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Development of Birdcage Resonator for Various Absorption Regions at 3T (3T MRI에서 흡수영역의 변화에 따른 Birdcage Resonator의 개발)

  • 이정우;최보영;윤성익;이형구;서태석;허순녕
    • Progress in Medical Physics
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    • v.15 no.1
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    • pp.54-58
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    • 2004
  • The aim of this study was to develop special birdcage resonators for small objects including the human wrist, hand and small animals, using 3T MRI/MRS. Before substantial development, different types of parameters were arranged, based on theoretical analysis, through lumped element transmission line theory. The primary analysis was peformed with a network analyzer (HP 4195A) and the final experimental analysis was carried out with 3T MRI (Medinus, Korea). The manufactured birdcage resonator is typically composed of 12-element structures to which a low-pass filter is fundamentally applied. The diameter and length of each element of the birdcage resonator were as follows: (1) diameter 12 cm, length of element 22 cm, (2) diameter 15 cm, length of element 22 cm, and (2) diameter 17 cm, length of element 25 cm. Copper tape with a width of 1 cm was used for the coils. MRI acquisition parameters were TR=500 ms, TE=17 ms, and Ave=2 for T1-WT images, and TR=4,000 ms, TE=96 ms, and Ave=2 for T2-WT images. The ratio of the samples diameter to the birdcage resonators diameter was approximately 55%, 63% and 70%, respectively, for the three elements. This study determined that the best image quality and S/N ratio were obtained when the ratio of the object's diameter was approximately 50∼80%. A general theoretical analysis of the birdcage coil differs in many respects from the experimental results which were influenced by many factors that were not considering when the general theoretical analysis of the birdcage coil was peformed. The induced resistance may be considered as part of the resistive loss if the quantitative value can be determined using a radiation resistance approach.

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Down Regulation of miR-34a and miR-143 May Indirectly Inhibit p53 in Oral Squamous Cell Carcinoma: a Pilot Study

  • Manikandan, Mayakannan;Rao, Arunagiri Kuha Deva Magendhra;Arunkumar, Ganesan;Rajkumar, Kottayasamy Seenivasagam;Rajaraman, Ramamurthy;Munirajan, Arasambattu Kannan
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.17
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    • pp.7619-7625
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    • 2015
  • Background: Aberrant microRNA expression has been associated with the pathogenesis of a variety of human malignancies including oral squamous cell carcinoma (SCC). In this study, we examined primary oral SCCs for the expression of 6 candidate miRNAs, of which five (miR-34a, miR-143, miR-373, miR-380-5p, and miR-504) regulate the tumor suppressor TP53 and one (miR-99a) is involved in AKT/mTOR signaling. Materials and Methods: Tumor tissues (punch biopsies) were collected from 52 oral cancer patients and as a control, 8 independent adjacent normal tissue samples were also obtained. After RNA isolation, we assessed the mature miRNA levels of the 6 selected candidates against RNU44 and RNU48 as endogenous controls, using specific TaqMan miRNA assays. Results: miR-34a, miR-99a, miR-143 and miR-380-5p were significantly down-regulated in tumors compared to controls. Moreover, high levels of miR-34a were associated with alcohol consumption while those of miR-99a and miR-143 were associated with advanced tumor size. No significant difference was observed in the levels of miR-504 between the tumors and controls whereas miR-373 was below the detection level in all but two tumor samples. Conclusions: Low levels of miR-380-5p and miR-504 that directly target the 3'UTR of TP53 suggest that p53 may not be repressed by these two miRNAs in OSCC. On the other hand, low levels of miR-34a or miR-143 may relieve MDM4 and SIRT1 or MDM2 respectively, which will sequester p53 indicating an indirect mode of p53 suppression in oral tumors.

