• 한국ITS학회 논문지
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• 제17권3호
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• pp.18-31
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• 2018

도로를 주행하는 위험물질 수송차량 사고는 재난형태의 심각한 피해를 야기하므로 해외국가들은 이미 오래전부터 위험물질 수송차량의 안전관리를 위하여 관련 법 제도를 구축하고 체계적인 관리를 수행해오고 있다. 최근 국내에는 인제양양터널, 금정산터널 등 10km이상의 초 장대터널이 고속도로 상에 개통되고 있으며, 화학기술의 발전과 함께 다양한 종류의 위험물질 유통량이 증가하고 있다. 그러나 위험물질 수송차량 안전운행과 관련된 법 제도는 여전히 부재하며, 이들을 관리하기 위한 체계적인 정책방안도 구체화되지 않은 실정이다. 위험물질 수송차량의 사고위험성을 인식하고, 도로관리자를 위한 체계적 관리방안을 구축하여 도로 안전성을 확보하는 것은 중요한 과제이다. 따라서 본 연구는 안전한 고속도로 위험물질 수송차량 운행을 위하여 국내 고속도로 터널통행규제에 대한 타당성을 분석함으로써 도로관리자를 위한 관리 방향을 제시하고자 하였다. 본 연구의 결과는 향후 도로 위험물질 수송차량 관련 법 개정과 위험물질수송차량 최적경로 도출을 위한 기초자료로 활용될 수 있을 것이다.

• 국제초고층학회논문집
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• 제6권3호
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• pp.227-235
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• 2017

This paper describes some of the challenges for structural design of a mid-story seismic isolated high-rise building, which is located near Tokyo station, completed in 2015. The building is a mixed-use complex and encompasses three volumes: one substructure including basement and lower floors, and a pair of seismic isolated superstructures on the substructure. One is a 136.5m high Main Tower (office use), and the other is a 98.5 m high South Tower (hotel use). The seismic isolation systems are arranged in the $3^{rd}$ floor of the Main Tower and $5^{th}$ floor of the South Tower, so that we call this isolation system as the mid-story seismic isolation. The primary goal of the structural design of this building was to secure high seismic safety against the largest earthquake expected in Tokyo. We adopted optimal seismic isolation equipment simulated by dynamic analysis to minimize building damage. On the other hand, wind-induced vibration of a seismic isolated high-rise building tends to be excited. To reduce the vibration, the following strategies were adopted respectively. In the Main Tower with a large wind receiving area, we adopted a mechanism that locks oil dampers at the isolation level during strong wind. In the South Tower, two tuned mass dampers (TMDs) are installed at the top of the building to control the vibration. In addition, our paper will also report the building performance evaluated for wind and seismic observation after completion of the building. In 2016, an earthquake of seismic intensity 3 (JMA scale) occurred twice in Tokyo. The acceleration reduction rate of the seismic isolation level due to these earthquakes was approximately 30 to 60%. These are also verified by dynamic analysis using observed acceleration data. Also, in April 2016, a strong wind exceeding the speed of 25m/s occurred in Tokyo. On the basis of the record at the strong wind, we confirmed that the locking mechanism of oil damper worked as designed.

• 대한본초학회지
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• 제22권4호
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• pp.253-260
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• 2007

Objectives : Intracerebral hemorrhage (ICH) is characterized by breakdown of blood vessels within the brain parenchyma. Fundamental therapeutic strategies for ICH, particularly those aimed at neuroprotection, have to be established. So in this experiment, the effects of Woowhangchongshim-won, a traditional prescription formula for treating Cerebral Apoplexy in Asian countries, were investigated. Methods : After intraperitoneal injection of chloralhydrate, rats were placed in a stereotaxic frame. ICH was induced by injection of 1 U collagenase type IV and drug was administered orally for 10 days. The molecular profile of cerebral hemorrhage in rat brain tissue was measured using micro array technique to identify up- or down- regulated genes in brain tissue. These genes induced by brain damage were mainly concerned with general metabolic process such as primary metabolic process, cellular metabolic process, macromolecule metabolic process, and biosynthetic process. Results : The number of genes increased in control and not-changed in experiment was 374, and decreased in control and not-changed in experiment was 527. We are concerned with genes that can be recovered by treatment with medicine, it is especially interesting to above types of genes. Conclusions : Upon medicine treatment to the rat having cerebral hemorrhage, expressions of some genes were restored to normal level. Further analysis using protein interaction database identified some key molecules that can be used for elucidation of therapeutical mechanism of medicine in future.

