• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.21 no.3
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• pp.133-140
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• 2010

Tic disorders, including Tourette syndrome, are known as neurobiologic disorders and as such, much emphasis has been placed on isolating genetic determinants. Although previous reports involving studies of discordance among monozygotic twins have shown the importance of genetic predisposition, they have also supported a role for environmental factors in the development of tic disorders. Therefore, it is important to consider that both genetic and environmental factors contribute to their clinical expression. The goal of this article was to review recent reports regarding the role of environmental factors in development and progression of tics. Specific environmental factors associated either with a more severe course of illness or improved outcomes were discussed. Given that accumulating evidence had suggested the usefulness of behavior therapies in the suppression of tic disorders, particular emphasis was placed on the impact of several contextual factors.

• Korean journal of applied entomology
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• v.19 no.1 s.42
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• pp.11-20
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• 1980

Percent penetration on a specific rice variety was more affected by blast fungus isolate or predisposition temperature than by temperature and isolate combinations. A susceptible variety tested remained continuously susceptible regardless of whether the variety was grown at different temperature regimes and exposed to isolates/races with differences in pathogenicity and virulence. The expression of virulence by a particular blast fungus isolate race was observed to be changed by subjecting rice host plants to different predisposing temperature conditions prior to inoculation.

• Journal of Periodontal and Implant Science
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• v.43 no.3
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• pp.111-120
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• 2013

Periodontitis is a common oral disease that is characterized by infection and inflammation of the tooth supporting tissues. While its incidence is highly associated with outgrowth of the pathogenic microbiome, some patients show signs of predisposition and quickly fall into recurrence after treatment. Recent research using genetic associations of candidates as well as genome-wide analysis highlights that variations in genes related to the inflammatory response are associated with an increased risk of periodontitis. Intriguingly, some of the genes are regulated by epigenetic modifications, supposedly established and reprogrammed in response to environmental stimuli. In addition, the treatment with epigenetic drugs improves treatment of periodontitis in a mouse model. In this review, we highlight some of the recent progress identifying genetic factors associated with periodontitis and point to promising approaches in epigenetic research that may contribute to the understanding of molecular mechanisms involving different responses in individuals and the early detection of predispositions that may guide in future oral treatment and disease prevention.

• Preventive Nutrition and Food Science
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• v.20 no.1
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• pp.1-7
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• 2015

Obesity has become one of the major public health problems all over the world. Recent novel eras of research are opening for the effective management of obesity though gene and nutrient intake interactions because the causes of obesity are complex and multifactorial. Through GWASs (genome-wide association studies) and genetic variations (SNPs, single nucleotide polymorphisms), as the genetic factors are likely to determine individuals' obesity predisposition. The understanding of genetic approaches in nutritional sciences is referred as "nutrigenomics". Nutrigenomics explores the interaction between genetic factors and dietary nutrient intake on various disease phenotypes such as obesity. Therefore, this novel approach might suggest a solution for the effective prevention and treatment of obesity through individual genetic profiles and help improve health conditions.

• Advances in pediatric surgery
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• v.12 no.2
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• pp.244-250
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• 2006

Splenic abscess is a rare clinical condition with a reported incidence of 0.14 % to 0.70 % in various autopsy series. Primary tuberculosis of the spleen as a cause of splenic abscess is even rarer, especially in the antitubercular era. Infants and children have a higher predisposition to extra-pulmonary tuberculosis than adults and tend to develop severe extra-pulmonary disease such as miliary tuberculosis and meningitis. The diagnosis of tuberculosis in infants and children can be difficult because of nonspecific symptoms and clinical findings. Computed tomography establishes the diagnosis of splenic abscess and demonstrates the number and location of abscesses. Splenectomy is the standard of care in most clinical setting. We present a 4-year-old girl who had multiple tuberculosis splenic abscesses and was treated successfully with splenectomy.

