• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.5
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• pp.724-731
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• 2012

This study was designed to elucidate whether combination with Korean red ginseng and Morus alba L. (MPM), traditional treatment for diabetes, ameliorates on high fructose-induced steatohepatitis and vascular inflammation. Animals were divided into four groups; Control receiving tap water, fructose-fed, rosiglitazone-treated fructose-fed rats, and MPM-treated fructose-fed rats both receiving supplemented with 60% fructose (n=10). The MPM or rosiglitazone groups initially received a high-fructose diet alone for 8 weeks, with supplementation with MPM or rosiglitazone, peroxisome proliferators-activated receptor gamma ($PPAR{\gamma}$) agonist, occurring during the final 6 weeks. Treatment with MPM significantly prevented the increase in c-reactive protein (CRP) levels in the high fructose group. MPM suppressed high fructose diet-induced vascular inflammation marker expression such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. MPM also reduced intima/media thickness of thoracic aorta. Histologic observation and oil red O staining demonstrated hepatic tissue damage and lipid accumulation were severe in high fructose group. Treatment with MPM ameliorated hepatic tissue morphology with minimized steatosis. In addition, MPM attenuated hepatitis by inhibition of monocyte chemoattractant protein-1 (MCP-1) expression. MPM-fed group showed lower serum GOT and GPT levels comparing with high fructose group. MPM and rosiglitazone (positive control) significantly decreased the size of epididymal adipocytes. Taken together, the administration of MPM inhibited high fructose-induced steatohepatitis and vascular inflammation. These results suggested that MPM is useful in the prevention or treatment of metabolic syndrome-related disorders such as fatty acid metabolism and vascular homeostasis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.1
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• pp.43-50
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• 2018

Korean Red Ginseng (RG) are used as a traditional treatment for improve blood circulation. This experimental study was designed to investigate the inhibitory effects of Korean red ginseng on lipid metabolism in high fat/cholesterol diet (HFCD)-induced hypertriglyceridemia. Sprague Dawley rats were fed the HFCD diet with/without fluvastatin (Flu, positive control) 3 mg/kg/day, and RG 125 or 250 mg/kg/day, respectively. All groups received regular diet or HFCD diet, respectively, for 13 weeks. The last three groups treatment of Flu and RG 125, and RG 250 orally for a period of 9 weeks. Group 1, reular diet; group 2, HFCD diet; group 3, Flu + HFCD diet; group 4, RG 125 + HFCD diet; group 5, RG 250 + HFCD diet. As a result, treatment with low or high doses of RG markedly attenuated plasma levels of triglycerides and augmented plasma levels of high-density lipoprotein (HDL) in HFCD-fed rats. RG and Flu also led to an increase in lipoprotein lipase activity in the HFCD group. On the other hand, RG and Flu led to an decrease in fatty acid synthase and free fatty acid activity in the HFCD group. Treatment with RG suppressed increased expressions of $PPAR-{\alpha}$ and AMPK in HFCD rat liver or muscle. In addition, the RG attenuated triglyceridemia by inhibition of $PPAR-{\gamma}$ and FABP protein expression levels and LXR and SREBP-1 gene expression in liver or muscle. The RG significantly prevented the development of the metabolic disturbances such as hypertriglyceridemia and hyperlipidemia. Taken together, the administration of RG improves hypertriglyceridemia through the alteration in suppression of triglyceride synthesis and accentuated of triglyceride decomposition. These results suggested that RG is useful in the prevention or treatment of hypertriglyceridemia.

• The Journal of Korean Society for School & Community Health Education
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• v.17 no.3
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• pp.11-25
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• 2016

Background & Objectives: There were increasing evidence about the relationship between allergy related disease such as asthma, atopic dermatitis and allergic rhinitis and suicide ideation. However little was known about the concrete relatedness between severity and comorbidity of allergy related disease with suicide ideation. The objective of this study was to investigate the cases of the prevalence of suicide ideation among adolescents with allergy related disease such as asthma, atopic dermatitis and allergic rhinitis, and examine the association between allergy related disease and suicidal ideation among adolescents in South Korea. Methods: Data was based on Korean Youth Risk Behavior Web-based Survey(2014) which was a cross-sectional study containing 34,874 Korean middle and high school students who diagnosed with allergy related disease. We used the weights, strata and primary sampling unit information provided by the public use dataset to compute descriptive statistics and logistic regressions. Computations were done with SPSS version 20.0. Results: 19.9%, 15.6%, 13.8% of adolescents who suffered from one, two and three of allergy related diseases respectively reported having been thought of suicide ideation. Socio-demographic factors were adjusted as control variables. Students with greater severity of disease were more likely to have suicide ideation. Odds ratio for students who were absent one to three days from school because of allergies was 1.96(95% CI 1.51-2.46), and odds ratio for those who were absent more than four days from school was 3.60(95% CI 2.46-5.28). Conclusions: Given that adolescents' severity and comorbidity of allergy related disease were clearly associated with suicide ideation, suicide prevention programs for adolescents with allergy related disease should be improved by strategic approaches towards the severity and comorbidity of disease.

