• Archives of Pharmacal Research
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• v.22 no.1
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• pp.48-54
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• 1999

These studies were designed to examine the differential effect of nitric oxide (NO) and cGMP on glutamate neurotransmission. In primary cultures of rat cerebellar granule cells, the glutamate receptor agonist N-methyl-D-aspartate (NMDA) stimulates the elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), the release of glutamate, the synthesis of NO and an increase of cGMP. Although NO has been shown to stimulate guanylyl cyclase, it is unclear yet whether NO alters the NMDA-induced glutamate release and ${[Ca^{2+}]}_i$ elevation. We showed that the NO synthase inhibitor, NG-monomethyl-L-arginine (NMMA), partially prevented the NMDA-induced release of glutamate and elevation of ${[Ca^{2+}]}_i$ and completely blocked the elevation of cGMP. These effects of NO on glutamate release and [Ca2+]i elevation were unlikely to be secondary to cGMP as the cGMP analogue, dibutyryl cGMP (dBcGMP), did not suppress the effects of NMDA. Rather, dBcGMP slightly augmented the NMDA-induced elevation of ${[Ca^{2+}]}_i$ with no change in the basal level of glutamate or ${[Ca^{2+}]}_i$. The extracellular NO scavenger hydroxocobalamine prevented the NMDA-induced release of glutamate providing indirect evidence that the effect of NO may act on the NMDA receptor. These results suggest that low concentration of NO has a role in maintaining the NMDA receptor activation in a cGMP-independent manner.

• Journal of Gastric Cancer
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• v.19 no.2
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• pp.157-164
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• 2019

Purpose: Although standard radical gastrectomy is recommended after noncurative resection of endoscopic submucosal dissection (ESD) for early gastric cancer in most cases, residual tumor and lymph node metastasis have not been identified after surgery. The aim of this study is to evaluate the feasibility of sentinel node navigation surgery after noncurative ESD. Materials and Methods: This trial is an investigator-initiated, multicenter prospective phase II trial. Patients who underwent ESD for clinical stage T1N0M0 gastric cancer with noncurative resections were eligible. Qualified investigators who completed the prior phase III trial (SENORITA 1) are exclusively allowed to participate. In this study, 2 detection methods will be used: 1) intraoperative endoscopic submucosal injection of dual tracer, including radioisotope and indocyanine green (ICG) with sentinel basins detected using gamma-probe; 2) endoscopic injection of ICG, with sentinel basins detected using a fluorescence imaging system. Standard laparoscopic gastrectomy with lymphadenectomy will be performed. Sample size is calculated based on the inferior confidence interval of the detection rate of 95%, and the calculated accrual is 237 patients. The primary endpoint is detection rate, and the secondary endpoints are sensitivity and postoperative complications. Conclusions: This study is expected to clarify the feasibility of laparoscopic sentinel basin dissection after noncurative ESD. If the feasibility is demonstrated, a multicenter phase III trial will be initiated to compare laparoscopic sentinel node navigation surgery versus laparoscopic standard gastrectomy in early gastric cancer after endoscopic resection.

• The Journal of Korean Association of Computer Education
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• v.16 no.1
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• pp.11-22
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• 2013

Due to the advent of new smart devices, the new technology addiction problems have been much severer than the Internet addiction recently. A lot of research about each technology addiction has been proposed, but the research about the changes in the addictions has been rare. In this paper, we analyze how the environmental factors such as parents and friends affect the personal factors such as time perspectives and technology usage time. In addition, we get the relative importances among the factors which influence on the Internet and mobile phone addictions. As a result, we can analyze the relationships among the factors and the differences between the two addictions with time perspective. In order to achieve our goals, we surveyed on 1,420 primary and secondary school students. We also provided the results produced by structural equation model and Budescu's Dominance analysis. Based on these analyses, we described the differences between the Internet and mobile phone addictions and proposed an alternative to prevent new technology addictions.