A Comparative Study of Range of Motion With or Without Distal Interphalangeal Joint Fixation in Replantation of the Amputated Fingertips (수지 첨부 절단창의 재접합술 시 원위지 관절 고정과 운동 범위의 관계)

  • Han, Seung-Kyu;Roh, Si-Young;Kim, Jin-Soo;Lee, Dong-Chul;Ki, Sae-Hwi;Yang, Jae-Won
    • Archives of Reconstructive Microsurgery
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    • v.20 no.1
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    • pp.18-25
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    • 2011
  • Purpose: In the process of replantation of the amputated fingertips, the primary concern was given to survival of the amputees, while the functional aspect of digits after the surgery has been easily neglected. Although an internal fixation with a K-wire is often a part of replantation of the amputated fingertips, little consideration had been given to the study of relationship between distal interphalangeal joint fixation and post operative range of motion. A comparative study in relation to post operative range of motion was done on two different groups, one group with K-wire insertion and the other group without a K-wire insertion at the distal interphalangeal joint. Materials and Methods: The study was done on the cases of a single digit amputation conducted at our institute (the age in the range of 10 to 60) in about four-year of time span from March of 2005 to March of 2009. The cases with a thumb replantation, osteomyelitis or articular surface injury have been excluded from this study. The cases of both head and shaft fracture, except the insertion site of tendon, of distal phalanx of internal fixation with a single K-wire were reviewed for this study. A group of 24 cases without distal interphalangeal joint fixation in comparison to a group of 22 cases with distal interphalangeal joint fixation was reviewed to assess the postoperative range of motion at distal interphalangeal joint on the 6th week after the surgery. And, on the 30th month after the surgery, a group of 10 cases without distal interphalangeal joint fixation in comparison to a group of 10 cases with joint fixation was reviewed. A K-wire was removed in about 5 weeks after the fracture was reunited under the radiographic image, immediately followed by a physical therapy. Result: The active range of motion for a group without interphalangeal joint fixation was measured $49.0^{\circ}$ on average, while $28.6^{\circ}$ was measured for a group with interphalengeal fixation on the 6th week after the surgery. On the 30th month after the surgery, the active range of motion was measured $52.0^{\circ}$ and $55.0^{\circ}$ on average for a group without and with interphalangeal fixation respectively. Conclusion: In the process of replantation of the amputated fingertips, short-term(on the 6th week) improvement of postoperative active motion of range can be expected in the cases without distal interphalangeal fixation in comparison to the cases of interphalangeal joint fixation with a K-wire. However, there seems to be no difference on motion of range in a long-term (on the 30th month) follow up period.

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A Study on the Development about Crisis Control Analyzes and the Realities of VIP Terrorism (요인(要人)테러의 위기관리 사례분석 및 발전방향에 관한 고찰)

  • Suh, Sang-Yul
    • Korean Security Journal
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    • no.14
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    • pp.235-259
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    • 2007
  • These days our society, no matter it is individual or community or nation it has diversity big and small trouble and Terrorism, disaster that gives national crisis in many different ways. Before we dont think disaster is big problem in nation crisis but now we have to think seriously and put the disaster problem in nation crisis. Also security terrorism is important in national crisis just same as security of nation and disaster in national crisis management. Specially, attacking national sovereign and the head of the government are still increasingly and if deadly terror happens than nation will get big crisis and can get aftereffect. Accordingly way of development about crisis control in security terrorism, first of all, for make confrontation system because of crisis management, need judical revision about escort law and prevention of terror. Second of all, need exclusion of guard danger element for strengthening guard safe action. Third of all, strengthening education to people so increase ability of conquest in the scene. Finally, security terror not only directly purpose also indirectly purpose increase, need to development about guards way and need a strong will to reduce terrorism, also put emphasis on prevention guards action and before the fact make perfection more perfect in crisis control to removal element of terror.

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Simultaneous Carbon and Nitrogen Removal Using an Integrated System of High-Rate Anaerobic Reactor and Aerobic Biofilter (고효율 혐기성반응조 및 호기성여상 조합시스템에 의한 질소·유기물 동시 제거)

