• Journal of Ginseng Research
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• 제21권2호
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• pp.98-103
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• 1997

On the precontracted rabbit cavernosal muscle strips with phenylephrine ($5\ast10^{-6}$M), Increasing concentrations of acetylcholine (10-7, 10-6, 10-5, 10-4M) showed relaxation effect dose-dependently in control group ($10^{-7}$M : 15.32%, $10^{-6}$M : 35.44%, 10-5M : 59.45%, 10-4M : 76.54%). After 3 months administering Korean red ginseng, the relaxation action of acetylcholine was significantly increased ($10^{-7}$M : 34.18%, $10^{-6}$M : 56.35%, $10^{-5}$M : 75.33%, $10^{-4}$M : 89.86%). Relaxation effect of Korean red ginseng was significantly increased after 3 months administering Korean red ginseng. Intracavernous pressure response to electrostimulation wan 107.52 cm$H_2O$ in control group and significantly increased to 138.34 cm $H_2O$ after 3 month administering Korean red ginseng. With these results, we can confirm that long-term administration of Korean red ginseng enhances the erectly capacity and that its action is mediated by endothelium derived relaxing factor and peripheral neurophysiologic enhancement.

• 한국의류학회지
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• 제38권4호
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• pp.440-454
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• 2014

This study examined the wearing effect of 3D compression suits on quantitative electroencephalogram (EEG) during walking and rest. Ten males in their 20s wore three types of experimental clothing, a loose-fit wear (BS), a 3D compression suit (3D CS), and a power film welded on CS (3D WCS); in addition, EEG signals were measured during resting, walking, after walking, and after sit-ups. The results showed that a higher pressure (due to 3D CS and 3D WCS) increased the 'Concentration' level and the 'Cognitive load' of brain waves during treadmill walking due to a higher cortex activity level when walking. Differentiation was shown between two compression suits and BS was enhanced during walking on a treadmill; however, the brain waves of 'Relaxation' between two compression suits were significantly different after walking, i.e., 'Relaxation' level of 3D WCS was the highest. Rigorous exercise such as sit-ups was inefficient to distinguish the effect of compression suits on EEG. Participants perceived a higher pressure due to compression suits; however, the wear comfort of two compression suits was maintained. Two compression suits were rated as supportive and helpful during walking. Various EEG parameters such as the indices of 'Relaxation', 'Concentration' and 'Cognitive load' were effective to observe the effect of 3D compression suits on wearers' brain waves during and after walking.

• 대한수의학회지
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• 제43권4호
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• pp.597-606
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• 2003

Although the antidepressant effects of imipramine (IMI) have been well known in several studies, the effects on cardiovascular system, particularly the vasorelaxant effects, have not known clearly. We hypothesis that IMI-induced vasorelaxation involves NO (nitrie oxide), activation of guanylate cyclase (GC) and $Ca^{2+}$ channel. The possible roles of the endothelium and $Ca^{2+}$ in IMI-induced responses were investigated using isolated rings of rat thoracic aorta and anesthesized rats. In KCl-precontracted rings. IMI produces endothelium-dependent and endothelium-independent relaxations in intact (+E) as well as endothelium-denuded (-E) rat aorta in a concentration-dependent manner. In phenylephrine (PE)-precontracted rings, the IMI-induced relaxation was significantly greater in +E rings. The IMI-induced relaxations were suppressed by nitric oxide synthase (NOS) inhibitors, N(G)-nitro-L-arginine (L-NNA), N(omega)-nitro-L-arginine methyl ester (L-NAME) and aminoguanidine, a non-selective GC inhibitor, methylene blue, $Na^+$ channel blockers, lidocaine and procaine, or $Ca^{2+}$ channel blockers, nifedipine and verapamil, in PE-precontracted +E rings, but not in PE-precontracted -E rings. These relaxations were also suppressed by lidocaine or procaine in -E aortic rings. However, IMI-induced relaxations were not inhibited by a PLC inhibitor 2-nitro-4-carboxyphenyl-n,n-diphenylcarbamate (NCDC), an inositol monophosphatase inhibitor, lithium, indomethacin and dexamethasone in +E and -E rings. In vivo, infusion of IMI elicited significant decrease in arterial blood pressure. After intravenous injection of saponin, NOS inhibitors. MB and nifedipine, infusion of IMI inhibited the IMI-lowered blood pressure markedly. These findings suggest that the endothelium-dependent relaxation induced by IMI is mediated by activation of NO/cGMP signaling cascade or inhibition of $Ca^{2+}$ entry through voltage-gated channel, and this mechanism may contribute to the hypotensive effects of IMI in rats.

