• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1997년도 춘계학술대회
• /
• pp.358-361
• /
• 1997

This paper describes a multichannel epileptic seizure detection algorithm based on wavelet transform(WT), artificial neural network(ANN) and expert system. First, through the WT, a small number of wavelet coefficients is used to represent the single channel epileptic spike. Next, 3-layer feed-forward network employing the error back propagation algorithm is trained and tested using parameters obtained above. Finally, 16 channel expert system which is based on clinical experience is introduced as a artifact rejection and reliable detection. The suggested algorithm was implemented on personal computer(PC). Two main events i.e., epileptiform and normal activities, were selected from 32 person's EEGs(normal: 20, seizure disorder: 12) in consensus among experts. The result was that WT reduced data input size and ANN detected 97 of the 100 EEGs containing definite spike - sensitivity of 97%. Expert rule system was capable of rejecting a wide variety of artifacts commonly found in EEG recordings. It also reduced false positive detections of ANN.

• 약학회지
• /
• 제37권2호
• /
• pp.143-148
• /
• 1993

The objective of this study was to evaluate the sedative activity of four aporphine alkaloids (APA) and nine cyclopeptide alkaloids(CPA), which had been isolated from the seeds (sanjoin) of Zizyphus vulgaris var. spinosus, and the fruits and stem bark of Zizyphus jujuba var. inermis. The assessment of sedative activity was carried out, employing a hexobarbital-induced sleeping time method in mice. When the relative sedative potency of sanjoinine-A(CPA) was given as one unit, those of nuciferine (APA), lysicamine (APA), chlorpromazine (positive control), and sanjoinine -Ahl (an epimer of sanjoinine-A) were 13, 6.5, 5, and 3, respectively. The sedatvie activities of other CPAs were much lower than those of sanjoinine-A and -Ahl, and other APAs were not active. On heat treatment, nuciferine and lysicamine were degraded into some artifacts which exhibited no sedative activity, while sanjoinine-A was converted into sanjoinine-Ahl which showed more potent sedative activity. These results suggested that nuciferine and sanjoinine-A were major sedative components of native sanjoin, and that sanjoinine-A and its epimeric artifact, sanjoinineAhl were the active principles of roasted sanjoin. It provides a scientific basis for heat-processing (roasting) of this Oriental medicine.

• International Journal of Computer Science & Network Security
• /
• 제23권6호
• /
• pp.49-58
• /
• 2023

Renewable energy is not a new terminology. One of the fastest growing renewable energies is solar energy. The implementation of solar energy provides several advantages including the reduction of some of the environmental risks of fossil fuel consumption. This research elaborated the importance of the adaption of solar energy by developing a spatial decision support system (SDSS), while the Residential Solar Energy Adoption (RSEA) is an instantiation artifact in the form of an SDSS. As a GIS web-based application, RSEA allows stakeholders (e.g., utility companies, policymakers, service providers homeowners, and researchers) to navigate through locations on a map interactively. The maps highlight locations with high and low solar energy adoption potential that enables decision-makers (e.g., policymakers, solar firms, utility companies, and nonprofit organizations) to make decisions. A combined qualitative and quantitative methodological approach was used to evaluate the application's usability and user experience, and results affirmed the ability of the factors of utility, usefulness, and a positive user experience of the residential solar energy adoption of spatial decision support system (RSEA-SDSS). RSEA-SDSS in improving the decision-making process for potential various stakeholders, in utility, solar installations, policy making, and non-profit renewable energy domains.

