• The Korean Journal of Physiology and Pharmacology
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• v.20 no.1
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• pp.41-51
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• 2016

Adult hippocampal dentate granule neurons are generated from neural stem cells (NSCs) in the mammalian brain, and the fate specification of adult NSCs is precisely controlled by the local niches and environment, such as the subventricular zone (SVZ), dentate gyrus (DG), and Toll-like receptors (TLRs). Epigallocatechin-3-gallate (EGCG) is the main polyphenolic flavonoid in green tea that has neuroprotective activities, but there is no clear understanding of the role of EGCG in adult neurogenesis in the DG after neuroinflammation. Here, we investigate the effect and the mechanism of EGCG on adult neurogenesis impaired by lipopolysaccharides (LPS). LPS-induced neuroinflammation inhibited adult neurogenesis by suppressing the proliferation and differentiation of neural stem cells in the DG, which was indicated by the decreased number of Bromodeoxyuridine (BrdU)-, Doublecortin (DCX)- and Neuronal Nuclei (NeuN)-positive cells. In addition, microglia were recruited with activating TLR4-NF-${\kappa}B$ signaling in the adult hippocampus by LPS injection. Treating LPS-injured mice with EGCG restored the proliferation and differentiation of NSCs in the DG, which were decreased by LPS, and EGCG treatment also ameliorated the apoptosis of NSCs. Moreover, pro-inflammatory cytokine production induced by LPS was attenuated by EGCG treatment through modulating the TLR4-NF-${\kappa}B$ pathway. These results illustrate that EGCG has a beneficial effect on impaired adult neurogenesis caused by LPS-induced neuroinflammation, and it may be applicable as a therapeutic agent against neurodegenerative disorders caused by inflammation.

• Journal of Environmental Impact Assessment
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• v.7 no.2
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• pp.89-102
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• 1998

The purpose of this study is to seek AEI(Air Environmental Indices), PSI(Pollutant Standard Index) and the urban air quality control goal(the best available alternative energy program) by assessing the best ratio of energy types used in urban enterprises, based on harmful health effect and air quality standard and costs. This study is focused on an urban area(Puchun), where area sourcees are associated with heavy traffic, large population, and its industrial sources with large emissions. In the first step, air modeling, estimation of AEI and PSI, and benefit-cost analysis were carried out. In the second step, we assessed that 660 scenarios about the ratio of B-C oil, light oil and LNG used in urban enterprises with regard to air quality and cost. In the third step, the best available alternative energy program was selected for the ratio of energy species(B-C oil, light oil and LNG) by using the lexicographic method. From the emission analysis, main source of $NO_2$ is identified as industries and air quality is evaluated according to the ratio of B-C oil, light oil and LNG used in urban enterprise. The modeling data of TSP, $SO_2$, $NO_2$, CO, $O_3$, by ISC3 and PBM are respectively $118{\mu}g/m^3$, 0.027ppm, 0.025ppm, 2.0ppm, 0.55ppm in indurstrial area. That data are close to Environmental Air Quality Standard. By means of sensitivity analysis, we obtained the difference in concentration between the areas(Nae-dong, Joong-dong) according to the ratio of B-C oil, light oil and LNG used in the industries. From the result of alternatives assessment the lowest AEI value and cost, the ratio of B-C oil, light oil and LNG are 2.5%, 20%, 77.5%, respectively.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.9B
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• pp.908-913
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• 2009

Mobile phones became important household appliance that cannot be without in our daily lives. And the short messaging service (SMS) in these mobile phones is 1.5 to 2 times more than the voice service. However, the spam filtering functions installed in mobile phones take a method to receive specific number patterns or words and recognize spam messages when those numbers or words are present. However, this method cannot properly filters various types of spam messages currently dispatched. This paper proposes a more powerful and more adaptive spam filtering system using SVM and thesaurus. The system went through a process of isolating words from sample data through pro-processing device and integrating meanings of isolated words using a thesaurus. Then it generated characteristics of integrated words through the chi-square statistics and studied the characteristics. The proposed system is realized in a Window environment and the performance is confirmed through experiments.

