• Journal of Pharmaceutical Investigation
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• 제35권2호
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• pp.89-94
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• 2005

The micron or nano-sized lysozyme as a model protein drug was prepared using solution enhanced dispersion by supercritical fluid (SEDS) process at various conditions (e.g., solvent, temperature and pressure) to investigate the feasibility of pulmonary protein drug delivery. The lysozyme particles prepared were characterized by laser diffraction particle size analyzer, scanning electron microscopy (SEM) and powder X-ray diffractometry (PXRD). The biological activity of lysozyme particles after/before SEDS process was also examined. Lysozyme was precipitated as spherical particles. The precipitated particles consisted of 100 - 200 nm particles. Particle size showed the precipitates to be agglomerates with primary particles of size $1\;-\;5 \;{\mu}m$. The biological activity varied between 38 and 98% depending on the experimental conditions. There was no significant difference between untreated lysozyme and lysozyme after SEDS process in PXRD analysis. Therefore, the SEDS process could be a novel method to prepare micron or nano-sized lysozyme particles, with minimal loss of biological activity, for the pulmonary delivery of protein drug.

• 대기
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• 제23권1호
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• pp.1-11
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• 2013

The angular momentum transport of an idealized axisymmetric vortex in the developing stage was investigated using the Weather Research and Forecast (WRF) model. The balanced axisymmetric vortex was constructed based on an empirical function for tangential wind, and the temperature, geopotential, and surface pressure were obtained from the balanced equation. The numerical simulation was carried out for 6 days on the f-plane with the Sea Surface Temperature (SST) set as constant. The weak vortex at initial time was intensified with time, and reached the strength of tropical cyclone in a couple of days. The Absolute Angular Momentum (AAM) was transported along with the secondary circulation of the vortex. Total AAM integrated over a cylinder of radius of 2000 km decreased with simulation time, but total kinetic energy increased rapidly. From the budget analysis, it was found that the surface friction is mainly responsible for the decrease of total AAM. Also, contribution of the surface friction to the AAM loss was about 90% while that of horizontal advection was as small as 8%. The trajectory of neutral numerical tracers following the secondary circulation was presented for the Lagrangian viewpoint of the transports of absolute angular momentum. From the analysis using the trajectory of tracers it was found that the air parcel was under the influence of the surface friction continuously until it leaves the boundary layer near the core. Then the air parcel with reduced amount of angular momentum compared to its original amount was transported from boundary layer to upper level of the vortex and contributed to form the anti-cyclone. These results suggest that the tropical cyclone loses angular momentum as it develops, which is due to the dissipation of angular momentum by the surface friction.

• 한국환경보건학회지
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• 제19권2호
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• pp.23-33
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• 1993

The anaerobic digestion of organic synthetic wastewater in anaerobic fluidized bed bioreactor (AFBBR) and anaerobic fluidized packed bed bioreactor (AFPBBR) was studied. This study was conducted to evaluate efficiency and reliability of two reactor. Experiment was performed to find the effect of upflow rate with AFBBR and the height of packed bed with AFPBBR. As a result, this program obtained several conclusion. These are given as follows: As applied the upflow rate increased in AFBBR the produced volume of biogas increased, while the gas production and COD removal decreased at above 0.3 m$^3$/h. When a upflow rate is 0.4 m$^3$/h in AFBBR the volatile suspended solid (VSS) became significantly increased. At an organic loading rate from 0.1 to 0.4 of upflow rate in AFBBR, the methane yield was 1.5584 m$^3$CH$_4$/kgCOD removed, and the observed cell yield coefficient was 0.0933 gVSS/gCOD. In case of AFPBBR, the results showed also that 20 cm of height of packed bed was superior to other in the aspect ot biogas production, the content of methane and COD removal. At 20 cm of height, the profile of microorganisms was stable, while at 30 cm the VSS of effluent became higher than AFBBR. Though COD removal of AFPBBR increased with packed bed, COD removal deteriorate with over packing because the loss of pressure became higher in the reactor. At an organic loading rate from 20 to 40 cm of packed bed in-AFPBBR, the methane yield was 2.5649 m$^3$CH$_4$/kgCOD removed, and the observed cell yield coefficient was 0.0506 gVSS/gCOD. Based upon the results obtained, it is suggested that AFBBR and AFPBBR is the most effective conditions at 0.3 m3/h of upflow rate, the 20cm of packed bed, respectively. The rate constant are summarized as follow:

• KIEAE Journal
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• 제16권6호
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• pp.167-172
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• 2016

Purpose: The solar water heater with natural circulation has been used for several decades in the world as it is automatically operated without a pump and controller and is easy to maintain and repair. After the subsidy was offered from 2012, the solar water heater with natural circulation is becoming increasingly popular in Korea. Recently, the development of a wall-integrated solar water heater, which improves the applicability of buildings and prevents the overheating in the summer, is being developed. On the other hand, the design and performance evaluation data of solar water heaters are very inadequate, and analysis of heat and flow is required to develop a new type of solar water heater. Method: Therefore, in this study, we proposed a new simplified system analysis model that reflects heat and pressure loss from the test results of KS B ISO 9806-1 (Solar collector test method), assuming that the collector is a simple pipe system, the validity of which was verified through experiments. Result: As a result, first, the RMSE of the system circulation flow rate and the average temperature of the inlet and outlet of the collector according to the experimental results and the simulation are 0.05563 and 0.88530, respectively, which are very consistent. Secondly, the mass flow rate is increased linearly with the increase of the solar radiation, and the mass flow rate is 0.0104 ~ 0.0180kg/s in the range of $200{\sim}380W/m^2$ of solar irradiance. Compared with the test flow rate 0.0764kg / s of the test collector, it showed a level of less than 20%.

• 대한기계학회논문집B
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• 제30권6호
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• pp.553-559
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• 2006

Most diesel injector, which is currently used in high-pressure common rail fuel injection system of diesel engine, is driven by the solenoid coil energy for its needle movement. The main disadvantage of this solenoid-driven injector is a high power consumption, high power loss through solenoid coil and relatively fixed needle response's problem. In this study, a prototype piezo-driven injector, as a new injector mechanism driven by piezoelectric energy based on the concept of inverse piezo-electric effect, has been designed and fabricated to know the effect of piezo-driven injection processes on the diesel spray structure and internal nozzle flow. Firstly we investigated the spray characteristics in a constant volume chamber pressurized by nitrogen gas using the back diffusion light illumination method for high-speed temporal photography and also analyzed the inside nozzle flow by a fully transient simulation with cavitation model using VOF(volume of fraction) method. The numerical calculation has been performed to simulate the cavitating flow of 3-dimensional real size single hole nozzle along the injection duration. Results were compared between a conventional solenoid-driven injector and piezo-driven injector, both equipped with the same micro-sac multi-hole injection nozzle. The experimental results show that the piezo-driven injector has short injection delay and a faster spray development and produces higher injection velocity than the solenoid-driven injector. And the predicted simulation results with the degree of cavitation's generation inside nozzle for faster needle response In a piezo-driven injector were reflected to spray development in agreement with the experimental spray images.

• Korean Chemical Engineering Research
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• 제58권2호
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• pp.224-229
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• 2020

머신러닝 기법을 활용하여 LDPE (Low Density Polyethylene) 공정의 이상을 사전 감지하고, 설비의 수명을 예측할 수 있는 기술을 소개한다. 안전성과 생산성 극대화를 위해, 화학 공정의 예상치 못한 이상을 사전에 감지하고 예방하는 것은 매우 중요하다. LDPE 공정은 3,000 kg/㎠g 이상까지 승압되는 고압 공정이기 때문에, ESD (Emergency Shutdown)가 발생하면 예상치 못한 부동이 발생하고, 그에 따른 보수 기간 증가로 인한 생산성 손실이 발생한다. 고압 공정의 주요 변수들의 운전 데이터를 수집하고, 비지도학습 머신러닝 기술을 활용하여, ESD의 사전 감지 모형을 개발하였다. 4회의 ESD를 2.4일 전에 감지하는 결과를 얻을 수 있었다. 더불어, 물리적으로 의미 있는 핵심 변수들을 활용하면, 고압 설비의 수명을 예측할 수 있음을 확인할 수 있었다.

• 대한기계학회논문집B
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• 제35권10호
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• pp.1075-1081
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• 2011

이중벽관 증기발생기에서 전열관의 내관과 외관 사이의 틈새에 채워진 헬륨가스의 압력변동으로 전열관의 파손을 감지하는 방법이 개발되고 있다. 이 현상을 모사하기 위해 압력으로 밀착된 두 평판사이의 미세한 틈새에서의 누설률을 측정하여 실험식을 개발하였다. 이 실험식에서는 틈새의 간격과 유동마찰계수가 표면조도에 의해 상호 결합된 형태로 기술되는데, 간단한 평판접촉 모델을 사용하여 유동마찰계수 식을 분리하였다. 이 실험식과 균열에서의 누설률 예측에 사용되고 있는 기존의 유동마찰계수 관련 실험식들을 상호 비교하였다. 레이놀즈 수의 적용범위가 상이함에도 불구하고 개발한 실험식이 0.1~0.35 에서는 레이놀즈 수가 높은 경우에 적용되는 실험식들과 유사한 값을 보였다.