• Sleep Medicine and Psychophysiology
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• v.12 no.2
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• pp.93-97
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• 2005

Nasal obstruction may cause or aggravate sleep disordered breathing but exact pathogenesis is not clear. The possible mechanism could be combination of alteration in upper airway aerodynaimcs, loss of nasal reflex or sensation, effect of mouth opening, and a genetic predisposition. Anatomical narrowing of nasal airway cause more rapid airflow and induce more negative inspiratory air pressure. So, it increases collapsibility of pharyngeal airway. Loss of nasal sensation to airflow block nasal reflex. Mouth opening decreases the activity of pharyngeal airway dilator muscles and narrowing the pharyngeal airway may occur. The treatment of nasal obstruction should be done according to the cause. The causes of nasal obstruction are various from problems of external nasal opening to nasopharynx. Relief of nasal obstruction may not cure sleep disordered breathing always. In some mild obstructive sleep apnea patients, treatment of nasal obstruction only may cure sleep disordered breathing. In some severe sleep apnea patients, treatment of nasal obstruction may increase compliance of continous nasal positive airway pressure.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5961-5964
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• 2013

Background: Breast cancer in Kazakhstan and its Kyzylorda oblast is the most prevalent cancer in women and features increasing trends of incidence. The aim of study was to reveal risk factors for breast cancer among women of Kyzylorda oblast of Kazakhstan. Materials and Methods: A hospital-based case-control study was conducted at Kyzylorda oblast Oncology Center, including 114 cases of breast cancer and 196 controls. Binary logistic regression analysis was performed. Results: Social and behavioral risk factors for breast cancer were evaluated, among which unfavorable living conditions, chronic stress, unilateral breastfeeding, breastfeeding less than 3 months and over 2 years, abortions, and hereditary predisposition were found to be related with increased breast cancer risk. Breastfeeding for 6-24 months was found to be protective. Conclusions: The findings may have significant impact on activity planning aimed towards breast cancer reduction among women in Kazakhstan.

• International Journal of Costume and Fashion
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• v.5 no.2
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• pp.11-27
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• 2005

La demarche et l'objet de cette recherche sont d'analyser, psychiquement, biologiquement, les marques de l'intersexualite presentent en Occident et les elements intersexuels, binaires dans le vetement, et egalement de comprendre l'ambiguite ou encore la fusion des identites sexuees. qui presente symboliquement a travers le vetement, dans la societe moderne. Malgre tous les points communs et differents, la base fondamentale dans les theories de I'Occident est que tout individu est psychiquement, biologiquement en quelque sorte un intersexuel qui s'ignore, avec des variations selon l'individu. En definitive, les compositions doubles des elements dans le vetement occidental montraient emblematiquement nos qualites doubles, masculins et feminins, et les trois elements semblent primordiaux pour l'elucidation de la predisposition du porteur : la couleur du tissu, sa texture et la forme du vetement. La mode d'aujourd'hui bascule entre masculin et feminin. Cette fusion de la mode semble le reflet d'une tendance intersexuelle et d'une fusion du genre.

• Molecules and Cells
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• v.37 no.8
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• pp.569-574
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• 2014

As a scaffold, SLX4/FANCP interacts with multiple proteins involved in genome integrity. Although not having recognizable catalytic domains, SLX4 participates in diverse genome maintenance pathways by delivering nucleases where they are needed, and promoting their cooperative execution to prevent genomic instabilities. Physiological importance of SLX4 is emphasized by the identification of causative mutations of SLX4 genes in patients diagnosed with Fanconi anemia (FA), a rare recessive genetic disorder characterized by genomic instability and predisposition to cancers. Recent progress in understanding functional roles of SLX4 has greatly expanded our knowledge in the repair of DNA interstrand crosslinks (ICLs), Holliday junction (HJ) resolution, telomere homeostasis and regulation of DNA damage response induced by replication stress. Here, these diverse functions of SLX4 are reviewed in detail.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.54-54
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• 1993

Two strains of genetically epilepsy-prone rats (GEPRs) have been derived from Sprague Dawley stock. One strain, known by the acronym GEPR-9, has a more pronounced epileptic condition than the other strain, known by the acronym GEPR-3. Only a small fraction of commercially available Sprague Dawley rats exhibits evidence of epilepsy. GEPRS are similar to most humans with epilepsy in that their general behaviors appear normal . GEPRS also share other traits with their non-epileptic counterparts. They are susceptible to forebrain and brainstem seizures produced by convulsant drugs and electrical currents. Because GEPRs and normal rats share these seizure non-epileptic brain rather than to an understanding of epilepsy. However, humans wi th epilepsy, the GEPR and other mammal inn models of genetic epilepsy are distinctive because they are characterized by seizure predisposition.