• Tuberculosis and Respiratory Diseases
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• v.47 no.1
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• pp.77-89
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• 1999

Background: High-dose chemotherapy is increasingly employed in many refractory malignant diseases. This therapy has been reported to increase response rate and survival benefits but it is also associated with higher treatment-related morbidity and mortality. We evaluated clinical characteristics and course of the pulmonary toxicity following high-dose chemotherapy with peripheral blood stem cell transplantation. Methods: Ninety-seven patients who had received high-dose chemotherapy with peripheral blood stem cell transplantation were evaluated. Five patients who developed lung lesions which were not related to infection nor primary malignant disease underwent transbronchial lung biopsy. The patients' clinical characteristics, treatments, and prognosis were reviewed retrospectively. Results: Five patients(5.1%) developed idiopathic pneumonia syndrome. The high dose chemotherapy regimens employed were cyclophosphamide, BCNU, and cisplatin in 3 cases, one case of BCNU, etoposide, Ara-C, and cyclophosphamide combination, and a regimen consisting of BCNU, etoposide, Ara-C, and melphalan. The total dose of BCNU used was 300-400 mg/$m^2$ and that of cyclophosphsmide was 6,000 mg/$m^2$. All of 5 patients received radiation therapy before this treatment. After an average duration of 14 weeks (4-26 weeks) of high-dose chemotherapy, patients developed cough, dyspnea and fever. The chest X-rays showed bilateral diffuse infiltration in 3 cases and the focal infiltration in the other 2 cases. All the patients received corticosteroid therapy as a treatment for the lung lesions. Two of them progressed to acute respiratory distress syndrome and died. Three patients recovered without residual lung lesion but one of them died of dilated cardiomyopathy. Conclusion: High-dose chemotherapy with peripheral blood stem cell transplantation especially which containing BCNU regimen may develop idiopathic pneumonia syndrome related to pulmonary toxicity and corticosteroid therapy may be bel1eficial in some cases.

• Journal of Gastric Cancer
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• v.5 no.4 s.20
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• pp.281-287
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• 2005

Purpose: This study was conducted to evaluate the effectiveness and the role of post-operative adjuvant chemoradiation therapy in a stage-II (UICC, 1997) primary gastric cancer. Materials and Methods: From September 1994 to December 2004, 954 stage-II gastric-cancer patients were seen, and all of them underwent a curative resection with extensive (D2) lymph-node dissection. The chemotherapy consisted of fluorouracil $(400mg/m^2)$ plus leucovorin $(20mg/m^2)$ for 5 days, followed by 4,500 cGy of radiotherapy for 5 weeks with fluorourcil and leucovorin on the first 4 days and the last 3 days of radiotherapy. Two five-day cycles of chemotherapy were given four weeks after the completion of radiotherapy. The Kaplan-Meier method was used to estimate the survival rates. To assess the importance of potential prognostic factors, we performed univariate and multivariate analyses using a log-rank test and Cox's proportional hazards regression model. A P value <0.05 was considered significant. Results: Univariate analysis revealed that age, tumor size, gross type, surgical method, and postoperative adjuvant therapy had statistical significance. Among these factors, age, surgical method, tumor size, surgical method, and postoperative adjuvant therapy were found to be independent prognostic factors by using a multivariate analysis. The postoperative adjuvant chemotherapy group and the chemoradiation therapy group had survival benefit compared to the surgery-only group. However the chemoradiation therapy group had no significant survival benefit compared to the chemotherapy group. Conclusion: The postoperative adjuvant therapy in stage-II gastric-cancer patients had significant benefit. Therefore, postoperative adjuvant chemoradiation therapy has an acceptable effect. A large-scale, randomized study is needed to evaluate the effectiveness and the role of postoperative radiation therapy.

