• The Korean Journal of Physiology and Pharmacology
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• 제10권1호
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• pp.7-11
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• 2006

Interstitial cells of Cajal (ICCs) are pacemakers in gastrointestinal tracts, regulating rhythmicity by activating nonselective cation channels (NSCCs). In the present study, we investigated the general characteristics and pH-mediated regulation of pacemaker activity in cultured interstitial cells of Cajal. Under voltage clamp mode and at the holding potential of -60 mV, the I-V relationships and difference current showed that there was no reversal potential and voltage-independent inward current. Also, when the holding potentials were changed from +20 mV to -80 mV with intervals of 20 mV, there was little difference in inward current. In pacemaker activity, the resting membrane potential (RMP) was depolarized (In pH 5.5, $23{\pm}1.5$ mV depolarized) and the amplitude was decreased by a decrease of the extracellular pH. However, in case of increase of extracellular pH, the RMP was slightly hyperpolarized and the amplitude was decreased a little. The melastatin type transient receptor potential (TRPM) channel 7 has been suggested to be required for intestinal pacemaking activity. TRPM7 produced large outward currents and small inward currents by voltage ramps, ranging from +100 to -100 mV from a holding potential of -60 mV. The inward current of TRPM7 was dramatically increased by a decrease in the extracellular pH. At pH 4.0, the average inward current amplitude measured at -100 mV was increased by about 7 fold, compared with the current amplitude at pH 7.4. Changes in the outward current (measured at +100 mV) were much smaller than those of the inward current. These results indicate that the resting membrane potential of pacemaking activity might be depolarized by external acidic pH through TRPM7 that is required for intestinal pacemaking activity.

• 한국진공학회지
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• 제9권4호
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• pp.428-435
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• 2000

정전 탐침을 이용하여 유도 결합형 반응기에서 발생하는 산소 플라즈마의 음이온 발생 특성을 관찰하였다. 입력전력과 운전압력 조건에 따른 산소 플라즈마에서 electronegative 음이온 플라즈마의 입력전력과 운전압력에 따른 정전 탐침에 흐르는 포화 양 전류 대 포화 음 전류(전자 전류와 음 이온 전류의 합)의 전류 비율과 플라즈마 부유 전위와 플라즈마 전위 차의 변화로부터 음이온 발생 특성관찰을 하였다. 전류비의 증가와 전위차 값의 감소는 입력전력이 증가함에 따라 약 30∼60 mTorr 운전압력 영역에서 나타났으며 이 조건에서 음이온의 발생량이 증가함을 의미하고, 플라즈마내의 이온들은 음이온과 재결합에 의한 손실이 증가하여 플라즈마 밀도가 감소함을 알 수 있었다.

• Journal of Electrochemical Science and Technology
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• 제15권2호
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• pp.268-275
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• 2024

The study examined the electrogeneration of hypochlorite ions (ClO^-) via electrolysis of aqueous NaCl solutions using a dimensionally stable anode-type (DSA-type) electrode based on platinum and palladium oxides supported on titanium mesh (Ti/PtPd(10%)O_x). The electrogenerated ClO^- was quantified on the basis of the absorption band at 292 nm (A_λ = 292) of the UV-Vis spectrum. The effect of initial pH, concentration of NaCl, cell potential difference and electrolysis time were investigated in this study. The results showed that the electrolysis of aqueous NaCl solutions increases the solution pH up to high values (≥ 8.0) that favor the formation of ClO^- over chlorine or hypochlorous acid. The hypochlorite concentration increases significantly at pH values > 7.0 and shows a linear trend with increasing NaCl concentration and with increasing cell potential difference. When the cell potential and NaCl concentration are held constant, the maximum hypochlorite value during electrolysis depends on both the cell potential and NaCl concentration. The Ti/PtPd(10%)O_x anode favors the production of hypochlorite ions, making this anode a promising material for use in electrochemical oxidation of wastewater via an indirect mechanism.