• Journal of Preventive Medicine and Public Health
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• 제13권1호
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• pp.13-18
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• 1980

The ultimate goal of treatment of carton monoxide poisoning is to promote dissociation of carboxyhemoglobin and to maintain arterial $PO_2$ above 50mmHg throughout the course of treatment to protect vital organs from damage caused by hypoxia. The hyperbaric chamber designed and manufactured for this purpose has obviousely made an enormous contribution and yet has several handicaps to be overcome by any means. These handicaps are: the financial impact to purchase the chamber (especially in a small, remote community), an extra manpower requirement to operate the device, limitation in the capacity of the chamber (one man type), and the possible hazard of oxygen intoxication and dysbarism. The primary objective of this study is to develope a new therapeutic measure as an alternative to the hyperbaric chamber when it is not available or contraindicated. The effect of intestinal perfusion with hydrogen peroxide has been studied by many investigators and was known to be an excellent way of extrapulmonary oxygen supply. the advantage of this method will include; 1) much more amount of oxygen is delivered to the tissue than one would expect from 100% saturation with oxygen at 1 ata, 2) the procedure is simple and most economical, 3) neither sophisticated equipment nor extra manpower is required. As a study preliminary to the clinical application, authors conducted a series of experiment to observe the effect of hydrogen peroxide enema on dissociation of carboxyhemoglobin in intoxicated rabbit blood. Using an animal gas chamber, 20 rabbits were exposed to CO gas of 6,000 ppm for 60 minutes. Ten rabbits of control group were given 10cc of warmed normal saline solution by reactal perfusion and for the other 10 of the experimental group, the same amount of 1% $H_{2}O_{2}$ solution was given by the same way. Two blood specimens were drawn from each rabbit: the first one immediately following the exposure and the second one after rectal perfusion, about 30 minutes after the first sampling. The result was as follows; 1) The decrease in carboxyhemoglobin concentration during the first 30 minutes in the control and experimental group were $18.18{\pm}4.49%\;and\;23.03{\pm}4.13%$ respectively shelving the significant difference (p<0.05) between the two groups. 2) Hemoglobin and hematocrit value showed no significant difference between two groups and not altered significantly by intestinal perfusion with $H_{2}O_{2}$.

• 한국지반신소재학회논문집
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• 제13권1호
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• pp.71-83
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• 2014

부산지역은 낙동강 하구에 위치하여 퇴적층, 매립층 등이 매우 잘 발달되어 있어 지진이 발생한다면 이러한 지층 등에서 증폭현상이 나타나 모래층과 성토층 및 매립지반에 액상화 발생 가능성이 매우 커진다. 만약 액상화가 발생한다면 지진에 의한 피해는 크게 가중되어 막대한 피해를 야기 시키게 된다. 그러므로 본 연구는 지진 발생 시 항만시설의 1차 보호구조물인 부산항 신항 방파제의 안정성을 검토하기 위하여, 국내 내진설계기준과 항만 및 어항 설계기준을 바탕으로 인공지진과 국내에 널리 사용되는 장주기 지진파와 단주기 지진파인 포함하여 지진규모 5.6~7.9 수준의 지진 13개 등을 사용하여 첫 번째로 여러 제시된 액상화 평가방법을 이용하여 방파제 하부 치환모래층의 액상화 발생 가능성을 검토하여 안정성을 평가하고, 두 번째 지진규모에 따른 지진에너지와 가속도 응답스펙트럼에 대한 특성분석을 수행하여 설계기준에 근접하는 지진파 제시하며, 세 번째 제시된 지진파를 이용하여 방파제의 동적 안정성을 검토하기 위해 유한요소해석을 실시하여 구조물의 안정성을 확인하고, Geotextile에 발생하는 변위 및 인장력의 변화에 대하여 확인하였다. 따라서 본 연구결과 방파제 하부 치환모래층에 대한 액상화 발생가능성과 방파제의 동적수평변위 및 Geotextile의 변화는 하부지반(치환모래층)에 의해 매우 큰 영향을 받는 것으로 나타났다.