• 한국농공학회지
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• 제30권4호
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• pp.134-153
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• 1988

This paper was carried out to investigate the existence of a unique stress- strain behavior by obtaining some factors influencing the time dependent stress- strain behavior of clay. The results obtained from this study were summarized as follows ; 1. The relationship between stress ratro and strain in normally consolidated clay was in- dependent on pre-shear consolidation pressure. Therefore, shear strain could be expressed as a function with stress ratio. 2. The constitutive equation of shear strain on Modified Carn Clay Model coincided better with the observed value than Cam Clay Model. 3. The relationships between deviator stress and shear strain, between pore water pressure and shear strain were unified by the mean equivalent pressure. 4. The shear strain contour in norrnally consolidated clay was increased linearly through origin, but that in overconsolidated clay was not in accordance with the result of the former. 5. Because the effective stress path of normally consolidated clay was unified by the mean equivalent pressure, state boundary surface in (e,p,q) space was transformed into two dimensional surface. But it was considered to be suitable that the unified stress- strain in overconsolidated clay be expressed by a function with overconsolidation ratio. 6. The deviator for constant strain was increased linearly with increment of strain rate ($\varepsilon$) on semi-log scale, but pore water pressure was decreased. 7. The behavior of stress relaxation was transformed from linear to curvilinear with inc - rement of strain rate before stress relaxation test, and pore water pressure was increased in total range. 8. The strain of creep was increased linearly with increment of time on semi-log scale. The greater the strain rate before creep test became, the greater the increment of strain of creep became. And the pore water pressure during creep test was increased generally with increment of time on semi-log scale.

• 대한한의학회지
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• 제23권3호
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• pp.63-73
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• 2002

Objective : This study aimed to investigate the effects Samyoo-tang Extract (SE) on the vascular systems, including changes in blood pressure and regional cerebral blood flow (rCBF), of male Sprague-Dawley rats. Methods : The changes in rCBF were determined by Laser-Doppler flowmetry through the opened cranial method and norepinephrine (NE)-induced blood vessel contractions were determined by physiograph in the pulmonary artery of isolated rabbits. Results and Conclusion : 1. Contractions evoked by NE ($ED_{50}$) were inhibited significantly by SE in the pulmonary artery. 2. SE inhibited the relaxation of NE induced contractions pretreated with propranolol. 3. SE did not inhibit the relaxation of NE induced contractions pretreated with ODQ and L-NNA. 4. Blood pressure was not affected by SE in rats. 5. rCBF was increased by SE in a dose-dependent manner. 6. Pretreatment with propranolol was increased by SE in a dose-dependent manner in blond pressure. 7. Pretreatment with methylene blue, ODQ and L-NNA did not inhibit SE induced increased in rCBF. These results indicate that SE can relax NE-induced contraction of rabbit blood vessels and increased the changes of rCBF in rats, that relate to the sympathetic nerve system.

• 한국진공학회지
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• 제6권4호
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• pp.354-358
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• 1997

다양한 질소 압력, 플라즈마 파워 상태에서 사파이어 기판위에 전자 사이클로트론 공명 MBE로 제작한 wurtzite GaN의 결정특성을 XRD의 반치폭, 주사전자 현미경으로 조 사하였다. 질소 압력은 XRD의 반치폭에 커다란 영향을 미치고 있으며 최적 질소 압력에서 제작한 시료에는 높은 dislocation density를 포함하고 있음을 알았다. 이러한 결과들은 갈륨 질소의 결정질(crystal quality)은 플라즈마 상태에 매우 민감하며 또한 스트레스 완화는 V/ III비에 의존하고 있음을 나타낸다. 그렇지만 사파이어 기판의 nitridation은 스트레스 완화에 커다란 영향을 미치지 않고 있었다.

