 급여효과는 돼지에 있어 증체량과 사료효율을 증가시키고 설사발생빈도를 낮춘다. 또한, 가금에 있어서는 산란계의 산란율을 개선하고, 장내 유익한 미생물의 수를 증가시키며, 육계의 증체량을 증가시키며, 혈중 콜레스테롤 수치를 낮춘다. 그러나 다른 연구에서는 생균제의 급여가 가축의 성적에 별다른 영향을 미치지 못하였다고 보고하여 이를 규명할 수 있는 연구의 진행이 이루어져야 할 것으로 보인다. 또한, 생균제의 효율적인 이용, 균주의 선발과 광합성미생물과 같은 친환경적인 생균제의 개발등도 해결되어야 할 과제일 것이다.

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