• Title/Summary/Keyword: Population-based study

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Age Distribution of Breast Cancer from a Thailand Population-Based Cancer Registry

  • Kotepui, Manas;Chupeerach, Chaowanee
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.6
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    • pp.3815-3817
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    • 2013
  • Background: Breast cancer is a common cancer worldwide. With the establishment of Thailand's population-based cancer registry and availability of complete data from 2002-2011, it is of interest to investigate the epidemiologic and clinic-pathological profiles of breast cancer based on the population-based registry data. Methods: The data of all breast cancer patients in the registry for the period of 2002-2011 were included. All medical records of the patients diagnosed from documents of National Cancer Registry of Thailand were retrieved and the following information abstracted: age, clinical characteristics, and histological variables. Thailand census data for the period of 2002-2011 were used to provide the general population's statistics on age, gender, and other related demographic factors. Results: Over the 10 year-period, 7,711 breast cancer cases were included. The disease incidence under age 40 years was relatively low (4.13/$10^5$) while the incidence in the age groups 40 and older was very high (39.2/$10^5$). The vast majority of breast cancer cases (88.8%) were diagnosed by histology as primary lesions in the breast. The most common of patients with breast cancer (36.4%) had regional lymph node involvement and the most common of histopathology diagnosed in patients (84.2%) was an infiltrating duct carcinoma. Conclusions: This study showed a high incidence of breast cancer in older subjects, and high rate of breast cancer in Thailand. Future studies should explore clinical and molecular disease patterns.

Estimated Number of Korean Adults with Back Pain and Population-Based Associated Factors of Back Pain : Data from the Fourth Korea National Health and Nutrition Examination Survey

  • Jhun, Hyung-Joon;Park, Jung-Yul
    • Journal of Korean Neurosurgical Society
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    • v.46 no.5
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    • pp.443-450
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    • 2009
  • Objective : We estimated the number of Korean adults with back pain and evaluated population-based associated factors of back pain from a representative sample data from the Fourth Korea National Health and Nutrition Examination Survey. Methods : The number of Korean adults who experienced back pain (experienced patients), those who experienced back pain lasting for three or more months during the past year (chronic patients), and those who were currently suffering from back pain (current patients) were estimated by analyzing the data from the fourth Korea National Health and Nutrition Examination Survey conducted in 2007 using surveyfreq procedure of the SAS statistical package. Population-based odds ratios for being experienced, chronic, and current patient according to demographic (age and gender), socioeconomic (education and occupation), and lifestyle factors (smoking, drinking, and exercise) were estimated using surveylogistic procedure. Results : It was estimated that there were 5,554,256 (proportion, 15.4%; 95% CI, 4,809,466 - 6,299,046) experienced patients, 2,060,829 (5.7%; 1,557,413-2,564,246) chronic patients, and 3,084,188 (8.5%; 2,600,197 - 3,568,179) current patients among 36,107,225 Korean adults aged 20-89 years in 2007. Each of explanatory variables was significantly associated with at least one of the response variables for back pain. Conclusion : Based on our study results, further efforts to investigate epidemiology of back pain, to evaluate associated factors, and to improve treatment outcomes are needed.

A Survey on Housing Environment of Vulnerable Population - Focused on the Recipients of Visiting Health Care Services - (취약계층의 주거환경 실태조사 -보건소 방문보건사업 대상을 중심으로-)

  • Kim, Hee Gerl;Nam, Hye Kyung
    • Journal of Korean Public Health Nursing
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    • v.29 no.3
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    • pp.528-539
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    • 2015
  • Purpose: The aim of this study is to provide baseline data on the housing environment of a vulnerable population. Methods: This study provides a descriptive survey on the housing environment of a vulnerable population of a city in Gyeong-gi province. A total of 9,061 households were selected as research participants. Data were collected through face-to-face interviews by visiting nurses from February 2014 to March 2014. Results: Interviewees answered "poor" on items including cold drafts, illumination, daylight penetration, inflow of polluted air, house odor, stairs safety, noise, mold, pests, and ventilation. The score for housing environment problems showed a significant group difference due to gender, age, economic status, family type, type of housing, and type of ownership. Conclusion: These results indicate that the vulnerable population is exposed to a poor housing environment. Thus, there is an urgent need to improve the housing environment for the vulnerable population. Based on this study, linking a visiting health care service program and housing environment improvement projects from relevant administrative agencies might be recommended in order to effectively improve the housing environment.