• 전자공학회논문지 IE
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• 제49권1호
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• pp.7-11
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• 2012

본 논문에서는 인지질 단분자인 DMPC 유기초박막에 압력 자극을 이용하여 표면압과 변위전류의 검출에 따른 유전 완화현상에 대한 물리적 특성 평가를 하였다. 유기초박막에서 약간의 유전 완화 시간이 소요되었는데 이는 분자 영역에 의존한다는 사실을 알 수 있었다. 또한, 유기박막의 누적 조건에 의해 제작된 MIM 소자에 전압을 인가시, LB막의 누적층수가 증가 할수록 저항이 증가한다는 것을 알 수 있었는데 이는 유기초박막의 층수가 증가하여 전극간의 거리가 멀어질수록 더 높은 전계에서도 파괴되지 않는 절연특성이 나타남을 알 수 있었으며 나노단위의 유기초박막의 비교적 양호한 절연성을 확인, 제시 하였다.

• 대한간호학회지
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• 제34권2호
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• pp.213-224
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• 2004

Purpose: This study was aimed to evaluate the effect of progressive muscle relaxation training using biofeedback on perceived stress, stress response, immune response and climacteric symptoms, Method: This was a crossover, pre-post test design, The study subjects are 36 middle-aged women who were selected at 2 public health centers, The independent variable was Biofeedback training for 4 weeks, twice a week and home training for 4 weeks, Dependent variables were perceived stress, stress response, immune response, and climacteric symptoms measured with Hildtch's scale (1996), Result: Progressive muscle relaxation training using biofeedback was not effective in reducing perceived stress, but it was shown to be effective in reducing physiological stress responses such as pulse rate and EMG, Though blood pressure and skin conductance were repeatedly down, and skin temperature slowly increased, there were no statistically significant differences. Progressive muscle relaxation training using biofeedback was not effective in reducing serum cortisol, enhancing immune responses, or decreasing climacteric symptoms. Conclusion: The findings point to a pressing need for further, well-controlled and designed research with consideration in selection of subjects and instruments, frequency of measurements, the sampling method, and intervention modalities.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
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• pp.182-189
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• 1998

Administration of ginsenosides, a mixture of saponin extracted from Panax ginseng, decreased blood pressure in rat. Previous studies have shown that ginsenosides caused endothelium-dependent relaxation, which was associated with the formation of cyclic GMP, suggested that ginsenosides caused release of nitric oxide (NO) from the vascular endothelium. The aim of the present study was to characterize the endothelium-independent relaxation to ginsenosides in the isolated rat aorta. Ginsenosides caused a concentration-dependent relaxation of rat aortic rings without endothelium constricted with 25 mM KCI but affected only minimally those constricted with 60 mM KCI. Ginsenoside Rg3 (Rg3) was a more potent vasorelaxing agonist than total ginsenoside mixture and also the ginsenoside PPT and PPD groups. Relaxation to ginsenosides were markedly reduced by TEA, but not by glibenclamide. Rg3 significantly inhibited Cal'-induced concentration-contraction curves and the "50a2'influx in aortic rings incubated in 25 mM KCI whereas those responses were not affected in 60 mM KCI. Rg3 caused efflux of $"Rb in aortic rings that was inhibited by tetraethy- lammonium (TEA), an inhibitor of Ca"-dependent K'channels, but not by glibenclamide, an inhibitor of AfP-dependent K'channels. These findings indicate that ginsenosides may induce vasorelaxation via activation of Ca2'-dependent K'channels resulting in hyperpolarization of the vas- cular smooth muscle with subsequent inhibition of the opening of voltage-dependent Caf'channels. These effects could contribute to explain the red ginseng-associated vasodilation and the beneficial effect on the cardiovascular system.

• 한국지반환경공학회 논문집
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• 제15권5호
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• pp.13-21
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• 2014

본 연구에서는 쉴드 TBM 공법의 다양한 세그먼트 모델링 기법에 따른 비교 해석을 통하여 해석기법에 따른 차이를 분석하고 이에 따른 합리적인 모델링 기법을 제안하였다. 또한 암반 이완하중 산정모델에 따른 하중 분석 및 3차원 유한요소해석을 통하여 실제 현장에서 적용 가능한 합리적인 하중산정 방법을 제시하였다. 암반분류에 의한 이완영역의 산정방법은 암반등급이 높은 지반에서는 결과의 차이가 크지 않으나 지반등급이 낮은 지반에서는 그 차이가 매우 크게 나타났으며, 3차원 해석에 의한 이완영역 산정결과 지반등급이 낮은 지반의 이완영역은 각 방법의 중간 정도 범위에 위치할 것으로 예측되었으며 지반등급이 낮은 지반의 세그먼트 계획 시에는 기계식 터널 굴착 특성을 반영한 3차원 해석을 통한 이완영역의 산정을 적극 검토할 필요가 있다.