• 대한수학회논문집
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• 제26권4호
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• pp.591-601
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• 2011

In this paper, we deal with the discrete p-Laplacian operators with a potential term having the smallest nonnegative eigenvalue. Such operators are classified as its smallest eigenvalue is positive or zero. We discuss differences between them such as an existence of solutions of p-Laplacian equations on networks and properties of the energy functional. Also, we give some examples of Poisson equations which suggest a difference between linear types and nonlinear types. Finally, we study characteristics of the set of a potential those involving operator has the smallest positive eigenvalue.

• Bulletin of the Korean Chemical Society
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• 제17권1호
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• pp.19-24
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• 1996

The potential energies of HIV-1 protease, inhibitor, and their complex have been calculated by molecular mechanics and the "binding energy", defined as the difference between the potential energy of complex and the sum of potential energies of HIV-1 protease and its inhibitor, has been compared to the free energy in inhibition reaction. The trend in these binding energies seems to agree with that in free energies.

• 대한물리치료과학회지
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• 제15권1호
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• pp.11-20
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• 2008

This study was designed to test the effects of comprehensive rehabilitation management on functional recovery after attack of cerebrovascular disease. 16 cerebrovascular disease patients applied comprehensive rehabilitation management of physical therapy at department of physical Therapy, C medical center in Gwang－ju. The collection of the data had been executed for 4months(April 15, 2007${\sim}$July 15, 2007). For evaluating, Functional Independence measure(FIM) and Somatosensory Evoked Potential(SSEP) were used to assess functional recovery. The results of this study were as follows: 1. In the comparison of latency of median nerve SSEP before and after treatment, the lat. N20 and P25 increased, the ampl. P25/N20 was decreased. In the comparison difference data of median nerve SSEP, however there was no significant difference in the group(p>0.05). 2. In the comparison of latency of Post Tibial nerve SSEP before and after treatment, the lat. P40, P50, P60 increased, the ampl. P40 was decreased. In the comparison difference data of post tibial nerve SSEP, however there was no significant difference in the group(p>0.05). 3. In the comparison of FIM scores of Self－care, Sphincter Control, Mobility: Transfer, Locomotion before and after treatment, the scores of FIM was significantly increased. In the comparison of difference of the motor part of FIM, however there was significant difference(p<0.05). 4. In the comparison of FIM scores of Communication, Social Cognition before and after treatment, the scores of FIM was significantly increased. In the comparison of difference of the motor part of FIM, however there was no significant difference in the group(p>0.05). Based on these results, it is concluded that the comprehensive rehabilitation management for cerebrovascular disease case was not significant difference in the SSEP, was significant difference in the motor part of FIM. Further study should be done to analyze the effect of intervention duration of treatment, optimal time to apply the treatment in more long period.

• 국제학술발표논문집
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• The 8th International Conference on Construction Engineering and Project Management
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• pp.425-432
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• 2020

In order to improve the sustainability and smart construction, it is discussed arguably that developing and applying consistent "standard model" to plan business, design, construct and operate a building is considered to be one of the effective and efficient approach. The scope of this article is to examine, from the international developer's perspective, the "standard model" approach of a hotel brand to building projects in the UK, and also to explore potential role of project team to mitigate any local difference at the project level. These projects are developed by the same developer adopting the same business plan, design and operation to each project. In order to clarify the actual and likely difference in construction results, reference is also made to those building projects located in other geographical markets including Japan, Germany and USA, and focus is given on the analysis of its programme and cost. Principle findings are that there exists geographical difference especially in environmental and planning system, and that major local difference is found at least in the programme at the design stage. In contrast, the difference in the building cost itself may not be necessarily considered major if currency exchange rate being taken into account appropriately. It is also observed that there were cases where any difference in the programme was mitigated by taking different approach to procuring and defining roles of management and professional team at the project level. In conclusion, from the international developer's perspective, the geographical difference of the "construction system" surrounding building projects can typically lead to major prolongation of programme, however, these different construction results could be mitigated at least to a certain extent by introducing appropriate changes to the role of project team.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6979-6983
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• 2013

