• 지능정보연구
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• 제23권1호
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• pp.95-108
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• 2017

최근 알파고의 등장으로 딥러닝 기술에 대한 관심이 고조되고 있다. 딥러닝은 향후 미래의 핵심 기술이 되어 일상생활의 많은 부분을 개선할 것이라는 기대를 받고 있지만, 주요한 성과들이 이미지 인식과 자연어처리 등에 국한되어 있고 전통적인 비즈니스 애널리틱스 문제에의 활용은 미비한 실정이다. 실제로 딥러닝 기술은 Convolutional Neural Network(CNN), Recurrent Neural Network(RNN), Deep Boltzmann Machine (DBM) 등 알고리즘들의 선택, Dropout 기법의 활용여부, 활성 함수의 선정 등 다양한 네트워크 설계 이슈들을 가지고 있다. 따라서 비즈니스 문제에서의 딥러닝 알고리즘 활용은 아직 탐구가 필요한 영역으로 남아있으며, 특히 딥러닝을 현실에 적용했을 때 발생할 수 있는 여러 가지 문제들은 미지수이다. 이에 따라 본 연구에서는 다이렉트 마케팅 응답모델, 고객이탈분석, 대출 위험 분석 등의 주요한 분류 문제인 이진분류에 딥러닝을 적용할 수 있을 것인지 그 가능성을 실험을 통해 확인하였다. 실험에는 어느 포르투갈 은행의 텔레마케팅 응답여부에 대한 데이터 집합을 사용하였으며, 전통적인 인공신경망인 Multi-Layer Perceptron, 딥러닝 알고리즘인 CNN과 RNN을 변형한 Long Short-Term Memory, 딥러닝 모형에 많이 활용되는 Dropout 기법 등을 이진 분류 문제에 활용했을 때의 성능을 비교하였다. 실험을 수행한 결과 CNN 알고리즘은 비즈니스 데이터의 이진분류 문제에서도 MLP 모형에 비해 향상된 성능을 보였다. 또한 MLP와 CNN 모두 Dropout을 적용한 모형이 적용하지 않은 모형보다 더 좋은 분류 성능을 보여줌에 따라, Dropout을 적용한 CNN 알고리즘이 이진분류 문제에도 활용될 수 있는 가능성을 확인하였다.

• 기술혁신연구
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• 제14권1호
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• pp.31-66
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• 2006

II절에서는 다수의 구조방정식에서 R&D투자가 산업구조를 결정하고 이가 다시 수출 및 경제성장을 결정하는 변수로 모형이 설정되었다. 동시에, 이같이 모형을 설정하는 이론적 근거를 살펴보았다. 본고에서는 R&D투자 등 혁신활동이 Grossman and Helpman(1991)기 신무역이론에서와 같이 제품차별화를 통해 무역과 성장에 미치는 효과를 실증분석하였다. 분석 결과를 통해 Grossman and Helpman(1991) 모형이 주장하는 R&D의 수출에 미치는 효과를 나타내는 회귀모형의 적합도(goodness of fit)가 높게 나타났고 데이터를 통해 관심의 대상이 되는 추정계수가 통계적으로 유의한 것으로 나타나 우리 경제에는 이미 R&D를 통한 산업내 무역 증대가 상당히 진행되고 있음을 확인할 수 있었다. 이를 통해 향후 우리 경제는 지속적 성장을 위해 기술혁신 활동을 통해 보다 지식 집약적이고 인적자본 집약적인 산업 내 무역 상품의 수출확대에 집중하여야 한다는 시사점을 얻을 수 있었다. 본고에서의 실증분석 결과가 시사하는 바를 요약하면 다음과 같다. 첫째, 인적자본의 부존이 상대적으로 많은 나라에서 보다 많은 R&D를 수행하게 된다. 이 같은 연구개발에서의 상대적 특화에 의해 이 국가는 보다 광범위한 혁신상품을 생산할 수 있는 know-how를 획득하게 되고 첨단기술(high-technology)이 국민경제에서 차지하는 몫은 상대적으로 더 커서 실질 GDP의 성장은 상대적으로 더 빨리 이루어지게 된다. 실증분석을 통해 이가 시사하는 R&D를 통한 산업 내 무역 증가와 빠른 경제성장의 효과는 데이터를 통해 인과관계를 확인할 수 있었다. 그러나, 아직 생산구조와 무역구조가 지식 및 인적자본 집약적인 형태로 충분히 전환되지 않아 전통적인 R&D와 산업간 무역의 관계도 광범위하게 존재하는 것으로 나타났다. 둘째, R&D 투자격차에 대한 Hughes(1986)의 주장과 달리 미국과 우리나라간의 R&D격차가 작아질수록 수출이 증가하지 않는 것으로 나타났다. 이는 우리나라의 R&D투자 등 기술활동 증가가 (대미)수출의 증가로 연결되지 않음을 시사하였다. 동일한 분석을 우리의 대일본 수출의 경우에 적용한 결과의 경우에도, 일본간 R&D 투자격차에 대한 Hughes의 주장이 우리나라와 일본간에도 타당하지 않은 것으로 나타난다. 실증분석과정에서 이상의 논의를 통해 나타난 우리나라 R&D 투자증가가 대미수출을 증가시키지 못하는 현상 즉, 미국과 우리나라의 R&D 투자격차 감소가 대미수출을 증가시키지 못하는 현상을 다음과 같이 설명할 수 있다. 첫째, 미국민(또는 미국기업)의 우리나라 수출품 R&D에 대한 수요탄력성이 낮을 수 있다. 즉, 규모의 경제가 존재하는 독점적 경쟁산업에서 각 기업은 차별화된 제품을 생산하게 된다. 미국 소비자도 다양한 상품을 소비하고자 하지만 수입국(한국) R&D 투자를 통한 기술혁신에 대한 수입수요 탄력성이 상대적으로 낮은 것으로 볼 수 있다. 우리나라 총생산(Q)은 내수(A)와 수출(X)로 구성되어 있다. (Q=X+A) 이 경우, 우리나라 R&D에 대한 총생산 수요탄력성($\eta$)은 다음과 같다. $${\eta}={\eta}_X(X/Q)+{\eta}_A(A/Q)$$ ${\eta}_X$ : R&D에 대한 수출수요(X) 탄력성 ${\eta}_A$ : R&D에 대한 내수수요(A) 탄력성 만일, ${\eta}_X$에 영향을 미치는 요인 중에서 R&D에 대한 미국의 수입탄력성이 작다면 이는 우리나라 R&D에 대한 총수출 수요탄력성을 감소시키는 요인으로 작용하게 된다. 둘째, 우리나라 무역에 있어 일반적으로 산업 내 무역지수는 낮은 경향을 보이는데 한미교역의 경우, 산업내 무역지수는 이 평균치보다 더 낮다. 이는 한미간 무역에 있어 아직 산업내 무역보다 산업특화의 중요성이 다른 국가간 무역보다 더 중요함을 나타낸다. 셋째, 대체적으로 1990년대에 들어와 한국의 경공업상품의 경쟁력이 떨어지고 있다. 특히, 1980년대 한국의 대미 주력 수출품이었던 의류 및 신발제품의 경우 대미수출이 감소세를 나타내고 있다. 넷째, 수출은 기술활동에 의해 많은 영향을 받는다. 분석과정에서 기술변수는 기술투입 또는 기술산출로 측정할 수 있다. 기술투입으로는 R&D 투자, 과학연구인력 등이 있고 기술산출 변수로는 특허, 생산성 등의 변수가 있다. 본고에서는 기술활동 또는 기술수준을 R&D 투자변수를 통해서만 측정하였지만, 과학연구인력 등 다른 변수 또는 둘 이상 다수의 변수를 사용하여 수출에 미치는 영향을 살펴볼 수도 있다. 이상에서 논의한 이론적 실증적 분석을 요약하면 다음과 같다. 우리나라의 대미수출이 증가하는 부문이 존재하게 된다. 그러나, 이 부문은 주로 규모의 경제가 존재하는 불완전경쟁적 산업이어서 산업내 무역의 형태로 대미수출은 증가하게 된다. 이 효과가 우리나라가 기존에 비교우위를 지니는 전통산업(경공업)에서의 수출규모만큼 크게 증가하지 못하게 되어 총 수출규모는 그리 크게 증가하지 못하게 된다. 즉, <그림 2>에서 우리나라의 기술혁신이 X수출을 다소 증가시키지만 규모의 경제가 존재하지 않은 경우의 총 수출 Y에 비해 Y