• Imaging Science in Dentistry
• /
• 제48권3호
• /
• pp.177-184
• /
• 2018

Purpose: This study was performed to evaluate the influence of voxel size and the accuracy of 2 cone-beam computed tomography (CBCT) systems in the detection of vertical root fracture (VRF) in the presence of intracanal metallic posts. Materials and Methods: Thirty uniradicular extracted human teeth were selected and randomly divided into 2 groups(VRF group, n=15; and control group, n=15). The VRFs were induced by an Instron machine, and metallic posts were placed in both groups. The scans were acquired by CBCT with 4 different voxel sizes: 0.1 mm and 0.16 mm (for the Eagle 3D V-Beam system) and 0.125 mm and 0.2 mm (for the i-CAT system) (protocols 1, 2, 3, and 4, respectively). Interobserver and intraobserver agreement was assessed using the Cohen kappa test. Sensitivity and specificity were evaluated and receiver operating characteristic analysis was performed. Results: The intraobserver coefficients indicated good (0.71) to very good (0.83) agreement, and the interobserver coefficients indicated moderate (0.57) to very good (0.80) agreement. In respect to the relationship between sensitivity and specificity, a statistically significant difference was found between protocols 1 (positive predictive value: 0.710, negative predictive value: 0.724) and 3 (positive predictive value: 0.727, negative predictive value: 0.632) (P<.05). The least interference due to artifact formation was observed using protocol 2. Conclusion: Protocols with a smaller voxel size and field of view seemed to favor the detection of VRF in teeth with intracanal metallic posts.

• International Journal of Stem Cells
• /
• 제16권1호
• /
• pp.93-107
• /
• 2023

Background and Objectives: Chronic periodontitis can lead to alveolar bone resorption and eventually tooth loss. Stem cells from exfoliated deciduous teeth (SHED) are appropriate bone regeneration seed cells. To track the survival, migration, and differentiation of the transplanted SHED, we used super paramagnetic iron oxide particles (SPIO) Molday ION Rhodamine-B (MIRB) to label and monitor the transplanted cells while repairing periodontal bone defects. Methods and Results: We determined an appropriate dose of MIRB for labeling SHED by examining the growth and osteogenic differentiation of labeled SHED. Finally, SHED was labeled with 25 ㎍ Fe/ml MIRB before being transplanted into rats. Magnetic resonance imaging was used to track SHED survival and migration in vivo due to a low-intensity signal artifact caused by MIRB. HE and immunohistochemical analyses revealed that both MIRB-labeled and unlabeled SHED could promote periodontal bone regeneration. The colocalization of hNUC and MIRB demonstrated that SHED transplanted into rats could survive in vivo. Furthermore, some MIRB-positive cells expressed the osteoblast and osteocyte markers OCN and DMP1, respectively. Enzyme-linked immunosorbent assay revealed that SHED could secrete protein factors, such as IGF-1, OCN, ALP, IL-4, VEGF, and bFGF, which promote bone regeneration. Immunofluorescence staining revealed that the transplanted SHED was surrounded by a large number of host-derived Runx2- and Col II-positive cells that played important roles in the bone healing process. Conclusions: SHED could promote periodontal bone regeneration in rats, and the survival of SHED could be tracked in vivo by labeling them with MIRB. SHED are likely to promote bone healing through both direct differentiation and paracrine mechanisms.

• 유통과학연구
• /
• 제17권1호
• /
• pp.95-103
• /
• 2019

Purpose - Recently, many theoretical researches suggested that arts-based marketing strategies provide many benefits for marketers to differentiate their brand or product from others. However, there has been little research focusing on consumers' response types from artwork (artifact-emotion appraisal; A-emotion vs. represented world-emotion appraisal; R-emotion). In order to deepen our understanding of arts-based marketing strategies, we addressed a research question related to how artwork-provoked consumers' emotional response can impact the perceived evaluation of art infused products. Research design, data, and methodology - To answer the research question, we conducted a pretest and one experimental study. The experimental study was 2(art-provoked response type: A-emotion vs. R-emotion) by 2(emotional valence: positive vs. negative) by 2(produce type: hedonic vs. utilitarian) mixed design. The art-provoked response type and emotional valence were between-subject design and product type was within subject design. For the experimental study, 108 undergraduate students and graduate students were randomly assigned to one of 4 conditions (A-emotion-positive, A-emotion-negative, R-emotion-positive, R-emotion-negative). Participants reported their evaluation of art-infused product and other items for a manipulation check. Results - The major results from the experimental study are as follow. First, participant's art-provoked response type influenced evaluation of art infused products differently. More specifically, the effect of emotional valence of artwork on product evaluation was not significant in A-emotion. However, in R-emotion, relative to the product with artwork provoked negative emotional valence, the product with artwork provoked positive emotional valence elicited significantly higher product evaluation. Second, product type also affected the art infusion effect significantly. Particularly, the differential effect of participant's art-provoked response type on product evaluation revealed when it is for a utilitarian product, but not for a hedonic product. Conclusions - Theoretically, the findings of this study expand academic research on art infusion. And the findings also can be extrapolated to generate lots of implication for marketers. In sum, when they plan art marketing strategies to build the favorable relationship with their customers, they need to consider customers' response type of an infused art and product type.