• Journal of Korean Society of Forest Science
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• v.96 no.1
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• pp.115-123
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• 2007

We investigated the effects of postfire logging on bird populations and communities through 57 point counts in unburned, burned and logged burned plots of coniferous forests in Samcheok, Korea. We found that lower species richness, abundance, and diversity in logged plots where were controlled by a typical postfire management. As results of guild analysis for nest sites and food resources, postfire logging reduced densities of ground-shrub nesters, primary and secondary cavity nesters, but was also related to reduction in densities of some foraging groups such as timber drillers and foliage searchers. These results suggest that snag-retention is essential for birds in burned forests and that postfire logging is incompatible with the maintenance of bird populations and communities. Consequently we need to develope guidelines of postfire management for snag-retention in burned forests through intensive researches focused on some target species such as Great spotted woodpeckers Dendrocopos major.

• Journal of Pharmacopuncture
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• v.6 no.1
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• pp.35-36
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• 2003

Background: Evidence based medicine has become main tools for medical practice. However, conducting a highly ranked in the evidence hierarchy pyramid is not easy or feasible at all times and places. There remains a room for descriptive clinical outcome measure studies with admitting the limit of the intepretation. Aims: Presents three Korean clinic based outcome measure studies with a view to encouraging Korean clinicians to conduct similar studies. Methods: Three studies are presented briefly here in치uding 1) Quality of Life of liver cancer patients after 8 Constitutional acupuncture; 2) Developing a Korean version of Measuring yourself Medical Outcome profile (MYMOP); and 3) Survey on 5 Shu points: a pilot In the first study, we have included 4 primary or secondary liver cancer patients collecting their diagnostic X-ray film and clinical data f개m their hospital, and asked them to fill in the European Organization Research and Treatment of Cancer, Quality of Life Questionnaire before the commencement of the treatment. The acupuncture treatment is set up format but not disclosed yet. The translation and developing a Korean version of outcome measures that is Korean clinician friendly has been sought for MYMOP is one of the most appropriate one. The permission was granted, the translation into Korean was done, then back translated into English only based on the Korean translation by the researcher who is bilingual in both languages. The back translation was compared by the original developer of MYMOP and confirmed usable. In order to test the existence of acupoints and meridians through popular forms of Korean acupuncture regimes, we aim at collecting opinions from 101 Korean clinicians that have used those forms. The questions asked include most effective symptoms, 5 Shu points, points those are least likely to use due to either adverse events or the lack of effectiveness, theoretical reasons for the above proposals, proposing outcome measures, and the time from insertion to be effective. The questionnaire is posted on the virtual notice board of the homepage of the communication KOMA (The official tool of Association of Korean Oriental Medicine).

• Journal of the Korea Society of Computer and Information
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• v.27 no.6
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• pp.117-122
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• 2022

In this paper, we developed a vehicle control terminal using IoT and low-power long-distance communication (NB-IoT) technology. This system collects information on the location and status of a parked vehicle, and transmits the vehicle status to the vehicle owner's terminal in real time with low power to prevent vehicle theft, and in the case of a vehicle in motion, When primary information about the vehicle, such as an impact, is collected and transmitted to the server, the server analyzes the relevant data to generate secondary information on traffic congestion, road damage, and safety accidents. By sending it, you can know the exact arrival time of the vehicle at its destination. This terminal device is an IoT gateway for a vehicle and can be connected to various wired and wireless sensors inside the vehicle. In addition, the data collected from vehicle maintenance, efficient operation, and vehicles can be usefully used in the private or public sector.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.27 no.3
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• pp.164-172
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• 2016

Objectives: This study attempted to evaluate the usefulness and direction of development of post-traumatic assessment and interventions based on the opinions of psychiatrics and disaster and trauma-related experts using the Delphi survey technique. Methods: In-depth individual interviews served as the pre-survey and were followed by Delphi primary and secondary surveys. Specialists in child and adolescent mental health, psychological support professionals specialized in disasters and related practitioners with experience of disasters in Korea completed a set of questionnaires and participated in focus group interviews and in-depth individual interviews on post-traumatic assessment and intervention. Results: We found that the following issues have a significant impact on the interventions after disasters: the proper time of the initial interview in the event of a disaster, assessment notices, aged assessment services, mandatory enforcement measures, scale screening and treatment intervention elements, symptoms degree classification, intervention standardization, the use of a levelled program, care unit environment, and operation plan. Conclusion: This study proposed effective mental health intervention measures and has implications for the development of evaluation treatment protocols after disasters.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7229-7235
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• 2013

