• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.4
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• pp.701-712
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• 2012

The concept of $k$-shortest disjoint paths is considered important because the establishment of primary and backup forwarding paths exploiting shorter distance and faster propagation time is a dominant consideration for the design of a survivable backbone network. Therefore, we need to evaluate how well the concept of $k$-shortest disjoint paths is exploited for the design of a survivable ship backbone network considering the international standard related to ship backbone networks, the IEC61162-410 standard specifying how to manage redundant message transmissions among ship devices. Performance evaluations are conducted in terms of following objective goals: link capacity, hop and distance of primary and backup paths, even distribution of traffic flows, restoration time of backup forwarding paths, and physical network topology connectivity.

• The Transactions of the Korean Institute of Power Electronics
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• v.21 no.3
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• pp.224-230
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• 2016

In this study, a single-power-conversion series-resonant ac-dc converter with high efficiency and high power factor is proposed. The proposed ac-dc converter consists of single-ended primary-inductor converter with an active-clamp circuit and a voltage doubler with series-resonant circuit. The active-clamp circuit clamps the surge voltage and provides zero-voltage switching of the main switch. The series-resonant circuit consists of leakage inductance $L_{lk}$ of the transformer and resonant capacitors $ C_{r1}$ and $ C_{r2}$. This circuit also provides zero-current switching of output diodes $D_1$ and $D_2$. Thus, the switching loss of switches and reverse-recovery loss of output diodes are considerably reduced. The proposed ac-dc converter also achieves high power factor using the proposed control algorithm without the addition of a power factor correction circuit and a dc-link electrolytic capacitor. A detailed theoretical analysis and the experimental results for a 1kW prototype are discussed.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.1
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• pp.35-41
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• 2017

To solve the shortage of radio spectrum and utilize spectrum resource more efficiently, cognitive radio technologies are proposed, and many studies on cognitive radio have been conducted. Multi-hop routing is one of the important technologies to enable the nodes to transmit data further with lower power in ad-hoc cognitive radio networks. In a multi-channel cognitive radio networks, each channel should be allocated to minimize interference to primary users. In the multi-hop routing, channel allocation should consider the inter-channel interference to maximize network throughput. In this paper, we propose multi-channel scheduling scheme which minimizes inter-channel interferences and avoids collision with primary users for the multi-hop multi-channel cognitive radio networks. The proposed scheduling is designed to determine both of routing path and channel selection. The performance of proposed channel allocation scheme is evaluated by the computer simulation in the aspect of capacity and collision rate.

• Education of Primary School Mathematics
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• v.2 no.1
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• pp.3-13
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• 1998

In mathematics education we have focused on how to improve the problem-solving ability, which makes its way to the new direction with the introduction of meta-cognition. As meta-cognition is based on cognitive activity of learners and concerned about internal properties, we may find a more effective way to generate learners problem-solving power. Its means that learners can regulate cognitive process according to their gorls of learning by themselves. Moreover, they are expected to make active participation through this process. If specific meta problems designed to develop meta-cognition are offered, learners are able to work alone by means of their own cognition and regulation while solving problems. They can transfer meta-cognition to the other subjects as well as mathematics. The studies on meta-cognition conducted so far may be divided into these three types. First in Flavell(［3］) meta-cognition is defined as the matter of being conscious of one's own cognition, that is, recognizing cognition. He conducted an experiment with presschoolers and children who just entered primary school and concluded that their cognition may be described as general stage that can not link to specific situation in line with Piaget. Second, Brown(［1］, ［2］) and others argued that meta-cognition means control and regulation of one's own cognition and tried to apply such concept to classrooms. He tried to fined out the strategies used by intelligent students and teach such types of activity to other students. Third, Merleary-Ponty (1962) claimed that meta-cognition is children's way of understanding phenomena or objects. They worked on what would come out in children's cognition responding to their surrounding world. In this paper following the model of meta-cognition produced by Lester (［7］) based on such ideas, we develop types of meta-cognition. In the process of meta-cognition, the meta-cognition working for it is to be intentionally developed and to help unskilled students conduct meta-cognition. When meta-cognition is disciplined through meta problems, their problem-solving power will provide more refined methods for the given problems through autonomous meta-cognitive activity without any further meta problems.

