• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제1회 추계심포지움 and 제2회 생리분자과학연구센터워크숍
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• pp.39-40
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• 1993

Hepatitis B virus (HBV)is a member of the Hepadna virus family whose members share a characteristic virion structure and genome size, around 3.2kb in a paritially double-stranded form. The genome of HBV contains four overlapping open reading frames designated as P(polymerase). C(core), S(surface antigen)and X. The X gene has potential to encode 154 amino acids protein.

• 한국재료학회지
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• 제18권12호
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• pp.640-644
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• 2008

ZnO/ZnS core/shell nanocrystals (${\sim}5-7\;nm$ in diameter) with a size close to the quantum confinement regime were successfully synthesized using polyol and thermolysis. X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HRTEM) analyses reveal that they exist in a highly crystalline wurtzite structure. The ZnO/ZnS nanocrystals show significantly enhanced UV-light emission (${\sim}384\;nm$) due to effective surface passivation of the ZnO core, whereas the emission of green light (${\sim}550\;nm$) was almost negligible. They also showed slight photoluminescence (PL) red-shift, which is possibly due to further growth of the ZnO core and/or the extension of the electron wave function to the shell. The ZnO/ZnS core/shell nanocrystals demonstrate strong potential for use as low-cost UV-light emitting devices.

• International Journal of Industrial Entomology and Biomaterials
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• 제2권1호
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• pp.87-89
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• 2001

The nucleotide sequence of the domestic silkworm (Bombyx mori) mitochondrial (mt) control region and its flanking genes was determined from PCR clones. The control region of the silkworm mt genome was located between the small ribosomal RNA gene and transfer RN $A^{Met}$. This 499 bp control region hale 95.4% A+T content. Extensive comparative analysis studies performed with similar control region of other insect genomes could not reveal a highly conserved region containing conserved motifs of animal mito-chondrial genome. The remarkable feature that found in this control region was the presence of tandem motifs containing nine repetitive sequences. The potential usefulness of this motif sequences for Bombyx species or their taxonomically related species is enhanced by its unique localization in the maternally inheritance mitochondrial molecule.e.

• 한국분말재료학회지
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• 제26권6호
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• pp.463-470
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• 2019

Fe₃O₄/SiO₂/YVO₄:Eu³⁺ multifunctional nanoparticles are successfully synthesized by facile stepwise sol-gel processes. The multifunctional nanoparticles show a spherical shape with narrow size distribution (approximately 40 nm) and the phosphor shells are well crystallized. The Eu³⁺ shows strong photoluminescence (red emission at 619 nm, absorbance at 290 nm) due to an effective energy transfer from the vanadate group to Eu. Core-shell structured multifunctional nanoparticles have superparamagnetic properties at 300 K. Furthermore, the core-shell nanoparticles have a quick response time for the external magnetic field. These results suggest that the photoluminescence and magnetic properties could be easily tuned by either varying the number of coating processes or changing the phosphor elements. The nanoparticles may have potential applications for appropriate fields such as laser systems, optical amplifiers, security systems, and drug delivery materials.

• 공업화학
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• 제18권2호
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• pp.183-187
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• 2007

대구경 실리카 입자를 사용하여 실리카/티타니아 코어-쉘 입자를 제조하였으며, 반복 코팅에 의해 티타니아 코팅 층의 두께를 조절하였다. 티타니아 코팅층의 두께는 코팅횟수를 1회에서 3회로 늘림에 따라 8 nm에서 38 nm로 증가하였다. 코팅 후 입자의 표면은 티타니아 코팅 층으로 인해 거칠어 졌으며 비표면적도 3~25배 증가하였다. 티타니아가 코팅된 실리카 입자의 특성은 FE-SEM, 제타전위기, BET, XRD 등을 이용해 분석하였다.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2367-2370
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• 2014

"Cat's eye"-shaped $[^{57}Co]CoO@SiO_2$ core-shell nanostructure was prepared by the reverse microemulsion method combined with radioisotope technique to investigate a potential imaging agent for a single photon emission computed tomography (SPECT) in nuclear medicine. The core cobalt oxide nanorods were obtained by thermal decomposition of $Co-(oleate)_2$ precursor from radio isotope Co-57 containing cobalt chloride and sodium oleate. The $SiO_2$ coating on the surface of the core cobalt oxide nanorods was produced by hydrolysis and a condensation reaction of tetraethylorthosilicate (TEOS) in the water phase of the reverse microemulsion system. In vivo test, micro SPECT image was acquired with nude mice after 30 min of intravenous injection of $[^{57}Co]CoO@SiO_2$ core-shell nanostructure.