• Tuberculosis and Respiratory Diseases
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• v.60 no.3
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• pp.321-329
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• 2006

Background : To evaluate the clinical characteristics of lung cancer patients in Korea, where there is a higher number of smokers than in Western countries. Methods : A retrospective study was performed on 1655 lung cancer patients, who were diagnosed at a university hospital between September 1996 and August 2005. Age, gender, cell types and clinical stage were analysed. Of 941 patients, who responded to a questionnaire at the time of diagnosis, the smoking habits, occupational history, family history of lung cancer in the first-degree relatives, coexisting diseases (diabetes mellitus and cardiovascular disease), body weight loss, ECOG performance status and presenting symptoms, were examined prospectively. In addition, coexisting diseases including chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and active pulmonary tuberculosis were evaluated. Results : Of the 1655 patients, the male to females ratio was 3.6. Squamous cell carcinoma was the most common cancer whereas adenocarcinoma was more common in lifetime nonsmokers or women. 19.9% of the patients were non smokers and 80.1% ever smokers. Since 2000, there was an increase in the incidence of adenocarcinoma with a corresponding decrease in the incidence of squamous cell carcinoma. 6.2% of patients were asymptomatic. A coincident diagnosis of chronic obstructive pulmonary disease, cardiovascular disease, diabetes mellitus, active pulmonary tuberculosis, and idiopathic pulmonary fibrosis was made in: 44.1%, 22.2%, 10.7%, 3.9%, and 1.6% of patients, respectively. A positive family history of lung cancer in the first-degree relatives was identified in 4.4% of patients. An occupational history relevant to lung cancer was identified in 12.2% of patients. Conclusion : There is a high proportion of cigarette smokers in Korean lung cancer patients. The most common cell type was squamous cell carcinoma. However, a more detailed, prospective study of the clinical characteristics will be needed to better characterize lung cancer in Korea.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.18 no.3
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• pp.111-121
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• 2013

Accurate prediction of sea water temperature has been emphasized to make precise local weather forecast and to understand change of ecosystem. The Yellow Sea, which has turbid water and strong tidal current, is an unique shallow marginal sea. It is essential to include the effects of the turbidity and the strong tidal mixing for the realistic simulation of temperature distribution in the Yellow Sea. Evaluation of ocean circulation model response to vertical mixing scheme and turbidity is primary objective of this study. Three-dimensional ocean circulation model(Regional Ocean Modeling System) was used to perform numerical simulations. Mellor- Yamada level 2.5 closure (M-Y) and K-Profile Parameterization (KPP) scheme were selected for vertical mixing parameterization in this study. Effect of Jerlov water type 1, 3 and 5 was also evaluated. The simulated temperature distribution was compared with the observed data by National Fisheries Research and Development Institute to estimate model's response to turbidity and vertical mixing schemes in the Yellow Sea. Simulations with M-Y vertical mixing scheme produced relatively stronger vertical mixing and warmer bottom temperature than the observation. KPP scheme produced weaker vertical mixing and did not well reproduce tidal mixing front along the coast. However, KPP scheme keeps bottom temperature closer to the observation. Consequently, numerical ocean circulation simulations with M-Y vertical mixing scheme tends to produce well mixed vertical temperature structure and that with KPP vertical mixing scheme tends to make stratified vertical temperature structure. When Jerlov water type is higher, sea surface temperature is high and sea bottom temperature is low because downward shortwave radiation is almost absorbed near the sea surface.

• Korean Journal of Agricultural and Forest Meteorology
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• v.17 no.3
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• pp.217-226
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• 2015

To investigate the distributions of BVOCs (Biogenic Volatile Organic Compounds) from mountain near mega city and their role in forest atmospheric, BVOCs and their oxidized species were measured at a 41 m tower in Mt. Taehwa during May, June and August 2013. A proton transfer reaction-mass spectrometer (PTR-MS) was used to quantify isoprene and monoterpenes. In conjunction with BVOCs, $O_3$, meteorological parameters, PAR (Photosynthetically Active Radiation) and LAI (Leaf Area Index) were measured. The average concentrations of isoprene and monoterpenes were 0.71 ppbv and 0.17 ppbv, respectively. BVOCs showed higher concentrations in the early summer (June) compared to the late summer (August). Isoprene started increasing at 2 PM and reached the maximum concentration around 5 PM. In contrast, monoterpenes concentrations began to increase 4 PM and stayed high at night. The $O_3$ maximum was generally found at 3 PM and remained high until 5 PM or later, which was concurrent with the enhancement of $O_3$. The concentrations of BVOCs were higher below canopy (18 m) than above canopy, which indicated these species were produced by trees. At night, monoterpenes concentrations were negatively correlated with these of $O_3$ below canopy. Using MEGAN (Model of Emissions of Gases and Aerosols from Nature), the emissions of isoprene and monoterpenes were estimated at 1.1 ton/year and 0.9 ton/year, respectively at Mt. Taehwa.

