• Title/Summary/Keyword: Pre-validation

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Quantitative impact response analysis of reinforced concrete beam using the Smoothed Particle Hydrodynamics (SPH) method

  • Mokhatar, S.N.;Sonoda, Y.;Kueh, A.B.H.;Jaini, Z.M.
    • Structural Engineering and Mechanics
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    • v.56 no.6
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    • pp.917-938
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    • 2015
  • The nonlinear numerical analysis of the impact response of reinforced concrete/mortar beam incorporated with the updated Lagrangian method, namely the Smoothed Particle Hydrodynamics (SPH) is carried out in this study. The analysis includes the simulation of the effects of high mass low velocity impact load falling on beam structures. Three material models to describe the localized failure of structural elements are: (1) linear pressure-sensitive yield criteria (Drucker-Prager type) in the pre-peak regime for the concrete/mortar meanwhile, the shear strain energy criterion (Von Mises) is applied for the steel reinforcement (2) nonlinear hardening law by means of modified linear Drucker-Prager envelope by employing the plane cap surface to simulate the irreversible plastic behavior of concrete/mortar (3) implementation of linear and nonlinear softening in tension and compression regions, respectively, to express the complex behavior of concrete material during short time loading condition. Validation upon existing experimental test results is conducted, from which the impact behavior of concrete beams are best described using the SPH model adopting an average velocity and erosion algorithm, where instability in terms of numerical fragmentation is reduced considerably.

A Study on the Comparison of Korea GMP with PIC/S GMP for Enhancing International Competecy of Medicinal Product Quality (의약품의 국제적 품질 경쟁력 확보를 위한 의약품실사상호협력기구(PIC/S)와 한국의 GMP 비교연구)

  • Kim, Jeong Yeon;Kwon, Kyenghee
    • YAKHAK HOEJI
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    • v.57 no.6
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    • pp.432-441
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    • 2013
  • It's been almost 20 years since the adoption of Good Manufacturing Practices (GMP) in Korea since 1994. There have been big progresses in the GMP regulations and its implementations. 'New GMP' in 2008 has adopted validation, pre-approval GMP evaluation, annual quality review, etc.. Upon the submission of PIC/S (Pharmaceutical Inspection Cooperation Scheme) application by Korea's Ministry of Food and Drug Safety in April, 2012, Korea is facing new opportunity to level up Korea GMP regulations. As such, this study suggested GMP revision points by comparing and analyzing the differences between PIC/S GMP and Korea GMP. Those areas which GMP is not required such as radiopharmaceuticals and medical gases should adopt GMP. And independent GMP regulation is needed for Active Pharmaceutical Ingredients and investigational medicinal products. Also, those regulations shall be implemented in the higher level of legal status. Finally, rather than pursuing GMP harmonization only for PIC/S membership, GMP improvement in the long term shall be taken into consideration by reflecting current quality issues such as ICH Q8 (Pharmaceutical development), Q9 (Quality Risk Management) and Q10 (Pharmaceutical Quality System).

Quantitative Immunoassay for Polychlorinated Biphenyl Compounds in Electrical Insulating Oils

  • Kim In Soo
    • Proceedings of the Microbiological Society of Korea Conference
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    • 2000.10a
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    • pp.119-127
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    • 2000
  • The development and performance of a competitive indirect immunoassay for the quantitative measurement of polychlorinated biphenyl compounds in insulating oils is presented. Reagent preparation and the assay characterisation, optimisation and validation steps are described. The dynamic range of the assay for Aroclors 1254 and 1260 in methanol was $50-800 {\mu}g\;ml^{-1}$ with $50\%$ signal inhibition values of 217 and $ 212 {\mu}g\;ml^{-1}$ respectively. Impending legislation in the UK is likely to decree that oils containing $ >50 {\mu}g\;ml^{-1}$ PCB be considered contaminated. Assay sensitivity increased with the degree of PCB chlorination. The assay of structurally related compounds of environmental concern yielded cross-reactivity values of under $0.6\%$. The immunoassay proved reliable for the analysis of transformer oils containing $>70{\mu}g\;ml^{-1}$ PCB, but over-estimated PCB levels in oils containing $<20{\mu}g\;ml^{-1}$ of the analyte with the oils requiring pre-treatment using either solid-phase extraction techniques or washing with KOH-ethanol/sulphuric acid to remove matrix interferents. The analytical performance of the assay was compared against a commercially available semi-quantitative immunoassay kit for PCBs in soil and water.