Background: Oral lichen planus (OLP) is categorized as premalignant lesion although its malignant potential is a matter of controversy. The objective of this study was to investigate Ki67 expression in OLP, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). Materials and Methods: Expression of Ki67 was evaluated through immunohistochemistry (IHC) in groups of A (17 cases of epithelial hyperplasia), B (16 cases of OLP), C1 (10 cases of mild epithelial dysplasia), C2 (10 cases of severe epithelial dysplasia), D1 (10 cases of well-differentiated OSCC), and D2 (10 cases of poorly-differentiated OSCC). Results: There was a significant difference in Ki67 expression based on quantitative analysis among the six studied groups as well as group B compared bilaterally with groups C2, D1 and D2 (p< 0.0001). However, there was no significant difference between groups B and C1 or between groups D1 and D2 (p> 0.05). Conclusions: Based on the results of the present study it may not be possible to definitely consider malignant transformation potential for OLP. However, expression of Ki67 was significantly higher in OLP than that of epithelial hyperplasia with no significant difference from that of mild epithelial dysplasia. This should be considered by clinicians to carefully and regularly follow up OLP lesions to detect potential subtle changes at an early stage.

• 한국전산구조공학회논문집
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• 제22권5호
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• pp.411-420
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• 2009

본 연구는 계면경계를 갖는 포텐셜 문제의 해석를 위한 이동최소제곱 기반의 확장된 유한차분법을 제시한다. 이동최소제곱법을 이용한 Taylor 전개로부터 얻어진 근사함수에 쐐기함수를 도입하여 계면경계의 특이성을 모사한다. 지배방정식은 요소나 그리드없이 절점만을 이용해 이산화한다. 계면경계의 특이성은 절점에서 구성되는 근사식에 매입되기 때문에 계면경계의 기하학적 모델링으로 발생하는 수치적인 어려움을 피할 수 있다. 계면경계 조건으로 인해 전체 계방정식에 추가되는 미지수는 없지만, 계방정식을 과결정 시스템으로 만드므로 강성도 행렬을 대칭화하여 미지수와 방정식의 개수를 일치시켰다. 이로 인한 계산량 증가는 계면경계 모델링의 간소화로 인한 수치적인 이득과 맞바꿀 수 있다. 다양한 수치적 검증을 통해 개발된 해석기법이 쐐기거동과 점프를 성공적으로 묘사할 뿐만 아니라 계면경계를 갖는 포텐셜 문제 효율적이고 정확하게 해석할 수 있음을 보였다.

• 한국수자원학회논문집
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• 제50권12호
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• pp.863-875
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• 2017

본 연구에서는 SC-PDSI를 이용하여 잠재증발산량 산정 방법이 가뭄지수 산정 결과에 미치는 영향을 평가하였다. 잠재증발산량 산정 방법으로 월열지수법, Penman-Monteith 방법, Hargreaves 공식 등 세 가지 방법을 이용하였으며, 기상청 56개 지점을 대상으로 세 가지 잠재증발산량 산정 방법에 따른 SC-PDSI를 산정하고 그 결과를 비교하였다. 분석 결과, Penman-Monteith 방법에 의한 결과와 Hargreaves 공식에 의한 결과는 월별로 큰 차이 없이 유사한 가뭄지수 산정 결과를 나타내고 있음을 확인하였으며, 월열지수법에 의한 결과는 상대적으로 큰 차이를 보이고 있음을 알 수 있었다. 월별로는 봄철과 겨울철 기간에 대해 산정된 가뭄지수와 가뭄상황 판단 결과가 차이를 보이고 있음을 확인하였다. 결론적으로 우리나라에서 PDSI를 산정하고자 할 경우에는 Penman-Monteith 방법이나 Hargreaves 공식을 이용하는 것이 바람직할 것으로 판단된다.