• Steel and Composite Structures
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• 제20권5호
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• pp.1155-1171
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• 2016

Post-tensioned (PT) steel moment resisting frames (MRFs) with semi-rigid connections (SRC) can be used to control the hysteretic energy demands and to reduce the maximum inter-story drift (${\gamma}$). In this study the seismic behavior of steel MRFs with PT connections is estimated by incremental nonlinear dynamic analysis in terms of dissipated hysteretic energy ($E_H$) demands. For this aim, five PT steel MRFs are subjected to 30 long duration earthquake ground motions recorded on soft soil sites. To assess the energy dissipated in the frames with PT connections, a new expression is proposed for the hysteretic behavior of semi-rigid connections validated by experimental tests. The performance was estimated not only for the global $E_H$ demands in the steel frames; but also for, the distribution and demands of hysteretic energy in beams, columns and connections considering several levels of deformation. The results show that $E_H$ varies with ${\gamma}$, and that most of $E_H$ is dissipated by the connections. It is observed in all the cases a log-normal distribution of $E_H$ through the building height. The largest demand of $E_H$ occurs between 0.25 and 0.5 of the height. Finally, an equation is proposed to calculate the distribution of $E_H$ in terms of the normalized height of the stories (h/H) and the inter-story drift.

• Steel and Composite Structures
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• 제21권4호
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• pp.863-882
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• 2016

This study aims to introduce a new bracing system by which even super-wide frames with large openings can be braced. The proposed system, hereafter called Cable-Pulley Brace (CPB), is a tension-only bracing system with a rectilinear configuration. In CPB, a wire rope passes through a rectilinear path around the opening(s) and connects the lower corner of the frame to its opposite upper one. CPB is a secondary load resisting system with a nonlinear-elastic hysteretic behavior due to its initial pre-tension load. As a result, the required energy dissipation would be provided by the MRF itself, and the main intention of using CPB is to contribute to the initial and post-yield stiffness of the whole system. Using a stiffness calibration technique, optimum placement of the CPBs is discussed to yield a uniform displacement demand along the height of the structure. A displacement-based design procedure is proposed by which the MRF with CPB can be designed to achieve a uniform distribution of inter-story drifts with predefined values. Obtained results indicated that CPB leads to significant reductions in maximum and residual deformations of the MRF at the expense of minor increase in the maximum base shear and developed axial force demands in the columns. In the case of a typical 5-story residential building, compared to SMRF system, CPB system reduces maximum amounts of inter-story and residual drifts by 35% and 70%, respectively. Moreover, openings of the frame are not interrupted by the CPB. This is the most appealing feature of the proposed bracing system from architectural point of view.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7409-7414
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• 2015

Loop-mediated isothermal amplification (LAMP) developed by Notomi et al. (2000) has made it possible to amplify DNA with high specificity, efficiency and rapidity under isothermal conditions. The ultimate products of LAMP are stem-loop structures with several inverted repeats of the target sequence and cauliflower-like patterns with multiple loops shaped by annealing between every other inverted repeats of the amplified target in the similar strand. Because the amplification process in LAMP is achieved by using four to six distinct primers, it is expected to amplify the target region with high selectivity. However, evaluation of reaction accuracy or quantitative inspection make it necessary to append other procedures to scrutinize the amplified products. Hitherto, various techniques such as turbidity assessment in the reaction vessel, post-reaction agarose gel electrophoresis, use of intercalating fluorescent dyes, real-time turbidimetry, addition of cationic polymers to the reaction mixture, polyacrylamide gel-based microchambers, lateral flow dipsticks, fluorescence resonance energy transfer (FRET), enzyme-linked immunosorbent assays and nanoparticle-based colorimetric tests have been utilized for this purpose. In this paper, we reviewed the best-known techniques for evaluation of LAMP amplicons and their applications in molecular biology beside their advantages and deficiencies. Regarding the properties of each technique, the development of innovative prompt, cost-effective and precise molecular detection methods for application in the broad field of cancer research may be feasible.

• Journal of Chest Surgery
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• 제25권11호
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• pp.1254-1260
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• 1992

