• 한국산학기술학회논문지
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• 제16권6호
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• pp.3926-3933
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• 2015

본 연구는 관절 수술을 받은 정형외과 환자에서 섬망의 이환 기간에 영향을 미치는 요인을 알아보고자 하였다. 대상자는 2012년 1월 에서 2014년 2월 사이에 일개 대학병원 정형외과에서 관절 수술 후 섬망 증상을 보인 환자 266명으로 하였으며, 섬망의 이환 기간에 따라 2일 이내의 짧은 기간 섬망을 가진 군(129명, 48%)과 3일 이상 장기간 섬망을 가진 군(137명, 52%)으로 나누었다. 뇌졸중과 치매는 짧은 기간 섬망을 가진 군에 비해 장기간 섬망을 가진 군에서 높은 비율을 보였으며, 다중회귀분석에서도 뇌졸중과 치매는 섬망의 장기간의 이환과 연관되어 있었다. 따라서 뇌졸중과 치매를 가진 환자들에서 관절 수술이 시행되는 경우에는 섬망의 예방과 관리에 더욱 주의를 기울여야 한다.

• Journal of Chest Surgery
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• 제47권3호
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• pp.249-254
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• 2014

Background: Delirium after cardiac surgery is associated with serious long-term negative outcomes and high costs. The aim of this study is to evaluate neurobehavioral, hemodynamic, and sedative characteristics of dexmedetomidine, compared with the current postoperative sedative protocol (remifentanil) in patients undergoing open heart surgery with cardiopulmonary bypass (CPB). Methods: One hundred and forty two eligible patients who underwent cardiac surgery on CPB between April 2012 and March 2013 were randomly divided into two groups. Patients received either dexmedetomidine (range, 0.2 to $0.8\;{\mu}g/kg/hr$; n=67) or remifentanil (range, 1,000 to $2,500\;{\mu}g/hr$, n=75). The primary end point was the prevalence of delirium estimated daily via the confusion assessment method for intensive care. Results: When the delirium incidence was compared with the dexmedetomidine group (6 of 67 patients, 8.96%) and the remifentanil group (17 of 75 patients, 22.67%) it was found to be significantly less in the dexmedetomidine group (p<0.05). There were no statistically significant differences between two groups in the extubation time, ICU stay, total hospital stay, and other postoperative complications including hemodynamic side effects. Conclusion: This preliminary study suggests that dexmedetomidine as a postoperative sedative agent is associated with significantly lower rates of delirium after cardiac surgery.

• 임상간호연구
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• 제21권1호
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• pp.43-52
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• 2015

Purpose: This study was aimed to develop the multicomponent intervention for preventing delirium among postoperative patients in a surgical intensive care unit (SICU). Methods: Using a quasi-experimental pre & post-test design with a non-equivalent control group, a total of 88 hospitalized patients in a SICU participated in this study. The 44 patients were allocated in each experimental and control group. The experimental group received the multicomponent intervention for delirium prevention including a delirium assessment and nursing intervention using a checklist, whereas the control group was provided with a standard care. The primary outcome of this study was the delirium incidence during the course of hospitalization. Results: There were no significant differences in the demographic and clinical characteristics between the two groups. The delirium occurred in 19.2% in the experimental group, whereas 38.6% in the control group ($x^2=4.526$, p<.05). Conclusion: The findings of the study demonstrated an effect of the multicomponent delirium prevention intervention in decreasing the delirium incidence rate over the standard care among the patients in SICU.

• 한국산학기술학회논문지
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• 제17권2호
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• pp.649-656
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• 2016

본 연구의 목적은 대퇴부골절로 수술 후 섬망 발생군과 섬망이 발생하지 않은 군을 비교하여 수술 후 섬망 발생이 임상 예후에 미치는 영향을 파악하고 섬망의 위험요인을 규명하기 위한 후향적 조사연구이다. 자료수집은 2010년 7월 1일부터 2014년 1월 31일까지 대퇴부골절로 일 대학병원에서 수술한 65세이상 노인환자 68명의 의무기록지를 3년간 추적조사하였다. 연구결과 섬망발생군은 31명(45.6%), 섬망이 발생하지 않은 군이 37명(54.4%)이었으며, 섬망이 발생한 환자의 평균나이는 80.8세, 섬망이 발생하지 않은 군은 81.8세로 대부분 여성이었으며, 통계학적 유의성은 없었다. 섬망유무에 따른 특성은 5종류 이상의 약물복용, 혈중 크레아티닌 수치, 총 의료비용이 섬망 발생군과 섬망이 발생하지 않은 군에 따른 유의한 차이를 보였다. 또한 대퇴부 수술 후 주요 임상경과 발생에 예측요인을 확인하기 위해 Cox의 비례위험 모형(Cox's proportional hazard regression model)을 이용한 결과, 섬망, 5가지이상의 다중약물복용, 수혈경험이 유의한 예측요인으로 나타났다. 따라서, 대퇴부 수술 후 노인의 섬망발생은 환자와 보호자에게 부정적인 결과를 초래할 수 있으므로, 수술 전 섬망과 관련된 위험인자에 대한 평가 및 처치를 시행해야 한다.