  • Sung, Moon Sung;Chang, Duk;Seo, Seong Cheol;Chung, Bo Rim
    • Journal of Korean Society of Water and Wastewater
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    • v.13 no.2
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    • pp.55-65
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    • 1999
  • AF(anaerobic filter)/BAF(biological aerated filter) system and UASB(upflow anaerobic sludge blanket)/BAF system, of which system effluents were recirculated to the anaerobic reactors in each system, were operated in order to investigate the performance in simultaneous removal of organics and nitrogen in high-strength dairy wastewater. Advanced anaerobic treatment processes of AF and UASB were evaluated on applicability as pre-denitrification reactors, and BAF was also evaluated on the performance in oxidizing the remaining organics and ammonia nitrogen. At system HRTs of 4.0 to 4.5 days and recirculation ratios of one to three, the AF/BAF system could achieve more than 99% of organics removals and 64 to 78% of total nitrogen removals depending upon the recirculation ratio. Although the UASB/BAF system also showed more than 99% of organics removals, total nitrogen removals in the UASB/BAF system were 53 to 66% which are lower than those in the AF/BAF system at the corresponding recirculation ratios. Optimum recirculation ratios considering simultaneous removal of organics and nitrogen and cost-effectiveness, were in the range of two to three. The upflow AF packed with crossflow module media, as a primary treatment of the anaerobic reactor/BAF system, showed better performances in denitrification, SS removals, and gas production than the UASB. Higher loading rate of suspended solids from the UASB increased the backwashing times in the following BAF. Especially, at a recirculation ratio of three in the UASB/BAF system, the increase in head loss due to clogging in the BAF caused frequent backwashing, at least once d day. The BAF showed the high nitrification efficiency of average 99.2% and organics removals more than 90% at organics loading rate less than $1.4KgCOD/m^3/d$ and $COD/NH_3-N$ ratio less than 6.4. It was proved that the simplified anaerobic reactor/BAF system could maximize the organics removal and achieve high nitrogen removal efficiencies through recirculation of system effluents to the anaerobic reactor. The AF/BAF system can, especially, be a cost effective and competitive alternative for the simultaneous removal of organics ana nitrogen from wastewaters.

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Case of Treatment Using Adaptive Servo-Ventilation in a Patient with Central Sleep Apnea after a Lateral Medullary Infarction (외측 연수 경색에 의해 발생한 중추성 수면 무호흡 환자의 자동-적응형 양압기를 사용하여 치료한 경험)

  • Kim, Dae Jin;Cho, Jae Wook;Kim, Hyun Woo;Choi, Jeong Su;Mun, Sue Jean
    • Korean Journal of Clinical Laboratory Science
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    • v.52 no.3
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    • pp.278-283
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    • 2020
  • Central sleep apnea (CSA) is characterized by respiratory failure of at least 10 seconds without any effort of the chest and abdomen in the absence of upper airway resistance during sleep. In this case, the patient experiences respiratory failure that does not meet the CSA diagnostic criteria and CSA symptoms. Magnetic resonance imaging diffusion-weighted imaging (MRI DWI) scans revealed a lateral medullary infarction. Continuous positive airway pressure (CPAP) was applied as a primary treatment for CSA and respiratory failure. During the titration of CPAP, the apnea-hypopnea index (AHI) and arousal index (AI) were worse than the results before its use (AHI: 42.5/hr→82.8/hr, AI: 21.7/hr→40.8h). As a result, adaptive servo-ventilation (ASV) was chosen as the secondary treatment. Compared to the night-polysomnography results before the ASV treatment, the AHI improved (42.5/hr→8.6/hr). Therefore, ASV is a potential treatment for CSA and respiratory failure in these patients.

MESIODENS EXTRACTION OF A PATIENT WITH ROBINOW SYNDROME UNDER GENERAL ANESTHESIA (로비노 증후군(Robinow syndrome) 환자의 전신마취 하 과잉치 발치)

  • Park, Sung-Hee;Shin, Teo-Jeon;Hyun, Hong-Keun;Kim, Young-Jae;Kim, Jung-Wook;Lee, Sang-Hoon;Kim, Chong-Chul;Jang, Ki-Taeg
    • The Journal of Korea Assosiation for Disability and Oral Health
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    • v.12 no.1
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    • pp.1-5
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    • 2016
  • Robinow syndrome is skeletal dysplasia with both autosomal dominant and recessive inheritance patterns. It is characterized by short-limbed dwarfism, abnormalities in the head and face, as well as vertebral segmentation. A 2-year-7-month old boy with Robinow syndrome had visited Seoul National University Dental Hospital, for the evaluation of tooth palatal eruption on maxilla. He had micrognathia, delayed tooth eruption, cleft lip with bifid uvula. He also had an erupted mesiodens on the palatal side of maxillary primary incisors, which was tuberculated and 8mm in major diameter. The patient was scheduled for mesiodens extraction under general anesthesia. He was a young child with delayed development, so general anesthesia was inevitable. General anesthesia was induced and maintained with inhalation agent, Sevoflurane. There were no postoperative complications related to anesthesia and dental treatment. Robinow syndrome patients have craniofacial dysmorphism and eruption disorders. Therefore, he requires regular check-ups as well as dental managements.