• The Korean Journal of Food And Nutrition
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• v.18 no.2
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• pp.140-145
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• 2005

Changes of plasma lipids, total cholesterol and phospholipids content according to diet of silkworm extract powder were as follows. Decrease ratios of plasma lipids at 3, $5\%(w/w)$ treating groups were plasma lipids 5.16, $9.15\%$, those of total cholesterols were 1.63, $2.76\%$ and those of phospholipids were 1.37, $2.00\%$, respectively. Decreasing effects of plasma triglyceride content according to diet of silkworm extract powder was higher than those of total cholesterols and phospholipids contents. Decrease of plasma glucose concentrations were $4.62\%\;and\;6.46\%\;at\;3\%,\;5\%(w/w)$ treating group than control group, respectively. These results were not proportional decrease according to treating amount. In the other hand, changes of insulin concentration of plasma, pancreas and femur were appeared the similar tendency with plasma glucose concentration. Relationship between treating amount of silkworm extract powder and insulin concentration had not positive relativity, In conclusion, treatment of silkworm extract powder about $3\%(w/w)$ could be expected to prevention and/or medical treatment effect of diabetic patients.

• Food Science of Animal Resources
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• v.30 no.5
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• pp.764-772
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• 2010

Staphylococcus aureus lipase is regarded as a virulence factor. The response of lipase activity to various factors can provide important insights concerning the prevention of S. aureus during meat fermentation. This study was conducted to evaluate the main effects of nutrients used in culture media, and their combined effects on the inhibition of lipase activity and cell growth of pathogenic S. aureus SK1593 isolated from fermented pork meat. A Plackett-Burman design was used to evaluate the main effects of variables, including olive oil, soybean oil, grapeseed oil, sesame oil, $CuSO_4$, $MgCl_2$, $KNO_3$, $CaCl_2$, and KCl. Significant negative effects on lipase activity were detected with soybean oil, grapeseed oil, $KNO_3$, and $CaCl_2$. Additionally, these nutrients were further selected as variables for the investigation of their combined effect on lipase activity, via response surface methodology. In order to confirm the regression model, a situation that only inhibits lipase activity was simulated. The predicted lipase activity and cell growth of the simulated situation were 14.0 U/mL and $9.6\;{\log}_{10}$ (CFU/mL), respectively, and the estimated value of those in the same medium showed 15.14 U/mL and $9.4\;{\log}_{10}$(CFU/mL) respectively. The lipase activity of the simulated medium was inhibited approximately 5-fold as compared to the basal medium, but no significant differences in cell counts were noted to exist between the basal and simulated media. These results suggest that soybean oil, grapeseed oil, $KNO_3$, and $CaCl_2$ can be used to inhibit the growth of pathogenic S. aureus during the process of meat fermentation.

• Korean Journal of Social Welfare
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• v.39
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• pp.103-127
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• 1999

This study investigated the relationship between parental control and adolescents' levels of drinking and the relationship by grades. Parental control was composed of three dimensions such as parental supervision, parental rules, and parental attitude toward respondents' drinking. Respondents' levels of drinking were broken down into no use, occasional use, experimental use, and heavy use based on the frequencies of drinking. This study found that parental supervision and parental attitude toward respondents' drinking were negatively related to respondents' levels of drinking. When the effect of respondents' grades was considered in the elaboration models, parental supervision was still significantly related to respondents' levels of drinking. Parental rules and parental attitude were significantly related to respondents' levels of drinking in the second-year respondents and the third-year respondents respectively. The strength of this study was to provide important preventive interventions. That is, prevention program should be designed to strength parental control. Social workers dealing with adolescents' problems including drinking should teach parents to set dear rules for adolescents' behavior, to monitor their behavior consistently, and to guide them the risks of potential social influences that may lead them to drink.

• Journal of agricultural medicine and community health
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• v.33 no.1
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• pp.1-10
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• 2008