• Journal of Bio-Environment Control
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• v.27 no.4
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• pp.332-340
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• 2018

Supplemental lighting with artificial light sources is a practical method that enables normal growth and enhances the yield and quality of fruit vegetable in greenhouses. The objective of this study was to investigate the effect of sulfur plasma lamp (SP) and high-pressure sodium lamp (HPS) as supplemental lighting sources on the growth and yield of paprika. For investigating the effectiveness of SP and HPS lamps on paprika, the effects of primary lighting on plant growth were compared in growth chambers and those of supplemental lighting were also compared in greenhouses. In the growth chamber, plant height, leaf area, stem diameter, number of leaves, fresh weight, and dry weight were measured weekly at SP and HPS from 2 weeks after transplanting. In the greenhouse, no supplemental lighting (only sunlight) was considered as the control. The supplemental lights were turned on when outside radiation became below $100W{\cdot}m^{-2}$ from 07:00 to 21:00. From 3 weeks after supplemental lighting, the growth was measured weekly, while the number and weight of paprika fruits measured every two weeks. In the growth chamber, the growth of paprika at SP was better than at HPS due to the higher photosynthetic rate. In the greenhouse, the yield was higher under sunlight with either HPS or SP than sunlight only (control). No significant differences were observed in plant height, number of node, leaf length, and fresh and dry weights between SP and HPS. However, at harvest, the number of fruits rather than the weight of fruits were higher at SP due to the enhancement of fruiting numbers and photosynthesis. SP showed a light spectrum similar to sunlight, but higher PAR and photon flux sum of red and far-red wavelengths than HPS, which increased the photosynthesis and yield of paprika.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1981.05a
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• pp.14.2-14
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• 1981

In 1859, Billroth used the term "Zylindrome" to describe a tumor arising in the paranasal sinuses. This neoplasm has been referred to by a variety of terms including cylindroma, basaloma, basaloid adenoma, cribriform adenocarcinoma, and "adenoid cystic carcinoma", now preferred by most authors. It most often arises in the major and minor salivary glands of the head and neck but has been noted in the trachea, lung, breast, skin and elsewhere. The tumors are characterized by a high incidence of local recurrence and ultimate distant metastases after agrressive attempts at surgical excision. Radiation therapy, while not curative, has proved uniformly useful in promoting tumor regression and pain relief as a palliative treatment. The present study was undertaken to review our experience with a group of 44 patients with adenoid cystic carcinoma of the head and neck, diagnosed at the Jeonju Presbyterian Medical Center between 1963 and 1980. The results are as follows: 1. Forty-four cases of adenoid cystic carcinoma represented 40% of the malignant salivary gland tumors during the same interval. 2. The most common primary sites were palate(8 cases) and submandibular gland (8 cases). 3. Thirteen patients (31%) had tumors. that arose in the major salivary glands; 29 (69%), minor salivary glands. 4. Of the 44 patients, there were 21 males. and 23 females. 5. Age at diagnosis ranged from 19 to 78 years; the average age was 50 years. 6. The tumor size was more than 4cm to 6cm in its greatest diamension in 10 patients. Clinically positive cervical lymph nodes were found in 7 patients; distant metastasis in one case at the time of diagnosis. 7. Radical excision was employed in 27 patients, 14 of whom combined with radiotherapy. 8. Of 29 patients available for follow-up the gross and determinate 3-year survival rates were 27.6% and 44.4%, respectively. Among twelve patients who received radical excision, the 3-year survival was 58%. 9. Ten of these 44 patients had local recurrence in an interval of 3 to 88 months. from the initial treatment. Of ten recurrences, 3 occured after 5 years. 10. Distant metastasis was found in 3 of the treated patients. All were pulmonary metastasis.