• 한국농림기상학회지
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• 제17권2호
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• pp.108-125
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• 2015

다수의 기후요소를 지수화하고 특정지역의 기후 자원량을 분석하여, 종합 및 판단하는 과정은 특정지역의 농업기후자원의 특성을 한 눈에 알 수 있게 한다. 농업기후자원의 특징을 단순 명료하게 표현한 것을 농업기후지수라고 하는데, 이 지수는 기후자원(예, 기온, 일사, 강수)으로부터 작물의 생육과 수량 추측을 위한 가능성과 여러 가지 영농기술을 실시하는데 필요한 기초자료를 제공함으로써 농업생산성의 주요 지표가 될 수 있다. 그러나 농업기후지수는 절대적인 것이 아니기 때문에 기후변화에 따라 항상 변화할 수 있다. 최근 IPCC 제5차 평가보고서에서 온실가스 대표경로(RCP)에 따른 시나리오가 많은 연구에 이용됨에 따라서 기후정보의 역학 및 통계적 규모축소를 통한 미래기후변화전망정보의 불확실성을 고려한 연구들이 활발히 진행되고 있다. 본 연구에서는 IPCC 제5차 평가 보고서에 사용된 RCP 시나리오를 기반으로 비모수적 분위사상법을 이용한 상세화된 기후변화 전망정보를 바탕으로 한반도의 농업기후지수(예, 식물기간 및 작물기간, 생장도일, 무상기간)의 시공간적인 변화와 불확실성을 평가하였다. 동일한 과거 기간에 대하여 기후모델(GCM)으로부터 계산된 농업기후지수와 관측자료에 의해 계산된 농업기후지수를 비교한 결과, KMA-12.5km를 제외하고 사용된 8개 개별 GCM의 농업기후지수의 각각의 평균은 4대강 유역 모두에서 관측자료에 의해 계산된 값의 평균과 비교적 잘 일치하여 개별 GCM 뿐만 아니라 다중모델앙상블(MME)의 과거기후 재현성에는 문제가 없는 것으로 확인하였다. 또한 불확실성을 고려하기 위한 MME 계산에서 사용되는 GCM의 개수가 무한적으로 증가한다고 해서 오차가 줄어들지 않았다. 추가 연구가 계속 필요하지만, 본 연구에서 3-4개의 GCM을 사용하는 경우 확실하게 오차가 개선되기 시작하였으며, 대체로 7-8개 이후부터는 더 이상 오차가 개선되지 않았다. 미래전망 결과에서, 4대강 유역 전체에 대하여 inmcm4가 과거 기간의 MME에 대한 RCP 4.5에서 1% 증가, RCP 8.5에서 2% 증가로 9개 개별 GCM 중에서 가장 낮았고, CanESM이 과거 기간의 MME에 대하여 RCP 4.5에서 10%, RCP 8.5에서 15% 증가로 가장 높은 증가를 보였다. 4대강 유역의 시공간분포의 변화에서 관측자료와 다른 경향을 보이는 개별 GCM이 있어서 지형 특성과 개별 GCM의 일변동 특성을 반영할 수 있는 상세화 방법의 개선 및 개발이 필요하다. 도출 및 평가된 본 연구의 농업기후지수는 농업용 상세 전자기후도와의 활용뿐만 아니라, 후속 연구를 위한 농업이상기후지수 및 생산성지수의 평가에 활용될 수 있을 것이다. 예를 들면, 낙동강 유역과 영산-섬진강 유역의 무상기간 증가로부터 '겨울기간이 짧아질 수 있다'라고 가정할 경우, 농업이상 기후지수(예, 저온발생빈도) 분석을 통해 겨울작물의 생산성지수의 불확실성 증감 혹은 재배시스템(예, 이모작 혹은 이기작 등)의 변화에 대한 불확실성 증감 등에 대한 평가에 활용될 수 있을 것이다.