• Journal of Korean Neurosurgical Society
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• 제59권3호
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• pp.287-291
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• 2016

Objective : Because elderly patients are undergoing more surgeries, the importance of postoperative cognitive impairment (CI) evaluations is rising, especially for spine surgery, which is related to subjective pain. We investigated the prevalence of undiagnosed CI among elderly patients who underwent spine surgery and the impact of CI on postoperative outcomes. Methods : The preoperative cognitive statuses of 129 patients over 65 who underwent lumbar spine surgery from 2012 to 2014 were determined with the Mini-Mental State Examination, and patients with scores under 24 were diagnosed with CI. The patients were then divided into a CI group (n=49) and non-cognitive impairment (NCI) group (n=80). Results : Among the 129 patients, 49 (38.0%) were diagnosed with CI, and 9 (7.0%) had severe CI. The age of the CI group ($72.88{\pm}6.20years$) was significantly greater than that of the NCI group ($69.96{\pm}4.53years$). In contrast, the postoperative visual analog scale scores and performance statuses did not differ significantly. However, postoperative delirium was more frequent and the hospital stay length was longer in the CI group compared with the NCI group (p<0.05). Conclusion : A high prevalence of undiagnosed CI was discovered among elderly patients undergoing spine surgery. The existence of CI was associated with higher rates of postoperative delirium and prolonged hospital stays, which affected clinical outcomes. Thus, CI assessments should be included in preoperative evaluations of elderly patients prior to spine surgery.

• 대한정형외과학회지
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• 제54권2호
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• pp.157-163
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• 2019

목적: 정형외과 수술 후 환자의 섬망 발생 빈도 및 섬망에 미치는 영향 인자를 분석하고자 하였다. 대상 및 방법: 1년간 단일 상급 종합병원에서 정형외과 수술을 시행 받은 성인 환자 2,122예를 대상으로 하였다. 이들 중 정신건강의학과 협의 진료하에 Diagnostic and Statistical Manual of Mental Disorders-V 진단 기준에 부합하며 섬망 관련 투약력이 확인된 환자 132예를 선별하였고 수술 원인 및 수술 부위에 따른 섬망 발생률의 차이와 입원 후 섬망 발생까지의 시간 및 지속 시간에 영향을 미치는 인자를 분석하였다. 결과: 전체 수술 환자 중 6.2% (132/2,122예)에서 섬망이 발생하였다. 섬망 환자군의 평균 나이는 77.4세(범위, 54-92세)로 비섬망 환자군의 평균 나이(58.1세)보다 많았고, 섬망 환자군의 여성 비율이 63.6% (84/132예)로 비섬망 환자군의 여성 비율(49.0%)보다 높았다. 외상에 의한 수술 후 9.3% (85/916예), 질환에 의한 수술 후 3.9% (47/1,206예)의 섬망 발생률을 보였다. 수술 부위별 섬망 증상의 발생률은 두 부위 이상 수술을 시행한 경우 29.2% (7/24예), 고관절 13.7% (72/526예), 척추 9.6% (14/146예), 슬관절 및 하퇴 3.5% (20/577예), 족부 및 족관절 2.5% (5/199예), 견주관절 2.4% (11/457예), 전완 및 수부 1.6% (3/189예)였다. 여성인 경우와 질환으로 수술하는 경우 입원 후 섬망이 빨리 발생하였고, 치매와 주요 우울 장애가 있는 경우 섬망 지속기간이 길게 나타났다. 결론: 외상으로 인해 수술한 경우, 두 부위 이상 수술을 받은 경우 섬망 발생 빈도가 높았고, 단일 부위에서 고관절, 척추, 슬관절 순서로 높았다. 본 연구를 통해 술 후 섬망 발생의 위험도를 예측하고 교정 가능한 인자에 대한 적극적 개입이 필요할 것으로 생각된다.