• 농업과학연구
• /
• 제47권4호
• /
• pp.995-1010
• /
• 2020

In this study, a multivariate analysis model of partial least square regression (PLSR) was developed to predict the moisture content of green peppers using hyperspectral imaging (HSI). In HSI, illumination is essential for high-quality image acquisition and directly affects the analytical performance of the visible near-infrared hyperspectral imaging (VIS/NIR-HSI) system. When green pepper images were acquired using a direct lighting system, the specular reflection from the surface of the objects and their intensities fluctuated with time. The images include artifacts on the surface of the materials, thereby increasing the variability of data and affecting the obtained accuracy by generating false-positive results. Therefore, images without glare on the surface of the green peppers were created using a polarization filter at the front of the camera lens and by exposing the polarizer sheet at the front of the lighting systems simultaneously. The results obtained from the PLSR analysis yielded a high determination coefficient of 0.89 value. The regression coefficients yielded by the best PLSR model were further developed for moisture content mapping in green peppers based on the selected wavelengths. Accordingly, the polarization filter helped achieve an uniform illumination and the removal of gloss and artifact glare from the green pepper images. These results demonstrate that the HSI technique with a polarized lighting system combined with chemometrics can be effectively used for high-throughput prediction of moisture content and image-based visualization.

• 인터넷정보학회논문지
• /
• 제20권5호
• /
• pp.27-36
• /
• 2019

본 연구에서는 공개된 뇌파 데이터인 DEAP(A Database for Emotion Analysis using Physiological Signals) 데이터 세트를 활용한 감정분류 분석 및 정확도 향상에 대한 실험을 진행하였다. 실험에는 32명에 대한 32개의 뇌파측정 채널 데이터가 모두 사용되었다. 전처리과정에서는 뇌파 데이터에 대한 256Hz 샘플링작업을 진행하였고, 유한 임펄스 응답 필터를 사용하여 주파수 대역별로 쎄타(4-8Hz), 슬로 알파(8-10Hz), 알파(8-12Hz), 베타(12-30Hz), 감마(31-45Hz) 파형에 대한 데이터를 추출하였다. 추출한 데이터는 시간-주파수 변형을 통하여 데이터의 상태를 구분한 후에, 독립성분분석방법을 통해 잡음(Artifact)을 제거하여 데이터를 정제했다. 도출된 데이터는 분류기 기계학습 알고리즘 실험을 시행할 수 있도록 CSV 파일로 변형 하였으며, 감정분류에는 Arousal-Valence 평면을 사용하였다. 감정은 "긍정적(Positive)", "부정적(Negative)" 이외에 평온한 상태로 존재하는 "중립적(Neutral)"의 3가지 상태로 분류하였다. 정확도를 개선하기 위해서 랜덤 포레스트(Random Forest) 알고리즘에 속성 선택적 분류기(Attribute Selected Classifier: ASC) 방식에 의해 선택된 속성을 적용하여 실험하였다. 정확도는 "각성(Arousal)" 부분에서 Koelstra의 결과보다 "32.48%" 높은 결과가 도출되었고, Liu의 실험의 "정서가(Valence)"와 비교해보면 ASC(Random Forest) 결과가 "8.13%" 더 높은 결과를 도출하였다. 정확도를 개선하기 위해 ASC 방식을 적용한 랜덤 포레스트 분류기 실험결과에서는 전체평균을 기준으로 기존 연구 결과와 대비하여 "2.68%" 높은 정확도가 도출되었다.