• 한국수자원학회논문집
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• 제54권10호
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• pp.795-805
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• 2021

본 연구는 소양강댐 유역을 대상으로 LSTM 기반의 일유출량 추정 딥러닝 모형을 개발한 후, 모형구조 및 입력자료의 다양한 조합에 대한 모형의 정확도를 살폈다. 첫 12년(1997.1.1-2008.12.31) 동안의 유역평균 일강수량, 일기온, 일풍속 (이상 입력), 일평균 유량 (출력)으로 이루어진 데이터베이스를 기반으로 모형을 구축하였으며, 이후 12년(2009.1.1-2020.12.31) 동안의 자료를 사용하여 Nash-Sutcliffe Model Efficiency Coefficient (NSE)와 RMSE를 살폈다. 가장 높은 정확도를 보인 조합은 64개의 은닉유닛을 가진 LSTM 모형 구조에 가능한 모든 입력자료(12년치의 일강수량, 일기온, 일풍속)를 활용한 경우로서 검증기간의 NSE와 RMSE는 각각 0.862와 76.8 m³/s를 기록하였다. LSTM의 은닉유닛이500개를 초과하는 경우 과적합으로 인한 모형의 성능 저하가 나타나기 시작했으며, 1000개를 초과하는 경우 과적합 문제가 두드러졌다. 12년치의 일강수만 입력자료로 활용한 경우에도 매우 높은 성능(NSE=0.8~0.84)의 모형이 구축되었으며, 한 해의 자료만을 활용하여 학습한 경우에도 충분히 활용 가능한 정확도(NSE=0.63~0.85)를 가진 모형을 구축할 수 있었다. 특히 유량의 변동성이 큰 한 해의 자료만을 활용하여 모형을 학습한 경우 매우 높은 정확도(NSE=0.85)의 모형이 구축되었다. 학습자료가 중유량과 양극한의 유량을 모두 포함한 경우라면 5년 이상의 입력자료는 모형의 성능을 크게 개선시키지 못했다.

• 지능정보연구
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• 제27권3호
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• pp.175-197
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• 2021

최근 딥 러닝 기술의 발전으로 뉴스, 블로그 등 다양한 문서에 포함된 텍스트 분석에 딥 러닝 기술을 활용하는 연구가 활발하게 수행되고 있다. 다양한 텍스트 분석 응용 가운데, 텍스트 분류는 학계와 업계에서 가장 많이 활용되는 대표적인 기술이다. 텍스트 분류의 활용 예로는 정답 레이블이 하나만 존재하는 이진 클래스 분류와 다중 클래스 분류, 그리고 정답 레이블이 여러 개 존재하는 다중 레이블 분류 등이 있다. 특히, 다중 레이블 분류는 여러 개의 정답 레이블이 존재한다는 특성 때문에 일반적인 분류와는 상이한 학습 방법이 요구된다. 또한, 다중 레이블 분류 문제는 레이블과 클래스의 개수가 증가할수록 예측의 난이도가 상승한다는 측면에서 데이터 과학 분야의 난제로 여겨지고 있다. 따라서 이를 해결하기 위해 다수의 레이블을 압축한 후 압축된 레이블을 예측하고, 예측된 압축 레이블을 원래 레이블로 복원하는 레이블 임베딩이 많이 활용되고 있다. 대표적으로 딥 러닝 모델인 오토인코더 기반 레이블 임베딩이 이러한 목적으로 사용되고 있지만, 이러한 기법은 클래스의 수가 무수히 많은 고차원 레이블 공간을 저차원 잠재 레이블 공간으로 압축할 때 많은 정보 손실을 야기한다는 한계가 있다. 이에 본 연구에서는 오토인코더의 인코더와 디코더 각각에 스킵 연결을 추가하여, 고차원 레이블 공간의 압축 과정에서 정보 손실을 최소화할 수 있는 레이블 임베딩 방법을 제안한다. 또한 학술연구정보서비스인 'RISS'에서 수집한 학술논문 4,675건에 대해 각 논문의 초록으로부터 해당 논문의 다중 키워드를 예측하는 실험을 수행한 결과, 제안 방법론이 기존의 일반 오토인코더 기반 레이블 임베딩 기법에 비해 정확도, 정밀도, 재현율, 그리고 F1 점수 등 모든 측면에서 우수한 성능을 나타냄을 확인하였다.

• 한국수자원학회논문집
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• 제54권spc1호
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• pp.1107-1118
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• 2021

지구온난화로 인해 발생한 기후변화는 한반도의 홍수, 가뭄 등의 발생빈도를 증가시켰으며, 이로 인해 인적, 물적 피해가 증가한 것으로 나타났다. 수재해 대비 및 대응을 위해서는 국가 차원의 수자원 관리 계획 수립이 필요하며, 유역 단위 수자원 관리를 위해서는 장기간 관측된 유량 자료를 이용하여 도출된 유량지속곡선이 필요하다. 전통적으로 수자원 분야에서 유량지속곡선을 도출하기 위하여 물리적 기반의 강우-유출 모형이 많이 사용되고 있으며, 최근에는 데이터 기반의 딥러닝 기법을 이용한 유출량 예측 기법에 관한 연구가 진행된 바 있다. 물리적 기반의 모형은 수문학적으로 신뢰도 높은 결과를 도출할 수 있으나, 사용자의 높은 이해도가 요구되며, 모형 구동 시간이 오래 걸릴 수 있는 단점이 있다. 데이터 기반의 딥러닝 기법의 경우 입력 자료가 간단하며, 모형 구동 시간이 비교적 짧으나 입력 및 출력자료 간의 관계가 블랙박스로 처리되어 수리·수문학적 특성을 반영할 수 없는 단점이 있다. 본 연구에서는 물리적 기반 모형으로 국내외에서 적용성이 검증된 Soil Water Assessment Tool (SWAT)의 매개변수 보정(Calibration)을 통해 장기간의 결측치 없는 데이터를 산출하고, 이를 데이터 기반 딥러닝 기법인 Long Short-term Memory (LSTM)의 훈련(Training) 데이터로 활용하였다. 시계열 데이터 분석 결과 검·보정 전체 기간('07-'18) 동안 Nash-Sutcliffe Efficiency (NSE)와 적합도 비교를 위한 결정계수는 각각 0.04, 0.03 높게 도출되어 모형에서 도출된 SWAT의 결과가 LSTM보다 전반적으로 우수한 것으로 나타났다. 또한, 모형에서 도출된 연도별 시계열 자료를 내림차순하여 산정된 유량지속곡선과 관측유량 기반의 유량지속곡선과 비교한 결과 NSE는 SWAT과 LSTM 각각 0.95, 0.91로 나타났으며, 결정계수는 0.96, 0.92로 두 모형 모두 우수한 성능을 보였다. LSTM 모형의 경우 저유량 부분 모의의 정확도 개선이 필요하나, 방대한 입력 자료로 인해 모형 구축 및 구동 시간이 오래 걸리는 대유역과 입력 자료가 부족한 미계측 유역의 유량지속곡선 산정 등에 활용성이 높을 것으로 판단된다.

