• 생명과학회지
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• 제19권9호
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• pp.1183-1189
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• 2009

조팝나무는 목본이며 약용으로 매우 중요하며 우리나라 산림청 지정 보호수종이다. 이 속내 7집단에서 85개체에 대해 ISSR (inter simple sequence repeats) 마커로 이들 집단에 대한 유전적 변이와 집단구조를 조사하였다. 65개의 다형성 좌위와 78개 ISSR 유전자형을 얻었다. 덕유산 집단과 능동산 집단에는 1개체 이상 공유하는 유전자형이 포함되어 있었다. 전체 유전적 다양도는 종수준과 집단수준에서 각각 0.293과 0.183이였다. 집단의 분화($G_{ST}$)는 0.373으로 나타났다. 따라서 전체 변이의 37.3%는 집단 간에 있었다. ISSR 마커로 한국 내 조팝나무 집단의 분화는 잘 분리되어 ISSR로 조팝나무 집단 연구에 유익하며 유전적 다양도와 집단구조의 통찰은 종보전에 대한 기초 정보로 활용할 수 있을 것으로 사료된다.

• ALGAE
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• 제27권3호
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• pp.189-196
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• 2012

Twelve morphological characters and the biochemical composition of Undaria pinnatifida f. distans sporophytes growing on the rocky shores of Jindo and Wando and on cultivation ropes in Kijang were measured to determine whether each population could be characterized by morphological features and biochemical composition. The goal of this study was to compare phenotypic variations between populations as they relate to environmental conditions. The sporophytes of the Kijang population were two times longer and 19 times heavier than those at Jindo. Sporophylls of the Jindo U. pinnatifida population were significantly smaller in length, width, frill number, and weight than those at Wando and Kijang. Kijang Undaria plants showed the highest contents of total protein, crude fiber, total amino acids, the amount of essential amino acids, the proportion of total unsaturated fatty acids, and eicosapentaenoic acid. However, the Jindo population showed the greatest content of carbohydrates, lipids, and minerals (Zn and Ca) of the three U. pinnatifida populations. In particular, Zn content of Jindo plants was 30 times greater than that of Kijang plants. Thus, the proximate composition, mineral composition, amino acids, and fatty acids of Undaria pinnatifida plants were distinguishable among the three representative Undaria populations evaluated. These results suggest that morphological and biochemical differences of the three U. pinnatifida populations can be attributed to differences in environmental conditions of their habitats.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3105-3112
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• 2014

Purpose: To examine breast cancer (BC) incidence trends in relation to mammographic screening and risk factor prevalence in South Australia (SA). Materials and Methods: Trends in annual BC incidence rates were calculated using direct standardisation and compared with projected incidence derived from Poisson regression analysis of pre-screening rates. Annual percentage change and change time points were estimated using Joinpoint software. Biennial mammography screening participation rates were calculated using data from BreastScreen SA. Trends in overweight/obesity, alcohol use and hormone replacement therapy (HRT) use were examined using 1991-2009 Health Omnibus Survey data. Trends in total fertility were examined using data from the Australian Bureau of Statistics. Results: BC incidence increased around the time BreastScreen commenced and then stabilised in the mid-1990s. However rates have remained higher than projected, even though the proportion and age distribution of first time screening attendees stabilised around 1998. A decrease in BC incidence was observed among women aged 50-59yrs from the late-1990's but not among older women. Obesity and alcohol use have increased steadily in all age groups, while HRT use declined sharply from the late-1990s. Conclusions: BC incidence has remained higher than projected since mammography screening began. The sustained elevation is likely to be due to lead time effects, though over-diagnosis cannot be excluded. Declining HRT use has also impacted incidence trends. Implications: Studies using individual level data, which can account for changes in risk factor prevalence and lead time effects, are required to evaluate 'over-diagnosis' due to screening.

