• Journal of Electrical Engineering and Technology
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• v.10 no.5
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• pp.2126-2134
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• 2015

The present study suggests a localization method for the first (S₁) and the second (S₂) feature of heart sounds, based on an algorithm involving frequency filtering, energy detection, and interval regulation. Localization accuracy was evaluated by comparing the algorithm with the traditional Hilbert transform-based localization method. Results show that the sensitivity and the positive predictivity value of proposed method, respectively, were 97.27 % and 99.94 % in S₁ detection and 94.99 % and 100 % in S₂ detection.

• Journal of Biomedical Engineering Research
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• v.21 no.2
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• pp.165-174
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• 2000

본 논문에서는 M 채널 필터 뱅크를 이용하여 심전도 자동 진단 시스템에서 매우 중요한 파라미터로 사용되는 QRS complex 검출을 실시하였다. 제안된 알고리즘에서는 심전도 신호를 M개의 균일한 주파수 대역으로 분할(decomposition)하고, 분할된 서브밴드(subband) 신호들 중에서 QRS complex의 에너지 분포가 가장 많이 존재하는 5∼25Hz 영역의 서브밴드 신호들을 선택하여 feature를 계산함으로써 QRS complex 검출을 실시하였다. 제안된 알고리즘의 성능 비교를 위하여 MIT-BIH arrhythmia database를 사용하였으며, sensitivity는 99.82%, positive predictivity는 99.82, 평균 검출율은 99.67%로 기존의 알고리즘에 비해 높은 검출 성능을 나타내었다. 또한 polyphase representation을 이용하여 M 채널 필터 뱅크를 구현한 결과 연산 시간이 단추되어 실시간 검출이 가능함을 확인하였다.

• Proceedings of the Korea Information Processing Society Conference
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• 2014.04a
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• pp.737-740
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• 2014

본 연구는 이종 생체 신호를 이용하여 심장 박동 신호를 검출하도록 고안되었다. 제안 알고리즘은 이종 생체 신호의 특징점을 추출하는 과정과 이를 이용하여 심장 박동의 특징점을 추정하는 과정으로 구성되어 있다. 특히, electrocardiogram(ECG)의 특징점과 동일한 위상의 잡음 신호로 인해 특징점 추출이 난해한 경우 이종 생체 신호를 이용해 특징점의 위치를 추정하는 방법을 사용하였다. Physionet 의 Challenge/2014 데이터베이스에서 잡음이 존재하는 레코드를 대상으로 수행한 심장 박동 검출 실험에서 Sensitivity 는 98.97%, positive predictivity 는 99.54%를 기록했다.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.3
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• pp.181-193
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• 2022

This paper seeks to investigate major macroeconomic factors and bond yield interactions in Thai bond markets, with the goal of forecasting future bond yields. This study examines the best predictive yields for future bond yields at different maturities of 1-, 3-, 5-, 7-, and 10-years using time series data of economic indicators covering the period from 1998 to 2020. The empirical findings support the hypothesis that macroeconomic factors influence bond yield fluctuations. In terms of forecasting future bond yields, static predictions reveal that in most cases, the BVAR model offers the best predictivity of bond rates at various maturities. Furthermore, the BVAR model has the best performance in dynamic rolling-window, forecasting bond yields with various maturities for 2-, 4-, and 8-quarters. The findings of this study imply that the BVAR model forecasts future yields more accurately and consistently than other competitive models. Our research could help policymakers and investors predict bond yield changes, which could be important in macroeconomic policy development.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.101-106
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• 2003

In this paper, we propose using Hotelling's T2 statistic for the detection of a set of a set of differentially expressed (DE) genes in colorectal cancer based on its gene expression level in tumor tissues compared with those in normal tissues and to evaluate its predictivity which let us rank genes for the development of biomarkers for population screening of colorectal cancer. We compared the prediction rate based on the DE genes selected by Hotelling's T2 statistic and univariate t statistic using various prediction methods, a regulized discrimination analysis and a support vector machine. The result shows that the prediction rate based on T2 is better than that of univatiate t. This implies that it may not be sufficient to look at each gene in a separate universe and that evaluating combinations of genes reveals interesting information that will not be discovered otherwise.