일개 농촌 마을에서 농한기를 활용하여 시행된 근골격계 질환 예방사업을 소개하고 주요 사업결과를 분석하여 농업인의 건강증진을 위한 기초자료로 활용하고자 본 연구를 수행하였다. 2006년 12월 5일부터 2007년 1월 26일까지 사곳리 마을회관을 12회 방문하여 4번의 기초교육과 5번의 심화교육 등 9번의 근력 및 유연성 강화교육을 실시하였다. 교육 전(사전평가), 기초교육과 심화교육 사이(중간평가), 교육 후(최종평가) 등 3회에 걸쳐 의사 2인에 의한 근골격계 질환 평가, 시각통증척도에 의한 근골격계 통증 평가, 생활체육 전문가 3인에 의한 좌우의 악력, 배근력, 하지근력, 몸통, 어깨, 하지, 무릎유연성 측정을 통한 근골격계 근력 및 유연성 평가, 설문지를 사용한 어깨, 허리, 무릎의 기능 평가를 실시하였다. 총 12회의 일정 중 1회 이상 참석한 농업인은 총 57명이었으며 남자가 20명(35.1%), 여자가 37명(64.9%)이었으며 평균 연령은 60.7(±8.1)세였다. 근골격계 질환 검진에서 한 번 이상의 검진을 받았던 43명중 32명(74%)이 한 가지 이상의 근골격계 질환을 가지고 있었으며, 퇴행성관절염이 26명(60.5%), 근막통 증후군이 19명(44.2%), 허리디스크가 10명(23.3%)이었다.목어깨, 허리, 무릎다리의 통증정도는 1차, 2차 평가 간, 2차, 3차 평가 간, 1차, 3차 평가 간의 비교에서 모두 감소하는 경향을 보였으며 3차 평가에서 1차 평가에 비해 목어깨, 허리, 무릎다리 모두 유의한 통증의 감소를 보였다(p<0.05). 근골격계의 기능을 1차, 2차 평가 간, 2차, 3차 평가 간, 1차, 3차 평가 간 비교한 결과 모두 기능점수가 우수하게 변화했으나 통계적으로 유의하지 않았다. 근력 및 유연성 정도는 좌우의 악력, 배근력, 하지근력, 몸통, 어깨, 하지, 무릎유연성을 측정하였으며 1차 평가에 비해 3차 평가에서 모든 항목에서 근력 및 유연성 정도가 통계적으로 유의하게 증가하였다(p<0.05).연구대상자의 수가 적었고, 농한기에 의한 근골격계 질환의 개선 효과를 배제할 수는 없었지만 이번연구를 통하여 일부 농업인에서 근골격계 질환 관리 프로그램 실시 후 근골격계 질환의 단기적인 개선효과를 볼 수 있었다. 근골격계 질환의 중장기적인 개선효과를 기대할 수 있는 추가적인 연구와 농번기를 통한 관리 프로그램에 대한 추가적인 연구가 필요하다.

• Journal of the Korean Data and Information Science Society
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• v.25 no.2
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• pp.337-347
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• 2014

There is no known publication about assessment of quality of life (QOL) in Korean HIV patients. We aimed to assess the QOL of HIV patients. We developed Korean version of the WHOQOL-HIV BREF (short forms of WHOQOL-HIV, 31 questions with 6 domains). Survey data from 220 HIV-positive adults were obtained in 14 centers in South Korea. Male were dominant (202/220, 91.8%). Mean age was $40.6{\pm}12.1$. Mean CD4+ T-cell count was $414.9{\pm}226.6/ml$. Overall of WHOQOL-HIV BREF were $53.2{\pm}14.9$ (perfect score=100) (Cronbach's ${\alpha}$ = 0.942). It is similar score comparing to another country (Portugal: 54.75/100, measured by WHOQOL-HIV). Correlations of WHOQOL-HIV BREF score with patients' subjective QOL and with subjective satisfaction were 0.747 (p <0.01) and 0.651 (p <0.01), respectively. WHOQOL-HIV BREF have internal reliability. There is in need of monitoring for QOL of HIV patients in the clinical practice and trials. This survey tool could be used to assess the effect of intervention. Additionally, comparison across countries would be possible and promising.

• Journal of the Korean Geotechnical Society
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• v.20 no.6
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• pp.95-107
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• 2004

In this paper, the rheological characteristics of slurry used fur slurry-shield tunnels were studied with emphasis on penetration characteristics. The slurry penetration was modeled by soil-filter clogging theory. The coefficient of particle deposition was suggested as an indicator of sin clogging during tunnel construction and calculated through model tests. The measured slurry weight, clogged in the base soil, was compared with the value obtained from clogging theory. Based on the testing results, a stability analysis of a tunnel face was performed to pinpoint the most influential factor affecting stability of slurry-shield tunnels. It was found that the stability of tunnel face is dependent on the ratio of infiltration velocity to the coefficient of particle deposition, and the penetration distance of slurry increases with the ratio of infiltration velocity to the coefficient of particle deposition. Since the stability of tunnel face decreases with the slurry penetration distance, it was necessary to add some additives in order to reduce the slurry penetration distance. It was found that the ground condition needs additives when the soil has the effective particle diameter$(D_{10})$ larger than 0.75mm. It was also found that the tunnel face stability due to slurry penetration is significantly affected by the tunnel advance rate.

• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.4
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• pp.531-538
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• 2009

Xylitol has the ability to reduce the adherence of Streptococcus mutans(S. mutans), which can make it easier to remove plaque, decrease acid production and inhibit dental caries. There are few reports on the effects of xylitol on the expression of the virulence related genes in S. mutans. This study examined the inhibitory effect of chewing gum containing xylitol on glucan synthesis related gene expression of S. mutans. Participants were voluntarily recruited for a women's oral health prevention program, classified into two groups(a control and a xylitol group), and then followed for 2 years. Twenty salivary samples were randomly selected from each group. Colony count and real-time reverse transcription polymerase chain reaction were used to analyze the characteristics of S. mutans. The following results were obtained: The S. mutans counts decreased steadily in the xylitol group over the study period(p<0.05). The expression of the virulence related genes (gtfB, gtfC and gtfD) was significantly lower in the xylitol group than in the control groups (p<0.05). In conclusion, these results suggest that chewing xylitol gum for a long period of time may reduce the expression of the genes associated with S. mutans virulence, which can result in a decrease growth of S. mutans colonies as a result.