• 생명과학회지
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• 제16권6호
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• pp.898-903
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• 2006

한국내 분포하는 장미과의 솜양지꽃(Potentilla discolor Bunge) 15집단에 대한 19 알로자임 대립유전자좌위에서 유전적 다양성과 집단구조를 분석하였다. 조사한 좌위에 대해 약 73.7%가 다형성을 나타내었다. 종과 집단 수준에서 유전적 다양도는 각각 0.215, 0.196이었으며, 집단간 분화정도는 낮았다$(G_{ST}\;=\;0.069)$. 전체 유전적 다양성은 0${\sim}$0.656이며 평균 0.292였다. 유전적 다양도 중 집단내 변이는 높았다$(H_{S}\;=\;0.274)$. 전체 유전적 변이에서 집단간 차이는 Pgm-2에서 0.010, Pgd-2에서 0.261로 평균 0.069였다. 이는 전체 알로자임 변이 중 약 6.9%가 집단간에 있음을 의미한다. 솜양지꽃의 특성으로 광범위한 분포, 다년생 초본, 여러 세대의 존재 등이 높은 유전적 다양성을 나타내는데 기여하는 것으로 설명된다. 조사한 솜양지꽃 집단에서 세대당 이주하는 개체수는 3.36으로 평가되었다.

• Journal of Korean Neurosurgical Society
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• 제62권2호
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• pp.243-255
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• 2019

Objective : Although traumatic brain injury (TBI) occurs in people of all age groups, the elderly population is at a particular risk. The proportion of elderly population in the society is markedly increasing and Korea is one of the most rapidly aging societies. Here, we analyzed the data from 904 patients older over 65 years who were registered in the Korean Neuro-Trauma Data Bank System (KNTDBS). Methods : The Korean Society of Neurotraumatology recorded data from 20 institutions between September 2010 and March 2014. This retrospective study examined the clinical epidemiology, sex difference, outcome epidemiology, sociodemographic variables, and outcomes in the geriatric population related to TBI based on data from the KNTDBS. Results : The study included 540 men and 364 women. The age distributions in the male and female groups were statistically significantly different. The most common cause of trauma was a fall and diagnosis was acute subdural hematoma. The incidence was the highest in men aged 80-84 years and in women aged 75-79 years. The most common time of arrival to hospital after TBI was within 1 hour and 119 rescue team provided first aid earliest to patients with TBI. The mortality rate stratified according to the cause of trauma was significantly different, with mortality rates of 3.77% in fall and 11.65% in traffic accident. The mortality rates according the severity of brain injury, Glasgow Coma Scale score, and treatment were statistically significant. Conclusion : To our knowledge, this study is the first to focus on elderly patients with TBI in Korea and particularly investigate mortality and characteristics related to TBI-related death based on data from the KNTDBS. Although the study has some limitations, our results may be used to obtain useful information to study targeted prevention and more effective treatment options for older TBI patients and establish novel treatment guidelines and health polish for the geriatric population.

• 농촌의학ㆍ지역보건
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• 제35권4호
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• pp.350-360
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• 2010

본 연구는 농어촌 보건지소에서 수행하는 진료실적에 영향을 미치는 관련 요인을 파악하여 향후 보건지소 기능을 활성화할 수 있는 방안을 마련하고자 하였다. 연구의 분석단위는 읍 면 지역에 위치한 보건지소이며, 2009년 12월 31일 현재 설치 운영 중인 1,242개소를 대상으로 하였다. 보건지소간 진료실적의 차이는 지역간 인구의 차이를 보정한 인구당 진료실적을 산출하여 분석하였다. 그 결과 보건지소 진료실적은 관할지역 내 민간 병 의원과 보건진료소가 없는 경우, 보건지소에서 보건소 및 가장 가까운 응급의료기관까지 거리가 먼 경우, 65세 이상 인구 비율이 높을수록 유의하게 많았다. 반면 0-4세 인구 비율과 공중보건의사 인턴 수료자 배치 유무는 유의한 영향요인이 되지 못하였다. 이상의 결과를 보면 읍 면에 소재한 보건지소의 진료실적은 관할지역 인구와 보건의료환경 특성에 의해 유의한 영향을 받고 있어 이러한 특성을 바탕으로 하여 차별화된 서비스 제공전략을 마련할 필요가 있겠다.

