• Archives of Pharmacal Research
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• 제18권3호
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• pp.169-172
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• 1995

The changes in blood pressure may relate to the alterations of the responsiveness to vasoconstrictors and vasodilators, and these alterations can arise the modifications in the properties of angiotensin II (AII) receptor. In order to examine the changes of AII receptor in the hypertensive mechanism of renin-dependent hypertensive rats (RHRs; two-kidney, one-ligated type), we compared the equilibrium binding characteristics of $[^3H]$All in adrenal cortex and medulla from RHRs and normotensive rats. The dissociation constants of AII binding in both tissues of RHRs were very similar to those in the respective tissue of normotensive rats. However, the maximum binding was increased from 805 to 1050 fmole/mg protein in the adrenal cortex of RHRs, and decreased from 172 to 126 fmole/mg protein in the adrenal medulla of RHRs. These results imply that the up- and down-regulation of the All receptor population on the cell surface of adrenal glands from RHRs are consorted with the elevation of blood pressure and the activation of renin-angiotensin system.

• 교육시설 논문지
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• 제18권1호
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• pp.29-38
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• 2011

ent years, the change of urban function and the decrease in birth rate have given rise to merge, abolition and relocation of the existing schools. This study explores the possibilities for various land utilizations of relocated school sites, using the trial case of 'A' elementary school in Eun-pyeong gu, Seoul. 'A' elementary school has happened transfer plan due to the urban development project of the redevelopment area, Eun-pyeong gu in Seoul. Firstly, it studies the land use categories and the development methodologies of 7 relocated school sites happened in Seoul. In addition, it analyzes the land utilization after relocation, development principals, area, building usage and changes in land use regulation. Finally, it proposes the commercial exploitation of school site targeting 'A' elementary school site. Throughout the profit analysis, this study concludes that it is available to exploit the relocated school sites by the variety of development methodologies, especially in a metropolis like Seoul.

• Journal of Electrical Engineering and Technology
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• 제13권1호
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• pp.460-467
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• 2018

Metaheuristic optimization approach has become the new framework for control synthesis. The main purposes of the control design are command (input) tracking and load (disturbance) regulating. This article proposes an optimal proportional-integral-derivative (PID) controller design for the DC motor speed control system with tracking and regulating constrained optimization by using the cuckoo search (CS), one of the most efficient population-based metaheuristic optimization techniques. The sum-squared error between the referent input and the controlled output is set as the objective function to be minimized. The rise time, the maximum overshoot, settling time and steady-state error are set as inequality constraints for tracking purpose, while the regulating time and the maximum overshoot of load regulation are set as inequality constraints for regulating purpose. Results obtained by the CS will be compared with those obtained by the conventional design method named Ziegler-Nichols (Z-N) tuning rules. From simulation results, it was found that the Z-N provides an impractical PID controller with very high gains, whereas the CS gives an optimal PID controller for DC motor speed control system satisfying the preset tracking and regulating constraints. In addition, the simulation results are confirmed by the experimental ones from the DC motor speed control system developed by analog technology.

• 환경영향평가
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• 제13권4호
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• pp.165-185
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• 2004

Assessment in Socio-economic items should be used to estimate social influence when policies and projects were introduced. To estimate current situation of socio-economic items 19 Environmental Impact Statement (EIS) of large scale projects were analyzed. The projects were selected based on magnitude of social impact when the projects were implemented. Environmental Impact Statement was categorized into line projects(road construction, railroad construction, stream development, etc), and surface projects(energy development, wetland reclamation, recreation and sport development, and housing and residential development, etc) thus being chosen for 19 projects in each categories. This report was based on the analysis of 7 items in socio-economic environmental items(i.e., population, residents, industry, public facilities, education, transport and historical monument). Most EIS did not follow the regulation suggested by Ministry of Environment, and only current circumstances were briefly described. Indifference of in-depth analysis of socioeconomic environmental items would influence the process of social and environment impact negatively in the midst of construction of National Projects such as Outer Circle Seoul Highways, Saemankeum Reclamation Projects, etc. This abrupt halt of construction was mostly based on a lack of public hearing or public participation. Socio-economic items are also very much lacking in quantitative method and strengthening socio-economic environmental items is needed via checklist or matrix that brings decision-makers better ideas objectively.

• The Journal of Asian Finance, Economics and Business
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• 제8권5호
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• pp.391-401
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• 2021

Technological developments facilitate payment transactions. In 2020, Bank Indonesia issued a regulation that supports QR payments using the Indonesian Standard Quick Response Code (QRIS). PT ABC is one of the banks that launched a QR payment feature on mobile banking with QRIS standards to make it easier for customers to make payment transactions at various merchants. In its implementation, the interest of QR payment users still tends to be small, so an analysis of the interests of QR payment users is carried out. The purpose of this study is to analyze the factors that influence user interest by using a modified UTAUT model. The UTAUT model was modified by adding variables to perceived trust, perceived risk, perceived regulatory support, and promotional benefits. The population taken is the company's customers in the DKI Jakarta area and it takes 403 samples for this case study. The results of empirical analysis show that 8 out of 12 hypotheses are considered proven where business expectations, social influence, perceived trust, perceived risk, perceptions of regulatory support, promotion benefits, age-moderated performance expectations, and age-moderate effort expectations have a significant effect on behavioral intentions, while performance expectations, facilitation conditions, business expectations are moderated by experience and social influence.

