• Molecules and Cells
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• 제37권8호
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• pp.569-574
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• 2014

As a scaffold, SLX4/FANCP interacts with multiple proteins involved in genome integrity. Although not having recognizable catalytic domains, SLX4 participates in diverse genome maintenance pathways by delivering nucleases where they are needed, and promoting their cooperative execution to prevent genomic instabilities. Physiological importance of SLX4 is emphasized by the identification of causative mutations of SLX4 genes in patients diagnosed with Fanconi anemia (FA), a rare recessive genetic disorder characterized by genomic instability and predisposition to cancers. Recent progress in understanding functional roles of SLX4 has greatly expanded our knowledge in the repair of DNA interstrand crosslinks (ICLs), Holliday junction (HJ) resolution, telomere homeostasis and regulation of DNA damage response induced by replication stress. Here, these diverse functions of SLX4 are reviewed in detail.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2018년도 춘계 학술논문 발표대회
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• pp.343-344
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• 2018

This study proposes a standard method of diagnosis and repair to prevent and maintain the problem of durability deterioration caused by leakage cracks in apartment basement structures in Korea. Following the announcement of the previous maintenance plan section, this is the second part of the study, focusing on inspection of methods for diagnosing and repairing leakage cracks in apartment basement structures. In this thesis, the matters required for the procedures, types, times and equipment of the inspection plan and the inspection methods, records, and decisions required for the actual inspection are described.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 춘계학술대회 논문집
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• pp.1014-1023
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• 2008

The K-AGT test line is managed similarly to revenue operation and operated automatically 120km per day, total 90,000km from August 2004 to December 2007. To enhance reliability of developed system, maintenance information system based on RCM is applied. The maintenance program applied in test line is based on RCM which prevent a fault before it happens and a fault made in test line is analysed by reliability growth test. Vehicle system, power supply system, signalling system, track and infrastructure are built in test line and it is reviewed enhancing system performance and changing designs to commercialize through reliability growth analysis method.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2018년도 추계 학술논문 발표대회
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• pp.191-192
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• 2018

This study presents the standard methods of diagnosis and repair to prevent and maintain the durability degradation caused by leakage cracks in underground structures in Korea. The third part after the announcement of the existing maintenance plan, The environmental characteristics and leakage condition of underground structures, the causes of deterioration of underground concrete structures, and countermeasures and leakage equipment were described.

• 농촌지도와개발
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• 제30권2호
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• pp.119-129
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• 2023

This study aims to identify the types of safety accidents that occur during maintenance and repair operations and analyze the root causes. We used the logic tree diagramming to extract the root causes of 65 safety incidents specifically related to maintenance and repair work out of a total of 1,024 agricultural safety incidents that occurred between 2007 and 2020 collected by investigation with interviews. The extracted root causes were analyzed by categorizing them into six different safety system classifications. The results of the analysis and suggestions are as follows. Incidents related to maintenance and repair work, which can lead to irreversible safety hazards, have occurred frequently. These incidents were found to be occurring due to the overlapping of various safety system errors such as personal protective system and safety operation procedure. In the short term, it is necessary to emphasize compliance with the use of personal protective equipment, and enhancement of maintenance training. In the long term, it is necessary to establish a legal distinction for maintenance and repair work and clarify the responsible parties. Introducing a maintenance system is also crucial to prevent occupational injuries during maintenance and repair in agriculture.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2010년도 춘계학술대회 논문집
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• pp.2048-2051
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• 2010

Almost all companies have paid much attention to the safety management ranging from maintenance to operation even at the stage of designing in order to prevent accidents, but fatal accidents continue to increase throughout the world. In particular, it is essential to systematically prevent such fatal accidents as fire, explosion or leakage of toxic gas at factories in order to not only protect the workers and neighbors but also prevent economic losses and environmental pollution. In addition, HRA may be used to detect the human errors which may cause accidents or trace back to any mistake on the part of workers. Usually, HRA technique is used in association with other risk assessment techniques. Moreover, it can serve to enumerate the human errors which may occur during operation or down-time or correct the existing system to reduce the mistakes. This work focuses on the coincidence of human error and mechanical failure for management of human error, and on some important performance shaping factors to propose a method for improving safety effectively of the process industries.