• Journal of Ecology and Environment
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• 제44권3호
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• pp.196-206
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• 2020

Background: The Himalayan forests are of great importance to sustain the nature and community resource demands. These forests are facing pressures both from anthropogenic activities and ongoing global climatic changes. Poor natural regeneration has been considered a major problem in mountainous forests. To understand the population structure and regeneration status of Larix (Larix griffithiana and Larix himalaica), we conducted systematic vegetation surveys in three high-altitude valleys namely Ghunsa (Kanchenjunga Conservation Area, KCA), Langtang (Langtang National Park, LNP), and Tsum (Manaslu Conservation Area, MCA) in Nepal Himalaya. The average values of diameter at breast height (DBH), height, and sapling height were compared for three sites and two species using Kruskal-Wallis test. Population structure was assessed in terms of proportion of seedlings, saplings, and trees. Regeneration was analyzed using graphical representation of frequencies of seedlings, saplings, and trees in histograms. Results: The results showed that the population structure of Larix in terms of the proportion of seedling, sapling, and tree varied greatly in the three study areas. KCA had the highest record of seedling, sapling, and tree compared to other two sites. Seedlings were the least among three forms and many plots were without seedlings. We found no seedling in MCA study plots. The plot level average DBH variation among sites was significant (Kruskal-Wallis χ² = 7.813, df = 2, p = 0.02) as was between species (Kruskal-Wallis χ² = 5.9829, df = 1, p = 0.014). Similarly, the variation in average tree height was significant (Kruskal-Wallis χ² = 134.23, df = 2, p < 0.001) among sites as well as between species (Kruskal-Wallis χ² = 128.01, df = 1, p < 0.001). All the sites showed reverse J-shaped curve but more pronounced for KCA and MCA. In comparing the two species, Larix griffithiana has clear reverse J-shaped diameter distribution but not Larix himalaica. Conclusion: The varied responses of Larix manifested through regeneration status from spatially distinct areas show that regeneration limitations might be more pronounced in the future. In all the three studied valleys, regeneration of Larix is found to be problematic and specifically for Larix griffithiana in MCA and Larix himalaica in LNP. To address the issues of disturbances, especially serious in LNP, management interventions are recommended to sustain the unique Himalayan endemic conifer.

• 한국인구학
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• 제24권1호
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• pp.149-182
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• 2001

인구고령화가 전세계적인 화두로 등장하는 이유는 사회가 공동으로 해결해야 할 복지욕구는 증대하는 한편, 이로 인한 사회적 부양부담의 증가는 경제적 생산력이 정체되고 있는 상황에서 인류사회의 지속 가능한 발전에 심각한 의문을 던져주기 때문이다. 특히 우리 나라는 인구고령화의 속도가 선진국에 비하여 매우 빠르게 가속적으로 진행되고 있으므로 효과적으로 대응하기 위해서는 보다 효과적이고 신축적인 경제사회시스템을 만들지 않으면 안된다. 특히 인구고령화 시대에도 지속 가능한 소득보장 체계의 확립은 무엇보다도 긴요하다. 본 논문은 노령화시대의 핵심과제라고 할 수 있는 \`소득보장\` 을 중심으로 개선방안을 제시해 보고자 하였다. 이를 위하여 먼저 노령화와 관련된 각종 경제·사회여건 변화 분석 및 현재 노인들의 소득원을 살펴보고(II 장), 현재의 공·사적연금제도의 문제점과 개선의 기본방향을 정리하며(III장), 공적연금제도의 개선방안에 대한 검토하고 (IV장), 마지막으로 퇴직금 등 사적 연금제도의 개선방안(V장)을 제시하고 있다. 본 논문은 현행 공적연금체계를 다층체계로 전환할 것을 제안하고 있다. 제1층은 전국민 1인 1 연금체계를 구축하여 기초연금을 지급하도록 하며, 제2층은 소득비례 공적 연금을 구축하며, 3층은 퇴직금, 기업연금, 개인연금의 민간 자율의 저축제도의 구축을 제안하고 있다. 이를 통하여 연금재정 안정화, 세대간·세대내 소득재분배의 적정화, 연금 사각지대의 해소가 가능하게 되어 인구노령화시대에 보다 효과적으로 대응할 수 있을 것으로 판단한다.