• Journal of the Korean association of regional geographers
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• v.4 no.1
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• pp.15-25
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• 1998

A stream plays an important role as the source of drinking water, the ecological space and the living space. But the today's urban stream whose ecosystem is destroyed and water quality become worse in consequence of covering, concrete dyke construction, and the adjustment of high-water-ground[dunchi], is deprived of the function as a stream. Therefore this paper aims to elucidate the role that urban stream plays ecologically and to try to find a improvement to the problem. A stream is the pathway through which several types of the solar radiation energy are transmitted and the place which is always full of life energy. In the periphery of a stream, primary productivity is high and carrying capacity of population is great. Thus ancient cities based on agricultural products grew out of the fertile surroundings of stream. In Korea most cities of the Chosen Dynasty Period based on the agriculture have grown out of the erosional basins where solar energy is concentrated. The role of a stream in this agricultural system is the source of energy and material(water and sediment) and a lifeline. In consequence of the growth of cities and the rapid growing demands of water supply after the Industrial Revolution, a stream has become a more important locational factor of city. However, because cities need the life energy of urban streams no longer, urban streams cannot play role as a lifeline. And As pollutant waste water has poured into urban streams after using external streams' water, urban streams have degraded to the status of a ditch. As the results of the progress of urbanization, the dangerousness of inundation of urban stream increased and its water quality became worse. For the sake of holding back it, local governments constructed concrete dyke, adjusted high-water-ground[dunchi], and covered the channel. But stream ecosystem went to ruin and its water quality became much worse after channelization. These problems of urban stream can be solved by transmitting much energy contained in stream to land ecosystem as like rural stream. We should dissipate most of the energy contained in urban stream by cultivating wetland vegetation from the shore of stream to high-water-ground, and should recover a primitive natural vigorous power by preparation of ecological park.

• Korean Journal of Breeding Science
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• v.43 no.1
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• pp.68-80
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• 2011

This study was conducted to investigate characteristics and variations of rice panicle traits for breeding temperate japonica varieties adapted to tropical environment. Eleven panicle traits were investigated from nine Korean rice varieties cultivated in Korea and wet season of the Philippines. Tested cultivars were composed of six temperate japonica varieties, three Tongil-type varieties, and one indica variety bred in the Philippines. The number of spikelets on secondary rachis branches (SRBs) was the most variable trait in both environments, while the mean number of spikelets on a primary rachis branch (PRB) was the least variable. Compared with PRB-related traits, SRB traits showed higher correlation with the number of spikelets per panicle. Compared with the plants grown in Korea, the number of spikelets on SRBs, the number of SRBs, spikelets, and rachis branches per panicle were decreased more than other traits in the Philippines. According to path analysis, the number of spikelets on SRBs per panicle affects the number of spikelets per panicle more than the number of spikelets on PRBs per panicle. Climatic factors such as growth duration, cumulative mean temperature, and integrated solar radiation were highly correlated with the relative rate of number of spikelets per panicle. To breed temperate japonica rice varieties adapted to tropical environment, it would be important to select lines which maintain proper growth duration and spikelets on SRBs in target region.

• Journal of Climate Change Research
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• v.5 no.1
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• pp.71-81
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• 2014

Using the Eddy Covariance technique, we analyzed seasonal variation in net ecosystem $CO_2$ exchange (NEE) and investigated the effects of environmental factors and aboveground biomass of rice on the $CO_2$ fluxes in a rice-barley double cropping paddy field of Gimje, Korea. Quality control and gap-filling were conducted before this investigation of the effects. The results have been showed that NEE, gross primary production (GPP), and ecosystem respiration (Re) during the rice growing period were -215.6, 763.9, and $548.3g\;C\;m^{-2}$, respectively. Relation between NEE and net radiation (Rn) could be described by a quadratic equation, and about 65 % of variation in NEE was explained by changes in Rn. On the other hand, an exponential function relating Re to soil temperature accounted for approximately 43 % of variation in Re under the flooded condition of paddy field. Aboveground biomass showed significant linear relationships with NEE ($r^2=0.93$), GPP ($r^2=0.96$), and Re ($r^2=0.95$), respectively.