• Korean Journal of Clinical Laboratory Science
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• v.47 no.4
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• pp.251-258
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• 2015

Curcumin, a major polyphenolic compound of turmeric, is well known to prevent non-alcoholic steatohepatitis (NASH) related to obesity. The aim of the study was to investigate the effect of curcumin on hepatic fibrosis induced by carbon tetrachloride ($CCl_4$) in obese mice. $CCl_4$ was administrated in mice fed a normal diet (ND) or a high fat diet (HFD) for 7 weeks together with or without curcumin. It was conducted to examine for metabolic profiles, adipocyte size, and liver fibrosis by serum biochemistry, histology and immunohistochemistry. Also, Apoptosis of hepatic cells was determined by the TUNEL method. Treatment with curcumin significantly lowered the body weight, fasting glucose, serum AST and ALT, and decreased the adipocyte size, the number of macrophage and mast cells in adipose tissue, and collagen deposition in liver tissue in the HFD+$CCl_4$ group compared with the findings of the HFD+$CCl_4$ group. In contrast, treatment with curcumin on the ND+$CCl_4$ group did not show a significant difference except the body weight and mast cell number when compared with the ND+$CCl_4$ group. Furthermore, curcumin significantly reduced the number of parenchymal apoptotic cells, whereas it increased the number of non-parenchymal apoptotic cells, especially resembling an activated hepatic stellate cell in the liver. Taken together, this data suggests that curcumin might be an effective antifibrotic drug for the prevention of liver disease progression in obese mice. Thus, the development of curcumin as a therapy for obesity and liver fibrosis is supported.

• Journal of the Korean Society of Radiology
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• v.12 no.5
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• pp.699-706
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• 2018

In this study, we measured signal intensities according to array coil position changes to provide reference data of coil directions and the distances as it deters image quality unless the coils are aligned properly. The multi-purpose MRI phantom was placed in body array coils, and it was moved to the top, bottom, left, and right directions by 2 cm from the center to 10 cm. After obtaining images, signal intensities were measured and compared. The results of this study were as follows: Except for the upward direction, the signal intensities of the reference signal was not significantly different from that of the reference signal intensity within 2cm in both T1 and T2-weighted images. In conclusion, in clinical circumstances which various challenges exist to align the coils exactly on the same lines, array coils should be positioned at least within 2 cm from the center except for the upward direction, on the same line to prevent the image qualities are lowered.

• Journal of Korean Public Health Nursing
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• v.12 no.1
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• pp.55-74
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• 1998

In the past most major accidents resulted in death, but today there is a dramatic increase in the number of people who survive such accidents but who are left with permanent injury. Particularly, children who are inquisitive about their surroundings but immature in their ability to assess danger, are more vulnerable to accidents and their causes as well as to determine attitudes towards prevention. The main objective of the study was to assess the effectiveness of using an accident prevention manual for accident for accident prevention education. The study was a quasi-experimental study using a questionnaire format. The subjects of the study were 393 mothers of children attending six day care centers in Seoul. Data collection was done between May 1 and June 15, 1997. The tools used for the study were a questionnaire developed the researchers and a manual for accident prevention. The collected data were analyzed using SPSS. The results of the study are as follows: 1. Types of accidents included stabbing, bums, falls from heights, choking, falls on slippery surfaces, traffic accidents, drowning, poisoning, and electrical shock in that order of frequency. 2. The main causes of accidents in children were from cosmetics and household medications. 3. The most frequent locations of accidents in the home were the bathroom, kitchen, and stairways in that order. 4. For $90.4\%$ of children safety seats were not used when the ridding in a car. 5. In examining the parents' accident prevention practices, it was found that many parents used only . one electrical outlet for many appliances, tending to overload the electricity lines and that they were not practically concerned bout the flammability of children's pajamas, indicating a less than positive attitude towards fire prevention. 6. The parents had not provided their children with any instruction on accident prevention or on what to do after an accident had occurred. 7. After the use of pamphlet in an accident prevention education program, it was found that there was a statistically significant difference in the degree to which children carried out safety measures (t=14.96, p=.000) and in their safety habits (t=-1.67, p<.1) indicating an effectiveness in this method of education. The results of this study showed that there are many things in a child's environment that can cause accidents and that the possibility of an accident occurring is high. So nurses looking after children should be aware of the need for safety education to prevent accidents in the home and plan to provide appropriate educational material to help parents with this education.

