• Korean Journal of Bronchoesophagology
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• v.3 no.1
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• pp.164-168
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• 1997

Multiple primary tumors in the head and neck are not uncommon, however those in the thyroid and the larynx are known to be very rare. In most cases of multiple primary tumors involving the thyroid and the larynx, lesions are observed usually simultaneously and thyroid tumors are found incidentally during the laryngeal tumor surgery. In rare cases, thyroid tumors are found metachronously after radiation therapy of laryngeal cancer. The authors recently experienced a case of multiple primary tumor involving the thyroid and the larynx, in which thyroid papillary carcinoma was the index tumor and the laryngeal squamous carcinoma was the meatachronous second tumor. Both tumors showed aggressive local extension and regional nodal meatastasis with tumor collision in the same node. The patient died of recurrent or of residual squamous carcinoma shortly after main surgical treatment index thyroid cancer.

• Korean Journal of Head & Neck Oncology
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• v.11 no.1
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• pp.100-105
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• 1995

• Korean Journal of Head & Neck Oncology
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• v.16 no.2
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• pp.216-219
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• 2000

Small cell carcinoma usually occurs in lung, but extrapulmonary small cell carcinomas can occur in any sites of body. Most sites of extrapulmonary small cell carcinoma reported were esophagus. And small cell carcinomas occurred in head and neck area were reported rarely. Extrapulmonary small cell carcinoma could be diagnosed when there is no evidence of primary lung lesion on chest X-ray, CT scan of chest and bronchoscopy. The authors experienced a case of small cell carcinoma of left submandibular lymph node in 64-year-old male patient. Biopsy specimen showed poorly differentiated carcinoma but immunohistochemical study showed small cell carcinoma. The chest X-ray and CT scan of chest showed no evidence of primary lung lesion. The patient received chemotherapy(etoposide plus cisplatin) and concurrent chemoradiotherapy using weekly taxol which resulted in good clinical remission. He is still alive 8 months after diagnosis without evidence of lung disease. We report our case with a brief review of literatures.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5175-5178
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• 2013

Background: The prognostic value of tumor osteopontin (OPN) in patients with squamous-cell head and neck cancer (SCHNC) was investigated. Materials and Methods: OPN expression was assessed by immunohistochemical methods in 50 patients, who were treated with primary radiotherapy (RT) for locally advanced SCHNC. The effects of OPN on clinical parameters, local-regional control after RT and metastasis-free survival, was assessed. Results: The rate of OPN expression in tumor tissue was 76%. OPN positive cases had lower Hb levels (p=0.088). Mean time to local recurrence was 53.8 months (SE 3.9) in OPN-negative cases and 39.1 months (SE 4.7) in OPN-positive cases (p=0.047). OPN increased the risk of local recurrence 5.9 times (p=0.085). It had no effect on metastasis-free (p=0.116) or overall survival (p=0.123). OPN was positive in 12 of 19 cases that developed grade 3-4 acute radiation dermatitis (p=0.096). Conclusions: OPN expression is associated with an increase in local recurrence in patients who were treated with primary RT for locally advanced SCHNC.

• Journal of ILASS-Korea
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• v.26 no.3
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• pp.127-134
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• 2021

Fire sprinkler initial spray was analyzed by Large eddy simulation (LES) and Volume of Fluid (VoF) integrated method. The IsoAdvector geometric VoF was used to identify the liquid-gas interface clearly even with the large Courant-Friedrichs-Lewy number. To reduce the computational costs, sector meshes and Adaptive Mesh Refinement up to level 3 were used. Base mesh size was 1 mm, which is roughly equivalent to the initial sprinkler droplet. Top surface radius of boss and deflector size were modified to investigate the effects of sprinkler head design on primary breakup process. When top surface radius of boss was increased, vertical liquid sheet was formed. This phenomenon reduced the sheet breakup radius, sheet thickness and velocity. Due to reduced liquid sheet thickness, a large amount of ligaments was created from the liquid sheet. As a result, there was a dramatic decrease in volume per surface area, indicating an increase in breakup process. Spray pattern viewed in radial direction also changed when top surface radius of boss increased. When top surface radius of boss was increased, a T-shaped pattern was observed while a V-shaped pattern was observed in all other cases. When the deflector size increases, the spray pattern remains V-shaped, even if the top surface radius of boss increased. Further studies on promoting atomization of the water supplied to the lower part of the sprinkler head in the T-shape pattern should be conducted.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7457-7461
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• 2015