• Journal of Biomedical Engineering Research
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• v.30 no.4
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• pp.294-305
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• 2009

The bio signals essentially have different characteristics in each person. And the main purpose of automatic diagnosis algorithm based on bio signals focuses on discriminating differences of abnormal state from personal differences. In this paper, we propose automatic ECG diagnosis algorithm which discriminates normal heart beats from premature ventricular contraction using optimization of wavelet parameterization to solve that problem. The proposed algorithm optimizes wavelet parameter to let energy of signal be concentrated on specific scale band. We can reduce the personal differences and consequently highlight the differences coming from arrhythmia via this process. The proposed algorithm using ELM as a classifier show high discrimination performance between normal beat and PVC. From the experimental results on MIT-BIH arrhythmia database the performances of the proposed algorithm are 98.1% in accuracy, 93.0% in sensitivity, 96.4% in positive predictivity, and 0.8% in false positive rate. This results are similar or higher then results of existing researches in spite of small human intervention.

• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4352-4360
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• 2011

A four dimensional quantitative structure activity relationship analysis was applied to a series of 50 flavonoid inhibitors of $p56^{lck}$ protein tyrosine kinase by the molecular comparative electron topological method. It was found that the -log (IC50) values of the compounds were highly dependent on the topology, size and electrostatic character of the substituents at seven positions of the flavonoid scaffold in this study. Depending on the negative or positive charge of the groups correctly embedded in these substituents, three-dimensional bio-structure to increase or decrease -log (IC50) values in the training set of 39 compounds was predicted. The test set of 11 compounds was used to evaluate the predictivity of the model. To generate 4D-QSAR model, the defined function groups and pharmacophore used as topological descriptors in the calculation of activity were of sufficient statistical quality ($R^2$ = 0.72 and $Q^2$ = 0.69). Ligand docking approach by using Dock 6.0. These compounds include many flavonoid analogs, They were docked onto human families of p56lck PTKs retrieved from the Protein Data Bank, 1lkl.pdb.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.50 no.4
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• pp.201-207
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• 2001

This paper describes an automated detection algorithm of ST-T episodes using global curvature which can connect the isoelectric level in ECG and can eliminate not only the slope of ST segment, but also difference of the baseline and global curve. This above method of baseline correction is very faster than the classical baseline correction methods. The optimal values of parameters for baseline correction were found as the value having the highest detection rate of ST episode. The features as input of backpropagation Neural Network were extracted from the whole ST segment. The European ST-T database was used as training and test data. Finally, ST elevation, ST depression and normal ST were classified. The average ST episode sensitivity and predictivity were 85.42%, 80.29%, respectively. This result shows the high speed and reliability in ST episode detection. In conclusion, the proposed method showed the possibility in various applications for the Holter system.

• Proceedings of the Korea Information Processing Society Conference
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• 2014.04a
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• pp.978-980
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• 2014

본 연구에서는 스트레스 상태 측정을 위한 심전도 신호 QRS 검출 알고리즘을 제안한다. 심전도 신호의 QRS 검출 과정은 4단계로 wavelet, moving average, squaring, threshold method로 구성된다. wavelet은 기저선 변동과 노이즈를 제거하고 moving average는 전체 신호를 부드럽게 하고 잔여 노이즈를 제거하며 squaring은 신호를 강조하는 역할을 한다. 마지막으로 threshold 기법을 이용해 검출간격을 설정하여 QRS를 검출하였다. 그 결과 Sensitivity는 99.54%, Positive Predictivity는 99.69%, Detection Error는 0.76%를 보였다. 또한, 피험자를 대상으로 게임을 이용해 스트레스 상태 변화에 대한 실험을 하였고, HRV 시간-주파수 파라미터를 분석함으로써 스트레스 상태 변화를 관찰할 수 있었다.

• Transactions of Materials Processing
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• v.32 no.2
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• pp.74-80
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• 2023

A deformation behavior of commercially pure titanium (CP-Ti) is highly dependent on material and processing parameters, such as deformation temperature, deformation direction, and strain rate. This study aims to predict the multivariable and nonlinear tensile behavior of CP-Ti using machine learning based on three algorithms: artificial neural network (ANN), light gradient boosting machine (LGBM), and long short-term memory (LSTM). The predictivity for tensile behaviors at the cryogenic temperature was lower than those in the room temperature due to the larger data scattering in the train dataset used in the machine learning. Although LGBM showed the lowest value of root mean squared error, it was not the best strategy owing to the overfitting and step-function morphology different from the actual data. LSTM performed the best as it effectively learned the continuous characteristics of a flow curve as well as it spent the reduced time for machine learning, even without sufficient database and hyperparameter tuning.