• Journal of Nutrition and Health
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• v.31 no.2
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• pp.166-178
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• 1998

The purpose of this study was no investigate serum lipid levels of primary school children and to estimate their intakes of total fat and fatty acids. Subjects fasting blood samples were obtained and analyzed for serum triglycerides(TG), total cholesterol(Chol) and high density lipoprotein-cholesterol (HDL-Chol). Low density lipoprotein cholesterol (LDL-Chol), LDL-Chol/HDL-Chol ratio(LPH), and atherogenic index(AI) were calculated,. Dietary intake of nutrients was assessed by means of a 24-hour recall method using food models and other measuring tools . The serum levels of TG, Chol and LDL-Chol in girls were higher than those in boys, but the serum HDL-Chol level of girls was lower than that of boys. As the degree of obesity increased, the serum TG level of girls was lower than that of boys. As the degree of oesity increased , the serum TG level of girls increased. The serum LDL-Chol level was higher in obese boys than in normal ones. Percentage s of subjects at risk of cardiovascular disease based on corresponding criteria of TG, Chol,HDL-CHol and LDL-Chol were 25.9%, 7.6%, 20.7% and 10.1%, respectively. The serum TG level of children provided with the national school lunch program(NSLP) was lower than that of children without NLSP. The total fat intake of boys was higher than that of girls, but calorie-adjusted fat intake became similar between the two groups. Intakes of polyunsaturated fatty acids(PUFA), monounsaturated fatty acids(MUFA) and saturated fatty acids(SFA) were 13.3$\pm$9.5g, 16.1$\pm$9.3g and 21.4$\pm$14.2g in boys, respecitively , and 12.6$\pm$11.3g, 15.3$\pm$9.7g and 19.9$\pm$13.1g in girls, respectively . The ratios of polyunsaturated /monoun-saturated /saturated /saturated fatty acids(P/M/S) in boys and girls were 0.7/0.8/1.0 and 0.8/0.8/1.0 respectively. The ratios of $\omega$6/$\omega$3 fatty acids in boys and girls were found to be 12.1 /1.0 and 8.6/1.0 , respectively. These results indicated the urgent need of nutritional education in primary schools to prevent further increase in childhood obesity and hyperlipidemia . Therefore, this study will contribute to the establishment of dietary guidelines and health recommendation for school children.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.10 no.1
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• pp.36-45
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• 2006

Background and purpose: Well being which emphasizes peace of mind and richness of spirit, has been already used from several thousands years ago, as the name of Yangsaeng(養生) when we regard it in the view point of oriental medicine. Yangsaeng means a person's daily life according to natural rules in order to compensate his essence qi spirit(精氣神) and to prevent and cure his disease for his long life, and there are environment, spirit, qigong, food, dwelling labor, sleeping and sexual intercourse as its methods. But in Korea, we are mainly using the health and concept of the health management and use of it, with the one developed in Western. Thus, in this study, literature study was made for the situation of research and feature of Yangsaeng method. Among them, I tried to study mainly on adapting method of Exercise Yangsaeng and its possibility which can derive harmonious development of Spirit and body for human body, in the view point of identity(整體觀). Methods: Diploma thesis and words of 'Yangsaeng', 'exercise cure', 'exercise therapy', and 'exercise prescription', in 'KERIS(Korea Education & Research Iformation Service).' Results and conclusion: In this study, in order to adapt oriental method of Yangsaeng to the reality, I selected and researched only Exercise Yangsaeng among various Yangsaeng methods including environment, spirit, qigong, food, dwelling labor, sleeping and sexual intercourse. The Exercise Yangsaeng has its advantage that it ran train both mind and body as well as it has various programs, but it is regarded at it is in need of more study as lows; First, it requires assessment on the effect of construction itself as well as degree management of Excercise Yangsaeng as a method of exercise which is being done in daily life or in the literature. Second, above all, standardization of Yangsaeng Exercise and specialized programs are required in order to introduce the Exercise Yangsaeng which was verified for its effect, to the cure of disease. Third, researches are required for the system of assessment management for measurement of relative effect of standardized programs. fourth, continuous compensation is required in the future by adapting researched and developed programs into the field.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.6 no.1
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• pp.125-137
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• 1996

