• Title/Summary/Keyword: Post-mortem radiology

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Neuroanatomical Localization of Rapid Eye Movement Sleep Behavior Disorder in Human Brain Using Lesion Network Mapping

  • Taoyang Yuan;Zhentao Zuo;Jianguo Xu
    • Korean Journal of Radiology
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    • v.24 no.3
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    • pp.247-258
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    • 2023
  • Objective: To localize the neuroanatomical substrate of rapid eye movement sleep behavior disorder (RBD) and to investigate the neuroanatomical locational relationship between RBD and α-synucleinopathy neurodegenerative diseases. Materials and Methods: Using a systematic PubMed search, we identified 19 patients with lesions in different brain regions that caused RBD. First, lesion network mapping was applied to confirm whether the lesion locations causing RBD corresponded to a common brain network. Second, the literature-based RBD lesion network map was validated using neuroimaging findings and locations of brain pathologies at post-mortem in patients with idiopathic RBD (iRBD) who were identified by independent systematic literature search using PubMed. Finally, we assessed the locational relationship between the sites of pathological alterations at the preclinical stage in α-synucleinopathy neurodegenerative diseases and the brain network for RBD. Results: The lesion network mapping showed lesions causing RBD to be localized to a common brain network defined by connectivity to the pons (including the locus coeruleus, dorsal raphe nucleus, central superior nucleus, and ventrolateral periaqueductal gray), regardless of the lesion location. The positive regions in the pons were replicated by the neuroimaging findings in an independent group of patients with iRBD and it coincided with the reported pathological alterations at post-mortem in patients with iRBD. Furthermore, all brain pathological sites at preclinical stages (Braak stages 1-2) in Parkinson's disease (PD) and at brainstem Lewy body disease in dementia with Lewy bodies (DLB) were involved in the brain network identified for RBD. Conclusion: The brain network defined by connectivity to positive pons regions might be the regulatory network loop inducing RBD in humans. In addition, our results suggested that the underlying cause of high phenoconversion rate from iRBD to neurodegenerative α-synucleinopathy might be pathological changes in the preclinical stage of α-synucleinopathy located at the regulatory network loop of RBD.

Study of Optimal Angle When Taking Foot AP Weight-Bearing Radiography (족부전후방향 체중부하 촬영 시 적정 입사각에 관한 연구)

  • Uhm, Min-Ji;Choi, Weon-Keun;Son, Soon-Yong;Lee, Kwan-Sup
    • Korean Journal of Digital Imaging in Medicine
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    • v.15 no.2
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    • pp.31-37
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    • 2013
  • Incident X-ray angles of weight bearing foot AP radiography which differ in each medical institution were compared. Optimal angles were derived from the study and suggested as basic data for clinical application. 19 patients with no abnormality on right foot took part in the study from June 2013 to July 2013. Weight bearing foot AP radiography in the correct position was examined with the incident X-ray angles of $10^{\circ}$, $15^{\circ}$, $20^{\circ}$, $25^{\circ}$, $30^{\circ}$, and $35^{\circ}$. All the images were evaluated subjectively by 5 radiological technologists of over 15 year work experience using Likert scale as 1 for 'very poor', 2 for 'poor', 3 for 'fair', 4 for 'good', 5 for 'very good', 6 for 'excellent', and analyzed with ANOVA and Scheffe. Image quality was the most optimal at $20^{\circ}$ as 4.53, and relatively good at $25^{\circ}$ as 4.38 and at $30^{\circ}$ as 4.18. $35^{\circ}$ and $10^{\circ}$ were relatively poor. The average points of 6 groups indicated statistically significant difference (p<.01). In the post-mortem, 3 subgroups showed no statistically significant difference, and the average point of the groups of $20^{\circ}$, $25^{\circ}$, $30^{\circ}$was evaluated relatively higher than the other 2 groups. An optimal incident X-ray angle within the range from $20^{\circ}$ to $30^{\circ}$ for weight bearing foot AP radiography could make it possible to obtain the image of high diagnostic value and would be useful for clinical application in the future.

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A pilot study of an automated personal identification process: Applying machine learning to panoramic radiographs

  • Ortiz, Adrielly Garcia;Soares, Gustavo Hermes;da Rosa, Gabriela Cauduro;Biazevic, Maria Gabriela Haye;Michel-Crosato, Edgard
    • Imaging Science in Dentistry
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    • v.51 no.2
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    • pp.187-193
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    • 2021
  • Purpose: This study aimed to assess the usefulness of machine learning and automation techniques to match pairs of panoramic radiographs for personal identification. Materials and Methods: Two hundred panoramic radiographs from 100 patients (50 males and 50 females) were randomly selected from a private radiological service database. Initially, 14 linear and angular measurements of the radiographs were made by an expert. Eight ratio indices derived from the original measurements were applied to a statistical algorithm to match radiographs from the same patients, simulating a semi-automated personal identification process. Subsequently, measurements were automatically generated using a deep neural network for image recognition, simulating a fully automated personal identification process. Results: Approximately 85% of the radiographs were correctly matched by the automated personal identification process. In a limited number of cases, the image recognition algorithm identified 2 potential matches for the same individual. No statistically significant differences were found between measurements performed by the expert on panoramic radiographs from the same patients. Conclusion: Personal identification might be performed with the aid of image recognition algorithms and machine learning techniques. This approach will likely facilitate the complex task of personal identification by performing an initial screening of radiographs and matching ante-mortem and post-mortem images from the same individuals.

Adequacy of Source to Image Receptor Distance with Chest Postero-Anterior Projection in Digital Radiology System (디지털방사선 환경에서 흉부 후-전 방향 검사 시 초점과 영상수용체간 거리의 적절성)

  • Joo, Young-Cheol;Lim, Cheong-Hwan;You, In-Gyu;Jung, Hong-Ryang;Lee, Sang-Ho
    • Journal of radiological science and technology
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    • v.39 no.2
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    • pp.135-142
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    • 2016
  • The purpose of this study is to evaluate propriety of using SID 180cm at Chest PA examination and to find effect of geometrical cause to the image. XGEO-GC80, INNOVISION-SH, CXDI-40EG detector and a chest phantom designed self-production was used for this study. Images were acquired at SID 180cm with changing the factor OID as 0, 75 and 83mm and were analyzed by Centricity Radiography RA1000 PACS system. Statistical program was used the SPSS (Version 22.0, SPSS, Chicago, IL, USA), p-value(under 0.05) was considered to be statistically significant. In OID 0 mm was enlarged about 2.7~3.5 mm than the actual degree of the HS, BS of phantom in all equipments. Compared with the calculated magnification has been expanded 1.6~2.8% when viewed. The OID 75 mm with OID 83 mm was extended from the CS and BS 6~8 mm range. Compared to the calculated values, the measured values are expanded from 6.1 to 7.9%. CS and BS according to the OID change showed a statistically significant difference (p<0.05) among each group, the post-analysis only OID 0 mm group appeared as an independent group, 75 mm and 83 mm are separated in the same group It was. But had no statistically significant difference could change depending on the OID (p>0.05), post-mortem analysis showed, both in the same group. Heart sizes appears larger than actual size 6~8 mm at chest PA examination which is enlarged 6.1~7.9% more than the actual theoretical value. We can find magnification of the image because of the increase of the OID due to technical limitations between cover of standing detector and the image plate. so we suggest to have occurred between them when considering the need to adjust the equipment installed by the SID to match the characteristics of the equipment.