• Proceedings of the KSME Conference
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• 2000.04b
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• pp.841-846
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• 2000

The compression wave produced when a high-speed train enters a tunnel propagates along the tunnel ahead of the train. The micro pressure wave related to He compression wave is a special physics Phenomena created by high-speed train-tunnel interfaces. On this work, the method for reducing the micro pressure wave is to delay the gradient of the compression wave by using aerodynamic structures. The objective of this paper is to determine the optimum angle of the slanted portal using the moving model rig. According to the results of the present study, the maximum value of micro pressure wave is reduced by 19.2% fer the $45^{\circ}$ slanted portal installed at the entrance of the tunnel and reduced by 41.9% far the $45^{\circ}$ slanted portals at the entrance and exit of the tunnel. Also it is reduced by 34.6% for the $30^{\circ}$ slanted portals installed at the entrance and exit of the tunnel.

• The Korean Journal of Pharmacology
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• v.23 no.1
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• pp.15-23
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• 1987

To elucidate the mechanism of splanchnic hyperemia associated with chronic portal hypertension, we have investigated the alteration in visceral reflexes in conjuction with circulatory hemodynamics in portal ligated portal hypertension in cats. When capsaicin, bradykinin and vasopressin were injected via splenic artery of sham cat, respectively, they caused not only reflex excitation of systemic arterial pressure, but also elevation of splenic venous pressure with unchanged heart rates. Simultaneously, they evoked the sympathetic efferent excitation of liver (spleno-hepatic reflex) as well as of spleen (spleno-splenic reflex). Similarly, capsaicin upon pledging on the liver surface evoked a significant increase in the pressor reflex with hepatic nerve excitation (hepato-hepatic reflex). After portal ligation, the splenic venous pressure was gradually elevated in association with decrease in systemic arterial pressure. However, the excitation of pressor reflex was enhanced on the and day, thereafter, being returned to the control, and the reflexly induced spleno-splenic, spleno-hepatic and hepato-hepatic sympathetic excitations were significantly diminished on the 8th day following portal vein ligation. In conclusion, it is suggested that sympathetic reflexes to spleen and liver are specifically intervened by the same central pathways and furthermore, the diminution of these viscero-visceral reflex excitations after portal ligation may be related to the intestinal hyperemia.

• Journal of Yeungnam Medical Science
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• v.35 no.1
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• pp.89-93
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• 2018

Idiopathic non-cirrhotic portal hypertension (INCPH) is a disease with an uncertain etiology consisting of non-cirrhotic portal hypertension and portal pressure increase in the absence of liver cirrhosis. In INCPH, patients exhibit normal liver functions and structures. The factors associated with INCPH include the following: Umbilical/portal pyremia, bacterial diseases, prothrombic states, chronic exposure to arsenic, vinyl chloride monomers, genetic disorders, and autoimmune diseases. Approximately 70% of patients present a history of major variceal bleeding, and treatment relies on the prevention of complications related to portal hypertension. Autoimmune disorders associated with INCPH are mainly systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis. To the best of our knowledge, a case of ankylosing spondylitis (AS) associated with INCPH has not been reported thus far. Therfore, we report our experience of a patient with AS accompanied by INCPH, who showed perisplenic varices with patent spleno-portal axis and hepatic veins along with no evidence of cirrhosis on liver biopsy, and provide a brief literature review.

• The Korean Journal of Nuclear Medicine
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• v.33 no.4
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• pp.388-397
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• 1999

Purpose: Propranolol is known to decrease portal pressure by reducing blood flow of portal vein. Perrectal portal scintigraphy with Tc-99m pertechnetate has been introduced to evaluate the portal circulation and early diagnosis of liver cirrhosis. We evaluated the effects of propranolol on portal circulation by using per-rectal portal scintigraphy. Materials and Methods: We analyzed the portal hemodynamics by per-rectal portal scintigraphy in 51 patients with liver cirrhosis, 10 chronic hepatitis and 10 normal subjects. 38 patients with cirrhosis underwent per-rectal portal scintigraphy before and after propranolol medication. Perrectal portal scintigraphy was performed after per-rectal administration of 370 MBq of Tc-99m pertechnetate. The shunt index was calculated as the ratio, expressed as a percentage of heart radioactivity to the sum of heart and liver radioactivity during the first 30 seconds. Results: The shunt index in 40 patients with cirrhosis ($59.8{\pm}27.2%$) was significantly higher than that of normal control ($5.0{\pm}1.2%$. p<0.01) and chronic hepatitis ($11.4{\pm}3.5%$, p<0.01). Shunt index was significantly different according to Child's classification and the degree of esophageal varix (p<0.01). After propranolol medication, shunt index was significantly decreased from $59.9{\pm}27.3%$ to $51.3{\pm}15.3%$ (p<0.01) in 38 patients with liver cirrhosis. There was no significant difference of the amount of shunt index reduction after propranolol according to Childs' classification and the degree of esophgageal varix. Conclusion : The effect of propranolol on portal circulation was demonstrated as decreasing shunt index on per-rectal portal scintigraphy in patients with liver cirrhosis. Per-rectal portal scintigraphy may be useful to evaluate the portal circulation and to predict the effect of propranolol in patients with liver cirrhosis.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.6
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• pp.758-765
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• 2001

Purpose of the present is to investigate the food configuration at a tunnel entrance for reducing the micro pressure wave that is generated according to train speed. Two configurations were examined for tunnel of 0.5 km length. The experimental results show that a slit cover hood installed at the entrance of the tunnel reduces the maximum micro pressure wave by 41.2%, and a configuration with a slit cover hood installed at the entrance and a 45$^{\circ}$slanted portal at the exit of the tunnel suppresses it by 47.7%.

