• JSTS:Journal of Semiconductor Technology and Science
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• v.17 no.1
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• pp.129-140
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• 2017

In this paper, a $4{\times}32$-channel neural recording system capable of acquiring neural signals is introduced. Four 32-channel neural recording ICs, complex programmable logic devices (CPLDs), a micro controller unit (MCU) with USB interface, and a PC are used. Each neural recording IC, implemented in $0.18{\mu}m$ CMOS technology, includes 32 channels of analog front-ends (AFEs), a 32-to-1 analog multiplexer, and an analog-to-digital converter (ADC). The mid-band gain of the AFE is adjustable in four steps, and have a tunable bandwidth. The AFE has a mid-band gain of 54.5 dB to 65.7 dB and a bandwidth of 35.3 Hz to 5.8 kHz. The high-pass cutoff frequency of the AFE varies from 18.6 Hz to 154.7 Hz. The input-referred noise (IRN) of the AFE is $10.2{\mu}V_{rms}$. A high-resolution, low-power ADC with a high conversion speed achieves a signal-to-noise and distortion ratio (SNDR) of 50.63 dB and a spurious-free dynamic range (SFDR) of 63.88 dB, at a sampling-rate of 2.5 MS/s. The effectiveness of our neural recording system is validated in in-vivo recording of the primary somatosensory cortex of a rat.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.78.2-78.2
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• 2014

MIRIS (Multi-purpose Infrared Imaging System) is the primary payload on the Korean science and technology satellite, STSAT-3, which was launched on 2013 November 21. It is designed to observe the near-infrared sky with a $3.67^{\circ}{\times}3.67^{\circ}$ field of view and a $51.6^{{\prime}{\prime}}{\times}51.6^{{\prime}{\prime}}$ pixel resolution. Using two narrow-band filters at $1.88{\mu}m$ (Pa ${\alpha}$ line) and $1.84+1.92{\mu}m$ (Pa ${\alpha}$ dual continuum), the Paschen ${\alpha}$ Galactic plane survey has been carrying out, and the area for the Galactic longitude from $+280^{\circ}$ to $+100^{\circ}$ (with the width of $-3^{\circ}$ < b < $+3^{\circ}$) has been covered by 2014 August 31. In this contribution, we present the preliminary results of the MIRIS Paschen ${\alpha}$ emission maps and compare them with other wavelength maps such as $H{\alpha}$ and dust maps. Many of the Paschen ${\alpha}$ features have been detected along the plane, and some of them are weak or invisible in the $H{\alpha}$ map and coincide well with dense cloud regions.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.267-268
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• 2002

Microbeam is a new avenue of radiation research especially in radiation biology and radiation protection. Selective irradiation of an ionizing particle to a targeted cell organelle may disclose such mechanisms as signal transaction among cell organelles and cell-to-cell communication in the processes toward an endpoint observed. Bystander effect, existence of which is clearly evidenced by application of the particle microbeam to biological experiments, suggests potential underestimation in the conventional risk estimation at low particle fluence rates, such as environment of space radiations in ISS (International Space Station). To promote these studies we started the construction of our microbeam facility (named as SPICE) to our HVEE Tandem accelerator (3.4 MeV proton and 5.1 MeV $^4$He$\^$2+/). For our primary goal, "irradiation of single particle to cell organelle within a position resolution of 2 micrometer in a reasonable irradiation time", special features are considered. Usage of a triplet Q magnet for focussing the beam to submicron of size is an outstanding feature compared to facilities of other institutes. Followings are other features: precise position control of cell dish holder, design of the cell dish, data acquisition of microscopic image of a cell organelle (cell nucleus) and data processing, a reliable particle detection, soft and hard wares to integrate all these related data, to control and irradiate exactly determined number of particles to a targeted spot.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.sup1
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• pp.39-45
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• 2008

PET or PET/CT detects only less than 50% of early gastric cancer and 62-98% of advanced gastric cancer. Therefore, mass screening programs are recommended for all adults over the age of 40 for early detection and early treatment of gastric cancer through endoscopy or various radiological tests. The most important step after diagnosis of gastric cancer is accurate staging, which mainly evaluates tumor resectability to avoid unnecessary surgery. Important factors that affect tumor resectability are whether the tumor can be separated from adjacent organs or important blood vessels, the extent of lymph node metastasis, presence of peritoneal metastasis, or distant organ metastasis. To evaluate the extent of local tumor invasion, anatomical imaging that has superior spatial resolution is essential. There are a few studies on prognostic significance of FDG uptake with inconsistent results between them. In spite of lower sensitivity for lymph node staging, the specificity of CT and PET are very high, and the specificity for PET tends to be higher than that for CT. Limited data published so far show that PET seems less useful in the detection of lung and bone metastasis. In the evaluation of pleural or peritoneal metastasis, PET seems very specific but insensitive as well. When FOG uptake of primary tumor is low, distant metastasis also tends to show low FDG uptake reducing its detection on PET. There are only a few data available in the evaluation of recurrence detection and treatment response using FDG PET or PET/CT.