• The Plant Pathology Journal
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• 제35권1호
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• pp.84-89
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• 2019

Two-component systems (TCSs) are critical to the pathogenesis of Xanthomonas oryzae pv. oryzae (Xoo). We mutated 55 of 62 genes annotated as responsive regulators (RRs) of TCSs in the genome of Xoo strain PXO99A and identified 9 genes involved in Xoo virulence. Four (rpfG, hrpG, stoS, and detR) of the 9 genes were previously reported as key regulators of Xoo virulence and the other 5 have not been characterized. Lesion lengths on rice leaves inoculated with the mutants were shorter than those of the wild type and were significantly restored with gene complementation. The population density of the 5 mutants in planta was smaller than that of PXO99A at 14 days after inoculation, but the growth curves of the mutants in rich medium were similar to those of the wild type. These newly reported RR genes will facilitate studies on the function of TCSs and of the integrated regulation of TCSs for Xoo pathogenesis.

• Asian-Australasian Journal of Animal Sciences
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• 제32권8_spc호
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• pp.1219-1232
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• 2019

The global goat population continues to grow and is now over one billion. The number of goats raised primarily for milk production is also growing, due to expanding demand. Most of the world dairy goat production and consumption is in Asia, but a global view of the dairy goat sector reveals important lessons about building successful modern dairy goat industries. The most organized market for goat milk is found in Europe, especially in France. The European goat sector is specialized for milk production, mostly for industrial cheesemaking, while also supporting traditional on-farm manufacturing. Government involvement is significant in sanitary regulation, research, extension, support for local producer organizations, and markets, and ensures safety and quality. Nonetheless, producers are still vulnerable to market fluctuations. New dairy goat industries are developing in countries without a long goat milk tradition, such as China, the United States, and New Zealand, due to rising consumer demand, strong prices, and climate change. The mix of policies, management and markets varies widely, but regardless of the country, the dairy goat sector thrives when producers have access to markets, and the tools and skills to sustainably manage their livestock and natural resources. These are most readily achieved through strong and inclusive producer organizations, access to technical services, and policies that enable the poor and marginalized groups to benefit from increasing demand.

• 한국표면공학회지
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• 제52권1호
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• pp.43-51
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• 2019

The environmental pollution which is global warming and abnormal climate is caused by increasing population and activated economics. To reduce environmental pollution, we have being efforts into reducing $CO_2$ emission and use of energy, resources. Especially, for the sake of light weight and fuel efficiency of automotive industry, many countries have defined the restrict environmental regulation which stipulate high magnitude of reducing $CO_2$ emission. In this study, we have predicted the problem of Mu-cell injection molding through the finite element analysis as a function of temperature controlled by Joule heating or in terms of mold temperature. From the result of finite element analysis, we have determined the optimized process and made the injection mold included electric current heating system with Mu-cell manufacturing. Lastly, we analyzed the surface characteristics of the injection products with mold temperature.

• Biomolecules & Therapeutics
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• 제29권4호
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• pp.353-364
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• 2021

The gastrointestinal (GI) tract is a series of hollow organs that is responsible for the digestion and absorption of ingested foods and the excretion of waste. Any changes in the GI tract can lead to GI disorders. GI disorders are highly prevalent in the population and account for substantial morbidity, mortality, and healthcare utilization. GI disorders can be functional, or organic with structural changes. Functional GI disorders include functional dyspepsia and irritable bowel syndrome. Organic GI disorders include inflammation of the GI tract due to chronic infection, drugs, trauma, and other causes. Recent studies have highlighted a new explanatory mechanism for GI disorders. It has been suggested that autophagy, an intracellular homeostatic mechanism, also plays an important role in the pathogenesis of GI disorders. Autophagy has three primary forms: macroautophagy, microautophagy, and chaperone-mediated autophagy. It may affect intestinal homeostasis, host defense against intestinal pathogens, regulation of the gut microbiota, and innate and adaptive immunity. Drugs targeting autophagy could, therefore, have therapeutic potential for treating GI disorders. In this review, we provide an overview of current understanding regarding the evidence for autophagy in GI diseases and updates on potential treatments, including drugs and complementary and alternative medicines.

• 운동영양학회지
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• 제24권3호
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• pp.32-38
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• 2020

[Purpose] Sarcopenia is considered one of the major causes of disability in the elderly population and is highly associated with aging. Exercise is an essential strategy for improving muscle health while aging and involves multiple metabolic and transcriptional adaptations. Although the beneficial effects of exercise modalities on skeletal muscle structure and function in aging are well recognized, the exact cellular and molecular mechanisms underlying the influence of exercise have not been fully elucidated. [Methods] We summarize the biochemical pathways involved in the progression and pathogenesis of sarcopenia and describe the beneficial effects of exercise training on the relevant signaling pathways associated with sarcopenia. [Results] This study briefly introduces current knowledge on the signaling pathways involved in the development of sarcopenia, effects of aerobic exercise on mitochondria-related parameters and mitochondrial function, and role of resistance exercise in the regulation of muscle protein synthesis against sarcopenia. [Conclusion] This review suggested that the beneficial effects of exercise are still under-explored, and accelerated research will help develop better modalities for the prevention, management, and treatment of sarcopenia.