• Title/Summary/Keyword: Pre-feasibility

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Development and Evaluation of a Patient-Reported Outcome (PRO) Scale for Breast Cancer

  • Zhang, Jun;Yao, Yu-Feng;Zha, Xiao-Ming;Pan, Li-Qun;Bian, Wei-He;Tang, Jin Hai
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.18
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    • pp.8573-8578
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    • 2016
  • Background: This study was guided by principles of the theoretical system of evidence-based medicine. In particular, when searching for evidence of breast cancer, a measuring scale is an instrument for evaluating curative effects in accordance with the laws and characteristics of medicine and exploring the establishment of a system for medically assessing curative effects. At present, there exist few tools for evaluating curative effects. Patient-reported outcomes (PROs) refer to outcomes directly reported by patients (without input or explanations from doctors or other intermediaries) with respect to all aspects of their health. Data obtained from PROs provide evidence of treatment effects. Materials and Methods: In accordance with the tenets of theoretical medicine and ancient medical theory regarding breast cancer, principles for developing a PRO scale were established, and a theoretical model was developed and a literature review was performed, items from this pool were combined and split, and an initial scale was constructed. After a pilot survey and additional modifications, a pre-questionnaire scale was formed and used in a field investigation. After the application of statistical methods, the item pool was used to create a formal scale. The reliability, validity and feasibility of this formal scale were then assessed. Results: In a clinical investigation, 479 responses were recovered, with an acceptance rate of 95%. a combination of various methods was employed, and the items that were selected by all methods or more than half of the methods were employed in the questionnaire. In these cases, the screening methods were combined with certain features of the item, A total of four domains and 38 items were reserved. The reliability analysis indicated that the PRO scale was relatively reliable. Conclusions: Scientific assessment proved that the proposed scale exhibited good reliability and validity. This scale was readily accepted and could be used to assess the curative effects of medical therapy. However, given the limited scope of this investigation, the capacity for adapting this scale to incorporate other theories could not be determined.

A Study on the Improved Parity Check Receiver for the Extended m-sequence Based Multi-code Spread Spectrum System with Code Set Partitioning and Constant Amplitude Precoding (코드집합 분할 방식의 확장 m-시퀀스 기반 정진폭 멀티코드 대역확산 통신 시스템을 위한 개선된 패리티 검사 기반 수신기에 관한 연구)

  • Han, Jun-Sang;Kim, Dong-Joo;Kim, Myoung-Jin
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.49 no.8
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    • pp.1-11
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    • 2012
  • The multi-code spread spectrum communication system, which spreads data bit stream by multiplexing orthogonal codes, can transmit data in high rate. However it needs the high-cost good linear amplifier because of the multi-level output signal. In order to overcome this drawback several systems making the amplitude of output signal constant with Walsh codes have been proposed. Recently constant amplitude pre-coded multi-code spread spectrum systems using extended m-sequence have been proposed. In this paper we consider an extended m-sequence based constant amplitude multi-code spread spectrum system with code set partitioning. By grouping the orthogonal codes into 4 subsets, not only is the computational complexity of the transceiver reduced but BER performance also improves. It has been shown that parity checking on four detected codes at the receiver can correct code detection error and result in BER performance enhancement. In this paper we propose a improved parity check receiver. We carried out computer simulation to verify feasibility of the proposed algorithm.

Practical Virtual Compensator Design with Dynamic Multi-Leaf Collimator(dMLC) from Iso-Dose Distribution

