• Speech Sciences
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• v.1
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• pp.261-274
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• 1997

In spite of the presumed importance of the strap muscles on laryngeal valving and speech production, there is little research concerning the physiological role and the functional differences among the strap muscles. Generally, the strap muscles have been shown to cause a decrease in the fundamental frequency(Fo) of phonation during contraction. In this study, an in vivo canine laryngeal model was used to show the effects of strap muscles on the laryngeal function by measuring the Fo, subglottal pressure, vocal intensity, vocal fold length, cricothyroid distance, and vertical laryngeal movement. Results demonstrated that the contraction of sternohyoid and sternothyroid muscles corresponded to a rise in subglottal pressure, shortened cricothyroid distance, lengthened vocal fold, and raised Fo and vocal intensity. The thyrohyoid muscle corresponded to lowered subglottal pressure, widened cricothyroid distance, shortened vocal fold, and lowered Fo and vocal intensity. It was postulated that the mechanism of altering Fa and other variables after stimulation of the strap muscles is due to the effects of laryngotracheal pulling, upward or downward, and laryngotracheal forward bending, by the external forces during strap muscle contraction.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.11a
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• pp.287-290
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• 2000

We give pressure stimulation into organic thin films and then manufacture a device under the accumulation condition that the state surface pressure is 20[mN/m]. LB layers of Arac. acid deposited by LB method were deposited onto y-type silicon wafer as x, y, z-type film. In processing of a device manufacture, we can see the process is good from the change of a surface pressure for organic thin films and transfer ratio of area per molecule. The structure of manufactured device is Au/arachidic acid/Al, the number of accumulated layers. Also, we then examined of the MIM device by means of I-V. The I-V characteristic of the device is measured from 0 to +2[V].

• Restorative Dentistry and Endodontics
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• v.21 no.1
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• pp.375-384
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• 1996

The purpose of this study was to investigate the functional involvement of sympathetic nerve in the control of the microcirculation in the dental pulp with the aim of elucidation of the involvement of neuropeptides and sympathetic nerve in neurogenic inflammation. Experiments were done on the 7 cats anesthetised with sodium pentobarbital, and sympathetic nerve to the' dental pulp was stimulated electrically (10 Hz, 4 V, 1.5 ms, 3.5 mins). Ana-adrenoceptor antagonist phentolamine and a neuropeptide Y antagonist D-myo-inositol-1,2,6-trisphosphate (PP56) were injected close intra-arterially into the dental pulp without changing the systemic blood pressure. The probe of laser Doppler flowmeter was placed on the buccal surface of ipsilateral canine teeth to the stimulation, and pulpal blood flow was measured. Stimulation of the sympathetic nerve decreased pulpal blood flow by $55.24{\pm}7.74\;%$ (mean${\pm}$SEM, n = 13). Stimulation of the sympathetic nerve following the injection of the ${\alpha}$-adrenoceptor antagonist phentolamine ($0.1{\mu}g$/kg) caused decrease of pulpal blood flow by $14.35{\pm}3.43%$ (mean${\pm}$SEM, n=5). Phentolamine attenuated the sympathetic nerve-induced pulpal blood flow decrease by $74.02{\pm}9.32%$ (mean${\pm}$SEM) Stimulation of the sympathetic nerve following the injection of the neuropeptide Y antagonist PP56 (2.3 mg/kg) caused decrease of pulpal blood flow by $30.64{\pm}7.92%$ (mean${\pm}$SEM, n=6). PP56 attenuated the sympathetic nerve-induced pulpal blood flow decrease by $44.37{\pm}11.01%$ (mean${\pm}$SEM). These data provide evidences of the co-contribution of nerepinephrine and neuropeptide Y on the sympathetic nerve-induced vasoconstriction in the feline dental pulp. In addition, they show functional evidences that sympathetic nerve plays an active role in controlling the microcirculation of the dental pulp.

• Journal of Biomedical Engineering Research
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• v.32 no.1
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• pp.61-73
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• 2011

The purpose of this study was to investigate changes in the center of pressure (COP), ground reaction force (GRF) and joint angles of elderly people and young people while stair-descent. The participants in this experiment were 5 elderly people and 5 young people, each of which was asked to descend stairs of three different heights (8 cm, 16 cm, and 32 cm). As they climbed down the stairs, they received vibration stimulation on the lower limb. The change of COP, GRF and joint angles were analyzed during the standing phase. COP decreased as the Achilles tendon and tibialis anterior tendon were vibrated. Vertical GRF increased as the Achilles tendon was vibrated, and the joint angle differed according to vibration stimulation conditions. These results mean that ankle joint, knee joint and hip joint were influenced by the vibrations on the lower limb as the participants descended the stairs. It was concluded that the vibration stimulation on the lower limb allowed the participants to efficiently climb down the stairs.