This study was designed to investigate effects of relative humidity on the breakthrough of charcoal tubes at a fixed vapor concentration and sampling time during mixed organic vapor sampling. A vapor generator was used to generate three different concentrations of mixed organic vapor and a stainless steel chamber was fabricated and utilized to maintain three different percentages of relative humidity while maintaining a constant temperature. The results were as follows; 1. At high relative humidity, breakthrough of mixed organic vapor occurred quickly at low vapor concentration than at high vapor concentration because of the reduced adsorption volume of charcoal tube due to humidity. 2. Breakthrough by competitive adsorption of vapors onto charcoal tube was observed at first from n-hexane having the lowest boiling point and highest vapor pressure among the three organic vapors investigated, followed by TCE. No breakthrough was observed from toluene under all experimental conditions. 3. For n-hexane, breakthrough was observed after 2 hours of sampling and breakthrough rates were increased as relative humidity increased. For TCE, breakthrough was found after 3 hours of sampling and breakthrough rates by sampling time were increased as vapor concentration increased. 4. The adsorbed amount of mixed organic vapor at breakthrough was shown to have statistically significant correlations with sampling time, relative humidity, and vapor concentration in descending order of correlation. Relative humidity and sampling time for n-hexane and sampling time and concentration for TCE were both statistically significantly correlated. 5. Relative humidity was found to affect the amount of breakthrough of mixed organic vapor and n-hexane. Among three percentages of relative humidity investigated, the amount of breakthrough at 85 % relative humidity was significantly larger than those of at lower percentages of relative humidity. No statistically significant difference was found between 25 % and 55 % relative humidity. 6. The results of multiple regression analysis between breakthrough and relative humidity, vapor concentrations showed that the coefficient of determination of mixed organic vapor was 0.263 and those of n-hexane and TCE were 0.275 and 0.189, respectively. 7. Flow rates of sampling pumps used were found to be affected by relative humidity present. At 25 %, 55 %, and 85 % relative humidity, the relative errors of sampling pump were 1.4 %, 13.4 %, and 18.6 %, respectively. In conclusion, the results of this study showed that high relative humidity could reduce the adsorption volume of charcoal tubes and subsequently increase breakthrough rates. Therefore, to prevent breakthrough when sampling mixed organic vapors, it is suggested that either sampling volume be reduced on the flow rate be lowered so as to minimize breakthrough of the most volatile organic vapor in the mixture. In addition, since the flow rates of a sampling pump can be adversely affected by high relative humidity, it is recommended to use a constant flow mode pump when sampling in the highly humid environment.

• Journal of the Korean Institute of Gas
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• v.16 no.4
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• pp.52-58
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• 2012

Recently, waste gas incineration is increasing due to strong environmental regulatory system in Korea. These incinerating facilities are usually connected with the top of the storage tank through pipeline and incinerate off gas with the flame. Therefore, the flame originated from these facilities is likely to move back into pipeline and might cause an explosion of the storage tank. Accordingly, the purpose of this study is to suggest the preventive measures and the way to improve the safety of these incineration systems through the cause analysis of a major industrial accident occurred in a acrylic acid manufacturing process in Korea. As a result of the study, the preventive measures are suggested as follows. (1) Air or inert gas inflow facilities should be well designed to dilute flammable gases into air or inert gas sufficiently before the blower is restarted in order to prevent the explosion (2) It is needed for the detonation-type flame arresters to be installed on the top of the storage tanks. (3) In case of using the deflagration-type flame arresters, it is necessary to install a rupture disk before the arresters, or blow off the flame outside tanks by connecting the tank top and the incinerator with hood-type pipe. (4) TDR should be installed to be restarted automatically after the momentary power failure.