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The Evaluation of Feasibility and Predictive Validity of Comprehensive Korean Frailty Instrument: Using the 2008 and 2011 Living Profiles of Older People Survey in Korea (포괄적 한국 노인 허약사정 도구의 적용가능성과 예측타당도 평가: 2008, 2011년 노인실태조사 자료 이용)

  • Oh, Eunmi;Hong, Gwi-Ryung Son
    • Research in Community and Public Health Nursing
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    • v.28 no.2
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    • pp.206-215
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    • 2017
  • Purpose: This study aimed to verify the predictive validity of Comprehensive Korean Frailty Instrument (CKFI) among older adults. Methods: A secondary analysis of data from a prospective cohort study was conducted. Frailty was determined in older adults (N=9,188) according to the data in 2008 and the effects of frailty on adverse outcomes (such as institutionalization and death) were evaluated according to the data in 2011. The Cardiovascular Health Study (CHS) index was used to compare with the predictive validity of CKFI. Results: The prevalence of frailty was 26.3%. With the CKFI, the frail group had a higher risk of negative health outcomes compared to the robust and pre-frail groups after three years. The two of the highest risks identified using the CKFI and CHS index were institutionalization (5.522 times higher) and mortality (3.210 times higher). For both instruments, the survival analysis revealed that the risk of death increased as the degree of frailty increased. Conclusion: The CKFI consisting of self-report items and multidimensional aspects of frailty can be used as a simple instrument for assessing the frailty of older adults residing in a local community in Korea.

Retrieval of background surface reflectance with pre-running BRD components

  • Choi, Sungwon;Lee, Chang Suk;Seo, Minji;Seong, Noh-hun;Lee, Kyeong-Sang;Han, Kyung-Soo
    • Korean Journal of Remote Sensing
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    • v.32 no.1
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    • pp.61-65
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    • 2016
  • Importance of remote sensing for surface is increased than past. So many countries try to many ways to retrieve surface reflectance. In this study, we study a Bidirectional Reflectance Distribution Function (BRDF) to retrieve surface reflectance. We apply BRDF using observed surface reflectance of SPOT/VEGETATION (VGT-S1) and angular data to get Bidirectional Reflectance Distribution (BRD) coefficients for calculating scattering. And then we apply BRDF in the opposite direction with BRD coefficients and angular data to retrieve Background Surface Reflectance (BSR). The range of BSR is not over $0.4{\mu}m$ (blue), $0.45{\mu}m$ (red), $0.55{\mu}m$ (NIR). And for validation we compare BSR with VGT-S1, there are bias is from 0.0116 to 0.0158 and RMSE is from 0.0459 to 0.0545. As a result, we confirm that BSR is similar to VGT-S1.

LOS Analysis Frame for COSMOS at Isolated Intersections (실시간신호제어 독립교차로 서비스수준 분석 방법론)

  • Kim, Jin-Tae;Kim, Kang-Huy;Lee, Don-Ju
    • Journal of Korean Society of Transportation
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    • v.26 no.4
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    • pp.161-172
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    • 2008
  • The level of service (LOS) evaluation method of the Highway Capacity Manual (HCM) is limited to intersections with pre-timed signal operation, while advanced real-time traffic control systems have been expending in the field. This paper proposes a preliminary framework for LOS analysis at isolated intersections controlled by COSMOS, the real-time traffic control systems robustly utilizing the degree of saturation as basic inputs. The proposed LOS evaluation framework was devised with a pilot model developed to estimate the average cycle length and green times of COSMOS. The validation test showed that the proposed framework was able to accurately project the LOS, which was separately evaluated based upon field data.

Design validation of a composite crash absorber energy to an emergency landing

  • Guida, Michele;Marulo, Francesco;Bruno, Massimiliano;Montesarchio, Bruno;Orlando, Salvatore
    • Advances in aircraft and spacecraft science
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    • v.5 no.3
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    • pp.319-334
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    • 2018
  • In this study, the failure mode and energy absorption capabilities of a composite shock absorber device, during an emergency landing are evaluated. The prototype has been installed and tested in laboratory simulating an emergency landing test condition. The crash absorber presents an innovative configuration able to reduce the loads transmitted to a helicopter fuselage during an emergency landing. It consists of a composite tailored tube installed on the landing gear strut. During an emergency landing this crash absorber system should be able to absorb energy through a pre-designed deformation. This solution, compared to an oleo-pneumatic shock absorber, avoids sealing checks, very high values of the shock absorber pressure, and results to be lighter, easy in maintenance, inspect and use. The activities reported in this paper have become an attractive research field both from the scientific viewpoint and the prospect of industrial applications, because they offer benefits in terms of energy absorbing, weight savings, increasing the safety levels, and finally reducing the costs in a global sense.