  • Song, Ju-Young;Suh, Tae-Suk;Lee, Hyung-Koo;Choe, Bo-Young;Ahn, Seung-Do;Park, Eun-Kyung;Kim, Jong-Hoon;Lee, Sang-Wook;Yi, Byong-Yong
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2002.09a
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    • pp.129-132
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    • 2002
  • The practical virtual compensator, which uses a dynamic multi-leaf collimator (dMLC) and three-dimensional radiation therapy planning (3D RTP) system, was designed. And the feasibility study of the virtual compensator was done to verify that the virtual compensator acts a role as the replacement of the physical compensator. Design procedure consists of three steps. The first step is to generate the isodose distributions from the 3D RTP system (Render Plan, Elekta). Then isodose line pattern was used as the compensator pattern. Pre-determined compensating ratio was applied to generate the fluence map for the compensator design. The second step is to generate the leaf sequence file with Ma's algorithm in the respect of optimum MU-efficiency. All the procedure was done with home-made software. The last step is the QA procedure which performs the comparison of the dose distributions which are produced from the irradiation with the virtual compensator and from the calculation by 3D RTP. In this study, a phantom was fabricated for the verification of properness of the designed compensator. It is consisted of the styrofoam part which mimics irregular shaped contour or the missing tissues and the mini water phantom. Inhomogeneous dose distribution due to the styrofoam missing tissue could be calculated with the RTP system. The film dosimetry in the phantom with and without the compensator showed significant improvement of the dose distributions. The virtual compensator designed in this study was proved to be a replacement of the physical compensator in the practical point of view.

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A Study for SCR Catalyst Reduction in Fast SCR Using Oxidation Catalyst (산화촉매를 이용한 Fast SCR에서의 SCR 촉매 저감 연구)

  • Lee, Jae Ok;Lee, Dae Hoon;Song, Young-Hoon;Oh, Dong-Kyu;Seo, Jung-Wook
    • Applied Chemistry for Engineering
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    • v.24 no.3
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    • pp.333-336
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    • 2013
  • Experimental investigation to estimate the feasibility of fast selective catalytic reduction (SCR) or oxidation catalyst combined ammonia SCR system to abate NOx in low temperature condition ($150{\sim}250^{\circ}C$) is reported. Because the conversion of NO to $NO_2$ is pre-requisite of the fast SCR process, the effect of the amount of oxidation catalyst to NO conversion to $NO_2$ was tested. 37, 45 and 51% of conversion rates were obtained for the OCV of 563000, 375000 and 281000 h, respectively. $De-NO_x$ performance in the case of $NO_2/NO_x$ ratio of 45% showed the best result in all tested temperature conditions. Comparison of the fast SCR and standard SCR with the condition of $NO_2/NO_x$ ratio of 45%, $200{\sim}250^{\circ}C$ and space velocity of 10000~30000 h showed that the fast SCR does not show much difference according to the variance of space velocity. Also it was shown that using the fast SCR, the volume of SCR catalyst can be reduced less than half of the standard SCR condition by increasing space velocity without the loss of $De-NO_x$ performance.

The Comparison of Effectiveness in Prehospital Protocol Education on CardioPulmonary Resuscitation (심폐소생술에 대한 현장업무 프로토콜 교육 효과 비교)

  • Shin, Sang-Yol;Jung, Ji-Yeon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.10 no.11
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    • pp.3418-3426
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    • 2009
  • The purpose of this study was to investigate the feasibility of field operation protocol for cardiopulmonary resuscitation(CPR) in person with non-traumatic arrest. This study was performed from May 1 through June 27, 2008, and subjects were 150 students who are attending the department of Emergency Medical Service in J and K universities which located in Jeollabuk-do and Jeollanam-do areas. Practical conformance was verified using by nonequivalent control group pretest-posttest design. This study divided into two groups; experimental group that employed field operation protocol and control group that applied conventional CPR protocol, and comparative analyzed statistically the necessary time of the items of each protocol. The results indicated that each performance time of 18 items was reduced over 3 seconds except 5 items(assessment of consciousness, airway control, two times of artificial respiration, check of circulation, and five cycles of CPR). And time of 6 items(intubation, peripheral intravenous line, reassessment of consciousness, pupil reaction, carotid artery pulse, and vital sign) was minimized more than 60 seconds, and total performing time was shortened 110.85 seconds. The results suggested that total performing time in pre and post test where the protocol was applied for two groups showed a statistically significant decrease(t=-6.580, p=.000). Consequently, field operation protocol for cardiopulmonary resuscitation(CPR) in person with non-traumatic arrest will be a available manual which support prompt and accurate decision making, and improve emergency medical service.