• Journal of the Korean Institute of Gas
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• v.16 no.4
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• pp.38-43
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• 2012

The purpose of this study is to carry out the consequence analysis of an accident related to the release of Hydrogen chloride occurred in a petrochemical company in Korea and suggest the measures to prevent similar accidents from happening again. The total amount released through the safety valve of HCl Column was calculated based on the rated capacity of the safety valve, the ideal gas equation and mechanical energy balance, respectively. As a result of the calculation, we found that the amount of HCl released through the safety valve was at least 76.8 kg. Also, we predicted the dispersion concentration at the position of the injured workers(more than 350 m away from the accident location) using simulation programs such as PHAST. The results of ALOHA and K-CARM are 304 ppm and 1,700 ppm respectively. However, PHAST calculation indicated that the concentration is less than l ppm. From these results, we can understand that workers were injured by HCl gas released from the safe valve and the concentration of gas might be less than 1 ppm. Also, it is important for toxic gases such as HCl to be vented safely to the atmosphere after scrubbing.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.1
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• pp.346-354
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• 2018

In the probe of a medical ultrasound device, three parts were selected randomly by the examiner and the bacteria in the probe were detected by the blood examiners. In addition, the degree of death of the pathogenic bacteria after each disinfection of the detected pathogens, disinfecting ethanol, and disinfecting tissue of the detected pathogens were analyzed quantitatively. The following was detected: S Aureus (32.3 %), Bacillus spp. (26.5 %), Micrococcus spp. (21.5 %), and CNS (20 %). With the conventional probe, S. aureus (26.2 %), a playback curve (24.2 %), and a micron (19.5 %), Micrococcus spp. (15.5 %), and CNS (14.6 %) were observed. In the fan probe, S. aureus (24.7 %), Enterococcus (24.7 %), Enterococcus (17.7 %), and CNS (13.8 %) were detected. The disinfection of the three pathogens detected revealed sterilization of most of the pathogens, and most cases contained at least 91.3 % of the total sterilizing effect (P>0.05). In addition, for the disinfection of Propolis extract and disinfecting tissue, the disinfection effect was lower than that of disinfecting ethanol, but the difference was not statistically significant (P>0.05). The results revealed bacteria on most of the ultrasound probes. Antiseptic disinfection of surgical instruments using an extract of propolis works with results similar to those of ethanol. A blood test along with disinfection can help prevent infection if an ultrasound probe is applied to food.

• Journal of Nutrition and Health
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• v.46 no.1
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• pp.15-25
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• 2013

The purpose of this study is to investigate the proportion and associated risk factors of hypertriglyceridemia in rural Vietnamese women. Research data were collected as part of the Korean Genome and Epidemiology Study (KoGES). A cross-sectional study of 957 Vietnamese women in their 20 to 30s was conducted in rural areas of Bavi, Vietnam. Subjects were classified as hypertriglyceridemic (serum TG ${\geq}$ 150 mg/dL). Demographic, socio-economic details, anthro-pometric measurements, and blood profiles were recorded. The proportion of hypertriglyceridemic subjects was 22.0%, and the mean age of hypertriglyceridemics subjects was older than that of normo-triglyceridemic subjects (p < 0.05). In hypertriglyceridemic subjects, height, HDL-cholesterol, and LDL-cholesterol were significantly lower, compared to subjects with normo-triglyceridemia, while weight, body mass index, waist hip ratio, body fat %, blood pressure, fasting blood sugar, total cholesterol, and atherogenic index were higher, compared to those with normo-triglyceridemia. Intake of cereal and cereal products, total plant food, and cereal/potato fiber in subjects with hypertriglyceridemia was significantly higher, compared to normo-triglyceridemic subjects. Hypertriglyceridemic subjects had a significantly lower intake of animal calcium and retinol than normo-triglyceridemic subjects. Significant positive relationships were observed between the prevalence of hypertriglyceridemia and consumption of total plant food [OR (95% CI) for the highest tertile, compared to the lowest: 1.764 (1.131-2.750); p for trend = 0.008] and crude fiber [OR (95% CI) for the highest tertile compared to the lowest: 1.651 (1.092-2.497); p for trend = 0.027]. In addition, a significant inverse relationship was observed between the prevalence of hypertriglyceridemia and cholesterol intake [OR (95% CI) for the highest tertile, compared to the lowest: 0.601 (0.400-0.901); p for trend = 0.012]. These findings may provide basic data for use by policymakers and dieticians in future development of nutrition and health programs to encourage healthier eating habits, and to prevent hypertriglyceridemia advancing cardiovascular disease in rural Vietnamese women.