Development of a Miniature Aerosol Separator for a Black Carbon Measuring Instrument (블랙카본 측정기용 초소형 사이클론 집진기 개발)

  • An, Ik-Hyun;Lim, Jun-Hyung;Lee, Hyo-Young;Yook, Se-Jin
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.19 no.12
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    • pp.42-48
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    • 2020
  • Given the increasing interest in air pollution, several technologies to measure black carbon (BC) aerosol particles have been developed. As most BC aerosol particles are smaller than 1 ㎛, it is necessary to pre-separate the particles by size before a BC measuring instrument samples the aerosol particles. In this study, a miniature cyclone separator for portable BC measuring instruments was developed. A numerical approach was used to design the miniature cyclone separator with operating flow rates of 50, 100, or 150 mLPM, and then a prototype cyclone separator was manufactured for experimental validation. The numerical results of the cut-off size and pressure drop of the miniature cyclone separator agreed well with the experimental data. The cut-off sizes of the miniature cyclone separator were determined to be 2.9, 0.94, and 0.63 ㎛ for operating flow rates of 50, 100, and 150 mLPM, respectively. Thus, the miniature cyclone separator is suitable for use as a sampling inlet for the portable black carbon measuring instrument to sample BC aerosol or PM2.5 aerosol.

Endoscopic slide-in orbital wall reconstruction for isolated medial blowout fractures

  • Kim, Taewoon;Kim, Baek-Kyu
    • Archives of Craniofacial Surgery
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    • v.21 no.6
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    • pp.345-350
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    • 2020
  • Background: This study evaluated the efficacy of the endoscopic medial orbital wall repair by comparing it with the conventional transcaruncular method. This surgical approach differs from the established endoscopic technique in that we push the mesh inside the orbit rather than placing it over the defect. Methods: We retrospectively reviewed 40 patients with isolated medial orbital blowout fractures who underwent medial orbital wall reconstruction. Twenty-six patients underwent endoscopic repair, and 14 patients underwent external repair. All patients had preoperative computed tomography scans taken to determine the defect size. Pre- and postoperative exophthalmometry, operation time, the existence of diplopia, and pain were evaluated and compared between the two methods. We present a case showing our procedure. Results: The operation time was significantly shorter in the endoscopic group (44.7 minutes vs. 73.9 minutes, p= 0.035). The preoperative defect size, enophthalmos correction rate, and pain did not significantly differ between the two groups. All patients with preoperative diplopia, eyeball movement limitation, or enophthalmos had their symptoms resolved, except for one patient who had preexisting strabismus. Conclusion: This study demonstrates that endoscopic medial orbital wall repair is not inferior to the transcaruncular method. The endoscopic approach seems to reduce the operation time, probably because the dissection process is shorter, and no wound repair is needed. Compared to the previous endoscopic method, our method is not complicated, and is more physiological. Larger scale studies should be performed for validation.

Development and Validation of Collegiate Accommodation Competency - Case of Korea National College of Agriculture and Fishery - (대학생의 학교생활 적응역량 진단도구 개발 - 한국농수산대학 사례 -)

  • An, Jinseon;Han, Myeon-Taek;Lee, Minsoo
    • Journal of Agricultural Extension & Community Development
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    • v.27 no.4
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    • pp.185-197
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    • 2020
  • This study aim to develope and validate accommodation competency assessment for college students that reflected the educational objective of agricultural college in South Korea. In order to accomplish this goal, firstly, scale for developing collegiate accommodation competency assessment and secondly we also modify of items based on pilot test results was implemented. The results of the study are summarized as follows. Based on a comprehensive literature review and the development cases of accommodation competency assessment of other college and universities, 3 accommodation competency areas that matched the students of the agricultural college were selected. 3 accommodation competencies such as self leadership, ego-resiliency, interpersonal relation, career preparation were derived as competencies. The developed assessment was pre-tested with 915 students and analyzed to verify the reliability and validity of the test empirically. The reliability and validity of the collegiate accommodation competency assessment developed in this study were some what satisfactory.