• The Korean Journal of Physiology and Pharmacology
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• v.3 no.6
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• pp.571-578
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• 1999

This study evaluated the effects of PKC activation using phorbol 12-myristate 13-acetate (PMA) and PKC inhibition using the isoquinoline sulfomide derivative H-7 on hemodynamics and glucoregulation in the isolated perfused rat liver. Livers were isolated from fed male Holtzman rats and perfused with Krebs Ringer bicarbonate solution under a constant flow of 50 ml/min at $35^{\circ}C.$ Portal vein pressure, glucose and lactate concentrations in the medium and oxygen consumption rates were continuously monitored by a Grass polygraph, YSI glucose and lactate monitors, and a YSI oxygen monitor, respectively. PMA at concentration of 2 to 200 nM increased the portal vein pressure, glucose and lactate production, but decreased oxygen consumption rate in a dose-dependent fashion. H-7 $(200\;{\mu}M)$ attenuated PMA (50 nM)-induced vasoconstriction $(15.1{\pm}1.36\;vs\;10.56{\pm}1.17\;mmHg),$ glucose production rate $(91.3{\pm}6.15\;vs\;71.8{\pm}2.50\;{\mu}moles/g/hr),$ lactate production rate $(72.4{\pm}6.82\;vs\;53.6{\pm}4.82\;{\mu}moles/g/hr)$ and oxygen consumption rate $(33.7{\pm}1.41\;vs\;27.9{\pm}1.75\;{\mu}l/g/min).$ The effects of PMA were blocked either by addition of verapamil $(9\;{\mu}M)$ or perfusion with $Ca^{2+}-free$ KRB. These results suggest that the hemodynamic and glucoregulatory changes in the perfused rat liver are mediated by protein kinase C activation and require $Ca^{2+}$ influx from the extracellular fluid.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.5
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• pp.634-644
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• 2001

The test facility of a 1/60-scale model for train-tunnel systems has been recently developed to investigate the effects of tunnel portal shapes, hood shapes and air-shafts for reducing the micro-pressure waves radiating towards the surroundings from the tunnel exit. The present test rig has been advanced from a 1/70-scale facility at NLR in Netherlands. The NLR test rig has the two-wise guidance system that needs two ears attached on the external surface of a model train nose. Therefore, their train models have irregular nose shapes. The main characteristics of the present facility are that the train model is guided by only one wire from the compressed air launcher to the absorber parts of test facility and the wire guidance hole is located at the axial center of a train model. In the present test rig, after a train model is launched, the air jet from the launcher does not enter the tunnel model. Experimental results were compared with numerical predictions to prove the performance of the test facility.

• The Korean Journal of Pharmacology
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• v.15 no.1_2 s.25
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• pp.29-37
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• 1979

The tension-length relationships and reactivity of vascular smooth muscle in longitudinal strips from portal vein ana in helical strips from thoracic aorta and pulmonary artery of normotensive control and cadmium-hypertensive rabbits were studied in vitro. 1. The mean arterial pressures of non-poisoned control rabbits was $87.0{\pm}4.7 mmHg$. However, Cd-poisoned group revealed the significant increase in pressure by $109.04{\pm}2.8 mmHg$ (p<0.005). 2. By tension-length studies, strips from portal vein of Cd-poisoned group stretched a greater percent increase in length in response to an applied resting force from 0.25 to 5 g than did those from non-poisoned group. On the contrary, strips from thoracic aorta of Cd-poisoned group showed less compliant than those from control, i.e. the former underwent a less percent increase in length than the latter. Passive tension-length relations of pulmonary artery was unaffected by Cd-hypertension. 3. The force of contraction(active tension) was significantly lowered in strips from aorta of Cd-hypertensive group throughout the range of $0.5{\sim}2g$ passive tension. However, there was no significant difference in the development of active tension of portal vein or pulmonary artery of both groups. 4. The $K^+$-contraction in the portal vein, aorta and pulmonary artery of Cd-poisoned group made no difference in the active force from those of control group. 5. The force of contraction in the strips from aorta of Cd-poisoned group was significanty decreased compared to that of control. The results suggested that the alterations in vascular reactivity to contracting substances and in distensibility to passive tension were induced in the Cd-hypertensive rabbits.

• Proceedings of the Korean Society for Rock Mechanics Conference
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• 2008.03a
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• pp.51-68
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• 2008

When the train enters into a tunnel a high speed, pressure waves are generated inside the tunnel. The pressure waves at propagate in a form of compression wave toward the tunnel exit and a fraction of the compression waves that arrives at the exit of the tunnel are discharged to outside of the tunnel and the remainder is reflected into the tunnel as expansion waves. The compression waves emitted from the tunnel does not radiate in a specific direction but in all directions. If the amplitude of the compression wave is great, it causes noise and vibration, and it is called "Micro-Pressure Wave." "Micro-Pressure Wave" must be considered as a decision for the optimum tunnel cross-section as the amplitude of the compression wave depends on train speed, tunnel length, area of tunnel and train. Therefore, this paper introduces the case study of Micro-Pressure Wave characteristics for determination of tunnel cross section in Honam high speed railway, the pressure inside the tunnel and the micro-pressure waves at tunnel exit were measured at Hwashin 5 tunnel in Kyungbu HSR line. At the same time. a test of train operation model was performed and then the measurement results and test results were compared to verify that the various parameters used as input conditions for the numerical simulations, which were appropriate. Also a model test was performed, in order to analysis of the Micro-Pressure Wave Mitigation Performance by Type of Hood at Entrance Portal.