• 지능정보연구
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• 제25권4호
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• pp.141-154
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• 2019

인터넷 기술과 소셜 미디어의 빠른 성장으로 인하여, 구조화되지 않은 문서 표현도 다양한 응용 프로그램에 사용할 수 있게 마이닝 기술이 발전되었다. 그 중 감성분석은 제품이나 서비스에 내재된 사용자의 감성을 탐지할 수 있는 분석방법이기 때문에 지난 몇 년 동안 많은 관심을 받아왔다. 감성분석에서는 주로 텍스트 데이터를 이용하여 사람들의 감성을 사전 정의된 긍정 및 부정의 범주를 할당하여 분석하며, 이때 사전 정의된 레이블을 이용하기 때문에 다양한 방향으로 연구가 진행되고 있다. 초기의 감성분석 연구에서는 쇼핑몰 상품의 리뷰 중심으로 진행되었지만, 최근에는 블로그, 뉴스기사, 날씨 예보, 영화 리뷰, SNS, 주식시장의 동향 등 다양한 분야에 적용되고 있다. 많은 선행연구들이 진행되어 왔으나 대부분 전통적인 단일 기계학습기법에 의존한 감성분류를 시도하였기에 분류 정확도 면에서 한계점이 있었다. 본 연구에서는 전통적인 기계학습기법 대신 대용량 데이터의 처리에 우수한 성능을 보이는 딥러닝 기법과 딥러닝 중 CNN과 LSTM의 조합모델을 이용하여 감성분석의 분류 정확도를 개선하고자 한다. 본 연구에서는 대표적인 영화 리뷰 데이터셋인 IMDB의 리뷰 데이터 셋을 이용하여, 감성분석의 극성분석을 긍정 및 부정으로 범주를 분류하고, 딥러닝과 제안하는 조합모델을 활용하여 극성분석의 예측 정확도를 개선하는 것을 목적으로 한다. 이 과정에서 여러 매개 변수가 존재하기 때문에 그 수치와 정밀도의 관계에 대해 고찰하여 최적의 조합을 찾아 정확도 등 감성분석의 성능 개선을 시도한다. 연구 결과, 딥러닝 기반의 분류 모형이 좋은 분류성과를 보였으며, 특히 본 연구에서 제안하는 CNN-LSTM 조합모델의 성과가 가장 우수한 것으로 나타났다.

• 대한의용생체공학회:의공학회지
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• 제6권2호
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• pp.1-8
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• 1985