Rupture of the posterior left ventricular wall following mitral valve replacement is a rare but fatal complication. Over a 10 year period from August 25 1980 to November 27 1990, we have experienced 6 such patients among 884 cases of mitral valve replacement with 4 deaths and 2 survivors. One patient had a type I rupture and another a type II rapture with the remaining four patients having suffered type III ruptures. All of the ruptures were dis covered intraoperatively enabling prompt reinstitution of the cardiopulmonary bypass and subsequent cardioplegic arrest prior to repair. Overzealous removal of calcified valve leaflets seemed to be responsible for the single type I rupture, and untethering of the so called ventricular loop appeared to be the main mechanism responsible for the type III ruptures. The single type II rupture that had occurred seemed to have been caused by inadvertent laceration of the papillary muscle with resultant rupture of the posterior LV wall at the base of the papillary muscle. Among the type III ruptures, 2 patients required intraaortic balloon pump[IABP] support only for mechanical assistance and 1 patient required both the IABP and the Biomedicus LV assist device for successfull weaning following repair of the LV rupture Another patient with a type II rupture also required the circulatory assistance of both the IABP and the bio-medicus LV assist device for weaning from the bypass. Attention to meticulous technical considerations such as avoiding over aggressive removal of heavily calcified valvular tissue, preservation of as much mural leaflet tissue and chordal stuctures as possible seemed helpful in preventing this catastrophic complication from occurring. Fusion and fibrous stricture of the chordal structures appeared particularly conducive to the type II ruptures as a result of the increased susceptibility to papillary injury during operation.

• 한국지반공학회논문집
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• 제18권6호
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• pp.43-59
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• 2002

본 연구에서는 국내에서 이용되고 있는 지하구조물 누수에 대한 지수공법과 재료에 대하여 이론적 고찰 및 실험을 실시하고 현장적용 자료의 수집을 통한 통계적인 분석.고찰을 통하여 지하구조물의 누수유형별 지수공법 선정을 위한 시스템을 구축하고자 하였다. 선정시스템의 구성은 데이터베이스 5개의 대구분과 73개 항목의 세분화된 체크리스트를 이용하여 다양한 현장 조건을 고려한 설문조사를 토대로 4개로 대분된 위계성 등급에 따른 26개의 주요 선정인자를 설정하였다. 지수공법 데이터베이스는 국내에 적용실적이 많은 10개의 공법으로 이루어졌다. 설계조건 데이터베이스에서는 10개의 지수공법에 대한 적용범위와 설계조건에 대한 자료를 제공한다. 연구결과에 의한 시스템은 선정인자 데이터베이스와 지수공법 데이터베이스 그리고 설계조건 데이터베이스에 의한 관계형 데이터베이스로 구성되었다. 본 선정시스템의 현장적용 결과, 설계단계에 적용할 경우 지수공법 선정을 위한 시간 단축과 지수공법 선정시의 오류를 감소시킬 수 있었다. 또한 시공단계에 적용할 경우에는 설계단계에서 선정된 지수공법을 현장조건에 따라 재확인함으로써 지수공법의 타당성 분석을 할 수 있고 향후 유지관리에도 활용될 수 있을 것으로 기대된다.

• 한국가스학회지
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• 제4권4호
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• pp.25-33
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• 2000

최근 들어 가혹한 온도 및 압력조건에서 운전이 요구되는 고온배관들의 잔여수명예측은 상당히 중요한 관심사로 부각되고 있다. 이에 고온손상을 정량적으로 평가하여 설비를 안전하게 사용하기 위한 유지기술 및 수명평가 기술을 확보하는 것은 매우 중요하다. 한편 이러한 고온배관내 대부분의 균열은 반타원 표면균열의 형태로 형상화되어 파괴역학의 실제응용에서 발견할 수 있는 가장 복잡한 형상과 하중특성을 갖게 된다. 이를 배경으로 본 연구에서는 먼저 축방향 및 원주방향 반타원 표면균열이 존재하는 직관의 완전 3차원 유한요소망 자동생성 프로그램을 작성하였다. 이렇게 생성된 유한요소 입력자료를 이용하여 3차원 유한요소 해석을 수행하면 반타원 표면균열선단을 따른 고온 크리프 파괴 지배변수 $C^{\ast}$-적분값을 구할 수 있다. 또한 $C^{\ast}$-적분값에 준해 균열진전량을 계산하는 후처리 균열진전 모듈을 추가하여 사용자 편의 수명평가 프로그램을 개발하였다. 최종적으로 개발된 통합 수명 평가 프로그램을 이용하여 여러 가지 해석변수들의 반타원 표면균열을 갖는 고온 직관 수명에 대한 영향을 살펴보았다.

• 대한기계학회논문집B
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• 제33권11호
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• pp.840-848
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• 2009

In the boiling heat transfer mechanism, CHF(critical heat flux) is the significantly important parameter of the system. So, many researchers have been struggling to enhance the CHF of the system in enormous methods. Recently, there were lots of researches about enormous CHF enhancement with the nanofluids. In that, the pool boiling CHF in nanofluids has the significantly increased value compared to that in pure water because of the deposition of the nanoparticle on the heater surface in the nanofluids. The aim of this study is the comparison of the effect of the nanoparticle deposited surface and the modified surface which has the similar morphology and made by MEMS fabrication. The nanoparticle deposited surface has the complex structures in nano-micro scale. Therefore, we fabricated the surfaces which has the similar wettability and coated with the micro size post and nano structure. The experiment is performed in 3 cases : the bare surface with 0.002% water-ZnO nanofluids, the nanoparticle deposited surface with pure water and the new fabricated surface with pure water. The contact angle, a representative parameter of the wettability, of the all 3 cases has the similar value about 0 and the SEM(scanning electron microscope) images of the surfaces show the complex nano-micro structure. From the pool boiling experiment of the each case, the nanoparticle deposited surface with pure water and the fabricated surface with pure water has the almost same CHF value. In other words, the CHF enhancement of the nanoparticle deposited surface is the surface effect. It also shows that the new fabricated surface follows the nanoparticle deposited surface well.