• 대한소아치과학회지
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• 제26권2호
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• pp.331-338
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• 1999

하악 좌측부위의 횡문근육종으로 2년동안의 화학요법과 6주간의 방사선요법으로 치료를 받았고, 이에 따른 후유증으로 치아의 발육장애를 동반한 8세 환아에 대해, 임상적, 방사선학적으로 관찰을 시행하고, 치료한 결과 다음을 보고하는 바이다. 1. 구강내 소견으로서 맹출한 영구치의 경미한 법랑질 형성부전과 치아우식이 관찰되었으며, 하악 좌측 부위의 미맹출된 제 1 대구치로 인해 수직고경이 상실되어 과개교합이 형성되었다. 2. 방사선학적으로 맹출한 영구치의 치근은 짧은 치근에서부터 무형성증에 이르기까지 다양한 치근으 발육장애를 보였으며, 미맹출 상태인 제 2 소구치와 제 2 대구치는 왜소치나 형성부전의 소견을 보였다. 3. 치료는 보존치료 및 저석회화 소견을 보이는 영구치를 위해 불소도포를 시행하였고, 향후 적절한 수직고경의 회복과 심미적 개선을 위한 포괄적인 보철치료가 수행되어야 할 것으로 사료된다.

• 한국항공운항학회지
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• 제12권3호
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• pp.41-63
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• 2004

The area covered by product liability in broadest sense is so vast that an attempt to analyse all its impact on the aviation world risk. Every effort has been made to confine our review of subject a closely as possible to its influence on aircraft manufacturers, airlines and passengers, in spite of strong connections with other spheres of commercial. Product Liability in aviation is the liability of aircraft's manufacturer, processor or non-manufacturing seller for injury to the person or property of a buyer or third party caused by a product which has been sold. Here-in a product is aircraft, third party is passengers who suffered damage by defective design, defective construction, inadequate instructions for handling in aircraft. Whenever a product turns out to be defective after it has been sold, there are under Anglo-American law three remedies available against the aircraft's manufacturer (1) liability for negligence (2) breach of warranty (3) strict liability in tort. There are Under continental law Three remedies available against the aircraft's manufacturer (1) liability for defective warranty (2) liability for non-fulfillment of obligation (3) liability in tort. It is worth pointing out here an action for breach of warranty or for defective warranty, for non-fulfillment of obligation is available only to direct purchaser on the basis of his contract with the aircraft's manufacturer, which of course weakness its range and effectiveness. An action for tort offers the advantage of being available also to third parties who have acquired the defective product at a later stage. In tort, obligations are constituted not only by contract, but also by stature and common law. In conclusion, There in no difference in principle of law. In conclusion I would like to make few suggestions regarding the product liability for aircraft's manufacturer. Firstly, current general product liability code does not specify whether government offices(e.g. FAA) inspector conducted the inspection and auditory certificate can qualify as conclusive legal evidence. These need to be clarified. Secondly, because Korea is gaining potential of becoming aircraft's manufacturer through co-manufacturing and subcontracting-manufacturing with the US and independent production, there needs legislation that can harmonize the protection of both aircraft's manufacturers and their injured parties. Since Korea is in primary stage of aviation industry, considerate policy cannot be overlooked for its protection and promotion. Thirdly, because aircraft manufacturers are risking restitution like air-carriers whose scope of restitution have widened to strict and unlimited liability, there needs importation of mandatory liability insurance and national warranty into the product liability for aircraft's manufacturers. Fourthly, there needs domestic legislation of air transportation law that clearly regulates overall legal relationship in air transportation such as carrier & aircraft manufacturer's liability, and aviation insurance.

• 생태와환경
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• 제52권4호
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• pp.306-315
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• 2019

