• 정신신체의학
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• 제21권2호
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• pp.114-121
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• 2013

연구목적 타과 입원 중 정신건강의학과에 자문 의뢰된 초로기와 노년기 환자의 특징에는 어떠한 차이가 있는지 알아보기 위하여 연구를 실시하였다. 방 법 일 대학병원 정신건강의학과에 자문 의뢰된 타과 입원환자 중 50세부터 64세 범위의 초로기 환자(N=162)와 65세 이상의 노년기 환자(N=171)의 자문기록지를 비교분석하였다. 결 과 1) 정신건강의학과 자문의 주소는 초로기에 신체증상, 불안, 수면장애 순, 노년기에 인지저하, 의식혼탁, 우울한 기분 순으로 많았다. 2) 자문 결과에 의한 정신의학적 진단명은 초로기에 섬망, 기분장애, 물질사용장애순, 노년기에 섬망, 기분장애, 주요 신경인지장애 순으로 많았다. 3) 신체질환 치료제의 수는 초로기보다 노년기에 더 많았다. 결 론 정신건강의학과 자문의 특성은 초로기와 노년기 환자에서 차이가 있었으므로, 노인정신의학 자문 활동에 있어서 더욱 세분화된 노인 연령층별 접근이 필요하다고 제시된다.

• 보험의학회지
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• 제20권
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• pp.70-77
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• 2001

Some characteristics of depression in the aged were elucidated. Compared with the previous thoughts, much more attention was given to the biological aspects of depression. However, we have to face up to and solve a variety of enigmas about depression in the aged people. They are:locations and underlying mechanisms in the cerebrum responsible for depression;relationship of senile depression to the presenile one;possible difference(s) between depression with and without psychotic features;possible neurotransmitter differences between senile and presenile depressions. New insights into these areas could bring some lights in the under standing and treatment of depresseion in the aged.

• 생물정신의학
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• 제3권2호
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• pp.203-210
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• 1996

알쯔즈하이머형 치매 환자의 뇌자기공명영상(腦磁氣共鳴影像)에 나타난 뇌위축(腦萎縮) 및 백질병변(白質病變)과 치매 발병연령(發病年齡)과의 상관관계(相關關係)를 밝히기 위해, NINCDS-ADRDA 진단기준(診斷基準)에 의한 조발성(早發性)(n=9) 및 만발성(慢發性)(n=18) 알쯔하이머형 치매군과 각각의 정상대조군(n=10 : n=11)에서 뇌위축(腦萎縮)은 대뇌피질위축(大腦皮質萎縮)과 뇌실확장(腦室擴張)의 체적(體積)을 계측(計測)하고 백질병변(白質病變)은 뇌실주변, 심부백질, 기저핵 및 천막하영역의 백질(白質) 신호(信號) 고강도(高剛度)의 반정량적(半定量的) 평가척도(評價尺度)로 측정하였다. 조발성(早發性) 환자군의 뇌위축(腦萎縮)은 대조군보다 유의하게 컸고(p<0.05) 백질병변(白質病變)에서는 모든 영역에서 차이가 없었으며, 만발성(慢發性) 환자군은 뇌위축(腦萎縮) 정도에서는 대조군과 차이가 없었으나 백질병변(白質病變)은 심부백질 및 시상에서 유의한 차이(p<0.05)를 보였고 나머지 모든 영역에서도 대조군보다 심한 경향을 보였다. 알쯔하이머형 치매가 (1) 뇌위축(腦萎縮)을 주로 보이고 백질병변(白質病變)은 심하지 않은 조기발병군(早期發病郡)과, (2) 백질병변(白質病變)이 두드러지고 뇌위축(腦萎縮)은 심하지 않은 만기발병군(晩期發病郡)으로 나누어질 가능성과 양군의 병태생리(病態生理)가 상이(相異)할 가능성이 시사되었다.

• 상하수도학회지
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• 제9권3호
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• pp.88-98
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• 1995

Several kinds of coagulants such as aluminum sulfate, PAC, PASS are being used to treat drinking water resulting in residual aluminum ions in the water. Recently, it has been reported that high intake of aluminum ion may cause neurological dieseases such as Alzheimer's diesease and presenile dementia. Because of the possible adverse effect, WHO and EEC recommand to regulate residual aluminum. The autorities in Korea also has plan of regulating residual alunimum from 1995. But there is not enough information about the range of residual aluminum ion concentration when the aluminum sulfate, PAC or PASS has been used as a coagulant. Therefore the study has been conducted to find out the range of residual aluminum ion concentration after using aluminum sulfate, PAC, and PASS. Furthermore the effect of turbidity and alkalinity have been investigated. The experimental results are summarized as; 1. Most of the residual aluminum ion concentrations were within $10^{-6}$ and $10^{-5}mole/l$. Three coagulants have not showed any considerable difference in the residual aluminum concentration up to 50 NTU. However PAC has showed the least residual aluminum in high turbidity water over 100 NTU. 2. The low alkalinity water having 25mg/l as $CaCO_3$ has showed less residual aluminum than the water having 50mg/l alkalinity. However, the difference was not significcant. 3. Even the lowest residual aluminum concentration was over 0.05mg/l. Therefore the process to reduce residual aluminum would be necessary in water treatment plants.

• 생물정신의학
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• 제15권1호
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• pp.46-53
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• 2008

Posterior cortical atrophy(PCA) is a presenile dementia that presents primarily with signs and symptoms of cortical visual dysfunction, while memory is relatively preserved until the late stage of the disease. We report a patient with PCA, confirmed by brain magnetic resonance imaging (MRI) and $F^{18}$-fluorodeoxyglucose positron emission tomography(FDG PET). A 58-year-old right-handed woman presented initially with visual dimness and difficulty finding things around her. She had partial Balint's syndrome, partial Gerstmann syndrome, and idiomotor apraxia. She also had a mild memory disturbance, but preserved insight of her disease. Neuropsychological evaluation showed decreased parietal and left temporal functions bilaterally. Brain MRI and $F^{18}$-FDG PET revealed typical bilateral occipitoparietal atrophy and hypometabolism, which were slightly worse on the right side. Cholinesterase inhibitor administration for 6 months improved the memory impairment slightly, but not the cortical visual dysfunction. This is a typical case of PCA, confirmed by neurologic signs and imaging findings.