• Nuclear Engineering and Technology
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• 제36권1호
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• pp.24-35
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• 2004

In order to analyze the hydrogen distribution during a severe accident in the APR1400 containment, GASFLOW II was used. For the APR1400 NPP, a hydrogen mitigation system is considered from the design stage, but a fully time-dependent, three-dimensional analysis has not been performed yet. In this study GASFLOW code II is used for the three-dimensional analysis. The first step to analysis involving hydrogen behavior in a full containment with the GASLOW code is to generate a realistic geometry model, which includes nodalization and modeling of the internal structures such as walls, ceilings and equipment. Geometry modeling of the APR1400 is conducted using GUI program by overlapping the containment cut drawings in a graphical file format on the mesh view. The total number of mesh cells generated is 49,476. And the calculated free volume of the APR1400 containment by GASFLOW is almost the same as the value from the GOTHIC modeling. A hypothetical SB-LOCA scenario beyond design base accident was selected to analyze the hydrogen behavior with the hydrogen mitigation system. The source of hydrogen and steam for the GASFLOW II analysis is obtained from a MAAP calculation. Combustion pressure and temperature load possibilities within the compartments used in the GOTHIC analysis are studied based on the Sigma-Lambda criteria. Finally the effectiveness of HMS installed in the APR1400 containment is evaluated from the point of severe accident management

• 한국추진공학회지
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• 제23권4호
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• pp.28-34
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• 2019

본 연구에서는 터빈 냉각에 널리 사용되는 핀-휜 배열에 대한 연구를 진행하였다. 본 연구에서 원형 튜브 전방에 익형 와류발생기가 위치하며, 익형 단면 형상은 NACA-9410을 사용하였다. 본 논문에서는 와류 발생기가 있는 핀-휜 배열 유동의 전열 성능과 유동 특성을 수직인 방향으로 변화시키며 기존의 핀-휜 유동과 비교하였다. 레이놀즈수 영역은 6000, 10000 그리고 15000 세 가지를 계산하였다. 전산 해석은 상용 프로그램인 ANSYS v18.0 CFX, 난류 모델은 $k-{\omega}$ SST를 사용하였다. 결과적으로 전열 성능은 최대 5.8% 증가하였고 압력 손실은 1% 미만으로 증가하였다.

• 가족자원경영과 정책
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• 제22권4호
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• pp.17-32
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• 2018

The purpose of this study was to explore the effects of family life stress and family values on marital stability among middle-aged couples. The subjects included a total of 302 men and women aged 45-64 who had been married for more than 20 years and were living in Seoul. The collected data were statistically analyzed with the SPSS 21.0 Package. First, Cronbach's alpha was calculated to measure the reliability of the scale that assessed the variables of the research model. Then, mean and standard deviation were calculated to determine the degrees of family life stress, family values, and marital stability among the subjects. Finally, a hierarchical multiple regression analysis was performed to identify factors that affected the subjects' marital stability. The results revealed that the level of family life stress in middle-aged married men and women was slightly higher than the mean value. Of all the sub-scales of family life stress, the subjects were found to experience the most stress from factors related to financial pressure, followed by family relationships, a sense of loss within a family, and work-family compatibility. Therefore, financial problems were one of the critical stressors for middle-aged married couples. Also, for this demographic, the levels of family values and marital stability were higher than the medians. The factors affecting marital stability in middle-aged couples were identified to be family relationship stress, financial stress, subjective economic status, family values, stress related to work-familycompatibility,religion,andage.Thedegreeofmaritalstabilitywashigherinmiddle-agedcouplesa stheirstresslevelsfromfamilyrelationshipsandfinancialproblemswerelower.Moreover,thehigherthes ubjectiveeconomicstatusandthemoretraditionalthefamilyvalues,thehigherthedegreeofmaritalstabili ty.Finally,marriedcoupleswhowerereligioushadalowerlevelofstressfromwork-family compatibility, and the younger the couples, the higher the degree of marital stability.