Application Analysis of GIS Based Distributed Model Using Radar Rainfall (레이더강우를 이용한 GIS기반의 분포형모형 적용성 분석)

  • Park, Jin-Hyeog;Kang, Boo-Sik;Lee, Geun-Sang
    • Journal of Korean Society for Geospatial Information Science
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    • v.16 no.1
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    • pp.23-32
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    • 2008
  • According to recent frequent local flash flood due to climate change, the very short-term rainfall forecast using remotely sensed rainfall like radar is necessary to establish. This research is to evaluate the feasibility of GIS-based distributed model coupled with radar rainfall, which can express temporal and spatial distribution, for multipurpose dam operation during flood season. $Vflo^{TM}$ model was used as physically based distributed hydrologic model. The study area was Yongdam dam basin ($930\;km^2$) and the 3 storm events of local convective rainfall in August 2005, and the typhoon.Ewiniar.and.Bilis.collected from Jindo radar was adopted for runoff simulation. Distributed rainfall consistent with hydrologic model grid resolution was generated by using K-RainVieux, pre-processor program for radar rainfall. The local bias correction for original radar rainfall shows reasonable results of which the percent error from the gauge observation is less than 2% and the bias value is $0.886{\sim}0.908$. The parameters for the $Vflo^{TM}$ were estimated from basic GIS data such as DEM, land cover and soil map. As a result of the 3 events of multiple peak hydrographs, the bias of total accumulated runoff and peak flow is less than 20%, which can provide a reasonable base for building operational real-time short-term rainfall-runoff forecast system.

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Simultaneous Treatment of Sewage Sludge and Food Wastewater Using Combined Digestion Process (혼합 소화공정을 통한 하수 슬러지와 음폐수 병합 처리)

  • Ha, Jeong Hyub;Park, Jong Moon
    • Applied Chemistry for Engineering
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    • v.28 no.5
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    • pp.581-586
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    • 2017
  • In this study, in order to find the feasibility of thermophilic biological pre-treatment for the co-digestion of food wastewater and sewage sludge, digestion efficiency of the combined thermophilic aerobic and mesophilic anaerobic process and its effect on methane production were investigated. Also, a lab-scale co-digestion process was operated to observe parameter changes according to the increase of organic loading rates using different dilution ratios of distilled water and food wastewater (1/3 [Run I], 2/3 [Run II] in addition to using the raw food wastewater [Run III]). The results indicated that co-digestion process maintained quite stable and constant pH during entire experiments. With regard to VS removal, the higher removal was observed in the combined process and the removal efficiency was 52.24% (Run I), 66.59% (Run II) and 72.53 (Run III), respectively. In addition, the combined process showed about an 1.6-fold improved methane production rate and significantly higher methane yield than that of using single anaerobic digestion process.

The Present Status and Vision of Virtual Construction System Development (가상 건설 시스템 개발 현황과 비전)

  • Kim, Jae-Jun;Choi, Cul-Ho;Shin, Hyun-Mok;Jin, Sang-Yoon;Lee, Kwang-Myung
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • 2008.11a
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    • pp.170-175
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    • 2008
  • The research team for the virtual construction development was established with the support of Korea Ministry of Construction and Transportation, and KICTEP (Korea Institute of Construction and Transportation Technology Evaluation and Planning). Its aims are to develop system that is to improve productivity & quality, to create a higher value-added business, and to cultivate international competitiveness in the construction industry. The virtual construction system is a design, engineering, and construction management information system that allows the project participants to effectively share the information throughout the construction life cycle with the support of 3D and design information. To achieve this, the research team focuses on developing several systems. First, the team focuses on developing for the pre-planning, the structural engineering, MEP, and the 3D based estimation system. Second, they focus on developing a simulation system for the construction process planning and feasibility study with help of the virtual reality technologies. Third, they focus on developing the CPLM (Construction Project Life-cycle Management) system for managing construction project data, and the decision support system that makes the collaboration among the project participants based on 3D technologies and information. We also focus on developing the SDAI (Standard Data Access Interface), the localized guideline for 3D design, and a training program. In addition, we focus on developing the undeveloped area of the commercial system and building an environment that can support the communication and collaboration in the construction life-cycle rather than developing the existing and commercialized system.

