• Korean Journal of Clinical Pharmacy
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• v.16 no.2
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• pp.101-106
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• 2006

The aim of the present study was to evaluate the bioequivalence of two talniflumate preparations. We used Somalgen tablet (Kun Wha Pharmaceutical Co., Korea.) as a reference drug for bioequivalence of Crimain tablet (Samjini Pharmaceutical Ind. Co., Korea), and performed this whole study according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty four healthy male volunteers, $22.8{\pm}2.2$ years in age and $64.6{\pm}5.3\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 370 mg of talniflumate was orally administered, blood was taken at predetermined time intervals and the concentrations of talniflumate in plasma were determined using HPLC method with UV-detector. The analysis system was validated in specificity, accuracy, precision and linearity. These items of the analysis condition in this study conform to the guideline of KFDA. The pharmacokinetic parameters such as $AUC_t\;and\;C_{max}$ were calculated using the analysis condition we established and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$ and Cmax. $Mean{\pm}SD$ of reference drug and test drug in $AUC_t\;and\;C_{max}$ value were $1.27{\pm}0.58\;({\mu}g/ml{\cdot}hr)\;and\;0.27{\pm}0.13\;({\mu}g/ml)$ and $1.14{\pm}0.46\;({\mu}g/ml{\cdot}hr)\;and\;0.26{\pm}0.10\;({\mu}g/ml)$ respectively. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log (1.25) for $AUC_t\;and\;C_{max}$, respectively. These results indicate that Samjin talniflumate tablet is bioequivalent to reference drug, Somalgen tablet.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.4 no.4
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• pp.95-103
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• 1984

This paper is a study on improving the accuracy of control points by suggesting angular requirements which make geometric conditions to be optimum. For this purpose, a equation, by which the accuracy of control point coordinates measured in an arbitrary station can be estimated, is derived. This equation is integrated and average standard error of the coordinates is computed, so that the optimum location of observatory station is determined. In the case of triangulation, a regular triangle has been generally considered as the best geometric condition, but because the precision of each side is different, the $52.77^{\circ}$ isosceles triangle is founded to be the best one. Also in trigonometric leveling, the geometric condition is founded to be optimum when the base angle of a isosceles triangle is $45^{\circ}$. In control surveying for close-range photogrammetry the optimum relation between base length($B_0$) and object distance($D_0$) can be founded to be as follow; $D_0=0.357587-0.357967B_0+0.308555B_0{^2}$.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.38 no.7
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• pp.607-618
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• 2014

An experimental investigation of turbulent heat transfer during the vertical upward flow of supercritical $CO_2$ was conducted in a circular tube with inner diameter of 4.5 mm. The experiments were conducted at bulk fluid temperatures ranging from 29 to $115^{\circ}C$, pressures from 74.6 to 102.6 bar, local wall heat fluxes from 38 to $234kW/m^2$, and mass fluxes from 208 to $874kg/m^2s$. At moderate wall heat and low mass fluxes, the wall temperature had a noticeable peak value. For observing the buoyancy and flow acceleration effects on heat transfer, the ratios of Nusselt numbers from the experimental data and a reference correlation were compared with the $Bo^*$ and $q^+$ distributions. The flow acceleration parameter $q^+$ appropriately represented the heat transfer phenomena in the experiments. A new heat transfer correlation for the vertical upward flow of the supercritical pressure fluid was developed, and was found to agree with the experimental data with an error margin of ${\pm}30%$.

• Journal of Korea Society of Industrial Information Systems
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• v.11 no.4
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• pp.82-92
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• 2006

In the field of image recognition, research on face recognition has recently attracted a lot of attention. The most important step in face recognition is automatic eye detection researched as a prerequisite stage. Existing eye detection methods for focusing on the frontal face can be mainly classified into two categories: active infrared(IR)-based approaches and image-based approaches. This paper proposes an eye region detection method in non-frontal faces. The proposed method is based on the edge--based method that shows the fastest computation time. To extract eye region in non-frontal faces, the method uses edge orientationhistogram of the global region of faces. The problem caused by some noise and unfavorable ambient light is solved by using proportion of width and height for local information and relationship between components for global information in approximately extracted region. In experimental results, the proposed method improved precision rates, as solving 3 problems caused by edge information and achieves a detection accuracy of 83.5% and a computational time of 0.5sec per face image using 300 face images provided by The Weizmann Institute of Science.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.33 no.2
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• pp.83-94
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• 2015

Recently, the necessity of spatial data in unaccessible area was challenged to set up various plans and policies for preparing the unification and the cooperative projects between South-North Korea. Therefore, this paper planned to evaluate the possibility of adopting the error tolerance in Geometric correction for 1/5,000 digital topographic mapping, using the PLEIADES images and the TerraSAR GCPs (Ground Control Points). The geometric correction was performed by changing the number and placement of GCPs by GPS (Global Positioning System) surveying, as the optimal placement of 5 GCPs were selected considering the geometric stability and steady rate. The positional accuracy evaluated by the TerraSAR GCPs, which were selected by optimal placement of GCPs. The RMSE in control points were X=±0.64m, Y=±0.46m, Z=±0.28m. While the result of geometric correction for PLEIADES images confirmed that the RMSE in control points were X=±0.34m, Y=±0.27m, Z=±0.11m, the RMSE in check points were X=±0.50m, Y=±0.30m, Z=±0.66m. Through this study, we believe if spatial data can integrate with the PLEIADES images and the optimal TerraSAR GCPs, it will be able to obtain the high-precision spatial data for adopting the regulation of 1/5,000 digital topographic map, which adjusts the computation as well as the error bound.