• KIEAE Journal
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• v.6 no.2
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• pp.67-74
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• 2006

As sustainable design technologies, advanced daylighting systems with lightshelves have been developed and are currently under monitoring the daylighting performance. This study aims to evaluate the comparative daylighting performance of sloped lightshelf and conventional glazing window with mock-up model, reconstructed as a prototype of Korean office building, sized $12.0m{\times}7.3m{\times}3.7m$ ($w{\times}d{\times}h$) and $1.8m{\times}4.8m$($w{\times}h$) for the south facing side-window was installed on the rooftop of engineering building, Kyung Hee University in Korea. It has an identical configuration of reference room and the test room. For the test room, the sloped type lightshelf system was designed as 10mm transparency sheet glass, tilt angle degree $29^{\circ}$, and total sized 1.28m (interior length 0.88m, exterior length 0.49m). It consisted of daylighting collector, entrance glazing and reflector. To assess daylighting performance, the totally 37 measuring points for illuminance and 2 view points of luminance were monitored in every 30 minutes from 12:00 to 15:00. For the detailed analysis, photometric sensors of each room were installed at work-plane (8 points), wall (7 points), ceiling (3points), and exterior horizontal illuminance (1 point). Luminance of window, rare of the room was measured under clear sky. It is to be monitored by Agilent data logger, photometric sensor Li-cor and the Radiant Imaging ProMetric 1400. Comparisons with a light factor, increase-decrease ratio, uniformity, and luminance are discussed.

• Biomedical Science Letters
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• v.24 no.3
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• pp.196-205
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• 2018

Reactive oxygen species (ROS) generated from metabolic reactions cause oxidative DNA damage, which results in oxidative tissue injury. Therefore, there is an increasing demand in the intake of high antioxidant sources in order to maintain a healthy environment in cells. In this study, we investigated the antioxidant and anti-inflammatory activities of Malus domestica (apple), Pyrus communis L. (pear), Daucus carota L. (carrot), Brassica oleracea var. (broccoli), Brassica oleracea var. capitata (cabbage), and Raphanus sativus L. (radish) obtained from the local market. Since these are common fruits and vegetables that are widely consumed, we aimed to investigate their beneficial properties, placing particular emphasis on their antioxidant and anti-inflammatory properties. The samples were processed via an indirect heating method and their properties were compared to their raw forms. Based on DPPH and ABTS assays, processed samples showed better antioxidant activities when compared to raw samples and processed pear samples exhibited the best antioxidant activity. The anti-inflammatory activities of the samples were also investigated in LPS-treated RAW 264.7 cells. mRNA expression of pro-inflammatory mediators and cytokines (iNOS, COX-2, $TNF-{\alpha}$, $IL-1{\beta}$, and IL-6) was assessed using RT-PCR. As expected, processed samples exhibited better iNOS inhibition when compared to their raw forms and processed broccoli and cabbage samples exhibited outstanding anti-inflammatory effects. The samples, up to 1 mg/mL concentration, did not exhibit cytotoxicity against RAW 264.7 cells as demonstrated by cell viability assays. Altogether, processed broccoli and cabbage samples exhibited the strongest anti-inflammatory properties.

• Molecules and Cells
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• v.43 no.3
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• pp.251-263
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• 2020