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Detection of m-toluate in Soils using Bioluminescence Producing Recombinant Bacteria (유전자 재조합 발광균주를 이용한 토양 오염원 m-toluate 탐지)

  • Kong, In-Chul;Kim, Myung-Hee;Jung, Yun-Ho;Ko, Kyung-Seok;Kim, Jae-Gon;Shin, Sung-Chun
    • Journal of Korean Society of Environmental Engineers
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    • v.27 no.5
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    • pp.507-512
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    • 2005
  • This research focuses on the development and application of a method for the detection of m-toluate in soils using a genetically engineered bioluminescent bacteria, Pseudomonas putida mt-2 KG1206. KG1206 produces light by direct (m-toluate and benzoate) and indirect (toluene analogs) inducers. For detection of m-toluate in soil system, 9.9 mL strain was amended with 0.1 mL soil ethanol extractant. A high correlation ($r^2>0.97$) was observed between bioluminescence and m-toluate concentration. The unknown concentrations of m-toluate in soil samples were pre-determined using a method developed based on bioluminescence activity of strain with extracted inducers. Values between by LC analysis and bioluminescence activity show moderate statistical results. These results demonstrate the feasibility of recombinant bioluminescent microorganism, engineered to generate a quantifiable bioluminescence signal in response to specific pollutants, may serve as combined sensing and reporting tools in environmental monitoring.

Study on Growth Characteristics of Sargassum fulvellum in the Integrated Multi-trophic Aquaculture (IMTA) System

  • Kim, Young-Dae;Park, Mi-Seon;Min, Byung-Hwa;Jeong, Seong-Jae;Kim, Hyung-Chul;Yoo, Hyun-Il;Lee, Won-Chan;Choi, Jae-Suk
    • Journal of Environmental Science International
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    • v.23 no.10
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    • pp.1703-1718
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    • 2014
  • An eco-friendly integrated multi-trophic aquaculture (IMTA) farming technique was developed with the goal of resolving eutrophication by excess feed and feces as fish-farming by-products. A variety of seaweed species were tried to remove inorganic nutrients produced by fish farming. However, there have been few trials to use Sargassum fulvellum in an IMTA system, a species with a relatively wide distribution across regions with various habitat conditions, great nutrient removal efficiency and importance for human food source and industrial purposes. In this regard, our study tried to examine feasibility of using S. fulvellum in an IMTA system by analyzing growth characteristics of the species in an IMTA system comprising of rockfish (Sebastes shlegeli), sea cucumber (Stichopus japonocus) and the tried S. fulvellum (October 2011 - November 2012). We also monitored environment conditions around the system including current speed, water temperature and inorganic nutrient level as they may affect growth of S. fulvellum. S. fulvellum in the IMTA system, which were $15.72{\pm}5.67mm$ long at the start of the experiment in October 2011, grew to a maximum of $1093{\pm}271.13mm$ by May 2012. In September, seaweed growth was reduced to a minimum of $280{\pm}70.43mm$ in length. Then, S. fulvellum began to grow again reaching $325{\pm}196.19mm$ by November 2012. Wet weight of the seaweed was $4.01{\pm}1.89g$ at the start of the experiment and reached a maximum of $109.26{\pm}34.23g$ in May. The weight gradually declined to a low of $15.12{\pm}8.40g$ in September 2012. Weight began to increase once more, rising to $39.27{\pm}21.69g$ by November. During the experiment, the average velocity at the surface and the bottom was 6.5 cm/s and 3.4 cm/s, respectively. The water temperature ranged $5.0-23.5^{\circ}C$, which was considered suitable for growing S. fulvellum. Results of the study indicated no significant differences in inorganic nutrients between pre- and post-IMTA installation. It was thus concluded that S. fulvellum can be a suitable seaweed species to be used in an IMTA system.