Some thyroid cancer patients undergone insufficient tumor removal in the primary surgery in China. our aim is to evaluate the impact of dissection of the recurrent laryngeal nerve during a salvage thyroid cancer operation in these patients to prevent nerve injury. Clinical data of 49 enrolled patients who received a salvage thyroid operation were retrospectively reviewed. Primary pathology was thyroid papillary cancer. The initial procedure performed included nodulectomy (20 patients), partial thyroidectomy (19 patients) and subtotal thyroidectomy (10 patients). The effect of dissection and protection of the recurrent laryngeal nerve and the mechanism of nerve injury were studied. The cervical courses of the recurrent laryngeal nerves were successfully dissected in all cases. Nerves were adherent to or involved by scars in 22 cases. Three were ligated near the place where the nerve entered the larynx, while another three were cut near the intersection of inferior thyroid artery with the recurrent laryngeal nerve. Light hoarseness occurred to four patients without a preoperative voice change. In conclusion, accurate primary diagnosis allows for a sufficient primary operation to be performed, avoiding insufficient tumor removal that requires a secondary surgery. The most important cause of nerve damage resulted from not identifying the recurrent laryngeal nerve during first surgery, and meticulous dissection during salvage surgery was the most efficient method to avoid nerve damage.

• Korean Journal of Head & Neck Oncology
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• v.33 no.2
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• pp.29-33
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• 2017

Verrucous carcinoma was first described by Ackerman who reported a case of verrucous carcinoma of the oral cavity. While it is primarily occurred in oral cavity, larynx is the second most affected site, accounting for nearly 35% of cases. It is a rare variant of well-differentiated squamous cell carcinoma and comprises 1% to 4% of all laryngeal carcinomas. It is characterized by locally invasive, slow growth and the surface shows papillary fronds with prominent hyperkeratosis. Because of the benign appearance and difficulty of the tissue diagnosis, it is often undiagnosed or misdiagnosed. The primary treatment modality is surgery and the extent of surgical resection may be guided by T stage. We experienced a case of verrucous carcinoma of larynx in a patient with hoarseness lasted for about 2 years and had difficult to diagnosis and treatment. Therefore we report this case with a brief review of literature.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2006.11a
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• pp.261-264
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• 2006

This paper deal with development of dredging equipment that proper water head elimination method changing transitional dredging method. Numerical simulation and model test were accomplished for development of seabed sediment inhalation equipment using water head. Sediment elimination system by the difference of water head has been analysed by numerical method. Model test was achieved for inhalation equipment performance test using water head by primary design. Also sediment elimination system has designed and developed that doesn't occur secondary pollution phenomenon. To verify the numerical results are compared with experimental results.

• Korean Journal of Head & Neck Oncology
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• v.33 no.1
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• pp.65-71
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• 2017

Primary malignant lymphoma of the parotid gland is extremely rare entity and seldom described in the literature. Extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue(MALT lymphoma) is a relatively indolent disease and tents to remain localized for prolonged period of time. MALT lymphoma can be diagnosed after immunohistopathological study. Clinically, most MALT lymphomas are localized at the time of diagnosis and may be curable with local therapy alone, either surgery or radiotherapy. We present a case of MALT lymphoma in both parotid glands of patient who detected a left infraauricular huge mass as a first symptom and underwent surgical excision and immediate reconstruction using sternocleidomastoid myocutaneous flap.

• Korean Journal of Head & Neck Oncology
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• v.13 no.2
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• pp.260-264
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• 1997

Metastatic cancer presenting as a cervical cyst is uncommon, and often misdiagnosed as branchial cleft cyst. Authors experienced two cases which presented clinically with features of branchial cleft cyst, but were subsequently found to be metastatic cancer. Radiologic examination and fine needle aspiration biopsy proved to be non-diagnostic, and pathologic findings after surgical excision showed metastatic cancer. Further evaluation and examination were made to find out the primary focus, which revealed tonsillar squamous cell cancer and thyroid papillary cancer in each case. When cervical cysts are noted in aged patients, it is mandatory to rule out metastatic cancer until it is proven otherwise. Surgical excision and pathologic diagnosis should be always accompanied to make correct diagnosis and further treatment.