• Smart Structures and Systems
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• 제26권5호
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• pp.657-666
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• 2020

A rotational pulse-echo ultrasonic propagation imager that can inspect cylindrical specimens for material nondestructive evaluations is proposed herein. In this system, a laser-generated ultrasonic bulk wave is used for inspection, which enables a clear visualization of subsurface defects with a precise reproduction of the damage shape and size. The ultrasonic waves are generated by a Q-switched laser that impinges on the outer surface of the specimen walls. The generated waves travel through the walls and their echo is detected by a Laser Doppler Vibrometer (LDV) at the same point. To obtain the optimal Signal-to-Noise Ratio (SNR) of the measured signal, the LDV requires the sensed surface to be at a right angle to the laser beam and at a predefined constant standoff distance from the laser head. For flat specimens, these constraints can be easily satisfied by performing a raster scan using a dual-axis linear stage. However, this arrangement cannot be used for cylindrical specimens owing to their curved nature. To inspect the cylindrical specimens, a circular scan technology is newly proposed for pulse-echo laser ultrasound. A rotational stage is coupled with a single-axis linear stage to inspect the desired area of the specimen. This system arrangement ensures that the standoff distance and beam incidence angle are maintained while the cylindrical specimen is being inspected. This enables the inspection of a curved specimen while maintaining the optimal SNR. The measurement result is displayed in parallel with the on-going inspection. The inspection data used in scanning are mapped from rotational coordinates to linear coordinates for visualization and post-processing of results. A graphical user interface software is implemented in C++ using a QT framework and controls all the individual blocks of the system and implements the necessary image processing, scan calculations, data acquisition, signal processing and result visualization.

• Journal of Microbiology and Biotechnology
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• 제15권1호
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• pp.105-111
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• 2005

End-stage renal disease is a fatal and devastating disease that is caused by progressive and irreversible loss of functioning nephrons in the kidney. Dialysis and renal transplantation are the common treatments at present, but these treatments have severe limitations. The present study investigated the possibility of reconstructing renal tissues by transplantation of renal precursor cells to replace the current treatments for end-stage renal disease. Embryonic renal precursor cells, freshly isolated from metanephroi of rat fetus at day 15 post-gestation, were seeded on biodegradable polymer scaffolds and transplanted into peritoneal cavities of athymic mice for three weeks. Histologic sections stained with hematoxylin & eosin and periodic acid-Schiff revealed the formation of primitive glomeruli, tubules, and blood vessels, suggesting the potential of embryonic renal precursor cells to reconstitute renal tissues. Immunohistochemical staining for proliferating cell nuclear antigen, a marker of proliferating cells, showed intensive nuclear expression in the regenerated renal structures, suggesting renal tissue reconstitution by transplanted embryonic renal precursor cells. This study demonstrates the reconstitution of renal tissue in vivo by transplanting renal precursor cells with biodegradable polymer scaffolds, which could be utilized as a new method for partial or full restoration of renal structure and function in the treatment of end-stage renal disease.

• Journal of Advanced Marine Engineering and Technology
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• 제22권2호
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• pp.139-145
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• 1998

Filament winding method is widely used for composite fabrications using low viscosity liquid for-mation and processing asymmetrical structures of pressure vessel pipe rocket motor case etc. The filament winding method is affected by several parameters such as pot life of process time viscosi-ty of resin filament winding temperature and schedules curing condition and post curing condi-tion of resin. To develope high functional composite materials the rotation(5, 15, 20, 30rpm) of the winding machine was controlled by D.C motor. And the wiper to give proper tension was equipped between strand and resin bath. The resin is hooked by the design wiper. The adequate cure schedule was found by DSC. NOL ring test is carried out to investigate the basic physical properties such as design technology. The void contents in filament winding is generally higher than that of the prepreg laminated plate. These high contents of void can make a crack in resin in spite of low deformation. These problem was solved by giving tension in processing. To improve the characteristics of fiber volume fraction void contents resin/fiber bonding the winding speedc is changed under constant tension. It was found that resin impregnation was not different from in fiber contents void contents at the range of 0.5~1kg tension but it was found that resin was not impregnated at the above of 1.5kg tension. In burst test a pure PE liner was failed at a nozzle part under the $14kg/\textrm{cm}^2$ pressure but a pressure vessel of CNG was failed at a cylinder part under the $200kg/\textrm{cm}^2$ pressure.