Background: To determine whether the Health Partner Program is effective in training long-term cancer survivors to be health coaches. Materials and Methods: We randomly assigned cancer survivors who were selected through a rigorous screening process to either the Health Partner Program or the waiting-list control group. The program consisted of 8 weeks of training in health management, leadership, and coaching. At baseline, 8, and 16 weeks, we measured primary outcomes using the Seven Habit Profile (SHP), the Korean Leadership Coaching Competency Inventory (KCCI), Ed Diner's Satisfaction with Life Scale (SWLS), and the Posttraumatic Growth inventory (PTGI) and secondary outcomes using the Hospital Anxiety and Depression Scale (HADS), the Impact of Event Scale-Revised (IES-R), and the Medical Outcomes Study (MOS) short form 36-item questionnaire (SF-36). Results: We recruited 70 subjects and randomly assigned 34 to the intervention group. The Sharpen the Saw habit of the SHP increased significantly more in intervention group than in the control group (p=0.049), as did most PTGI factors. The intervention group also showed a significantly greater enhancement of vitality (p=0.015) and mental health (p=0.049) SF-36 scores but no improvement in KCCI, SWLS, HADS, or IES-R scores. The intervention group also showed a greater clinically meaningful improvement in the "Think Win-Win" of SHP (p=0.043) and in the personal strength score (p=0.025) and total score (p=0.015) of the PTGI. Conclusions: Long-term cancer survivors can benefit from the Health Partner Program to become health coaches.

• Korean Journal of Health Education and Promotion
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• v.31 no.3
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• pp.109-117
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• 2014

Objectives: Although many cities have adopted Healthy Cities approach in Republic of Korea, few studies have been reported about city health profile. So we report a case of city health profile made of subjective indexes and objective indicators using available recent evidence. Methods: To assess subjective city health indexes, questionnaire survey was implemented to public officers and citizen adapting the 'Signs of progress, signs of caution of 12 stage tool from Ontario Healthy Community Coalition. Based on recent literature objective city health indicators were collected for time-series comparison and for the comparison with those of larger province mainly using Korean Statistical Information Service. Results: Subjective city health indexes were successfully constructed in four areas including human health, environment, social and economic area. The score was especially low in environmental area. Specific items in each area for improvement were identified. Objective city health indicators were collected for three year time-series comparison and for the compared with those of larger province. Conclusions: City health profile comprised of subjective city health indexes and objective city health indicators could successfully be made from primary survey and secondary data in a medium-sized Korean city. That City health profile was useful in subsequent city health planning through participatory process.

• Journal of Korean Academy of Nursing Administration
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• v.2 no.1
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• pp.17-33
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• 1996

The primary purpose this descriptive study was to identify, describe, and compare the patterns of shared governance and nursing unit culture in the hospital settings. The secondary purpose of the research was to identify, describe whether the participation style or responsibility style of nursing management activities shared through nurses in a consistent way. Methodology included survey and in-depth interviews with a total 145 members of 15 nursing units in 3 hospitals. One was a national hospital, another was a corporation hospital and the other was a teaching hospitals. Conclusions from this research included the following: 1. The degree of shared governance in nursing management activities was the highest in the corporation hospital. 2. In the participation style of nursing management activities, 'all participation' was the highest in the corporation hospital. 'Nursing administration only' was the highest in the national hospital. 3. Distribution of responsibility style differed from that of participation style. Three hospitals showed high in nursing management activities such as 'nursing administration only' and 'head nurse only' style. 4. Five experts surveyed showed that the ideal level of nurses' participation in nursing management activities was a traditional nursing governance pattern. 5. There was a distinct difference in the nursing unit culture throughout the institutions in the professional growth. 6. There was no significant difference in the same nursing units of three hospitals in nursing unit culture. According to these results, the following implications can be made; 1. In nursing administration, there should be an emphasis on preparing staff nurses' potential decision-making ability through continuing education so that staff nurses' autonomy and responsibility will be developed and increased. 2. It is necessary to develop a strategic nursing unit for improving nursing quality in hospital setting. 3. The relationship of shared governance, nursing unit culture and nursing outcome should be researched further.