• Journal of the Korean Magnetic Resonance Society
• /
• v.20 no.2
• /
• pp.46-49
• /
• 2016

MiRNA-155, upregulated in various cancers, is one of the miRNAs that suppress apoptosis of human cancer. Thus, inhibition of the maturation of miRNA-155 could be an effective way to induce apoptotic cancer cell death. The apical stem-loop of the pre-miRNA-155 has been known as a Dicer biding site for RNA cleavage. Here, to understand the molecular basis of the tertiary interaction between pre-miRNA-155 with Dicer, we characterize the structure of the apical stem-loop of pre-miRNA-155 using NMR spectroscopy. The RNA has a stem-bulge-stem-loop-stem structure, which is consist of G-C Watson-Crick and G-U Wobble base pairs. The assignments of imino- protons were further confirmed by 2D $^{15}N-^1H$ HSQC NMR spectrum. The NMR parameters obtained in this study can be further used to investigate the tertiary interaction between pre-miRNA-155 and other biomolecules such as protein, nucleic acids, or small chemicals which might be used to control the apoptosis of cancer.

• Structural Engineering and Mechanics
• /
• v.72 no.5
• /
• pp.617-629
• /
• 2019

Based on the finite element method of traditional straight Euler-Bernoulli beams and the coupled relations between linear displacement and angular displacement of a pre-twisted Euler-Bernoulli beam, the shape functions and stiffness matrix are deduced. Firstly, the stiffness of pre-twisted Euler-Bernoulli beam is developed based on the traditional straight Euler-Bernoulli beam. Then, a new finite element model is proposed based on the displacement general solution of a pre-twisted Euler-Bernoulli beam. Finally, comparison analyses are made among the proposed Euler-Bernoulli model, the new numerical model based on displacement general solution and the ANSYS solution by Beam188 element based on infinite approach. The results show that developed numerical models are available for the pre-twisted Euler-Bernoulli beam, and which provide more accurate finite element model for the numerical analysis. The effects of pre-twisted angle and flexural stiffness ratio on the mechanical property are investigated.

• Korean Journal of Childcare and Education
• /
• v.14 no.6
• /
• pp.205-218
• /
• 2018

Objective: The purpose of this study is to explore and analyze the way pre-service early childhood teachers think about teacher happiness through metaphor analysis. Methods: A total of 225 pre-service teachers were selected from 4-year universities in the Gyeongnam area and open questionnaires were distributed to the participants. A total of 207 out of the 225 questionnaires were selected for the study. Results: First, based on psychological well-being, positive interpersonal relationship, self-acceptance, autonomy, environmental control, and life purpose were derived. Pre-service early childhood teachers typified teacher happiness into five types: positive interpersonal relationships, self-acceptance, autonomy, environmental control, and life purpose. Second, pre-service early childhood teachers perceived teacher happiness as positive. Third, pre-service early childhood teachers perceived interpersonal relationships, self-acceptance, and purpose of life as positive, while environmental control and autonomy were perceived as negative. Conclusion/Implications: The results of this study suggest that it is necessary to improve the quality of teachers' education and to develop a program to raise positive awareness of future early childhood teachers. These study results can also be used as basic data for high quality teacher education.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.20 no.1
• /
• pp.10-21
• /
• 2010

Equations of chordwise and flapwise bending motions for the vibration analysis of rotating pre-twisted blades having tapered cross section and setting angle are derived by using hybrid deformation variable modeling. The two motions are couples to each other due to the pre-twisted angle of the beam cross section. The derived equations are transformed into dimensionless forms in which dimensionless parameters are identified. The effects of the dimensionless parameters on the modal characteristics of rotating pre-twisted blades having tapered cross section and orientation angle are investigated. The eigenvalue loci veering phenomena are also investigated and discussed in this work.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 1994.04a
• /
• pp.17-24
• /
• 1994