The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70$\pm$1.32mmHg/min)compared to CF dialyzers(4.32$\pm$0.55mmHg/min)(p<0.05). However, there was no observable difference in the UFR between the two dialyzers. Neither APD nor UFR showed any significant increase with an increasing number of reuses for up to more than 20reuses. A substantial number of failures observed in APD(larger than 20mmHe/min)on the reused dialyzers(2 out of 40 CP and S out 26 C-DAK) were attributed to the Possible damage on the fibers. The CF 15-11 HFDs which failed APD test did not show changes in the UFR compared to normal dialyzers indicating that APD is a more sensitive test than UFR test to evaluate the integrity of the fibers. 30527 T00401030527 ^x For quantitative measurement of reflected light from a clinical diagnostic strip, a prototype old reflectance photometer was designed. The strip loader and cassette were made to obtain more accurate reflectance parameters. The strip was illuminated at 45˚c through optical fiber and the intensity of reflected light was determined at rectanguLat angle using a photodiode. The kubelka-munk coefficient and reflection optical density were determined ar four different wavelengths(500, 550, 570 and 610nm) for blood glucose strip. For higher concentration than 300mg/41 about glucose, a saturation state of abforbance was observed at 500, 550 and 570nm. The correlation between glucose concentration and parameters was the best at 610nm. 30535 T00401030535 ^x Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100, 300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise. 30536 T00401030536 ^x We investigated the structural geometry of thirty-eight Korean femurs. The purpose of this study is to identify major geometrical differences between Korean femurs 3nd others that we believe belong to Caucasians so that we would be able to get insights into the femoral component design that fits Asians including Koreans. We utilized computerized tomography (CT) images of femurs extracted from cadavers. The CT images were transformed into bitmap data by using a film scanner, and then analyzed by using a commercially available software called Image v.1.0 and a Macintosh IIci computer.The resulting data were compared with already published data. The major results show that the geometry of the Korean femurs is significantly different from that of Caucasians: (1) the anteversion angle and the canal flare index are greater by the amount of approximately 8˚ and 0.5, respectively, (2) the shape of the isthmus cross section is more round, and (3) the distance between the teaser trochanter and the proximal border of the isthmus is shelter by about 15 mm. The results suggested that the femoral component suitable for Asians should be different from the currently-used components designed and manufactured mostly by European or American companies. 30537 T00401030537 ^x It is well known that nonlinear propagation characteristics of the wave in the tissue may give very useful information for the medical diagnoisis. In this paper, a new method to detect nonlinear propagation characteristics of the internal vibration in the tissue for the low frequency mechanical vibration by using bispectral analysis is proposed. In the method, low frequency vibration of f0( = 100Hz) is applied on the surface of the object, and the waveform of the internal vibration x (t) is measured from Doppler frequency modulation of silmultaneously transmitted probing ultrasonic waves. Then, the bispectra of the signal x (t) at the frequencies (f0, f0) and (f0, 2f0) are calculated to estimate the nonlinear propagation characteristics as their magnitude ratio, w here since bispectrum is free from the gaussian additive noise we can get the value with high S/N. Basic experimental system is constructed by using 3.0 MHz probing ultrasonic waves and the several experiments are carried out for some phantoms. Results show the superiority of the proposed method to the conventional method using power spectrum and also its usefulness for the tissue characterization. 30541 T00401030541 ^x This paper describes the implementation of a computerized radial pulse diagnosis by aids of a clinical expert. On this base, we composed of the radial pulse diagnosis system in korean traditional medicine. The system composed of a radial pulse wave detection system and a radial pulse diagnosis system. With a detection system, we detected Inyoung and Cheongu radial pulse wave and processed it. Then, we have got the characteristic parameters of radial pulse wave and also quantified that according to the method of Inyoung-Cheongu Comparison Radial Pulse Diagnosis. We defined the jugement standard of radial pulse diagnosis system and then we confirmed the possibility for realization of automatic radial pulse diagnosis in korean traditional medicine. 30545 T00401030545 ^x Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, immunomagnetic cell separation. To synthesize microspheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio of synthesized microspheres was always smaller than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6~13 times higher than that of the microspheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin).The effect of the kind and the amount of surface functional group was also examined. 30575 T00401030575 ^x A medical image workstation was developed using multimedia technique. The system based on PC-486DX was designed to acquire medical images produced by medical imaging instruments and related audio information, that is, doctors' reporting results. Input information was processed and analyzed, then the results were presented in the form of graph and animation. All the informations of the system were hierarchically related with the image as the apex. Processing and analysis algorithms were implemented so that the diagnostic accuracy could be improved. The diagnosed information can be transferred for patient diagnosis through LAN(local area network). 30592 T00401030592 ^x In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensional optic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the intfrared thermography system composed of the proposed optic system has the temperature resolution of 0.1˚c under the spatial resolution of lmrad, the image matrix size of 256 X 240, and tile imaging time of 4 seconds. 30593 T00401030593 ^x In this paper, MIIS (Medical Image Information System) has been designed and implemented using INGRES RDBMS, which is based on a client/server architecture. The implemented system allows users to register and retrieve patient information, medical images and diagnostic reports. It also provides the function to display these information on workstation windows simultaneously by using the designed menu-driven graphic user interface. The medical image compression/decompression techniques are implemented and integrated into the medical image database system for the efficient data storage and the fast access through the network. 30594 T00401030594 ^x In this paper, computerized BEAM was implemented for the space domain analysis of EEG. Trans-formation from temporal summation to two-dimensional mappings is formed by 4 nearest point inter-polaton method. Methods of representation of BEAM are two. One is dot density method which classify brain electrical potential 9 levels by dot density of gray levels and the other is colour method which classify brain electrical 12 levels by red-green colours. In this BEAM, instantaneous change and average energy distribution over any arbitrary time interval of brain electrical activity could be observed and analyzed easily. In the frequency domain, the distribution of energy spectrum of a special band can easily be distinguished normality and abnormality. 30608 T00401030608 ^x Laboratory information system (LIS) is a key tool to manage laboratory data in clinical pathology. Our department has developed an information system for routine hematology using down-sized computer system. We have used an IBM 486 compatible PC with 16MB main memory, 210 MB hard disk drive, 9 RS-232C port and 24 pin dot printer. The operating system and database management system were SCO UNIX and SCO foxbase, respectively. For program development, we used Xbase language provided by SCO foxbase. The C language was used for interface purpose. To make the system use friendly, pull-down menu was used. The system connected to our hospital information system via application program interface (API), so the information related to patient and request details is automatically transmitted to our computer. Our system interfaced with fwd complete blood count analyzers(Sysmex NE-8000 and Coulter STKS) for unidirectional data tansmission from analyzer to computer. The authors suggests that this system based on down-sized computer could provide a progressive approach to total LIS based on local area network, and the implemented system could serve as a model for other hospital's LIS for routine hematology. 30609 T00401030609 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength. 30618 T00401030618 ^x This paper is a study on the design of adptive filter for QRS complex detection. We propose a simple adaptive algorithm to increase capability of noise cancelation in QRS complex detection with two stage adaptive filter. At the first stage, background noise is removed and at the next stage, only spectrum of QRS complex components is passed. Two adaptive filters can afford to keep track of the changes of both noise and QRS complex. Each adaptive filter consists of prediction error filter and FIR filter The impulse response of FIR filter uses coefficients of prediction error filter. The detection rates for 105 and 108 of MIT/BIH data base were 99.3% and 97.4% respectively. 