• Fisheries and Aquatic Sciences
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• 제5권1호
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• pp.59-63
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• 2002

Swim up fry of the Nile tilapia, Oreochromis niloticus, were fed 0 or 60 mg l7-methyltestos­terone (MT) per kg feed for 30 days. Fish that had been fed 0 or 60 ppm MT for the first 30 days were subsequently fed a commercial diet for 56 weeks to evaluate growth, survival, sex ratio, body composition, gonadosomatic index and the total edible portion. Mean body weight of MT treated group and untreated group were 1.7 g and 1.1 g, respectively at the end of the treatment for 30 days $(P<0.05)$. The experiment was terminated after a total of 60 weeks, the mean body weight of the MT treated population was 1,016 g and that of the untreated population was 762g $(P<0.05)$. However, the final mean body weight of untreated males (l, 086g) was not significantly different from treated males (l,016 g), but the mean body weight of the female group was 512 g. Therefore, the reason for the lower mean body weight of the untreated group was entirely due to stunted females. The percentage fillet yield of MT treated fish$(34.6\%)$ was not significantly different from that of the untreated males $(34.4\%)$, but the untreated females were lower than those of both treated and untreated male groups $(32.4\%)$ (P<0.05). There were no significant differences in the percentage of the all edible portion (AP) between MT treated and untreated males, but females were lower than males. Females are smaller fish in size and the gonads are larger in proportion which were discarded along with the intestine this explains the observed difference. Total biomass of the two groups were 134.8kg and 104.5kg per $m^3$, respectively. The proportion of fish reaching a marketable size of over 800 g in body weight within 14 months were $78\%$ in the MT treated group and $41\%$ in the untreated group.

• 대한한방내과학회지
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• 제39권4호
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• pp.751-763
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• 2018

Objective: This study was undertaken to investigate how magnolia bark extract affects ob/ob mouse in terms of metabolic inflammation and insulin resistance. Methods: Leptin-deficient ob/ob mice were divided into 2 groups (n=5): a normal saline treatment (=control) and magnolia bark treatment. Wild type mice were the lean group (n=5). After 5 weeks, we measured fasting blood sugar (FBS) and conducted oral glucose tolerance tests (OGTTs) in each group. After 6 weeks, we measured body weight, epididymal fat pad weight, liver weight, serum glucose, serum insulin, and gene expression of tumor necrosis factor-${\alpha}$, interferon-${\gamma}$, and interleukin-6. We characterized the phenotype of adipose tissue macrophages (ATMs) and analyzed fractions of the phenotype in each group by flow cytometry. Results: In the magnolia bark group, fasting blood sugar, oral glucose tolerance levels, and insulin resistance (HOMA-IR) were significantly decreased. The population and proportion of ATMs among leukocytes in adipose tissue were significantly decreased in the magnolia bark group. The population and proportion of M1 type ATMs among ATMs were significantly decreased in the magnolia bark group. Gene expression of tumor necrosis factor-${\alpha}$ was significantly decreased in the magnolia bark group. Conclusions: These results support a positive effect of magnolia bark on metabolic diseases such as insulin resistance and metabolic inflammation in leptin-deficient ob/ob mice.