한강 하구는 오염물질과 병원성 미생물의 유입 및 확산 가능성으로 인해 이곳에 서식하는 수산생물에 피해가 발생할 수 있다. 하지만 지금까지 이 지역 서식 생물에 대한 법정전염병 병원체 감염 여부가 조사된 자료는 찾아보기 힘들다. 본 연구에서는 한강 하구 전류리에 서식하는 수산 생물 중 잉어과 어류와 갑각류를 대상으로 법정전염병(잉어봄바이러스병, SVC; 잉어허피스바이러스병, KHVD; 유행성궤양증후군, EUS; 흰반점병, WSD) 및 기생충의 감염 여부를 조사하였다. 전류리 유역에서 채집된 어류는 잉어과 어류가 가장 많았으며 주연성 어류와 일차 담수어가 같이 관찰되었고, 갑각류는 해산종이 채집되었다. 채집된 잉어과 어류와 갑각류에 대해 PCR을 이용한 법정전염병 검사 결과 이들 질병에 감염된 개체는 없었다. 기생충성 질병 검사 결과 공중보건상 위협요인인 간흡충이 검출되지는 않았지만 일부 어류에서 다른 흡충류의 metacercaria와 nematode, cestode, copepod, 단생충 및 구두충 등의 감염을 확인할 수 있었다. 이상의 결과는 아직 한강 하구가 주요 수산생물 전염병 병원체에 심각하게 오염되지 않았음을 의미한다. 그러나 한강의 수질 상태는 지속적으로 변화하고 수서 생태계에 대한 전염병의 파괴력은 예측하기 힘들 정도로 위험하므로, 지속적인 방역 노력이 진행되어야 할 것이다. 이를 위해 조사 지역을 전류리뿐만 아니라 이곳보다 상류로 확대하고 조사 개체 수를 늘려서 질병모니터링을 실시할 필요성이 제기된다.

• 동의생리병리학회지
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• 제18권5호
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• pp.1485-1489
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• 2004

Panax ginseng is the one of best famous phytochemical plant in the world and it's various positive effects such as antioxidant, regulation of immunity are very well known. In this study, we investigated primary the cell viability and morphological change and secondary an antioxidative effect and liver function improvement of extract from Ginseng folium and stem in CCl4 intoxicated rats. The NCTC cell line were used for cell viability and sirius red staining before the animal experiment. The female Sprague-Dawley rats (90-100g) were divided into 3 groups (Normal, AC: CCl₄ treated group, GFS: CCl₄+ extract of Ginseng folium and stem treated group) and acute liver damage was developed by one time administration of CCl₄ mixture (0.5㎖/rat). The liver tissue and sera were collected and used for quantitative measurement of enzyme activity (AST, ALT, ALP, BUN), MDA and Hyp. As a result, cell viability in GFS treated group (in concentration of 3.33-33.33㎎ GFS/200㎕ medium) was 180.9-241.0% significantly and dose dependently higher than in control group. And potential state of cell growth and differentiation and no criteria of cytoplasm lysis and nucleus breaking were observed in control and GFS group. The parameters of liver function (AST and ALP) in sera of GFS group showed significantly 93% and 67.6% lower than AC group (p<0.005-0.05). And the level of ALT and BUN showed fast similar in AC group and GFS group. The concentration of MDA in liver was decreased 576.5% significantly in GFS group when compared with AC group (p<0.005). The content of Hyp in GFS group is merely lower than in AC group. In conclusion, the water extract of Ginseng folium and stem such as Ginseng radix may be possessed the antioxidative effect and improvement of liver function in CCl₄ intoxicated rats.

• 동의생리병리학회지
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• 제21권5호
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• pp.1081-1086
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• 2007

This study was performed to investigate the medicinal effects of the herbal combination extracts-2 (HCE-2), consisting of Artemisia capillaris Thunb., Lonicera japonica Thunb., Prunella vulgaris var. lilacina, and Hovenia dulcis Thunb. on the alcohol-induced liver injury in rats. The rats were randomly divided into four groups: normal group (n =6), non-treated control group (n =6), saline-treated group (n =6) and the herbal combination extract (HCE-2)-treated group (n =6). The rats in the alcohol-loaded groups were orally administered with ethanol at a daily dose of 4 g/kg-body weight for 5 weeks. Thirty minutes before the ethanol injection, saline or herbal combination extracts was administered by using a gastrogavage. Blood and liver tissue samples were taken out from the hearts and livers of the rats, respectively, on 15th and 38th days. The activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured using an enzyme-linked immunosorbent assay (ELISA). We also investigated the protective effect of the herbal combination extracts by Hematoxylin-Eosin staining on histological sections of rat liver. In this study, the oral administration of the herbal combination extracts significantly reduced the serum levels of AST and ALT, which had been raised by alcohol-induced liver injury. Histological analysis and apparent observation of liver also showed the preventive effect of the herbal combination extracts in a chronic alcohol-induced rat model. Theses results revealed that the herbal combination extracts effectively prevented hepatic damage consequent to the chronic exposure to repetitive administration of ethanol and could be used as a primary resource of a health beverage or herbal medicine, alleviating the alcohol-induced hepatic injury and hangover symptoms.