30619 T00401030619 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased. 30620 T00401030620 ^x We have developed a monoleaflet polymer valve as an inexpensive and viable alternative, especially for short-term use in the ventricular assist device or total artificial heart. The frame and leaflet of the polymer valve were made from polyurethane, To evaluate the hemodynamic performance of the polymer valve a comparative study of flow dynamics past a polymer valve and a St. Jude Medical prosthetic valve under physiological pulsatile flow conditions in vitro was made. Comparisons between the valves were made on the transvalvular pressure drop, regurgitation volume and maximum valve opening area. The polymer valve showed smaller regurgitation volume and transvalvular pressure drop compared to the mechanical valve at higher heart rate. The results showed that the functional characteristics of the polymer valve compared favorably with those of the mechanical valve at higher heart rate. 30621 T00401030621 ^x Explosive evaporative removal process of biological tissue by absorption of a CW laser has been simulated by using gelatin and a multimode Nd:YAG laser. Because the point of maximun temperature of laser-irradiated gelatin exists below the surface due to surface cooling, evaporation at the boiling temperature is made explosively from below the surface. The important parameters of this process are the conduction loss to laser power absorption (defined as the conduction-to-laser power parameter, Nk), the convection heat transfer at the surface to conduction loss (defined as Bi), dimensionless extinction coefficient (defined as Br.), and dimensionless irradiation time (defined as Fo). Dependence of Fo on Nk and Bi has been observed by experiment, and the results have been compared with the numerical results obtained by solving a 2-dimensional conduction equation. Fo and explosion depth (from the surface to the point of maximun temperature) are increased when Nk and Bi are increased.To find out the minimum laser power for explosive evaporative removal process, steady state analysis has been also made. The limit of Nk to induce evaporative removal, which is proportional to the inverse of the laser power, has been obtained. 30622 T00401030622 ^x N1 and N2 gross neural action potentials were measured from the round window of the guinea pig cochlea at the onset of the acoustic stimuli. N1-N2 audiograms were made by means of regulating stimulant intensities in order to produce constant N1-N2 potentials as criteria for different input tone pip frequencies. The lowest threshold was measured with an input tone pip I5 dB SPL in intensity and 12 KHz in frequency when the animal was in normal physiological condition. The procedure of experimental measurements is explained in detail. This experimental approach is very useful for the investigation of the Cochlear function. Both noN1inear and active functions of the Cochlea can be monitored by N1-N2 audiograms. 30623 T00401030623 ^x In electrical impedance tomography(EIT), we use boundary current and voltage measurements toprovide the information about the cross-sectional distribution of electrical impedance or resistivity. One of the major problems in EIT has been the inaccessibility of internal voltage or current data in finding the internal impedance values. We propose a new image reconstruction method using internal current density data measured by NMR. We obtained a two-dimensional current density distribution within a phantom by processing the real and imaginary MR images from a 4.77 NMR machine. We implemented a resistivity mage reconstruction algorithm using the finite element method and sensitivity matrix. We presented computer simulation results of the mage reconstruction algorithm and furture direction of the research. 30624 T00401030624 ^x A new method of digital image analysis technique for discrimination of cancer cell was presented in this paper. The object image was the Thyroid eland cells image that was diagnosed as normal and abnormal (two types of abnormal: follicular neoplastic cell, and papillary neoplastic cell), respectively. By using the proposed region segmentation algorithm, the cells were segmented into nucleus. The 16 feature parameters were used to calculate the features of each nucleus. A9 a consequence of using dominant feature parameters method proposed in this paper, discrimination rate of 91.11% was obtained for Thyroid Gland cells. 30625 T00401030625 ^x An electrical stimulator was designed to induce locomotion for paraplegic patients caused by central nervous system injury. Optimal stimulus parameters, which can minimize muscle fatigue and can achieve effective muscle contraction were determined in slow and fast muscles in Sprague-Dawley rats. Stimulus patterns of our stimulator were designed to simulate electromyographic activity monitored during locomotion of normal subjects. Muscle types of the lower extremity were classified according to their mechanical property of contraction, which are slow muscle (msoleus m.) and fast muscle (medial gastrocneminus m., rectus femoris m., vastus lateralis m.). Optimal parameters of electrical stimulation for slow muscles were 20 Hz, 0.2 ms square pulse. For fast muscle, 40 Hz, 0.3 ms square pulse was optimal to produce repeated contraction. Higher stimulus intensity was required when synergistic muscles were stimulated simultaneously than when they were stimulated individually. Electrical stimulation for each muscle was designed to generate bipedal locomotion, so that individual muscles alternate contraction and relaxation to simulate stance and swing phases. Portable electrical stimulator with 16 channels built in microprocessor was constructed and applied to paraplegic patients due to lumbar cord injury. The electrical stimulator restored partially gait function in paraplegic patients. 30626 T00401030626 ^x Two-Dimensional modelling of the Cochlear biomechanics is presented in this paper. The Laplace partial differential equation which represents the fluid mechanics of the Cochlea has been transformed into two-dimensional electrical transmission line. The procedure of this transformation is explained in detail. The comparison between one and two dimensional models is also presented. This electrical modelling of the basilar membrane (BM) is clearly useful for the next approach to the further. Development of active elements which are essential in the producing of the sharp tuning of the BM. This paper shows that two-dimension model is qualitatively better than one-dimensional model both in amplitude and phase responses of the BM displacement. The present model is only for frequency response. However because the model is electrical, the two-dimensional transmission line model can be extended to time response without any difficult. 30627 T00401030627 ^x A method has been proposed for the fully automatic detection of left ventricular endocardial boundary in 2D short axis echocardiogram using geometric model. The procedure has the following three distinct stages. First, the initial center is estimated by the initial center estimation algorithm which is applied to decimated image. Second, the center estimation algorithm is applied to original image and then best-fit elliptic model estimation is processed. Third, best-fit boundary is detected by the cost function which is based on the best-fit elliptic model. The proposed method shows effective result without manual intervention by a human operator. 30628 T00401030628 ^x The intelligent trajectory control method that controls moving direction and average velocity for a prosthetic arm is proposed by pattern recognition and force estimations using EMG signals. Also, we propose the real time trajectory planning method which generates continuous accelleration paths using 3 stage linear filters to minimize the impact to human body induced by arm motions and to reduce the muscle fatigue. We use combination of MLP and fuzzy filter for pattern recognition to estimate the direction of a muscle and Hogan's method for the force estimation. EMG signals are acquired by using a amputation simulator and 2 dimensional joystick motion. The simulation results of proposed prosthetic arm control system using the EMf signals show that the arm is effectively followed the desired trajectory depended on estimated force and direction of muscle movements. 30638 T00401030638 ^x A new neural network architecture for the recognition of patterns from images is proposed, which is partially based on the results of physiological studies. The proposed network is composed of multi-layers and the nerve cells in each layer are connected by spatial filters which approximate receptive fields in optic nerve fields. In the proposed method, patterns recognition for complicated images is carried out using global features as well as local features such as lines and end-points. A new generating method of matched filers representing global features is proposed in this network. 30659 T00401030659 ^x An implementation scheme of the magnetic nerve stimulator using a switching mode power supply is proposed. By using a switching mode power supply rather than a conventional linear power supply for charging high voltage capacitors, the weight and size of the magnetic nerve stimulator can be considerably reduced. Maximum output voltage of the developed magnetic nerve stimulator using the switching mode power supply is 3, 000 volts and switching time is about 100 msec. Experimental results or human nerve stimulations using the developed stimulator are presented. 30768 T00401030768 ^x In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.SpO2 with Plethysmograph.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
• /
• 한국우주과학회 1993년도 한국우주과학회보 제2권2호
• /
• pp.17-17
• /
• 1993