Development of the Work Information Management System of Pavement Crack Sealing Using IT (정보기술을 활용한 도로면 크랙실링 작업정보 관리시스템 개발)

  • Byun, Woong-Ho;Oh, Se-Wook;Lee, Jeong-Ho;Kim, Young-Suk
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • 2006.11a
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    • pp.613-618
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    • 2006
  • Crack in Pavements have been continually increased aby water penetration Therefore, the cracks can result in deterioration of the pavements that could be extremely dangerous fro road users. Creak sealing work performed in outdoor is very dangerous, costly and labor intensive. To slove these problems, automated crack sealing systems have been developed. it Would be needed that work information related to crack sealing must be gathered in an effort to used for existing or future crack sealing work. Furthermore, work information related to crack sealing could be utilized in analyzing work productivity and condition. The primary objective of this study is to propose a PDA and Web-based system for work information management of crack sealing which enables to effectively interchange work information between head office and fieds, and to accurately collect work information. Finally, it is anticipated that the effective use of the developed PDA and web-based system would be able to effectively share work information, measure productivity, estimate costs as well as plan future work schedule.

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Fungal Distribution and Varieties Resistance to Kernel Discoloration in Korean Two-rowed Barley (국내 육성 2조 겉보리 변색 종실에서의 곰팡이 분포와 품종 저항성)

  • Shin, Sang-Hyun;Seo, Eun-Jo;Choi, Jae-Seong;Kang, Chun-Sik;Lee, JungKwan;Park, Jong-Chul
    • Research in Plant Disease
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    • v.19 no.3
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    • pp.183-187
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    • 2013
  • Barley kernel discoloration (KD) leads to substantial loss in value through downgrading and discounting of malting barley. The objective of this research is to investigate fungal distribution and varieties resistance to KD in Korean two-rowed barley. Several fungal organisms including Alternaria spp., Fusarium spp., Aspergillus spp., Epicoccum spp. and Rhizopus spp. were isolated from Korean two-rowed barley representing KD. The symptoms of KD were brown and black discolorations of the lemma and palea. The most frequently detected fungal species was Alternaria spp. which exhibited 69.1% and 72.2% in 2011 and 2012, respectively. Epicoccum spp., Fusarium spp., and Aspergillus spp. were also detected. Fusarium spp., primary pathogen of barley head blight, were rarely occurred in the 2011 and their occurrence increased to 4.7% in 2012. Twenty cultivars of Korean two-rowed barely were evaluated to KD. The average percentage of KD was 8.0-36.0% in 2011 and 5.2-36.6% in 2012. Two cultivars ('Sacheon 6' and 'Dajinbori') showed KD of 6.2% to 8.8% and determined resistant, however 'Samdobori' and 'Daeyeongbori' demonstrating KD of 22.2-36.6% were highly susceptible. 'Jinyangbori', 'Danwonbori', 'Sinhobori' and 'Kwangmaegbori' showing KD of less than 15% were moderately resistant cultivar.

Monte Carlo Simulation of a Varian 21EX Clinac 6 MV Photon Beam Characteristics Using GATE6 (GATE6를 이용한 Varian 21EX Clinac 선형가속기의 6 MV X-선 특성모사)

  • An, Jung-Su;Lee, Chang-Lae;Baek, Cheol-Ha
    • Journal of radiological science and technology
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    • v.39 no.4
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    • pp.571-575
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    • 2016
  • Monte Carlo simulations are widely used as the most accurate technique for dose calculation in radiation therapy. In this paper, the GATE6(Geant4 Application for Tomographic Emission ver.6) code was employed to calculate the dosimetric performance of the photon beams from a linear accelerator(LINAC). The treatment head of a Varian 21EX Clinac was modeled including the major geometric structures within the beam path such as a target, a primary collimator, a flattening filter, a ion chamber, and jaws. The 6 MV photon spectra were characterized in a standard $10{\times}10cm^2$ field at 100 cm source-to-surface distance(SSD) and subsequent dose estimations were made in a water phantom. The measurements of percentage depth dose and dose profiles were performed with 3D water phantom and the simulated data was compared to measured reference data. The simulated results agreed very well with the measured data. It has been found that the GATE6 code is an effective tool for dose optimization in radiotherapy applications.