• Journal of Biosystems Engineering
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• v.24 no.6
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• pp.539-546
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• 1999

Some stress for a plant could be detected to a certain degree by plant physiological measuring technique of the state of the art. The capability of early detection of my measuring system depends on kind of plant and kind and level of stress. The objectives of this study were to evaluate the capability of several fast and intact type plant stress detection systems to detect nitrogen deficiency of cucumber in the field. A series of experiment was carried out with four kinds of intact type measuring devices - a chlorophyll content meter, a chlorophyll fluorescence measurement system, an infrared thermometer and an optical spectrometer. The experiments resulted that the chlorophyll content meter could detect the stress of N deficiency at a confidence level higher than 95% on 3rd day for the earliest case and the detection of high precision was possible from 7th day after the stress was applied. The chlorophyll fluorescence measurement system detected the stress at a confidence level higher than 95% on 3rd day for the earliest case but the detection was not as much precise as the chlorophyll content meter. Leaf temperature measurement noted very poor results to detect the stress. Using the spectrometer, sensitive wavelength regions to detect the stress were searched and found out as 562∼564 nm, 700∼724 nm and 1,886∼1,894 nm. With the spectrometer using any of wavelength within the sensitive wavelength region, detection of the stress at a confidence level higher than 95% was possible from 3rd or 4th day after the stress was applied.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.554-560
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• 2020

In the manufacturing process of flat panel displays, a high-precision planar motion stage is used to position a specimen. Stages of this type typically use frictionless linear motors and air bearings, and laser interferometers. Real-time dynamic correction of the yaw motion error is very important because the inevitable yaw motion error of the stage means a change in the specimen orientation. Gantry control is generally used to compensate for yaw motion errors. Flexure units that allow rotational motion are applied to the stage to apply this method to a stage using an air-bearing guide. This paper proposes a method to improve the constant speed motion performance of a H-type XY stage equipped with air bearing and flexure units. When applying the gantry control to the stage, including the flexure units, the cause of the mutual ripple generated from the linear motors is analyzed, and adaptive learning control is proposed to compensate for the mutual ripple. A simulation was performed to verify the proposed method. The speed ripple was reduced to approximately the 22 % level. The ripple reduction was verified by simulating the stage state where yaw motion error occurs.

• Korean Journal of Remote Sensing
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• v.29 no.2
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• pp.209-218
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• 2013

The Sonoran Desert, which is located in North America, has been frequently used for vicarious calibration of many optical sensors in satellites. Although the desert area has good conditions for vicarious calibration (e.g. high reflectance, little vegetation, large area, low precipitation), its adjacency to the sea and large variability in atmospheric water vapor are the disadvantages for vicarious calibration. For vicarious calibration using top-of-atmospheric (TOA) reflectance, the atmospheric variability brings about degraded precision in vicarious calibration results. In this paper, the location with the smallest radiometric variability in TOA reflectance is sought by using 12-year Landsat 5 data, and corrected the TOA reflectance for bidirectional reflectance distribution function (BRDF) which is another major source of variability in TOA reflectance. Experiments show that the mid-western part of the Sonoran Desert has the smallest variability collectively for visible and near-infrared bands, and the variability from the sunarget-sensor geometry can be reduced by the BRDF correction for the visible bands, but not sufficiently for the infrared bands.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.5 no.2
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• pp.109-120
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• 1985

This thesis is a study on multiple close range photogrammetry, and the purpose of this study is to develop the most accurate adjustment method of three dimensional object coordinates. This was achieved by comparing the standard errors of actual data to the computed values from 2 photos and multiple photos. The conventional methods for multiple photos have been analyzed by using geometric model formation. But in this study, the equation of collinearity condition which has been applied to aerial photogrammetry was derived to be a basic principle of close range photogrammetry, and the algorithm for analyzing multiple photos was developed using simultaneous bundle adjustment. The method used in this study, showed more homogeneous accuracy in coordinate and more consistent variance of error than those of conventional methods. It was found that the cases using 3, 4, and 5 photos were more accurate than using 2 photos; the accuracies were improved to 15%, 35%, and 50%, for each case. Thus this study is expected to be useful in measuring the geometry of historic monuments and other structures requiring high accuracy. Also the combined case of multiple photos is considered to be effective for the precise analysis of the objects which are difficult to measure for obstacles.

• Journal of the Korean Institute of Gas
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• v.24 no.5
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• pp.29-38
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• 2020

It is practically difficult to accurately measure the temperature and concentration of a large combustion systems at industrial sites in real time. Temperature measurement using thermocouple, which are mainly used, is a point-measuring method that is less accurate and less reliable to analyze the wide area range of inner combustion system, and has limitations to internal accessibility. In terms of concentration analysis, most measurement methods use sampling method, which are limited by the difficulty of real-time measurement. As a way to overcome these limitations, laser-based measurement methods have been developed continuously. Laser-based measurement are line-average measurement methods with high representation and precision, which are beneficial for the application of large combustion systems. In this study the temperature and concentration were measured in real time by water vapor and oxygen generated during combustion using Tunable Diode Laser Absorption Spectroscopy (TDLAS). The results showed that the average temperature inside the combustion system was 1330℃ and the mean oxygen concentration was 3.3 %, which showed similar tendency with plant monitoring data.