• Annals of dermatology
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• 제30권6호
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• pp.742-744
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• 2018

• Annals of dermatology
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• 제30권6호
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• pp.731-732
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• 2018

• Clinical Endoscopy
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• 제57권2호
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• pp.268-269
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• 2024

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7497-7500
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• 2013

Background: This study concerns clinical characteristics and survival of renal cell carcinoma (RCC) patients in University Malaya Medical Centre (UMMC), as well as the prognostic significance of presenting symptoms. Materials and Methods: The clinical characteristics, presenting symptoms and survival of RCC patients (n=151) treated at UMMC from 2003-2012 were analysed. Symptoms evaluated were macrohaematuria, flank pain, palpable abdominal mass, fever, lethargy, loss of weight, anaemia, elevated ALP, hypoalbuminemia and thrombocytosis. Univariate and multivariate Cox regression analyses were performed to determine the prognostic significance of these presenting symptoms. Kaplan Meier and log rank tests were employed for survival analysis. Results: The 2002 TNM staging was a prognostic factor (p<0.001) but Fuhrman grading was not significantly correlated with survival (p=0.088). At presentation, 76.8% of the patients were symptomatic. Generally, symptomatic tumours had a worse survival prognosis compared to asymptomatic cases (p=0.009; HR 4.74). All symptoms significantly affect disease specific survival except frank haematuria and loin pain on univariate Cox regression analysis. On multivariate analysis adjusted for stage, only clinically palpable abdominal mass remained statistically significant (p=0.027). The mean tumour size of palpable abdominal masses, $9.5{\pm}4.3cm$, was larger than non palpable masses, $5.3{\pm}2.7cm$ (p<0.001). Conclusions: This is the first report which includes survival information of RCC patients from Malaysia. Here the TNM stage and a palpable abdominal mass were independent predictors for survival. Further investigations using a multicentre cohort to analyse mortality and survival rates may aid in improving management of these patients.

• 한국콘텐츠학회논문지
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• 제18권5호
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• pp.376-385
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• 2018

본 연구는 3차원 멀티미디어를 활용한 모바일 과제정보 제시가 치아카빙지식, 수행 및 실습만족도에 미치는 효과를 검증하고자 하였다. 이러한 연구목적을 달성하기 위하여 치의학 전공 대학생 66명을 대상으로 3D 모델링 어플리케이션을 활용한 실험집단과 텍스트와 삽화로 구성된 2차원 수업자료를 활용한 통제집단에 각각 33명씩 배정하여 실험을 하였다. 연구결과 첫째, 2차원 수업자료를 활용한 과제정보 집단(통제집단)이 3차원 멀티미디어를 활용한 모바일 과제정보 집단보다 치아형태에 대한 이해가 높은 것으로 나타났다. 둘째, 3차원 멀티미디어를 활용한 수업이 학생들의 치아카빙 수행 능력 향상에서 유의미한 효과가 나타났다. 셋째, 3차원 멀티미디어를 활용한 모바일 과제정보 제시 집단의 수업만족도가 통제집단보다 더 높은 것으로 나타났다. 따라서 치아형태학 수업에서 3D 모델링을 제공하는 것은 수업만족도를 높여주며, 치아카빙 수행 향상을 돕는 교육콘텐츠로 활용이 가능할 것으로 보인다.

• Journal of Periodontal and Implant Science
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• 제34권2호
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• pp.449-459
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• 2004

Bacterial byproducts and volatile sulfur compounds(VSC) have been found to be the leading intra-oral agents, specifically, the byproducts of gram negative anaerobic bacteria have been implicated as primary factors of halitosis in patients presenting with periodontal disease. The objective of this study was to determine the correlation between periodontal treatment and the subsequent reduction in the level of halitosis. Forty-three subjects presenting with periodontal disease were examined before periodontal treatment, one week after treatment, one month after treatment, and finally, two months after treatment, using a portable sulfide monitoring $Halimeter^{(R)}$ to measure the VSC concentrations at the prescribed intervals. The results of the study were as follows: 1. Significant decreases in the mean VSC concentration were observed at the one week, one month, and two month post-op intervals relative to the pre-op measurement. (p<0.05) 2. Significant decreases in the mean VSC concentration were observed in subjects after completion of flap operations. Significant decreases in the mean VSC concentration were observed at the one and two month post-flap operation measurement relative to the VSC concentration at one week (p<0.05), but no significant differences between the one month and two month VSC concentrations were found. (p<0.05) 3. Significant decreases in the mean VSC concentration were observed in subjects after completion of subgingival curettage (p<0,05). Significant decreases were found between the one week and one month measurements and between the one month and two month measurements, but significant differences were not observed between the one week and two month measurements. (p<0.05) The results of this study show significant decreases in VSC concentration in test subjects after periodontal treatment. It can be inferred from the results above, that periodontal disease is a significant contributing factor of halitosis, and that treatment of periodontal disease can been an effective means of reducing VSC concentration in patients presenting with halitosis concurrent with periodontal disease.