Analysis of the Genetic Diversity and Population Structure of Amaranth Accessions from South America Using 14 SSR Markers

  • Oo, Win Htet;Park, Yong-Jin
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.58 no.4
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    • pp.336-346
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    • 2013
  • Amaranth (Amaranthus sp. L.) is an important group of plants that includes grain, vegetable, and ornamental types. Centers of diversity for Amaranths are Central and South America, India, and South East Asia, with secondary centers of diversity in West and East Africa. The present study was performed to determine the genetic diversity and population structure of 75 amaranth accessions: 65 from South America and 10 from South Asia as controls using 14 SSR markers. Ninety-nine alleles were detected at an average of seven alleles per SSR locus. Model-based structure analysis revealed the presence of two subpopulations and 3 admixtures, which was consistent with clustering based on the genetic distance. The average major allele frequency and polymorphic information content (PIC) were 0.42 and 0.39, respectively. According to the model-based structure analysis based on genetic distance, 75 accessions (96%) were classified into two clusters, and only three accessions (4%) were admixtures. Cluster 1 had a higher allele number and PIC values than Cluster 2. Model-based structure analysis revealed the presence of two subpopulations and three admixtures in the 75 accessions. The results of this study provide effective information for future germplasm conservation and improvement programs in Amaranthus.

A Study on the Standards for Public Library Opening Hours in Foreign Countries and Korea (국내외 공공도서관 개관시간 기준 연구)

  • Yoon, Hee-Yoon
    • Journal of Korean Library and Information Science Society
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    • v.44 no.1
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    • pp.49-71
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    • 2013
  • Public Libraries should be open at times when the community can make the most effective and convenient use of library collections and services. In other words, public library must provide adequate open hours for local residents. In this respect, this study analyzed the minimum opening hours per week in public library standards of international organizations(IFLA/UNESCO) and major countries (USA, Canada, UK, France, Australia, China, Taiwan, Japan, Korea) and suggested a desirable minimum standards(under 10,000 population-45 hours ; over 10,000~20,000 population-50 hours ; over 20,000~50,000 population-55 hours ; over 50,000~100,000 population-60 hours ; over 100,000~300,000 population-65 hours ; over 300,000 population-70 hours) for opening hours per week of public library based on population size in Korea.

Establishing a Korean Goral (Nemorhaedus caudatus raddeanus Heude) Reserve in Soraksan National Park, Korea: Based on Habitat Suitability Model, Habitat Capability Model, and the Concept of Minimum Viable Population (설악산 국립공원의 산양 보호구역 설정기법에 관한 연구: 서식지 적합성 모형, 서식지 수용능력, 최소 존속 개체군 이론을 이용하여)

  • Choi, Tae-Young;Park, Chong-Hwa
    • Journal of the Korean Institute of Landscape Architecture
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    • v.32 no.6 s.107
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    • pp.23-35
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    • 2005
  • Korean goral (Nemorhaedus caudatus raddeanus) is an endangered species in Korea, and the rugged terrain of the Sorksan National Park $(373km^2)$ is a critical habitat for the species. Since the goral population is threatened by habitat fragmentation, it is essential to establish a reserve for the isolated goral population. The objective of this study was to propose a reserve for Korean goral in the national Park We employed habitat suitability model, habitat capability model, and the concept of minimum viable population. The results of the study were as follows. First, the carrying capacity and optimal density of gorals in the national park were projected to be 449 gorals, and 251 gorals, respectively Second, since only one patch was projected to satisfy the criteria of minimum viable population (50 individuals/during 50 years), the long term extinction possibility of gorals in the site would be very high. Finally, the patch that satisfy the minimum viable population of goral was proposed as the core zone of the goral reserve and adjacent patches were included as buffer zones.

Genetic Susceptibility to Esophageal Cancer due to CYP1A1 Gene Variant rs4646903 in Tobacco Addicted Patients of Pashtun Ethnicity: a Case Control Study in Khyber Pakhtunkhwa Province of Pakistan