• Nuclear Engineering and Technology
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• 제32권4호
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• pp.379-394
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• 2000

As an in-vessel retention (IVR) design concept in coping with a severe accident in the nuclear power plant during which time a considerable amount of core material may melt, external cooling of the reactor vessel has been suggested to protect the lower head from overheating due to relocated material from the core. The efficiency of the ex-vessel management may be estimated by the thermal margin defined as the ratio of the critical heat flux (CHF）to the actual heat flux from the reactor vessel. Principal factors affecting the thermal margin calculation are the amount of heat to be transferred downward from the molten pool, variation of heat flux with the angular position, and the amount of removable heat by external cooling In this paper a thorough literature survey is made and relevant models and correlations are critically reviewed and applied in terms of their capabilities and uncertainties in estimating the thermal margin to potential failure of the vessel on account of the CHF Results of the thermal margin calculation are statistically treated and the associated uncertainties are quantitatively evaluated to shed light on the issues requiring further attention and study in the near term. Our results indicated a higher thermal margin at the bottom than at the top of the vessel accounting for the natural convection within the hemispherical molten debris pool in the lower plenum. The information obtained from this study will serve as the backbone in identifying the maximum heat removal capability and limitations of the IVR technology called the Cerium Attack Syndrome Immunization Structures (COASISO) being developed for next generation reactors.

• Advances in aircraft and spacecraft science
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• 제6권6호
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• pp.479-495
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• 2019

Periodic cellular core structures included in sandwich panels possess good stiffness while saving weight and only lately their potential to act as passive vibration filters is increasingly being studied. Classical homogeneous honeycombs show poor vibracoustic performance and only by varying certain geometrical features, a shift and/or variation in bandgap frequency range occurs. This work aims to investigate the vibration filtering properties of the AUXHEX "hybrid" core, which is a cellular structure containing cells of different shapes. Numerical simulations are carried out using two different approaches. The first technique used is the harmonic analysis with commercially available software, and the second one, which has been proved to be computationally more efficient, consists in the Wave Finite Element Method (WFEM), which still makes use of finite elements (FEM) packages, but instead of working with large models, it exploits the periodicity of the structure by analysing only the unit cell, thanks to the Floquet-Bloch theorem. Both techniques allow to produce graphs such as frequency response plots (FRF's) and dispersion curves, which are powerful tools used to identify the spectral bandgap signature of the considered structure. The hybrid cellular core pattern AUXHEX is analysed and results are discussed, focusing the investigation on the possible spectral bandgap signature heritage that a hybrid core experiences from their "parents" homogeneous cell cores.

• Journal of Magnetics
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• 제13권4호
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• pp.170-172
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• 2008

Fe-6.5% Si alloys have good magnetic properties due to their high electrical resistivity, very low magneto-striction, and low crystalline anisotropy. Despite their strong potential, these alloys have seldom been used in magnetic applications because of the very poor ductility of Si-steel above 3.0 wt% Si [1-4]. It is difficult to achieve compressed Fe-6.5% Si powder cores with excellent properties because of the low density due to poor ductility. In compressed powder cores, high density is essential in order to obtain high magnetization and permeability. In this study, an attempt was made to produce Fe-3%Si powder cores because the Fe-3.0 wt% Si alloys have relatively good magnetic properties and room temperature ductility. Gas atomized Fe-3.0 wt% Si powder was compressed into toroid shape cores. By reducing the Si content to 3.0 wt%, the hysteresis loss could be greatly reduced and thus the total core loss could be minimized. The total core loss is 600 mW/$cm^3$ at 0.1 T and 50 kHz.

• Bulletin of the Korean Chemical Society
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• 제28권4호
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• pp.561-566
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• 2007

Adenosine kinase (AK) is a ubiquitous intracellular enzyme, which catalyzes the phosphorylation of adenosine (ADO) to adenosine monophosphate (AMP). AK inhibitors have therapeutic potential as analgesic and antiinflammatory agents. A chemical feature based pharmacophore model has been generated from known AK inhibitors (26 training set compounds) by HypoGen module implemented in CATALYST software. The top ranked hypothesis (Hypo1) contained four features of two hydrogen-bond acceptors (HBA) and two hydrophobic aromatics (Z). Hypo1 was validated by 124 test set molecules with a correlation coefficient of 0.905 between experimental and estimated activity. It was also validated by CatScramble method. Thus, the Hypo1 was exploited for searching new lead compounds over 238,819 chemical compounds in NCI database and then the selected compounds were screened based on restriction estimated activity and Lipinski's rules to evaluate their drug-like properties. Finally we could obtain 72 new lead candidates and the two best compound structures from them were posted.