• Journal of Microbiology and Biotechnology
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• v.23 no.4
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• pp.527-533
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• 2013

Polyclonal antibodies labeled with a tracer have been commonly used as secondary antibodies in immunochemical assays to quantify the concentration of antibody-antigen complexes. The majority of these antibodies conjugated with a tracer are commercially available, with the exception of few untouched targets. This study focused on the production and application of mouse anti-quail IgY as an intermediate antibody to link between quail egg yolk IgY and goat anti-mouse IgG-HRP as primary and secondary antibodies, respectively. Subsequently, the produced mouse anti-quail IgY was labeled with horseradish peroxidase (HRP) and its efficiency on enzyme linked immunosorbent assay (ELISA) was compared with that of commercial rabbit anti-chicken IgY-HRP. As an intermediate antibody, mouse anti-quail IgY was successfully produced with good affinity and sensitivity (1:10,000) to the primary and secondary antibodies. Subsequently, mouse anti-quail IgY was effectively conjugated with HRP enzyme, resulting in a secondary antibody with good sensitivity (1:10,000) to quail anti-V. parahaemolyticus and V. vulnificus IgY. The detection limit was $10^5$ CFU/ml for both V. parahaemolyticus and V. vulnificus. The efficiency of the produced conjugate to detect quail IgY on ELISA was comparable to that of the commercial rabbit anti-chicken IgY-HRP, and hence the produced and labeled mouse anti-quail IgY-HRP can be used as a secondary antibody to detect any antibody produced in quail.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.18 no.2
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• pp.143-155
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• 2000

With the increasing needs for the integrated use of topographic and cadastral data in order to build an efficient geo-spatial information system. it is urgently necessary to research into its solution. The intention of this study is to detect error types of data and to propose adjustment methods for solving the problems caused by integrating topographic and cadastral data. For this purpose a primary integrated data model is created to link attribute data(land management system) and graphic data within cadastral information in the first step. In next, a secondary integrated data model based on the improved method is formed to coincide the graphic data of cadastral map with that of topographic map. At the first, because a numerous error types md sources caused by separate management of graphic and attribute data are easily checked, it is possible to suggest an improved method to correct these errors using the primary integrated data model. In addition, the accuracy in position and area with coordinate transformation method based on multi-block adjustment is more efficient than rubber-sheeting method. As a result, the secondary integrated data model could be built by harmonizing cadastral map with topographic map using the improved solution.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.607-612
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• 2001

Endogenous carbon monoxide (CO) shares with nitric oxide (NO) a role as a putative neural messenger in the brain. Both gases are believed to modulate CNS function via an increase in cytoplasmic cGMP concentrations secondary to the activation of soluble guanylate cyclase (sGC). Recently CO and NO were proposed as a possible mediator of febrile response in hypothalamus. NO has been reported to activate both the constitutive and inducible isoform of the cyclooxygenase (COX). Thus, we investigated whether CO arising from heme catabolism by heme oxygenate (HO) is involved in the febrile response via the activation of COX in the hypothalamus. $PGE_2$ which is a final mediator of febrile response released from primary cultured hypothalamic cells was taken as a marker of COX activity. $PGE_2$ concentration was measured with EIA kits. Exogenous CO (CO-saturated medium) and hemin (a substrate and potent inducer of HO) evoked an increase in $PGE_2$ release from hypothalamic cells, and these effects were blocked by methylene blue (an inhibitor of sGC). And membrane permeable cGMP analogue, dibutyryl-cGMP elicited significant increases in $PGE_2$release. These results suggest that there may be a functional link between HO and COX enzymatic activities. The gaseous product of hemin through the HO pathway, CO, might play a role through the modulation of the COX activity in the hypothalamus.

• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.14.1-14.14
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• 2018

The link between antibiotic treatment and IF-associated liver disease (IFALD) is unclear. Here, we study the effect of antibiotic treatment on bile acid (BA) metabolism and investigate the involved mechanisms. The results showed that pediatric IF patients with cholestasis had a significantly lower abundance of BA-biotransforming bacteria than patients without cholestasis. In addition, the BA composition was altered in the serum, feces, and liver of pediatric IF patients with cholestasis, as reflected by the increased proportion of primary BAs. In the ileum, farnesoid X receptor (FXR) expression was reduced in patients with cholestasis. Correspondingly, the serum FGF19 levels decreased significantly in patients with cholestasis. In the liver, the expression of the rate-limiting enzyme in bile salt synthesis, cytochrome P450 7a1 (CYP7A1), increased noticeably in IF patients with cholestasis. In mice, we showed that oral antibiotics (gentamicin, GM or vancomycin, VCM) reduced colonic microbial diversity, with a decrease in both Gram-negative bacteria (GM affected Eubacterium and Bacteroides) and Gram-positive bacteria (VCM affected Clostridium, Bifidobacterium and Lactobacillus). Concomitantly, treatment with GM or VCM decreased secondary BAs in the colonic contents, with a simultaneous increase in primary BAs in plasma. Moreover, the changes in the colonic BA profile especially that of tauro-beta-muricholic acid ($T{\beta}MCA$), were predominantly associated with the inhibition of the FXR and further altered BA synthesis and transport. In conclusion, the administration of antibiotics significantly decreased the intestinal microbiota diversity and subsequently altered the BA composition. The alterations in BA composition contributed to cholestasis in IF patients by regulating FXR signaling.

• Clinical and Experimental Reproductive Medicine
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• v.48 no.2
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• pp.163-173
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• 2021

Objective: This study aimed to characterize a validated model for predicting oocyte retrieval in controlled ovarian stimulation (COS) and to construct model-based nomograms for assistance in clinical decision-making regarding the gonadotropin protocol and dose. Methods: This observational, retrospective, cohort study included 636 women with primary unexplained infertility and a normal menstrual cycle who were attempting assisted reproductive therapy for the first time. The enrolled women were split into an index group (n=497) for model building and a validation group (n=139). The primary outcome was absolute oocyte count. The dose-response relationship was tested using modified Poisson, negative binomial, hybrid Poisson-E_max, and linear models. The validation group was similarly analyzed, and its results were compared to that of the index group. Results: The Poisson model with the log-link function demonstrated superior predictive performance and precision (Akaike information criterion, 2,704; λ=8.27; relative standard error (λ)=2.02%). The covariate analysis included women's age (p<0.001), antral follicle count (p<0.001), basal follicle-stimulating hormone level (p<0.001), gonadotropin dose (p=0.042), and protocol type (p=0.002 and p<0.001 for short and antagonist protocols, respectively). The estimates from 500 bootstrap samples were close to those of the original model. The validation group showed model assessment metrics comparable to the index model. Based on the fitted model, a static nomogram was built to improve visualization. In addition, a dynamic electronic tool was created for convenience of use. Conclusion: Based on our validated model, nomograms were constructed to help clinicians individualize the stimulation protocol and gonadotropin doses in COS cycles.

• Journal of Power Electronics
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• v.12 no.1
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• pp.145-156
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• 2012

These days, the application of electronic power transformers (EPTs) is expanding in place of ordinary power transformers. These transformers can transmit power via three or four wire converters. Their dynamic performance is extremely important, due to their complex structure. In this paper, a new method is proposed for improving the dynamic performance of distribution electronic power transformers (DEPT) by using sliding mode control (SMC). Hence, to express the dynamic characteristics of a system, different factors such as the voltage unbalance, voltage sag, voltage harmonics and voltage flicker in the system primary side are considered. The four controlling aims of the improvement in dynamic performance include: 1) maintaining the input currents so that they are in sinusoidal form and in phase with the input voltages so they have a unity power factor, 2) keeping the dc-link voltage within the reference amount, 3) keeping the output voltages at a fixed amount and 4) keeping the output voltages in sinusoidal and symmetrical forms. Simulation results indicate the potential and capability of the proposed method in improving DEPT behavior.