• Journal of Chest Surgery
• /
• 제32권8호
• /
• pp.693-701
• /
• 1999

최근 혈관 질환의 진단을 위한 비침습적 영상이 발달하면서, 기존의 도자술은 중재적 치료에 국한되는 실 정이다. 그러나 관상동맥이나 우회로는 작은 직경, 심박동 움직임 등으로 도자술이 아직도 진단에 필수적이 며, 비침 응\ulcorner영상 진단의 마지막 도전 영역이다. 전자선 단층 촬영기는 높은 시간 해상능으로 심장 영상을 얻을 수 있다. 전자선 단층 촬영을 이용하여 모관상 동맥 협착이나 관상동맥 우회로 이식술 후 개존성의 평 가가 시도되고 있으며, 이중 관상동맥 우회로술 평가의 정확도는 매우 높아서 임상 적용이 가능하다. 저자와 다른 연구자의 경험에 의하면 복재 정맥은 넓은 직경, 비교적 짧고 직선적인 경로, 심박동에 덜 영 향 받음으로써 EBT조영술의 정확도가 높았다. 전향적 민감도와 특이도가 각각 92%, 97%를 보였다. 그러나 위양성과 위음성을 보인 두 예는 후향적으로 분석 할 때 경험 부족에 의한 초기의 판독 오류로 사료되어 복 재 정맥의 경우 후향적으로는 100%의 정확도를 보였다. 반면 내유동맥 이식혈관은 작은 내경과 주변의 수술 클립에 의한 인공산물로 개존성을 확인하기가 대체로 어려웠고, 역동적 검사를 병행하여 우회로내 혈류를 확인하는 것이 필요하다. 내유동맥의 경우 상대적으로 정확도가 낮아 민감도, 특이도가 각각 100%, 80%를 보였으며, 위양성을 보인 2예는 후향적으로도 개존을 확인할 수 없었다. 전자선 단층 촬영 혈관 조영술은 관상 동맥 우 막\ulcorner이식술 후의 우회 혈관 개존성의 평가, 특히 복재 정맥 우회로의 경우 매우 정확도가 높은 비침습적 검사로써, 임상 적용이 기대된다. 앞으로 촬영 기기와 영상 재구성 software의 발달로 정확도를 더욱 높일 수 있는 잠재성이 있다.

• Journal of Microbiology and Biotechnology
• /
• 제27권3호
• /
• pp.480-491
• /
• 2017

Fluorescent pseudomonads have been isolated from halophytes, mesophytes, and xerophytes of Pakistan. Among these, eight isolates, GS-1, GS-3, GS-4, GS-6, GS-7, FS-2 (cactus), ARS-38 (cotton), and RP-4 (para grass), showed antifungal activity and were selected for detailed study. Based on biochemical tests and 16S rRNA gene sequences, these were identified as strains of P. chlororaphis subsp. chlororaphis and aurantiaca. Secondary metabolites of these strains were analyzed by LC-MS. Phenazine-1-carboxylic acid (PCA), 2-hydroxy-phenazine, Cyclic Lipopeptide (white line-inducing principle (WLIP)), and lahorenoic acid A were detected in variable amounts in these strains. P. aurantiaca PB-St2 was used as a reference as it is known for the production of these compounds. The phzO and PCA genes were amplified to assure that production of these compounds is not an artifact. Indole acetic acid production was confirmed and quantified by HPLC. HCN and siderophore production by all strains was observed by plate assays. These strains did not solubilize phosphate, but five strains were positive for zinc solubilization. Wheat seedlings were inoculated with these strains to observe their effect on plant growth. P. aurantiaca strains PB-St2 and GS-6 and P. chlororaphis RP-4 significantly increased both root and shoot dry weights, as compared with uninoculated plants. However, P. aurantiaca strains FS-2 and ARS-38 significantly increased root and shoot dry weights, respectively. All strains except PB-St2 and ARS-38 significantly increased the root length. This is the first report of the isolation of P. aurantiaca from cotton and cactus, P. chlororaphis from para grass, WLIP and lahorenoic acid A production by P. chlororaphis, and zinc solubilization by P. chlororaphis and P. aurantiaca.