The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70${\pm}$1.32mmHg/min)compared to CF dialyzers(4.32${\pm}$0.55mmHg/min)(p<0.05). However, there was no observable difference in the UFR between the two dialyzers. Neither APD nor UFR showed any significant increase with an increasing number of reuses for up to more than 20reuses. A substantial number of failures observed in APD(larger than 20mmHe/min)on the reused dialyzers(2 out of 40 CP and S out 26 C-DAK) were attributed to the Possible damage on the fibers. The CF 15-11 HFDs which failed APD test did not show changes in the UFR compared to normal dialyzers indicating that APD is a more sensitive test than UFR test to evaluate the integrity of the fibers. 30527 T00401030527 ^x For quantitative measurement of reflected light from a clinical diagnostic strip, a prototype old reflectance photometer was designed. The strip loader and cassette were made to obtain more accurate reflectance parameters. The strip was illuminated at 45˚c through optical fiber and the intensity of reflected light was determined at rectanguLat angle using a photodiode. The kubelka-munk coefficient and reflection optical density were determined ar four different wavelengths(500,550,570 and 610nm) for blood glucose strip. For higher concentration than 300mg/41 about glucose, a saturation state of abforbance was observed at 500,550 and 570nm. The correlation between glucose concentration and parameters was the best at 610nm. 30535 T00401030535 ^x Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100,300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise. 30536 T00401030536 ^x We investigated the structural geometry of thirty-eight Korean femurs. The purpose of this study is to identify major geometrical differences between Korean femurs 3nd others that we believe belong to Caucasians so that we would be able to get insights into the femoral component design that fits Asians including Koreans. We utilized computerized tomography (CT) images of femurs extracted from cadavers. The CT images were transformed into bitmap data by using a film scanner, and then analyzed by using a commercially available software called Image v.1.0 and a Macintosh IIci computer.The resulting data were compared with already published data. The major results show that the geometry of the Korean femurs is significantly different from that of Caucasians: (1) the anteversion angle and the canal flare index are greater by the amount of approximately 8˚ and 0.5, respectively, (2) the shape of the isthmus cross section is more round, and (3) the distance between the teaser trochanter and the proximal border of the isthmus is shelter by about 15 mm. The results suggested that the femoral component suitable for Asians should be different from the currently-used components designed and manufactured mostly by European or American companies. 30537 T00401030537 ^x It is well known that nonlinear propagation characteristics of the wave in the tissue may give very useful information for the medical diagnoisis. In this paper, a new method to detect nonlinear propagation characteristics of the internal vibration in the tissue for the low frequency mechanical vibration by using bispectral analysis is proposed. In the method, low frequency vibration of f0( = 100Hz) is applied on the surface of the object, and the waveform of the internal vibration x (t) is measured from Doppler frequency modulation of silmultaneously transmitted probing ultrasonic waves. Then, the bispectra of the signal x (t) at the frequencies (f0, f0) and (f0, 2f0) are calculated to estimate the nonlinear propagation characteristics as their magnitude ratio, w here since bispectrum is free from the gaussian additive noise we can get the value with high S/N. Basic experimental system is constructed by using 3.0 MHz probing ultrasonic waves and the several experiments are carried out for some phantoms. Results show the superiority of the proposed method to the conventional method using power spectrum and also its usefulness for the tissue characterization. 30541 T00401030541 ^x This paper describes the implementation of a computerized radial pulse diagnosis by aids of a clinical expert. On this base, we composed of the radial pulse diagnosis system in korean traditional medicine. The system composed of a radial pulse wave detection system and a radial pulse diagnosis system. With a detection system, we detected Inyoung and Cheongu radial pulse wave and processed it. Then, we have got the characteristic parameters of radial pulse wave and also quantified that according to the method of Inyoung-Cheongu Comparison Radial Pulse Diagnosis. We defined the jugement standard of radial pulse diagnosis system and then we confirmed the possibility for realization of automatic radial pulse diagnosis in korean traditional medicine. 30545 T00401030545 ^x Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, immunomagnetic cell separation. To synthesize microspheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio of synthesized microspheres was always smaller than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6~13 times higher than that of the microspheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin).The effect of the kind and the amount of surface functional group was also examined. 30575 T00401030575 ^x A medical image workstation was developed using multimedia technique. The system based on PC-486DX was designed to acquire medical images produced by medical imaging instruments and related audio information, that is, doctors' reporting results. Input information was processed and analyzed, then the results were presented in the form of graph and animation. All the informations of the system were hierarchically related with the image as the apex. Processing and analysis algorithms were implemented so that the diagnostic accuracy could be improved. The diagnosed information can be transferred for patient diagnosis through LAN(local area network). 30592 T00401030592 ^x In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensional optic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the intfrared thermography system composed of the proposed optic system has the temperature resolution of 0.1˚c under the spatial resolution of lmrad, the image matrix size of 256 X 240, and tile imaging time of 4 seconds. 30593 T00401030593 ^x In this paper, MIIS (Medical Image Information System) has been designed and implemented using INGRES RDBMS, which is based on a client/server architecture. The implemented system allows users to register and retrieve patient information, medical images and diagnostic reports. It also provides the function to display these information on workstation windows simultaneously by using the designed menu-driven graphic user interface. The medical image compression/decompression techniques are implemented and integrated into the medical image database system for the efficient data storage and the fast access through the network. 30594 T00401030594 ^x In this paper, computerized BEAM was implemented for the space domain analysis of EEG. Trans-formation from temporal summation to two-dimensional mappings is formed by 4 nearest point inter-polaton method. Methods of representation of BEAM are two. One is dot density method which classify brain electrical potential 9 levels by dot density of gray levels and the other is colour method which classify brain electrical 12 levels by red-green colours. In this BEAM, instantaneous change and average energy distribution over any arbitrary time interval of brain electrical activity could be observed and analyzed easily. In the frequency domain, the distribution of energy spectrum of a special band can easily be distinguished normality and abnormality. 30608 T00401030608 ^x Laboratory information system (LIS) is a key tool to manage laboratory data in clinical pathology. Our department has developed an information system for routine hematology using down-sized computer system. We have used an IBM 486 compatible PC with 16MB main memory, 210 MB hard disk drive, 9 RS-232C port and 24 pin dot printer. The operating system and database management system were SCO UNIX and SCO foxbase, respectively. For program development, we used Xbase language provided by SCO foxbase. The C language was used for interface purpose. To make the system use friendly, pull-down menu was used. The system connected to our hospital information system via application program interface (API), so the information related to patient and request details is automatically transmitted to our computer. Our system interfaced with fwd complete blood count analyzers(Sysmex NE-8000 and Coulter STKS) for unidirectional data tansmission from analyzer to computer. The authors suggests that this system based on down-sized computer could provide a progressive approach to total LIS based on local area network, and the implemented system could serve as a model for other hospital's LIS for routine hematology. 30609 T00401030609 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength. 30618 T00401030618 ^x This paper is a study on the design of adptive filter for QRS complex detection. We propose a simple adaptive algorithm to increase capability of noise cancelation in QRS complex detection with two stage adaptive filter. At the first stage, background noise is removed and at the next stage, only spectrum of QRS complex components is passed. Two adaptive filters can afford to keep track of the changes of both noise and QRS complex. Each adaptive filter consists of prediction error filter and FIR filter The impulse response of FIR filter uses coefficients of prediction error filter. The detection rates for 105 and 108 of MIT/BIH data base were 99.3% and 97.4% respectively. 