• 한국가축번식학회지
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• 제23권4호
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• pp.365-369
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• 1999

Interferon tau (IFN$\tau$), the pregnancy recognition signal in ruminants, suppresses transcription of the estrogen receptor (ER) gene in the endometrial luminal (LE) and superficial glandular epithelium (sGE) to prevent oxytocin receptor (OTR) expression and pulsatile release of luteolytic prostaglandin $F_{2{\alpha}}$ (PGF), Interferon regulatory factors one (IRF-l) and two (IRF-2) are transcription factors induced by IFN$\tau$ that activate and silence gene expression, respectively. Available results suggest that IFN$\tau$ acts directly on LE and sGE during pregnancy to induce sequentially IRF-l and then IRF-2 gene expression to silence transcription of ER and OTR genes, block the luteolytic mechanism to maintenance a functional corpus luteum (CL) and, signal maternal recognition of pregnancy. The theory for maternal recognition of pregnancy in pigs is that the uterine endometrium of cyclic gilts secretes PGF in an endocrine direction, toward the uterine vasculature for transport to the CL to exert its luteolytic effect. However, in pregnant pigs, estrogens secreted by the conceptuses are responsible, perhaps in concert with effects of prolactin and calcium, for exocrine secretion of PGF into the uterine lumen where it is sequestered to exert biological effects and / or be metabolized to prevent luteolysis.

• 한국압력기기공학회 논문집
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• 제7권4호
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• pp.1-11
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• 2011

This paper presents the effects of preventive maintenance schemes on the residual stress distributions in dissimilar metal welds. Dissimilar metal weld is known susceptible to PWSCC and thus, effective maintenance schemes to prevent PWSCC are needed. Three preventive maintenances schemes, i.e. weld overlay, MSIP and inlay weld which are widely used in nuclear power plants, are selected and their effects on welding residual stresses are investigated via finite element analyses. As results, weld overlay and MSIP were proved effective method to mitigate residual stresses and inlay weld, on the other hand, produces strong tensile residual stresses in the inner surface. Although Alloy 690 known to be resistant to PWSCC are used in inlay weld, continuous careful observation are needed since tensile welding residual stresses are key parameter for PWSCC.

• 한국터널지하공간학회 논문집
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• 제24권2호
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• pp.183-192
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• 2022

터널구조물의 기능 및 성능저하는 도로의 기능상실 등을 유발할 수 있으므로 초기 손상이 심화된 손상으로 진전되지 않도록 선제적 유지관리가 필요하다. 이에 관련 법령에 따라 정기적인 점검/진단이 시행되고 있으나, 점검/진단, 보수/보강 계획 수립 및 실시 등 일련의 과정을 충분히 반영하지 못하고 있다. 따라서 본 연구에서는 도로터널 1,728개소에 대해 시행한 5,540건의 정밀안전점검, 정밀안전진단 사례에 대한 조사/분석을 통하여 합리적인 유지관리 개선 방안을 제시하였다.

• 한국산학기술학회논문지
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• 제18권11호
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• pp.130-137
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• 2017

교량의 목표 수명 동안 통행 안전성을 유지하기 위해서는 적정한 보수보강 예산의 확보와 확보된 예산의 합리적인 배분이 필요하다. 기존의 단순 교량 규모 기반 예산 배분 방식을 개선하여 다양한 영향인자를 고려한 합리적인 예산 배분 결정 체계를 제안하였다. 전체 교량을 하위 관리주체별로 일정한 관리 수준이 확보되도록 교량의 보수보강 예산을 적정하게 배분하기 위하여 과거 보수보강 이력에 기초한 조치율 모델과 단위 비용 모델을 개발하였다. 제안된 모델을 이용하여 관리주체별 적정 예산 배분 비율 결정 방법을 제안하고 사례 분석을 수행하였다. 교량의 보수보강 예산 배분의 영향 인자로 교량 규모뿐만 아니라 종별 현황과 현재 안전등급, 공용년수가 고려되어야 적정 예산 배분이 이루어지는 것으로 나타났다. 개발된 방법을 활용하여 관리 주체별 예산 소요를 명확하게 반영한 예산 분배를 시행함으로서 불필요한 예산 낭비를 방지하고 예산 배분의 합리적인 근거를 제공할 수 있을 것으로 판단된다.