In the analysis pre-cast large panel structures, we can use the new discrete analyzing method to be consisted of rigid bodies. Because the pre-cast panels we still more rigid than the connection, the rigid element method is more efficient numerical method than F. E. M. The characteristics of R. E. M. is that strains in element are not occurred by external loadings and the deformation of the structures by external loadings is transmitted through springs around elements. In this study, we focus on the comparison of the results from the R. E. M. and the F. E. M. in order to establish the validity of the R. E. M. to analysis of pre-cast panel structures.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2009.04a
• /
• pp.288-295
• /
• 2009

Equations of chordwise and flapwise bending motions for the vibration analysis of rotating pre-twisted blades having tapered cross section and orientation angle are derived by using hybrid deformation variable modeling. The two motions are couples to each other due to the pre-twisted angle of the beam cross section. The derived equations are transformed into dimensionless forms in which dimensionless parameters are identified. The effects of the dimensionless parameters on the modal characteristics of rotating pre-twisted blades having tapered cross section and orientation angle are investigated. The eigenvalue loci veering phenomena is also investigated and discussed in this work.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2008.04a
• /
• pp.393-399
• /
• 2008

A modeling method for the modal analysis of a pre-twisted multi-packet blade system undergoing rotational motion is presented in this paper. Blades are idealized as pre-twisted cantilever beams that are fixed to a rotating disc. The stiffness coupling effects between blades due to the flexibilities of the disc and the shroud are modeled with discrete springs. The coupling effect between chordwise and flapwise bending deflection is also considered. Hybrid deformation variables are employed to derive the equations of motion. To obtain more general information, the equations of motion are transformed into dimensionless forms in which dimensionless parameters are identified. The effects of the dimensionless parameters and the number of packets as well as blades on the modal characteristics of the rotating multi-packet pre-twisted blade system are investigated with some numerical examples.

• Proceedings of the Korea Concrete Institute Conference
• /
• 1996.04a
• /
• pp.270-274
• /
• 1996

Until recently pre & post-processing of finite element model has been heavily relied on expensive graphic peripheral devices. But today, with the aid of inexpensive microcomputers, very effective pre & postprocessor graphics has been developed. In this study, Pre & Post processor(MASSPRE, MASSPOST) of prediction analysis of thermal stress in mass concrete structure is developed. The developed pre & post processors are raise to the efficiency in making input data for the main program and analysis of the results produced by the main program. This MASSPOST presents a stress contour graph, volume slice, time-temperature history graph, time-stress history graph, etc.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.64 no.10
• /
• pp.1501-1507
• /
• 2015

The contact wire pre-sag in railway overhead catenary has been considered as a innovative idea which improves the current collection quality and is expected to evenly distribute wear along a span. However, long term studies on the effects of pre-sag, especially on the quantitative wear pattern of the contact wire, have not yet been reported. Therefore, in this study, the pre-sag and wear pattern of the contact wire along a span from long term operation of railway in Korea was surveyed. The examination was conducted on 3 lines, the Gyeongbu high-speed line with pre-sag of span/2000, the Gyeongbu existing line without pre-sag, and Gyeongchun line with pre-sag installation on 1/1000 of its span. The wear measurements of 58 sample spans were examined. The wear pattern analysis show no interrelationships between pre-sag and evenly distributed wear, but more wear occurred at the center of a span compared to the ends of the span, especially more noticeable as span length increases.

• Journal of the Korean Society for Precision Engineering
• /
• v.28 no.11
• /
• pp.1316-1322
• /
• 2011

Most of the mechanical structures use bolting or spot welding for the whole structure. In recent years, bolting & rivets are used rather than the welding due to reassembly and repair. Analysis of bolted joints is so complicate that many conditions must be considered such as pre-load and contact, etc.. Bolted joint analysis is done by theoretical, experimental & numerical methods. However, numerical analysis in the bolted joint is used because the contact and stress in the joints are changed due to the pre-load. In this study, we analysis the slip and the deformation of the contact area in the joint depending on the pre-load and find the optimized bolting condition.