• Journal of Korean Neurosurgical Society
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• v.60 no.2
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• pp.138-145
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• 2017

Objective : High frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment of advanced Parkinson's disease. However, the neurochemical basis of its effects remains unknown. The aim of this study is to investigate the effects of STN HFS in intact and 6-hydroxydopamine (6-OHDA)-lesioned hemiparkinsonian rat model on changes of principal neurotransmitters, glutamate, and gamma-aminobutyric acid (GABA) in the striatum. Methods : The authors examined extracellular glutamate and GABA change in the striatum on sham group, 6-OHDA group, and 6-OHDA plus deep brain stimulation (DBS) group using microdialysis methods. Results : High-pressure liquid chromatography was used to quantify glutamate and GABA. The results show that HFS-STN induces a significant increase of extracellular glutamate and GABA in the striatum of 6-OHDA plus DBS group compared with sham and 6-OHDA group. Conclusion : Therefore, the clinical results of STN-HFS are not restricted to the direct STN targets but involve widespread adaptive changes within the basal ganglia.

• Biomolecules & Therapeutics
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• v.22 no.6
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• pp.477-490
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• 2014

Non-thermal atmospheric-pressure plasma, also named cold plasma, is defined as a partly ionized gas. Therefore, it cannot be equated with plasma from blood; it is not biological in nature. Non-thermal atmospheric-pressure plasma is a new innovative approach in medicine not only for the treatment of wounds, but with a wide-range of other applications, as e.g. topical treatment of other skin diseases with microbial involvement or treatment of cancer diseases. This review emphasizes plasma effects on wound healing. Non-thermal atmospheric-pressure plasma can support wound healing by its antiseptic effects, by stimulation of proliferation and migration of wound relating skin cells, by activation or inhibition of integrin receptors on the cell surface or by its pro-angiogenic effect. We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma. The outcome of first clinical trials regarding wound healing is pointed out.

• Journal of Chest Surgery
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• v.29 no.5
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• pp.477-486
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• 1996

Endogenous analgesic systems are known to be activated by peripheral noxious stimulation as well as arterial carbon dioxide elevation. In the present study, neuronal Activities in the rostral ventrolateral med- ulla were identified and classified in according to their rhythmic activities, and their responses to noxious peripheral nerve stimulations before and after elevating the arterial carbon dioxide partial pressure were investigated Using extracellular recording technic, a total of 53 spontaneously active neurons were recorded from the rostral ventrolateral medulla in u-chloralose anesthetized cats. These were classified as cardiovascular (28), respiratory (16), both cardiovascular and respiratory (2) and noncardiovascular - nonrespiratory (7). - Among the 28 cardiovascular neurons eleven showed increased activities during arterial hypercapnia, thirteen showed decreased responses, and four showed no change. Nine respiratory neurons showed increased responses to arterial hypercapnia, six showed decreased responses and one showed no change. neither of the cardiovascular and respiratory neurons showed significant change in its activity during ar- terial hypercapnia, however, four of the noncardiovascular - nonrespiratory neurons exhibited decreased their activities in response to arterial hypercapnia while two exhibited increased activities. Arterial hypercapnia increased the responses of cardiovascular neurons to peripheral nerve stimulation with C-inteniity, while not changing the responses to Ak_stimulation significantly . From the above results it was conclllded that during arterial hypercapnia, some cardiovascular neurons and respiratory neurons have increased activities as well as increased reponses to C-Hber stimulation.