• Korean Journal of Optics and Photonics
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• v.15 no.3
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• pp.241-247
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• 2004

The collimator is necessary for the assembly and evaluation of high resolution satellite telescope. Traditionally, the off-axis paraboloid has been used as a collimator. However, it has some disadvantages in that it can suffer from air turbulence when the focal length of a collimator is long, which may result in some error in the measurement. In contrast, since the Cassegrain type collimator folds the beam, it occupies smaller space compared to the off-axis paraboloid for the same focal length. This can reduce the air turbulence, which can improve the measurement accuracy. In this paper, we explain the process of design and manufacturing of a diameter 450 mm Cassegrain type collimator, to evaluate the diameter 300 mm satellite telescope. After assembly of primary and secondary mirrors, the final wavefront error of the collimator was 0.07λ(λ=633 nm), which is the diffraction limit.

• Journal of Korean Society of Rural Planning
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• v.19 no.3
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• pp.51-59
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• 2013

The objective of this study was to make a map of farmland vulnerability to flood inundation based on morphologic characteristics from the flood-damaged areas. Vulnerability mapping based on the records of flood damages has been conducted in four successive steps; data preparation and preprocessing, identification of morphologic criteria, calculation of inundation vulnerability index using a fuzzy membership function, and evaluation of inundation vulnerability. At the first step, three primary digital data at 30-m resolution were produced as follows: digital elevation model, hill slopes map, and distance from water body map. Secondly zonal statistics were conducted from such three raster data to identify geomorphic features in common. Thirdly inundation vulnerability index was defined as the value of 0 to 1 by applying a fuzzy linear membership function to the accumulation of raster data reclassified as 1 for cells satisfying each geomorphic condition. Lastly inundation vulnerability was suggested to be divided into five stages by 0.25 interval i.e. extremely vulnerable, highly vulnerable, normally vulnerable, less vulnerable, and resilient. For a case study of the Jinju, farmlands of $138.6km^2$, about 18% of the whole area of Jinju, were classified as vulnerable to inundation, and about $6.6km^2$ of farmlands with elevation of below 19 m at sea water level, slope of below 3.5 degrees, and within 115 m distance from water body were exposed to extremely vulnerable to inundation. Comparatively Geumsan-myeon and Sabong-myeon were revealed as the most vulnerable to farmland inundation in the Jinju.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.1
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• pp.29.1-29.1
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• 2017

I present new near-infrared (NIR) photometry of globular cluster (GC) systems associated to a cD galaxy NGC 4874 in the core of the Coma cluster and 16 early-type galaxies in the Fornax and Virgo clusters of galaxies using the Infrared Channel of the Wide Field Camera 3 (WFC3/IR) on board the Hubble Space Telescope (HST). Combining these high-resolution NIR data with new HST Advanced Camera for Surveys (ACS) optical photometry for NGC 4874 and existing ACS GC catalogs from the ACS Fornax and Virgo Cluster Surveys, I have examined for the first time the GC systems in a statistically significant optical/NIR sample of galaxies spanning a wide range of luminosities and colors. A primary goal of this study is to explore empirically whether the distributions of purely optical and hybrid optical - NIR color indices for extragalactic GCs have different forms and whether the relations between these color indices are nonlinear, indicating that they behave differently with underlying metallicity. I find that some GC systems of large galaxies in our sample show color bimodalities that differ between the optical and optical - NIR colors, in the sense that they have disparate ratios of "blue" and "red" peak GCs, as well as differing ratios in their color dispersions. Consistent with these results, I find empirically that the dependence of hybrid optical-NIR color on purely optical color is nonlinear, with an inflection at intermediate metallicities. These findings underscore the importance of understanding the nature of galaxy-to-galaxy variations in the GC color distributions and color-color relations, as well as the exact forms of the color-metallicity transformations, in interpreting the observational data on GC color bimodality. Our ACS data for NGC 4874 shows that its GC system exhibits a very strong blue tilt, implying a very steep mass-metallicity scaling, and the centroid of this GC system is offset by $4{\pm}1kpc$ from the luminosity center of NGC 4874, in the direction of NGC 4872. Finally, I discuss the asymmetrical GC distribution around a dwarf elliptical galaxy in Coma that has a very high relative velocity with respect to the cluster mean at small clustercentric radius.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.65.2-65.2
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• 2018