  • Zakiullah, Zakiullah;Saeed, Muhammad;Ali, Sajid;Javed, Nabila;Khisroon, Muhammad;Muhammad, Basir;Khuda, Fazli;Ahmad, Saeed;Ismail, Mohammad
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.16
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    • pp.6715-6720
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    • 2014
  • The purpose of this study was to evaluate associations of the CYP1A1 gene variant rs4646903 polymorphism with the risk of developing esophageal cancer (EC). A case-control study was carried out in Pashtun population of Khyber Pakhtunkhwa province of Pakistan in which 140 hospital based EC cases and 196 population based healthy controls exposed to similar environmental conditions were included. A specific method based on the real time polymerase chain reaction (RT-PCR) was used to detect genotypes in case and control groups and results were then analyzed with SPSS version 20. In our population, individuals with CC and TC genotypes of the CYP1A1 rs4646903 polymorphism had significantly higher risk of EC (adjusted odds (OR): 15.709, 95%CI: 6.065-40.686, OR: 3.256 95%CI: 1.902-5.574 respectively). The 'C' allele was strongly associated with the disease (p< 0.0001). Adjusted OR was higher (1.5 times in C/C) in case of variant alleles that show the contribution of environmental and nutritional factors towards the development of EC. Our findings suggest that presence of the 'C' allele of rs4646903 (T>C) may be one of the risk alleles for EC susceptibility in Pashtun population.

Age-Specific Thyroid Internal Dose Estimation for Koreans

  • Kwon, Tae-Eun;Yoon, Seokwon;Ha, Wi-Ho;Chung, Yoonsun;Jin, Young Woo
    • Journal of Radiation Protection and Research
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    • v.46 no.4
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    • pp.170-177
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    • 2021
  • Background: The International Commission on Radiological Protection is preparing to provide reference dose coefficients for environmental radioiodine intake based on newly developed age-specific biokinetic models. However, the biokinetics of iodine has been reported to be strongly dependent on the dietary intake of stable iodine; for example, the thyroidal uptake of iodine may be substantially lower in iodine-rich regions than in iodine-deficient regions. Therefore, this study attempted to establish a system of age-specific thyroid dose estimation for South Koreans, whose daily iodine intakes are significantly higher than that of the world population. Materials and Methods: Korean age-specific biokinetic parameters and thyroid masses were derived based on the previously developed Korean adult model and the Korean anatomical reference data for adults, respectively. This study complied with the principles used in the development of age-specific biokinetic models for world population and used the ratios of baseline values for each age group relative to the value for adults to derive age-specific values. Results and Discussion: Biokinetic model predictions based on the Korean age-specific parameters showed significant differences in iodine behaviors in the body compared to those predicted using the model for the world population. In particular, the Korean age-specific thyroid dose coefficients for 129I and 131I were considerably lower than those calculated for the world population (25%-76% of the values for the world population). Conclusion: These differences stress the need for Korean-specific internal dose assessments for infants and children, which can be achieved by using the data calculated in this study.

Estimation of Denominators- a New Approach for Calculating of Various Rates in Cancer Registries

  • Haroon, A.S.;Gupta, S.M.;Tyagi, B.B.;Farhat, J.
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.7
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    • pp.3229-3232
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    • 2012
  • In this study, cancer incidence data were assessed to provide various rates of five year age groups for a given year, lying between two census years. The individual exponential growth rate method is most useful in both population-based and non-population cased cancer registries in India to estimate the population by five yearly age groups and also find the rates of crude rates, age standard rates and cumulative rates. This method has been shown to endure from bias and often results sacrificing the overall growth rate and correction factor must be needful in five year age group population to maintain it. A second method, the difference distribution method is also able to maintain the overall growth rate and overcome the bias in estimation of five yearly age group populations. From this point of view these methods serving a new technique for population estimation by five yearly age groups for inter census years.

Genetic Diversity and Population Structure of Peanut (Arachis hypogaea L.) Accessions from Five Different Origins

  • Zou, Kunyan;Kim, Ki-Seung;Lee, Daewoong;Jun, Tae-Hwan
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.65 no.4
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    • pp.447-456
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    • 2020
  • Peanut is an allotetraploid derived from a single recent polyploidization. Polyploidization has been reported to have caused significant loss in genetic diversity during the domestication of cultivated peanuts. Single nucleotide polymorphism (SNP)-based markers such as cleaved amplified polymorphic sequences (CAPS) derived from next-generation sequencing (NGS) have been developed and widely applied for breeding and genetic research in peanuts. This study aimed to identify the genetic diversity and population structure using 30 CAPS markers and 96 peanut accessions from five different origins. High genetic dissimilarities were detected between the accessions from Korea and those from the other three South American origins generally regarded as the origin of peanuts, while the accessions from Brazil and Argentina presented the lowest genetic dissimilarity. Based on the results of the present study, accessions from Korea have unique genetic variation compared to those from other countries, while accessions from the other four origins are closely related. Our study identified the genetic differentiation in 96 peanut accessions from five different origins, and this study also showed the successful application of SNP information derived from re-sequencing based on NGS technology.