• Proceedings of the KSME Conference
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• 2000.04b
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• pp.619-624
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• 2000

The purpose of present study is to investigate for reducing micro pressure waves generated according to train speeds $(240km/h{\sim}380km/h)$ through tunnels with countermeasures as followings; the hood configuration in tunnel entrance. We developed hoods for tunnel of 0.5 km length in the condition of tunnel cross-section area of $107m^2$ on the slab track. According to the results the maximum micro-pressure wave is reduced by 41.2% for the slit hood installed at the entrance of the tunnel and reduced by 47.7% for the slit hood installed at the entrance of the tunnel and the $45^{\circ}$ slanted portal at the exit of the tunnel

• 기술발표회
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• s.2006
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• pp.342-355
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• 2006

The Tunnel portal is designed on temporary support system which is composed by 28m height H-Pile method and Ground Anchor method. The tunnel has excavated about 30m from the portal, but some deformation is found on the surface ground just above the tunnel face. It was investigated very carefully to find out the causes of deformation. By the observation and study, two main causes of deformation are found out. The one is earth pressure increase compared with classical earth pressure theory. That was due to the direction of ground rock mass's discontinuities. It causes the increase of earth pressure that are activated by the direction of discontinuity. The other one is that present design method neglect the transferred force by removal of temporary support members and ground anchor within the tunnel contour line as the tunnel excavation proceeds As the result of removals of the member and anchor, some force transferred from removed systems to remaining supporting systems. In designing the portal support systems, lt must be considered the discontiunity of ground mass and the transfered force due to excation.

• Journal of Yeungnam Medical Science
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• v.16 no.2
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• pp.181-192
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• 1999

Background: Nitric oxide, a vasodilator synthesized from L-arginine by vascular endothelial cells, accounts for the biological activity of endothelium derived relaxing factor. Previous studies demonstrated that nitric oxide inhibitor, $N^{\omega}$-Nitro-L-Arginine(NNA) diminished the hyperdynamic splanchnic and systemic circulation in portal hypertensive rats The present study was done to determine the role of nitric oxide in the development of hyperdynamic circulations in the prehepatic portal hypertensive rat model produced by partial portal vein ligation. Methods: The portal hypertensive rats were divided into water ingestion group and NNA ingestion group. After partial portal vein ligation, NNA ingestion group and water ingestion group received NNA 1mg/kg/day and plain water through the mouth for 14 days, respectively. Cardiac output, mean arterial pressure, organ blood flow and porto-systemic shunting were measured by radioisotope labeled microsphere methods. Vascular resistances were calculated by standard equation. Results: There were significant decreases in mean arterial pressure, increases in cardiac output and cardiac index, and decreases in total systemic and splanchnic vascular resistance in portal hypertensive rats compared to normal control group (p<0.01). Compared to the water ingestion group, significantly increased mean arterial pressure with decreased cardiac output and cardiac index were developed in the NNA ingestion group. Total systemic and splanchnic vascular resistance were significantly increased in the NNA ingestion group compared to water ingestion group (p<0.05). But, there was no significant difference in portal pressure between the two groups. Conclusion: The hemodynamic results of this study indicate that hyperdynamic circulation in prehepatic portal hypertensive rat mode1 was attenuated by ingestion of NNA. Nitric oxide may play an important role in the development of hyperdynamic circulation with splanchnic vasodilation in chronic portal hypertension.

• Journal of Korean Tunnelling and Underground Space Association
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• v.2 no.2
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• pp.3-10
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• 2000

The compression wave produced when a high-speed train enters a tunnel propagates along the tunnel ahead of the train. The micro pressure wave related to the compression wave is a special physics phenomena created by high-speed train-tunnel interfaces. A among methods for the purpose of reducing the micro pressure wave is to delay the gradient of the compression wave by using aerodynamic structures. The objective of this paper is to determine the optimum slanted portal using the moving model rig. According to the results, the maximum value of micro pressure wave is reduced by 19.2% for the $45^{\circ}$ slanted portal installed at the entrance of the tunnel and reduced by 41.9% for the $45^{\circ}$ slanted portals at the entrance and exit of the tunnel. Also it is reduced by 34.6% for the $30^{\circ}$ slanted portals installed at the entrance and exit of the tunnel.

• Journal of Korean Tunnelling and Underground Space Association
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• v.2 no.3
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• pp.3-11
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• 2000

Purpose of this paper is to investigate the hood configuration at a tunnel entrance to reduce the micro pressure wave that is generated according to train speed. Two configurations were examined for the tunnel of 0.5 km in length. The experimental results show that a slit cover hood installed at the entrance of the tunnel reduces the maximum micro pressure wave by 41.2%, and the configuration with a slit cover hood installed at the entrance and the $45^{\circ}$ slanted portal at the exit of the tunnel suppress the pressure wave by 47.7%.