• Journal of the Korean Society for Railway
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• v.18 no.1
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• pp.8-14
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• 2015

This paper describes a prediction method for micro-pressure wave emitted from a tunnel on the Kyung-bu high-speed railway. Pressure and micro-pressure wave were measured simultaneously to obtain some constants for the prediction method. The change of a micro-pressure wave were analyzed according to the speed of the train, the track bed type, and the distance from a tunnel portal. At a train speed of 300km/h, the micro-pressure wave of 4.0km long ballast track tunnel is about 7.5Pa; that of 3.3km long slab track tunnel is about 14.3Pa The strength of the micro-pressure wave decreases in inverse proportion to the distance and becomes about 0.5~1.0Pa at a point of 100m from the tunnel exit. Micro-pressure waves were predicted using the formula with the obtained the constants. Using a comparison between the predicted data and field measurement data, it was confirmed that micro-pressure wave can be predicted easily through the prediction formula.

• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.427-432
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• 1999

When a high-speed train enters a tunnel, a compression wave is generated. This wave subsequently emerges from the exit portal of the tunnel, which causes an impulsive noise called 'Sonic boom' or 'micro-pressure wave'. In the present study, new method is presented for prediction of sonic boom noise, especially focusing on the effect of the nose shape of the train on the resultant noise. Acoustic theory for monopole source is used to represent a nose shape of the train in wave equation. Compression wave propagation in tunnel considering tunnel track condition and emission of sonic boom was calculated. The predicted compression waves and impulsive sound waves are compared with recent measurements, and show reasonable agreements.

• Biomolecules & Therapeutics
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• v.13 no.3
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• pp.127-132
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• 2005

We investigated whether ischemic preconditioning (IPC) protects liver against cold ischemic injury using isolated perfused rat liver. Rat livers were preconditioned by 5 minutes of ischemia and 5 minutes of reperfusion and preserved for 30 hours at $4^{\circ}C$ in University of Wisconsin solution. Livers were then reperfused for 120 minutes. Oxygen uptake and bile flow in ischemic livers markedly decreased during reperfusion. These decreases were prevented by IPC. Portal pressure was elevated in cold ischemic and reperfused livers and this elevation was prevented by IPC. Lactate dehydrogenase and purine nucleoside phosphorylase activities markedly increased during reperfusion. These increases were prevented by IPC. The ratio of reduced glutathione to glutathione disulfide was lower in ischemic livers. This decrease was prevented by IPe. Our findings suggest that IPC protects the liver against the deleterious effect of cold ischemia/reperfusion, and this protection is associated with the reduced oxidative stress.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.51 no.3
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• pp.112-121
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• 2002

This paper describes a new bike system for the postural balance rehabilitation training. Virtual environment and three dimensional graphic model is designed with CAD tools such as 3D Studio Max and World Up. For the real time bike simulation, the optimized WorldToolKit graphic library is embedded with the dynamic geometry generation method, multi-thread method, and portal generation method. In this experiment, 20 normal adults were tested to investigate the influencing factors of balancing posture. We evaluated the system by measuring the parameters such as path deviation, driving velocity, COP(center for pressure), and average weight shift. Also, we investigated the usefulness of visual feedback information by weight shift. The results showed that continuous visual feedback by weight shift was more effective than no visual feedback in the postural balance control It is concluded this system might be applied to clinical use as a new postural balance training system.

• Journal of Chest Surgery
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• v.27 no.8
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• pp.710-713
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• 1994

The Budd-Chiari syndrome is a rare type of portal hypertension caused by complete or incomplete obstruction of the hepatic vein or the corresponding portion of the inferior vena cava or both. In this case, the obstruction was located just beneath the diaphragm, above the right hepatic vein opening, which was confirmed by vena cavography preoperatively. Budd-Chiari syndrome with stenosis or thrombosis of the inferior vena cava may be cured by prosthetic bypass to the right atrium. This case is caused by thrombus of unknowed primary origin. Combined mesoatrial and cavoatrial shunt should be encouraged in this specific situation. Postoperatively, there were marked fall of venous pressure and symptoms and signs improved remarkably.

• Proceedings of the KSR Conference
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• 1999.11a
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• pp.146-154
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• 1999

The test facility of the 1/60-scale models for the train-tunnel interactions was recently developed to investigate the effects of entry portal shapes, flood shapes and air-shafts for reducing the micro-pressure waves radiating to the surroundings of the tunnel exits by KRRI in Korea. The launching system of train model was chosen as air-gun type. In present test rig, after train model is launched, the blast wave by the driver did not enter to inside of the tunnel model. The train model is guided on the one-wire system from air-gun driver to the brake parts of test facility end. Some cases of the experiments were compared with numerical simulations to prove the test facility.