• 한국전자통신학회논문지
• /
• 제12권6호
• /
• pp.1197-1210
• /
• 2017

본 연구는 음경의 특성에 따른 조루증 및 발기능을 비교하고자 하였다. 99명의 성인 남성은 음경의 특성, 조루증, 발기능에 대한 설문조사에 응답하였다. 설문을 확인하는 과정에서 누락이 있거나 불완전한 응답을 제외한 69명의 설문을 분석하였다. 수집한 모든 데이터는 SPSS 22를 이용하여 독립 t 검정, 카이제곱 검정을 통하여 확인하였다. 연구 결과, 귀두가 음경보다 더 굵은 유형은 비슷한 유형과 비교하여 주관적 조루, 객관적 조루에서 유의한 차이가 있었다(p<.05). 주관적 조루인 자는 없는 자와 비교하여 객관적 조루, 치료의향, 성교 만족도에서 유의한 차이가 있었다(p<.05). 객관적 조루의 유무, 조루증 치료의향의 유무, 결혼 유무는 성교 만족도에서 유의한 차이가 있었다(p<.05). 경제 수준이 높은 자는 보통 또는 낮은 자와 비교하여 발기능 자신감에서 유의한 차이가 있었다(p<.05). 본 조사연구의 결과는 음경의 특성에 따른 조루 및 발기능은 차이를 나타낼 수 있음을 시사하며, 조루증과 발기능 장애가 있는 남성의 성기능 재활을 위한 중재 프로그램 개발의 기초자료로 사용될 수 있을 것이다.

• 대한한의학회지
• /
• 제19권1호
• /
• pp.444-469
• /
• 1998

Premature ejaculation is the most common sexual dysfunction seen in the male, and it is found in 30 to 50% adult male population. It is defined as the inability to control the ejaculatory process for a sufficient length of time during intravaginal containment to satisfy his partner in at least fifty percent of his coital connections The majority of men with premature ejaculation have underlying psychologic origin of performance-anxiety type, but it is not always psychogenic and may also be a presenting symptom in certain organic disorders. In oriental medicine, the point of treatment of premature ejaculation is recovery of the good ejaculatory control, and the treatment can be approached in three ways as psychological therapy involving behavioral therapy, herb drugs, and acupuncture. This study has aims to investigate and summarize the current trend of treatment for premature ejaculation so as to suggest the effective and available way to treat the disease.

• Bulletin of the Korean Chemical Society
• /
• 제29권10호
• /
• pp.1946-1950
• /
• 2008

The synthesis of new 5-cyano-1,1-disubstituted phthalans having aromatic and aminoalkyl groups at C-1 position of phthalan ring and their biological evaluation are described. Most compounds exhibited comparable ejaculation-retarding effects to citalopram. Of these compounds, 3a, e showed excellent efficacy in delaying ejaculation.

• The Korean Journal of Physiology and Pharmacology
• /
• 제4권6호
• /
• pp.439-444
• /
• 2000

Tricyclic antidepressant clomipramine or selective serotonin reuptake inhibitors (SSRIs) have been commonly used for the treatment of premature ejaculation. In the present study, we analyzed the concentrations of serotonin and 5-hydroxyindoleacetic acid (5-HIAA) in the medial preoptic area (MPOA) of the hypothalamus by awakening animal microdialysis following administration of clomipramine and various SSRIs. We then compared the serotonin metabolism and clinical effects of clomipramine and SSRIs on premature ejaculation. Basal extracellular serotonin level in the MPOA was higher than other brain regions and it was significantly increased by clomipramine and the SSRIs. The rank order of the concentration of serotonin at the MPOA was clomipramine, sertraline, paroxetine and fluoxetine and the concentrations of 5-HIAA was vice versa. The changes in serotonin concentration at the MPOA appeared closely associated with the clinical effects of these drugs on premature ejaculation. These results suggest that the serotonergic neuronal activity in the MPOA may have an selective inhibitory influence on ejaculation, and the effects of clomipramine and SSRIs on erectile function are mainly mediated by MPOA of the hypothalamus.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권4호
• /
• pp.1961-1966
• /
• 2016

Background: To investigate the prevalence of premature ejaculation (PE) and erectile dysfunction (ED) in a sample of patients with prostate cancer and to determine the utility of the previously suggested cutoffs of the Premature Ejaculation Diagnostic Tool (PEDT) for the diagnosis of PE and that of International Index of Erectile Function (IIEF-5) for ED. Materials and Methods: A total of 1,202 men with prostate cancer were invited from urology clinics at the universities of Iran, Tehran, Qazvin, Ahvaz, Guilan and Tabriz. Clinical characteristics were collected through medical records. PE and ED diagnoses were made by trained urologists. In addition to the clinical diagnoses, PE and ED were measured through self-report using the PEDT and the IIEF-5. Questionnaire cutoff scores were determined using receiver operating characteristic (ROC) curves and confirmed by predictive ability using logistic regression. Results: The prevalence of PE was 63.7% and that of ED was 66.2%. Prevalences of PE decreased and that of ED increased with advanced TNM stages. According to ROC, the suggested cutoff for the PEDT to diagnose a PE was ${\geq}11$ (sensitivity=0.988, 1-specificity=0.084, and predictive ability=0.914) and ${\leq}17$ for the IIEF-5 (sensitivity=0.966, 1-specificity=0.031, and predictive ability=0.967). Conclusions: Prevalence of sexual problems was high in prostate cancer patients in Iran, therefore oncologists should take into account these potential problems when deciding on treatment modalities.