• Science of Emotion and Sensibility
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• v.24 no.4
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• pp.69-78
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• 2021

The development of smart healthcare wearables for health is accelerating. Among them, many wearable products using EMS electrical stimulation, which is one of the active research fields, have been released. However, the EMS wearable, which has been studied or released, is released in a comprehensive full-body suit that does not focus on muscle segmentation or a belt that covers the entire abdomen. Therefore, this study intends to use two breathing methods by applying an EMS pattern that subdivides specific muscles and attach a stretch sensor that can measure breathing to the abdominal pressure belt. The measurement method was conducted by inhaling and exhaling, and the subjects were 10 men in their 20s with healthy bodies. As a result of this study, the sensor's sensitivity was 5 and 3 mm, and the basic sensor in both thoracic and abdominal breathings and the EMS abdominal pressure belt showed improved respiration activation after applying electrical stimulation before and after application. It is concluded that, because of the two patterns produced based on the physical function, the difference in respiration activation effect and sensitivity between sensors could be confirmed with three sensors rather than not applying electrical stimulation suitable for the respiration method. Based on the results of this study, a follow-up study aims to develop breathing smart clothing that can be monitored in real time in clothing-type wearable products that incorporate EMS patterns and stretch sensors.

• The Journal of Korean Physical Therapy
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• v.14 no.3
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• pp.174-202
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• 2002

Twenty five patients, 14 males and 11 females with an average age of 75years with chronic Low Back Pain were tested before, during, and after 10minutes transcutaneous electrical nerve stimulation. It is important to consider the effect of TENS on the autonomic function because the pain pathway and the ANS pathway are somehow correlated to each other. There is still controversy among researchers who have reported the effect of TENS on autonomic function. So the purpose of this study is to measure the effect of TENS on the ANS and to see the relation of the pain control mechanism and the change in the ANS. The results were as follows : 1) Systolic blood pressure between before and during the experiment was apt to be a little increased, but statistically there was no significant change(P>.05). 2) Systolic blood pressure between during and after 10 minutes the experiment was apt to be a little decreased, but statistically there was no significant change(P>.05). 3) Systolic blood pressure between before and after 10 minutes experiment was apt to be a little decreased, but statistically there was no significant change(P>.05). 4) Diastolic blood pressure between before and during experiment was apt to be a little increased, but statistically there was no significant change(P>.05). 5) Diastolic blood pressure between during and after 10 minutes experiment was significantly decreased(P<.05). 6) Diastolic blood pressure between before and after 10 minutes the experiment was apt to be a little decreased, but statistically there was no significant change(P>.05). 7) Heart rate between before and during the experiment was apt to be a little decreased, but statistically there was no significant change(P>.05). 8) Heart rate between during and after 10 minutes the experiment was significantly decreased(P<.05). 9) Heart rate between before and after 10 minutes the experiment was significantly decreased(P<.05). 10) Skin temperature between before and during the experiment was significantly increased(P<.05). 11) Skin temperature between during and after 10 minutes the experiment was apt to be a little increased, but statistically there was no significant change(P>.05). 12) Skin temperature between before and after 10 minutes the experiment was significantly increased(P>.05). 13) Respiratory rate between before and during the experiment was apt to be a little increased, but statistically there was no significant change(Pgt;.05). 14) Respiratory rate between during and after 10 minutes the experiment was apt to be a little decreased, but statistically there was no significant change(Pgt;.05). 15) Respiratory rate between before and after 10 minutes the experiment was apt to be a little decreased, but statistically there was no significant change(P>.05).

• Tunnel and Underground Space
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• v.25 no.4
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• pp.320-331
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• 2015

This paper presents a case study of an enhanced geothermal system(EGS) demonstration project conducted in $Gro{\ss}$ $Sch{\ddot{o}}nebeck$, Northerm Germany, focusing on hydraulic stimulation. The project was conducted with doublet system in sandstone and volcanic formations at 4 - 4.4 km depth. Under normal faulting to strike-slip faulting stress regime, hydraulic stimulations were conducted at injection and production wells by massive waterfrac and gel-proppant fracturing. Injectivity index increased from $0.97m^3/(hr^*MPa)$ to $7.5m^3/(hr^*MPa)$ and productivity index increased from $2.4m^3/(hr^*MPa)$ to $10.1m^3/(hr^*MPa)$ by a series of hydraulic stimulations at both wells. After circulation tests through injection and production wells, however, productivity index decreased from $8.9m^3/(hr^*MPa)$ to $0.6m^3/(hr^*MPa)$ in two years. Slip tendency analysis for the stimulation in volcanic layer estimated the required pressure for shear slip and its preferred orientations and it showed reasonable match with actual stimulation results. Through the microseismicity observation for the stimulation of volcanic formation, only 80 seismic events with its moment magnitudes in -1.8<$M_W$<-1.0 were observed, which are unexpectedly low for EGS hydraulic stimulation.