30619 T00401030619 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased. 30620 T00401030620 ^x We have developed a monoleaflet polymer valve as an inexpensive and viable alternative, especially for short-term use in the ventricular assist device or total artificial heart. The frame and leaflet of the polymer valve were made from polyurethane, To evaluate the hemodynamic performance of the polymer valve a comparative study of flow dynamics past a polymer valve and a St. Jude Medical prosthetic valve under physiological pulsatile flow conditions in vitro was made. Comparisons between the valves were made on the transvalvular pressure drop, regurgitation volume and maximum valve opening area. The polymer valve showed smaller regurgitation volume and transvalvular pressure drop compared to the mechanical valve at higher heart rate. The results showed that the functional characteristics of the polymer valve compared favorably with those of the mechanical valve at higher heart rate. 30621 T00401030621 ^x Explosive evaporative removal process of biological tissue by absorption of a CW laser has been simulated by using gelatin and a multimode Nd:YAG laser. Because the point of maximun temperature of laser-irradiated gelatin exists below the surface due to surface cooling, evaporation at the boiling temperature is made explosively from below the surface. The important parameters of this process are the conduction loss to laser power absorption (defined as the conduction-to-laser power parameter, Nk), the convection heat transfer at the surface to conduction loss (defined as Bi), dimensionless extinction coefficient (defined as Br.), and dimensionless irradiation time (defined as Fo). Dependence of Fo on Nk and Bi has been observed by experiment, and the results have been compared with the numerical results obtained by solving a 2-dimensional conduction equation. Fo and explosion depth (from the surface to the point of maximun temperature) are increased when Nk and Bi are increased.To find out the minimum laser power for explosive evaporative removal process, steady state analysis has been also made. The limit of Nk to induce evaporative removal, which is proportional to the inverse of the laser power, has been obtained. 30622 T00401030622 ^x N1 and N2 gross neural action potentials were measured from the round window of the guinea pig cochlea at the onset of the acoustic stimuli. N1-N2 audiograms were made by means of regulating stimulant intensities in order to produce constant N1-N2 potentials as criteria for different input tone pip frequencies. The lowest threshold was measured with an input tone pip I5 dB SPL in intensity and 12 KHz in frequency when the animal was in normal physiological condition. The procedure of experimental measurements is explained in detail. This experimental approach is very useful for the investigation of the Cochlear function. Both noN1inear and active functions of the Cochlea can be monitored by N1-N2 audiograms. 30623 T00401030623 ^x In electrical impedance tomography(EIT), we use boundary current and voltage measurements toprovide the information about the cross-sectional distribution of electrical impedance or resistivity. One of the major problems in EIT has been the inaccessibility of internal voltage or current data in finding the internal impedance values. We propose a new image reconstruction method using internal current density data measured by NMR. We obtained a two-dimensional current density distribution within a phantom by processing the real and imaginary MR images from a 4.77 NMR machine. We implemented a resistivity mage reconstruction algorithm using the finite element method and sensitivity matrix. We presented computer simulation results of the mage reconstruction algorithm and furture direction of the research. 30624 T00401030624 ^x A new method of digital image analysis technique for discrimination of cancer cell was presented in this paper. The object image was the Thyroid eland cells image that was diagnosed as normal and abnormal (two types of abnormal: follicular neoplastic cell, and papillary neoplastic cell), respectively. By using the proposed region segmentation algorithm, the cells were segmented into nucleus. The 16 feature parameters were used to calculate the features of each nucleus. A9 a consequence of using dominant feature parameters method proposed in this paper, discrimination rate of 91.11% was obtained for Thyroid Gland cells. 30625 T00401030625 ^x An electrical stimulator was designed to induce locomotion for paraplegic patients caused by central nervous system injury. Optimal stimulus parameters, which can minimize muscle fatigue and can achieve effective muscle contraction were determined in slow and fast muscles in Sprague-Dawley rats. Stimulus patterns of our stimulator were designed to simulate electromyographic activity monitored during locomotion of normal subjects. Muscle types of the lower extremity were classified according to their mechanical property of contraction, which are slow muscle (msoleus m.) and fast muscle (medial gastrocneminus m., rectus femoris m., vastus lateralis m.). Optimal parameters of electrical stimulation for slow muscles were 20 Hz, 0.2 ms square pulse. For fast muscle, 40 Hz, 0.3 ms square pulse was optimal to produce repeated contraction. Higher stimulus intensity was required when synergistic muscles were stimulated simultaneously than when they were stimulated individually. Electrical stimulation for each muscle was designed to generate bipedal locomotion, so that individual muscles alternate contraction and relaxation to simulate stance and swing phases. Portable electrical stimulator with 16 channels built in microprocessor was constructed and applied to paraplegic patients due to lumbar cord injury. The electrical stimulator restored partially gait function in paraplegic patients. 30626 T00401030626 ^x Two-Dimensional modelling of the Cochlear biomechanics is presented in this paper. The Laplace partial differential equation which represents the fluid mechanics of the Cochlea has been transformed into two-dimensional electrical transmission line. The procedure of this transformation is explained in detail. The comparison between one and two dimensional models is also presented. This electrical modelling of the basilar membrane (BM) is clearly useful for the next approach to the further. Development of active elements which are essential in the producing of the sharp tuning of the BM. This paper shows that two-dimension model is qualitatively better than one-dimensional model both in amplitude and phase responses of the BM displacement. The present model is only for frequency response. However because the model is electrical, the two-dimensional transmission line model can be extended to time response without any difficult. 30627 T00401030627 ^x A method has been proposed for the fully automatic detection of left ventricular endocardial boundary in 2D short axis echocardiogram using geometric model. The procedure has the following three distinct stages. First, the initial center is estimated by the initial center estimation algorithm which is applied to decimated image. Second, the center estimation algorithm is applied to original image and then best-fit elliptic model estimation is processed. Third, best-fit boundary is detected by the cost function which is based on the best-fit elliptic model. The proposed method shows effective result without manual intervention by a human operator. 30628 T00401030628 ^x The intelligent trajectory control method that controls moving direction and average velocity for a prosthetic arm is proposed by pattern recognition and force estimations using EMG signals. Also, we propose the real time trajectory planning method which generates continuous accelleration paths using 3 stage linear filters to minimize the impact to human body induced by arm motions and to reduce the muscle fatigue. We use combination of MLP and fuzzy filter for pattern recognition to estimate the direction of a muscle and Hogan's method for the force estimation. EMG signals are acquired by using a amputation simulator and 2 dimensional joystick motion. The simulation results of proposed prosthetic arm control system using the EMf signals show that the arm is effectively followed the desired trajectory depended on estimated force and direction of muscle movements. 30638 T00401030638 ^x A new neural network architecture for the recognition of patterns from images is proposed, which is partially based on the results of physiological studies. The proposed network is composed of multi-layers and the nerve cells in each layer are connected by spatial filters which approximate receptive fields in optic nerve fields. In the proposed method, patterns recognition for complicated images is carried out using global features as well as local features such as lines and end-points. A new generating method of matched filers representing global features is proposed in this network. 30659 T00401030659 ^x An implementation scheme of the magnetic nerve stimulator using a switching mode power supply is proposed. By using a switching mode power supply rather than a conventional linear power supply for charging high voltage capacitors, the weight and size of the magnetic nerve stimulator can be considerably reduced. Maximum output voltage of the developed magnetic nerve stimulator using the switching mode power supply is 3,000 volts and switching time is about 100 msec. Experimental results or human nerve stimulations using the developed stimulator are presented. 30768 T00401030768 ^x In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.