• Journal of Korean Biological Nursing Science
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• 제20권3호
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• pp.177-186
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• 2018

Purpose: Increasing number of older adults are receiving cancer surgeries especially for gastrointestinal cancers, which brings forth attention to age-related postoperative complication prevention. Postoperative delirium (POD) is a common complication that rises after surgical procedures involving general anesthesia, largely in the elderly population. Due to its sudden onset and fluctuating symptoms, POD often goes underdiagnosed and undertreated even though it may lead to various adverse outcomes. POD in GI cancer surgical elderly patients is poorly understood in terms of prevalence, pathophysiology, assessment, treatment and nursing management. We aimed to identify available literature and investigate study results to broaden our understanding of geriatric GI cancer POD. Methods: The search process involved six databases to identify relevant studies abided by inclusion criteria. Results: Eleven studies were selected for this review. Geriatric POD is closely related to frailty and surgical complications. Frailty increases vulnerability to surgical stress and causes cerebral changes that affect stress-regulating neurotransmitter proportions, brain blood flow, vascular density, neuron cell life and intracellular signal transductions. These conditions of frailty result in increased risks of surgical complications such as blood loss, cardiovascular events and inflammation, which all may lead to the POD. Mini Metal State Examination (MMSE), Confusion Assessment Method (CAM) and Delirium Rating Scale-revised-98 (DRS-R-98) are recommended for POD assessment to identify high-risk patients. Conclusion: The POD prevalence ranged from 8.2% to 51.0%. The multifactorial causative mechanism suggests nurses to identify highrisk elderly GI-cancer surgical patients by reviewing patient-specific factors and surgery-specific factors.

• 한국간담췌외과학회지
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• 제27권3호
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• pp.301-306
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• 2023

Backgrounds/Aims: Postoperative delirium (POD) is a common complication that increases mortality and morbidity in older patients. This study aimed to evaluate the clinical significance of post-cholecystectomy delirium in older patients. Methods: This retrospective study included 201 patients aged > 75 years who underwent cholecystectomy for acute or chronic cholecystitis between January 2016 and December 2019. Patients were divided into the POD (n = 21) and non-POD (n = 180) groups, and their demographic features and clinical results were compared. Results: The mean patient age was 78.88 years; the female/male ratio was 44.8%/55.2%. Laparoscopic surgery was performed in 93.5% of patients. The univariate analysis showed that lower body mass index (BMI), immobilized admission status, neuropsychiatric disease history, preoperative intervention (percutaneous drainage), high C-reactive protein, hypoalbuminemia, neutrophilia, hypo-/hyperkalemia, and longer operative time were more frequently observed in the POD group. The multivariate analysis showed that lower BMI (odds ratio [OR], 2.796; p = 0.024), neuropsychiatric disease history (OR, 3.019; p = 0.049), hyperkalemia (OR, 5.972; p = 0.007), and longer operative time (OR, 1.011; p = 0.013) were significant risk factors for POD. Conclusions: POD was associated with inflammation degree, general condition, poor nutritional status, electrolyte imbalance, and stressful conditions. Recognizing risk factors requiring multidisciplinary team approaches is important to prevent and treat POD.

• Journal of Chest Surgery
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• 제18권2호
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• pp.232-240
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• 1985

Preoperative and postoperative psychiatric evaluation were done for 51 patients who were undergoing open-heart surgery. The incidence of postoperative psychopathological complications following open-heart surgery was 27.5%. This rate is comparable to that of previous studies. Neurotic reactions occurred in eight patients, delirium in five, and acute psychotic reaction in one. Of those variables which were previously suggested to influence the high incidence, the demographic factors and the severity of preoperative illness were correlated with postoperative psychopathologic dysfunctions. No somatic variable associated with intraoperative or postoperative procedures has been proven to correlate. By preoperative psychiatric evaluations, the patients could be divided into three groups: the Anxiety group, the Denial group, and the Adjusted group. The most important psychological finding was that in patients who demonstrated a high degree of preoperative anxiety or who could not express preoperative anxiety, postoperative psychological complications developed more frequently. With these findings, the preoperative psychiatric interview was recommended for prevention and reduction of postoperative psychiatric complications.

• 대한두경부종양학회:학술대회논문집
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• 대한두경부종양학회 1995년도 제12차 학술대회 연제순서 및 초록집
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• pp.203.1-203.1
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• 1995