• Biomolecules & Therapeutics
• /
• 제9권1호
• /
• pp.51-54
• /
• 2001

Bufonis Venenum is a toad venom and its main components are bufadienolides, namely resibufogenin, bufalin and cinobufagin. The desensitizing effect of Bufonis Venenum is useful for the treatment of the premature ejaculation in Chinese medicine. But, minor components of Bufonis Venenum cause problems such as topical burring, pain, and erectile dysfunction. To clarify and eliminate the components responsible for these side effects, we prepared two extracts of Bufonis Venenum with either 70% ethanol or ethylacetate and tested their pharmacological effects. The extract of Bufonis Venenum with 70% ethanol produced pain response in rat hind paw, and exhibited contraction of rabbit corpus cavernosal muscle in vitro. On the other hand, the ethylacetate extract did not cause pain and smooth muscle contraction. The desensitizing effect of the ethylacetate extract was similar to that of the 70% ethanol extract. In conclusion, these results show that the extract of Bufonis Venenum with ethylacetate does not have the components causing side effects and deserve further study for therapeutic potential in premature ejaculation in men.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
• /
• pp.259.1-259.1
• /
• 2000

• 대한약학회:학술대회논문집
• /
• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
• /
• pp.258.1-258.1
• /
• 2000

• 혜화의학회지
• /
• 제10권1호
• /
• pp.167-174
• /
• 2001

According to the literatual study on the external treatment of premature ejaculation, the results were as follows. 1. Linition is inunction glans penis after infiltrate ASARI HERBA CUM RADICE(細辛), CARYOPHYLLI FLOS(丁香), CHEBULAE FRUCTUS(訶子), PAPAVERIS FRUCTUS(罌粟殼), FOSSILIA OSSIS MASTODI(龍骨), OSTREAE CONCHA(牡蠣 in oenostagma. 2. Retrojection or hypoatmism method is boiling CHINENSIS GALLA(五倍子), CNIDII FRUCTUS(蛇牀子) and hypoatmism, down temperature infiltrate glans penis. 3. Mesompharion apposition method is calorization VESPAE NIDUS(露蜂房), ANGELICAE DAHARICAE RADIX(白芷), and utilization vineger apposite mesompharion. 4. Medicament belt method is belt on lumbus and bythus by ROSAE LAEVIGATAE FRUCTUS(金櫻子), EURYALES SEMEN, OSTREAE CONCHA(牡蠣), TRIBULI FRUCTUS, AIPINIAE OXYPHYLLAE FRUCTUS(益智仁), NELUMBINIS SEMEN(蓮子肉) Powders. 5. Enema is injection in the rectum ANGELICAE GIGANTIS RADIX(當歸) effusion. 6. Much utilization agent are ASARI HERBA CUM RADICE(細辛), CHINENSIS GALLA(五倍子), OSTREAE CONCHA(牡蠣), CNIDII FRUCTUS(蛇床子), GRANATI PERICARPIUM(石榴皮), CARYOPHYLLI FLOS(丁香), CHEBULAE FRUCTUS(訶子), FOSSILIA OSSIS MASTODI(龍骨), VESPAE NIDUS(露蜂房), PAPAVERIS FRUCTUS(罌粟殼) etc. They are occupied in adstringentia, juventia, divergence agent, liver stabilizer agent.

• Journal of Pharmaceutical Investigation
• /
• 제30권4호
• /
• pp.273-278
• /
• 2000

Several topical preparations containing lidocaine, a widely used local anesthetic agent, have been developed and marketed recently for the treatment of premature ejaculation. In this study, microemulsion(ME)-based hydrogels containing lidocaine were prepared by dispersing ME to hydrogel bases such as Carbopol, sod. alginate, and sod. carboxymethylcellulose. Lidocaine-containing ME was thermodynamically stable over 6 months and had a diameter ranging from 10 to 100 nm. In vitro skin penetration of lidocaine from ME-based hydrogels followed apparent zero-order kinetics. ME-based hydrogel showed higher drug penetration during fifteen minutes after application than alcoholic hydrogel, reference preparation. Tail flick test in rat was introduced to compare in vivo local anesthetic effects of different hydrogels, and the results showed that ME-based hydrogels are superior to other hydrogels. In optical microscopy, recrystallization of lidocaine was observed within 5 min after application of reference hydrogel, but there was no change in ME-based hydrogels even after 30 minnute. These results indicated that ME-based hydrogels had some advantages in skin penetration, anesthetic effect and physical stability compared with alcoholic hydrogels. Finally it is possible to conclude that ME-based hydrogels containing lidocaine is a good topical drug delivery system for the treatment of premature ejaculation.