Through MIRIS $Pa{\alpha}$ Galactic plane survey, a lot of $Pa{\alpha}$ blobs were detected along the plane. To reveal their characteristics, we are planning to collect NIR high-resolution spectroscopic data for them by using Immersion GRating INfrared Spectrograph (IGRINS). Here, we present the preliminary results of the IGRINS observations for a Herbig Be star, MWC 1080, which is one of the $Pa{\alpha}$ blobs detected in Cepheus. This Herbig Be star is known to possess a lot of young stellar objects (YSOs) and bright MIR ($10-20{\mu}m$) nebulosity in its vicinity. From IPHAS $H{\alpha}$ data, we revealed large extended $H{\alpha}$ features that correlate well with MIR and 13CO morphologies around MWC 1080. A part of the $H{\alpha}$ features shows a bow shock shape to the northeast of the primary star MWC 1080A, which seems to be due to an outflow from MWC 1080A. Through IGRINS observations, we detected faint [Fe II] ${\lambda}1.644{\mu}m$ and H2 1-0 S(1) ${\lambda}2.122{\mu}m$ emission lines around the bow shock feature. Interestingly, to the east region of MWC 1080A, we also detected strong [Fe II] and H2 emission lines with a couple of velocity components, which suggests the detection of a new outflow from another YSO. Broad $Br{\gamma}$ ${\lambda}2.1662{\mu}m$ line and H2 lines with various velocity components were detected around the bright MIR and $H{\alpha}$ nebulosity as well.

• Journal of Arbitration Studies
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• v.16 no.2
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• pp.3-49
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• 2006

The purpose of this paper is to make research on the settlement mechanism of the commercial disputes between the South and the North of Korea. Also, this paper is to make research on the south-north Korea's cooperative tasks to promote the disputes settlement, including the operation and management of the South-North Arbitration Commission as well as the enactment of the South-North Arbitration Rules. To realize the spirit of the South-North Joint Declaration of June 15, 2000, the Authorities concerned of the South and the North of Korea have reached an agreement titled 'Agreement on Settlement Procedure of Commercial Disputes' on December of the same year. As the follow-up measures of the said Agreement, the South-North Authorities have signed an another agreement called 'Agreement on Organization and Administration of the South-North Arbitration Commission' on October, 2003, which is becoming vital importance for settlement of the commercial disputes between south and north Korea including the Gaeseong Industrial Complex. Gaeseong, a city surrounded by the North Korean military and a symbol of inter-Korean tensions, is now turning into a peace zone where thousands of North and South Koreans are working side by side. The Gaeseong Industrial Complex project, driven by the logic and economic necessity of cooperation, has been steadily moving forward since the North designated it as a special economic zone and has enacted related laws and regulations for its development. Under the situation, the matter of primary concern is how to organize and conduct the Arbitration Commission for the prompt and effective settlement of the south-north commercial disputes. First of all, the South-North Authorities should recognize that the availability of prompt, effective and economical means of dispute resolution such as arbitration and mediation to be made by the Arbitration Commission would promote the orderly growth and encouragement of the south-north trade and investment. In this connection, the Korean Commercial Arbitration Board(KCAB) should be designated as the arbitral institution of the south Korean side under the Agreement on Organization and Administration of the South-North Arbitration Commission. The KCAB is the only authorized arbitral organization in South Korea to settle all kinds of commercial disputes at home and abroad.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.219-223
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• 2016

Background: Promoter hypermethylation is a frequent epigenetic mechanism for gene transcription repression in cancer and is one of the hallmarks of the disease. Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) contributes to cell contact-mediated communication. Dysregulation of promoter methylation has been reported in various cancers. Objectives: The objectives of this study were to investigate the CELSR3 hypermethylation level in oral squamous cell carcinomas (OSCCs) using methylation-sensitive high-resolution melting analysis (MS-HRM) and to correlate CELSR3 methylation with patient demographic and clinicopathological parameters. Materials and Methods: Frozen tissue samples of healthy subjects' normal mucosa and OSCCs were examined with regard to their methylation levels of the CELSR3 gene using MS-HRM. Results: MS-HRM analysis revealed a high methylation level of CELSR3 in 86% of OSCC cases. Significant correlations were found between CELSR3 quantitative methylation levels with patient ethnicity (P=0.005), age (P=0.024) and pathological stages (P=0.004). A moderate positive correlation between CELSR3 and patient age was also evident (R=0.444, P=0.001). Conclusions: CELSR3 promoter hypermethylation may be an important mechanism involved in oral carcinogenesis. It may thus be used as a biomarker in OSCC prognostication.