Flagellin, a major structural protein of the flagellum found in all motile bacteria, activates the TLR5- or NLRC4 inflammasome-dependent signaling pathway to induce innate immune responses. Flagellin can also serve as a specific antigen for the adaptive immune system and stimulate anti-flagellin antibody responses. Failure to recognize commensal-derived flagellin in TLR5-deficient mice leads to the reduction in anti-flagellin IgA antibodies at steady state and causes microbial dysbiosis and mucosal barrier breach by flagellated bacteria to promote chronic intestinal inflammation. Despite the important role of anti-flagellin antibodies in maintaining the intestinal homeostasis, regulatory mechanisms underlying the flagellin-specific antibody responses are not well understood. In this study, we show that flagellin induces interferon-β (IFN-β) production and subsequently activates type I IFN receptor signaling in a TLR5- and MyD88-dependent manner in vitro and in vivo. Internalization of TLR5 from the plasma membrane to the acidic environment of endolysosomes was required for the production of IFN-β, but not for other pro-inflammatory cytokines. In addition, we found that anti-flagellin IgG2c and IgA responses were severely impaired in interferon-alpha receptor 1 (IFNAR1)-deficient mice, suggesting that IFN-β produced by the flagellin stimulation regulates anti-flagellin antibody class switching. Our findings shed a new light on the regulation of flagellin-mediated immune activation and may help find new strategies to promote the intestinal health and develop mucosal vaccines.

• Human Ecology Research
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• v.51 no.3
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• pp.293-306
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• 2013

The aim of this study is to examine the effects of the story sharing activity on-conflicting situations by the use of children's story on the theory of mind and peer competences of preschoolers so that appropriate teaching materials can be allocated for the actual preschool education site. The subjects of this study were 46 preschoolers under the age 4 at the attached kindergarten of P University in Pohang City, Gyeongbuk and in which 23 children among them were assigned to a test group and the other 23 to a control group. The collected data was analyzed by SPSS ver. 15.0 program and Cronbach's ${\alpha}$ coefficient was yielded to verify the reliability for each scale. The multivariate analysis of covariance (MANCOVA) was conducted. The analysis results are as follows. First, the story sharing activity on conflict situations by using children's story had a significant effect on the preschoolers' general appearance and actual task as sub-factors of the theory of mind, whereas no significant effects were found regarding the content change task and position change task. Second, the story sharing activity on conflict situations by using children's story had significant effect on the preschoolers' overall sensitivity, insecurity and pro-sociability as sub-factors of the peer competences, whereas no significant effects were found regarding the aggression, exclusivity and anti-sociability.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.05a
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• pp.563-565
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• 2010

LED is low power and pro-environment semiconductor element. That can be used not only as the lighting function but also for Visible Light Communication(VLC). The VLC is the communication technology that can send data by blinking a fluorescent or LED using visible spectrum. That velocity of blinking can not be usually recognized by eyesight. Visible Light Communication using LED can be used in many fields. In the field of ITS(Intelligent Transportation System), Under construction on the road, Emitting traffic signs can be applied to transfer the vehicle information. In this paper, Emitting traffic signs in addition to the VLC give information about road condition, safety distance and the lane change. We design Communication protocol to provide safety service and verify protocol by experiment.

• Korean Journal of Remote Sensing
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• v.26 no.2
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• pp.167-173
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• 2010

This paper introduces Geostationary Ocean Color Imager, IMage Pre-processing Subsystem (GOCI IMPS) of Communication, Ocean, and Meteorological Satellite (COMS), and describes its functions, development states, and operational concepts. The primary and backup systems of GOCI IMPS have been installed in Korea Ocean Satellite Center (KOSC) and Satellite Operation Center (SOC) and the system are the prelaunch test phase after completing all required tests. It is expected that the GOCI data observed continuously over the Korea Peninsular in the geostationary orbit will be usefully utilized in marine environment research fields such as sea surface temperature changes or marine ecosystems.

• 한국노년학
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• v.36 no.3
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• pp.827-846
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• 2016

The presented study was based on the notions that 1)the age-separated perspective would not be functional for post modern society which characterized by a diversity of life styles and 2)effects of wage peak system have been investigated mainly through managemental efficiency with quantitative analysis. In those notions, this study aimed to investigate effects of wage peak system based on age integration perspective with a qualitative method. Deep case study were executed with four workers who fully understand regarding wage peak system. Results showed that three sub categories were drawn in the meaning focused on issues of wage peak system; uneasy attention on workers who applied for wage peak system; pro and con of wage peak system for aged workers; achieving age integrated environment through mutual understanding.