• IMMUNE NETWORK
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• 제10권4호
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• pp.135-143
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• 2010

Background: Cordyceps militarys water extract (CME) has been reported to exert antitumor and immunomodulatory activities in vivo and in vitro. However, the therapeutic mechanism has not yet been elucidated. In this study, we examined the effects of CME on the antigen presenting function of antigen presenting cells (APCs). Methods: Dendritic cells (DCs) were cultured in the presence of CME, and then allowed to phagocytose microspheres containing ovalbumin (OVA). After washing and fixing the efficacy of OVA, peptide presentation by DCs were evaluated using CD8 and CD4 T cells. Also, we confirmed the protein levels of proinflammatory cytokines through western blot analysis. Results: CME enhanced both MHC class I and class II-restricted presentation of OVA in DCs. In addition, the expression of both MHC class I and II molecules was enhanced, but there was no changes in the phagocytic activity of exogenous OVA. Furthermore, CME induced the protein levels of iNOS, COX-2, proinflammatory cytokines, and nuclear p65 in a concentration-dependent manner, as determined by western blot. Conclusion: These results provide an understanding of the mechanism of the immuno-enhancing activity of CME on the induction of MHC-restricted antigen presentation in relation to their actions on APCs.

• Child Health Nursing Research
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• 제21권2호
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• pp.98-106
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• 2015

Purpose: This study was done to develop and evaluate an algorithm-based simulation scenario for emergency measures for high-risk newborns presenting with apnea. Methods: A one shot case study design was used to evaluate the algorithm-based simulation scenario. Effects of the developed simulation scenario were evaluated using the Simulation Effectiveness Tool (SET) and the Lasater Clinical Judgement Rubric (LCJR). From March to November 137 senior nursing students completed the simulation using this scenario. Results: The eight-frame simulation scenario was developed based on the Neonatal Resuscitation Program (NRP) and the nursing clinical judgment process. After use of the scenario, overall scores for SET and LCJR were 21.0 out of 26.0 and 32.4 out of 44.0 respectively. There were no significant differences in scores according to general characteristics. Positive correlation coefficients were identified among overall and subcategories of SET and LCJR. In addition, students provided positive feedback on the simulation experience. Conclusion: Considering that nursing students have limited access to high-risk newborns during their clinical experience and that newborns presenting apnea are common in the neonatal intensive care unit, the simulation scenario developed in this study is expected to provide nursing students with more opportunities to practice emergency measures for high-risk newborns.

• 융합정보논문지
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• 제10권6호
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• pp.164-176
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• 2020

인체 적응 면역 반응을 일으키는데 중요한 항원 특이적 T 세포를 활용한 면역 세포 치료에서 T 세포를 체외에서 배양하고 클론 확장시키는 과정은 매우 섬세하고 복잡하여 조절하기가 쉽지 않아 T 세포의 활성화와 클론 확장을 유도하면서도 조절 및 취급이 용이한 인공 항원제시세포 개발의 필요성이 대두되고 있다. 인공 항원제시세포는 인체의 항원제시세포의 세포 표면 분자와 작용을 모방하게 되는데, 기본적인 신호 분자인 MHC-항원 복합체, 공동 자극 분자, 그리고 용해성 면역 조절 분자를 필수적으로 발현하여야 한다. 또한 T 세포가 항원과 접촉할 때, 이들 분자들이 잘 조직화되어 작용하는 것이 효과적인 T 세포 활성화에 중요하다. 본 논문에서는 여러 인공 항원제시세포 제작 방법과 세포 표면 분자들의 결합 방법과 물리적인 특성이 T 세포와의 상호작용에 중요함을 고찰하였으며, 효과적인 T 세포 활성화를 유도하며 면역세포치료에 적용 가능한 인공항원제세세포의 제작 방법을 살펴보았다.

• 한국초등수학교육학회지
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• 제5권1호
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• pp.77-98
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• 2001

사회 구조가 산업사회에서 정보화 사회로 전환됨에 따라 학생들이 배양해야 할 능력은 단순한 지식이나 기능의 습득보다는 이러한 지식과 기능을 이용하여 새로운 상황에서 문제를 해결하는 능력, 즉 문제 해결력이다. 문제 해결력 신장을 위하여 문제 만들기가 효과적이라 생각된다. 본 연구자는 제 7차 교육과정이 적용되고 있는 상황에서 4학년을 대상으로 문제 상황에 따른 문제 만들기 활동을 적용하여 문제 해결력에 미치는 영향을 분석하였다. 연구 대상을 실험반과 비교반으로 나누어 연구 분석한 결과 실험반이 수학과 학습에 대한 흥미를 더 가질 수 있었으며, 문제 해결력에 도움이 된 것으로 나타났다. 본 연구 결과를 바탕으로 문제 상황 제시 형태에 따른 연구가 전문적으로 지속되길 기대한다.